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| 1 | Intravitreal dexamethasone implants for diabetic macular edema显示文摘AIM: To evaluate the safety and efficacy of a dexamethasone(DEX) intravitreal implant for diabetic macular edema(DME).METHODS: Totally 113 eyes of 84 patients were divided in three subgroups: naive patients(n=11), pseudophakic patients(n=72) and phakic patients(n=30). Inclusive criterion comprised adult diabetic patients with central fovea thickening and impaired visual acuity resulting from DME for whom previous standard treatments showed no improvement in both central macular thickness(CMT) and best corrected visual acuity(BCVA) after at least 3 mo of treatment. Outcome data were obtained from patient visits at baseline and at months 1, 3, 5, 9 and 12 after the first DEX implant injection. At each of these visits, patients underwent measurement of BCVA, a complete eye examination and measurement of CMT and macular volume(MV) carried out with optical coherence tomography(OCT) images. RESULTS: Seventy-three eyes(64.5%) received a single implant, 30(26.5%) received two implants and 10(9%) received three implants. At baseline, average in BCVA, CMT and MV were 43.5±20.8, 462.8±145 and 12.6±2.5 respectively. These values improved significantly at 1 mo(BCVA: 47.2±19.5, CMT: 339.6±120, MV: 11.11±1.4) and 3 mo(BCVA: 53.2±18.1, CMT: 353.8±141, MV: 11.3±1.3)(P≤0.05). At 5 mo(BCVA: 50.9±19.8, CMT: 425±150, MV: 12.27±2.3), 9 mo(BCVA: 48.4±17.6, CMT: 445.5±170, MV: 12.5±2.3) and 12 mo(BCVA: 47.7±18.8, CMT: 413.2±149, MV: 12.03±2.5), improvements in the three parameters were no longer statistically significant and decreased progressively but did not reach baseline values. There were no clinical differences between subgroups. Ocular complications were minimal.CONCLUSION: Patients with DEX implants show maximum efficacy at 3 mo which then declined progressively, but is still better than baseline values at the end of follow-up. | Alicia Pareja-Ríos Paloma Ruiz-de la Fuente-Rodríguez Sergio Bonaque-González Maribel López-Gálvez Virginia Lozano-López Pedro Romero-Aroca | 2018 | International Journal of Ophthalmology(English edition)2018，11，1： | 8 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Minimal processing of a Granny Smith apple puree by microwave heating显示文摘 | PIERRE A P ANDREAS L MARIBEL A | 2009 | Innovative Food Science and Emerging Technologies2009，10，4： | 1 |
| 4 | Antioxidant response of rice seedlings to salinity stress显示文摘 | Dionisio S Maribel L Tobita S | 1998 | Plant Science1998，135，1： | 1 |
| 5 | Changes in photosynthetic characteristics induced by transferring air-grown cells of Chlorococcum littorale to high-CO2 conditions显示文摘 | Iskra Pesheva Minoru Kodama Maribel L | 1994 | Plant Cell Physiol1994，35，3： | 1 |
| 6 | Changes in endocarmabinoid transmission in the basal ganglia in a rat model of Huntington's disease显示文摘 | Isabel L Filomena F Maribel C | 2001 | Neuroreport2001，12，10： | 1 |
| 7 | Antioxidant responses of rice seedlings to salinity stress显示文摘 | DIONISIO S MARIBEL L | 1998 | Plant Science1998，135，： | 1 |
| 8 | Epitope specificity of protective lactogenic immunity against swine transmissible gastroenteritis virus显示文摘 | Maribel D D Maria D L Luis E | 1992 | Virology1992，11，66： | 1 |
| 9 | Importance of telemedicine in diabetes care: Relationships between family physicians and ophthalmologists显示文摘Diabetic retinopathy(DR) is the worldwide leading cause of legal blindness. In 2010, 1.9% of diabetes mellitus(DM) patients were legally blind and 10.2% had visual impairment. The control of DM parameters(glycemia, arterial tension and lipids) is the gold standard for preventing DR complications, although, unfortunately, DR still appeared in a 25% to 35% of patients. The stages of severe vision threading DR, include proliferative DR(6.96%) and diabetic macular edema(6.81%). This review aims to update our knowledge on DR screening using telemedicine, the different techniques, the problems, and the inclusion of different professionals such as family physicians in care programs. | Pedro Romero-Aroca Ramon Sagarra-Alamo Alicia Pareja-Rios Maribel López | 2015 | World Journal of Diabetes2015，6，8： | 1 |
| 10 | Mode of chemical-degradation of s-triazines by montmorillonite显示文摘 | RUSSELL J D MARIBEL C WHITE J L | 1968 | Science1968，160，： | 1 |
| 11 | Antioxidant responses of rice seedlings to salinity stress显示文摘 | Maribel L Dionisio S Satoshi T | 1998 | Plant Science1998，135，： | 1 |
| 12 | Antioxidant response of rice seedings to salinity stress显示文摘 | MARIBEL L DIONISIO S S SATOSHI T | 1998 | Plant Seienee1998，135，： | 1 |
| 13 | Antioxidant responses of rice seedlings to salinity stress显示文摘 | Maribel L Dionisio-Sese Satoshi Tobita | 1998 | Plant Science1998，135，： | 1 |
| 14 | Antioxidant response of rice seedlings to salinity stress显示文摘 | DIONISIO S MARIBEL L TOBITA S | 1998 | Plant Science1998，135，： | 1 |
| 15 | Effect of hydrothermal treatment on physicochemical and digestibility properties of oat starch显示文摘 | MARIBEL O M KRISTIN W BRADLEY L R | 2013 | Food Research International2013，52，1： | 1 |
| 16 | Yield Gap Analysis between Dry and Wet Season Rice Crop Grown under High-Yielding Management Conditions显示文摘 | Yang Woonho Peng Shaobing Laza Rebecca C Visperas Romeo M Dionisio-Sese Maribel L | 2008 | Agronomy Journal2008，，5： | 1 |
| 17 | Grain filling duration, acrucial determinant of genotypic variation of grain yield in field- grown tropical irrigated rice显示文摘 | Woonho Y Shaobing P Maribel L D | 2008 | Field Crops Research2008，105，3： | 1 |
| 18 | Antioxidant responses of rice seedlings to salinity stress显示文摘 | Maribel L Dionisio-Sese Satoshi T | 1998 | Plant Science1998，135，： | 1 |
| 19 | Antioxidant responses of rice seedlings to salinity stress显示文摘 | DIONISIO-SESE MARIBEL L TOBITA S | 1998 | Plant Science1998，135，： | 1 |
| 20 | Antioxidant responses of rice seedlings to salinity stress显示文摘 | Maribel L Dionisio-Sese Satoshi Tobita | 1998 | Plant Science1998，，1： | 1 |
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