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| 1 | Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes显示文摘Macro and microvascular disease are the main cause of morbi-mortality in type 1 diabetes(T1DM).Although there is a clear association between endothelial dysfunction and atherosclerosis in type 2 diabetes,a cause-effect relationship is less clear in T1 DM.Although endothelial dysfunction(ED) precedes atherosclerosis,it is not clear weather,in recent onset T1 DM,it may progress to clinical macrovascular disease.Moreover,endothelial dysfunction may either be reversed spontaneously or in response to intensive glycemic control,long-term exercise training and use of statins.Acute,long-term and post-prandial hyperglycemia as well as duration of diabetes and microalbuminuria are all conditions associated with ED in T1 DM.The pathogenesis of endothelial dysfunction is closely related to oxidative-stress.NAD(P)H oxidase over activity induces excessive superoxide production inside the mitochondrial oxidative chain of endothelial cells,thus reducing nitric oxide bioavailability and resulting in peroxynitrite formation,a potent oxidant agent.Moreover,oxidative stress also uncouples endothelial nitric oxide synthase,which becomes dysfunctional,inducing formation of superoxide.Other important mechanisms are the activation of both the polyol and protein kinase C pathways as well as the presence of advanced glycation end-products.Future studies are needed to evaluate the potential clinical applicability of endothelial dysfunction as a marker for early vascular complications in T1 DM. | Marcello C Bertoluci Gislaine V Cé Antonio MV da Silva Marco V Wainstein Winston Boff Marcia Punales | 2015 | World Journal of Diabetes2015，6，5： | 5 |
| 2 | Prehnite-pumpellyite ~acies metamorphism in the Cenozoic Abanico Formation,Andes of central Chile (33~50'S) :chemical and scale controls on mineral assemblages, reaction progress and the equilibrium state显示文摘 | Marcia M Luis /~ Mario V | 2010 | Andean Geology2010，37，1： | 1 |
| 3 | Methyl tert-butyl ether biodegradation by microbial consortia obtained from soil samples of gasoline-polluted sites in Mexico显示文摘 | Marcia M Elia V Janet J | 2004 | Biotechnology Letters2004，26，3： | 1 |
| 4 | Time-resolved fluorescence spectroscopy of cationic dyes incor- porated in silica matrix by high pressure compaction 显示文摘 | Marcelo H Gehlen Robson V Pereira Marcia R Gallas | 2006 | Jour- nal of Photochemistry and Photobiology A: Chemistry2006，181，： | 1 |
| 5 | Blog functions as risk and crisis communication during Hurricane Katrina 显示文摘 | Marcias W Hilyard K Freimuth V | 2009 | Journal of Computer-Mediated Communication2009，15，1： | 1 |
| 6 | Implementing the Collaborative Care Model as Part of a Countywide Initiative显示文摘 | Marcia V Gregory WD Teague S | 2016 | Psychiatr Serv2016，，： | 1 |
| 7 | Polyphenols of selected peach and plum genotypes reduce cell viability and inhibit proliferation of breast cancer cells while not affecting normal cells显示文摘 | Marcia V Weston P David B | 2014 | Food Chemistry2014，164，： | 1 |
| 8 | Cancer nursing appletion and lange a pub lishing division of pretice Hall Printed in the United States of A- merica显示文摘 | Marcia M Geraldine V | 1990 | Int cancer J1990，83，： | 1 |
| 9 | Women's knowledge of congenital cytomegalovirus: Results from the 2005 heahhstyles^TM survey 显示文摘 | Danielle SR Marcia V Esther S | 2008 | J Womens Health2008，17，5： | 1 |
| 10 | Arsenic-induced alteration in the expression of genes related to type 2 diabetes mellitus显示文摘 | Andrea D V Anna L B Marcia H | 2007 | Toxicology and Applied Pharmacology2007，225，2： | 1 |
| 11 | Methyl tert-butyl ether biodegradation by microbial consortia obtained from soil samples of gasoline-polluted sites in Mexico显示文摘 | Marcia M Elia V Janet J | 2004 | Biotechnology Letters2004，26，： | 1 |
| 12 | Determination of chlorine, bromine and iodine in milksamples by ICP-OES 显示文摘 | Juliana N Marcia A Mesquita S Pedro V Elisabeth 0 | 2003 | Journal of Analytical AtomicSpectrometry2003，18，： | 1 |
| 13 | Rat Liver NAD(P)H:Quinone Reductase显示文摘 | Richard M B Marcia R M Leonard V F ct al | 1989 | The Journal of Biological Chemistry1989，264，21： | 1 |
| 14 | A globally convergent filter method for nonlinear programming 显示文摘 | CLOVIS G C ELIZABETH K MARCIA V | 2003 | SIAM Journal on Optimization2003，14，3： | 1 |
| 15 | Structure,properties and applications of rhamnolipidsproduced by Pseudomonas aeruginosa L2-1 from cassavawastewater显示文摘 | Siddhartha G V A O Costa Marcia Nitschke Francois Lépine etal | 2010 | Process Biochemistry2010，45，： | 1 |
| 16 | Evolution of Pre-Columbian Metallurgy from the North of Peru Studied with a Portable Non-invasive Equipment Using Energy-Dispersive X-Ray Fluorescence显示文摘 | Roberto Cesareo Angel Bustamante D Julio Fabian S Sandra Zambrano A Walter Alva Luis Chero del Carmen Espinoza C Rosendo Rodriguez R Marco Seclen F Fidel Gutierrez V E.B. Ldvano Gonzales A. Marcia A. Rizzutto Enrico Poli Cristiane Calza Marcelino dos Anjos Ricardo T. Lopes Giovanni E. Gigante Gabriel M. Ingo Cristina Riccucci Carlos Elera Izumi Shimada Victor Curay Castillo G and Fabio Lopes | 2011 | 材料科学与工程(中英文B版)2011，1，1： | 0 |
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