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| 1 | Poly IC pretreatment suppresses B cell-mediated lupus-like autoimmunity through induction of Peli1显示文摘 | Yan Wang Jia Yuan Dongfang Dai Junli Liu Jing Xu Xiang Miao Huan Wang Chaoming Mao Yichuan Xiao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 3 |
| 2 | GA Associated Dwarf 5 encodes an ent-kaurenoic acid oxidase required for maize gibberellin biosynthesis and morphogenesis显示文摘Gibberellin(GA)functions in plant growth and development.However,genes involved in the biosynthesis and regulation of GA in crop plants are poorly understood.We isolated the mutant gad5-1(GAAssociated Dwarf 5),characterized by dwarfing,short internodes,and dark green and short leaves.Map-based gene cloning and allelic verification confirmed that ZmGAD5 encodes ent-kaurenoic acid oxidase(KAO),which catalyzes KA(ent-kaurenoic acid)to GA12 conversion during GA biosynthesis in maize.ZmGAD5 is localized to the endoplasmic reticulum and is present in multiple maize organs.In gad5-1,the expression of ZmGAD5 is severely reduced,and the levels of the direct substrate of KAO,KA,is increased,leading to a reduction in GA content.The abnormal phenotype of gad5-1 was restored by exogenous application of GA3.The biomass,plant height,and levels of GA12 and GA3 in transgenic Arabidopsis overexpressing ZmGAD5 were increased in comparison with the corresponding controls Col-0.These findings deepen our understanding of genes involved in GA biosynthesis,and could lead to the development of maize lines with improved architecture and higher planting-density tolerance. | Zuliang Li Baozhu Li Junli Zhang Hongliang Wang Mao Wang Siyi Guo Pengtao Wang Zhi Li David WGalbraith Dandan Li Chun-Peng Song | 2023 | The Crop Journal2023，11，6： | 1 |
| 3 | Quantitative Analysis on Shale Oil Accumulations Conditions for 4th Member of Shahejie Formation in Liaohe Western Depression显示文摘The 4th member of Shahejie Formation in Liaohe Western Depression had experienced rapid subsidence,which resulted into massive shale with the characteristics of high organic matter abundance and sapropelic kerogen.Most shale samples have the total organic carbon(TOC)over 2%,and the value can excess 4%for dolomitic shale | JING Tieya HUANG Xiao SUN Rui MAO Junli ZHANG Jian | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 0 |
| 4 | Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation显示文摘Excessive inflammatory responses contribute to the pathogenesis and lethality of highly pathogenic human coronaviruses,but the underlying mechanism remains unclear.In this study,the N proteins of highly pathogenic human coronaviruses,including severe acute respiratory syndrome coronavirus(SARS-CoV),middle east respiratory syndrome coronavirus(MERS-CoV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),were found to bind MASP-2,a key serine protease in the lectin pathway of complement activation,resulting in excessive complement activation by potentiating MBL-dependent MASP-2 activation,and the deposition of MASP-2,C4b,activated C3 and C5b-9.Aggravated inflammatory lung injury was observed in mice infected with adenovirus expressing the N protein.Complement hyperactivation was also observed in SARS-CoV-2-infected patients.Either blocking the N protein:MASP-2 interaction,MASP-2 depletion or suppressing complement activation can significantly alleviate N protein-induced complement hyperactivation and lung injury in vitro and in vivo.Altogether,these data suggested that complement suppression may represent a novel therapeutic approach for pneumonia induced by these highly pathogenic coronaviruses. | Ting Gao Lin Zhu Hainan Liu Xiaopeng Zhang Tingting Wang Yangbo Fu Hongzhen Li Qincai Dong Yong Hu Zhang Zhang Jing Jin Zijing Liu Weihong Yang Yaoning Liu Yanwen Jin Kaitong Li Yongjiu Xiao Junli Liu Huailong Zhao Yue Liu Ping Li Jibo Song Lu Zhang Yuwei Gao Sisi Kang Shoudeng Chen Qingjun Ma Xiuwu Bian Wei Chen Xuan Liu Qing Mao Cheng Cao | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 0 |
| 5 | Al-modification for PS-PVD 7YSZ TBCs to improve particle erosion and thermal cycle performances显示文摘Plasma spray-physical vapor deposition(PS-PVD)as a novel process was used to prepare feather-like columnar thermal barrier coatings(TBCs).This special microstructure shows good strain tolerance and non-line-of-sight(NLOS)deposition,giving great potential application in aero-engine.However,due to serious service environment of aero-engine,particle erosion performance is a weakness for PS-PVD 7YSZ TBCs.As a solution,an Al-modification approach was proposed in this investigation.Through in-situ reaction of Al and ZrO2,anα-Al2O3 overlay can be formed on the surface of 7YSZ columnar coating.The results demonstrate that this approach can improve particle erosion resistance since hardness improvement of Al-modified TBCs.Meanwhile,as another important performance of thermal cycle,it has a better optimization with 350-cycle water-quenching,compared with the as-sprayed TBCs. | Xiaofeng ZHANG Ming LI Ao ZHANG Shuangquan GUO Jie MAO Chunming DENG Panpan WANG Changguang DENG Junli FENG Min LIU Kesong ZHOU Cheng LAI | 2022 | Journal of Advanced Ceramics2022，11，7： | 0 |
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