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| 1 | IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treat- ment of Cancer Brain Tumor Group显示文摘 | van den Bent M J Dubbink HJ Marie Y Brandes AA Taphoorn MJ Wesseling P Frenay M Tijssen CC Lacombe D ldbaih A van Marion R Kros JM Dinjens WN Gorlia T. Sanson M. | 2010 | 中国神经肿瘤杂志2010，8，1： | 22 |
| 2 | Reduced expression ofβ-catenin inhibitor Chibby in colon carcinoma cell lines显示文摘AIM: To analyse the Chibby expression and its function in colon carcinoma cell lines and colorectal carcinoma (CRC). METHODS: Chibby expression levels were investigated by quantitative RT-PCR in a panel of seven different colon carcinoma cell lines. By sequencing, we analysed mutational status of Chibby. To test whether Chibby exhibited effects onβ-catenin signalling in colon carcinoma cells, we transfected SW480 cells with Chibby expression plasmid and, subsequently, analysed activity of p-catenin and tested for alterations in cellular phenotype. In addition, we examined Chibby mRNA levels in samples of colorectal carcinomas and adjacent normal tissues by using quantitative RT-PCR and hybridised gene chips with samples from CRC and normal tissues. RESULTS: Chibby mRNA expression was strongly down-regulated in colon carcinoma cell lines in comparison to normal colon epithelial cells and no mutation in any of the examined colon carcinoma cell lines was found. Further, we could show that Chibby inhibited p-catenin activity in TOPflash assays when over-expressed in SW480 cells. Proliferation and invasion assays with Chibby transfected SW480 cells did not reveal profound differences compared to control cells. In contrast to these in vitro data, quantitative RT-PCR analyses of Chibby mRNA levels in CRC tumor samples did not show significant differences to specimens in adjacent non-cancerous tissue. Consistent with these findings, gene chips analysing tissue samples of tumors and corresponding normal tissue did not show altered Chibby expression CONCLUSION: Altered Chibby expression might be observed in vitro in different colon carcinoma cell lines. However, this finding could not be confirmed in vitro in CRC tumors, indicating that Chibby is not likely to promote CRC tumor development or progression. As Chibby is an important inhibitor ofβ-catenin signalling, our data implicate that the usability of colon carcinoma cell lines for in vitro studies analysing the Wnt/β-catenin pathway in colorectal carcinoma needs extensive verification. | Marion M Schuierer Elisabeth Graf Ken-Ichi Takemaru Wolfgang Dietmaier Anja-Katrin Bosserhoff | 2006 | World Journal of Gastroenterology2006，12，10： | 5 |
| 3 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 4 | Essential oil of Eupatorium odoratum显示文摘 | BAMBA D BESSIER J M MARION C | 1993 | Planta Medica1993，59，2： | 2 |
| 5 | Therapeutic efficiency of everolimus and lapatinib in xenograft model of human colorectal carcinoma with KRAS mutation显示文摘 | Céline Chu Marie‐Sophie No?l‐Hudson Valérie Boige Diane Goéré Sylvie Marion Mélanie Polrot Ludovic Bigot Patrick Gonin Robert Farinotti Laurence Bonhomme‐Faivre | 2013 | Fundamental & Clinical Pharmacology2013，，4： | 2 |
| 6 | The role of XRCC1 polymorphisms in base excision repair of etheno-DNA adducts in French vinyl chloride workers 显示文摘 | Li Y Marion M J Zipprich J | 2006 | Int J Occup Med Environ Health2006，19，1： | 1 |
| 7 | Search for the Variation of Fundamental Constants Using Atomic Fountains显示文摘 | Marion H Pereira Dos Santos F Abgrall M | 2003 | Phys Rev Lett2003，90，15： | 1 |
| 8 | Self-extubation risk assessment tool:predictive validity in a real-life setting显示文摘 | Philip M Marion B Patrick F | 2008 | Nursing in Critical Care2008，13，6： | 1 |
| 9 | Chemotherapy augments TRAIL-induced apoptosisi in breast cell lines显示文摘 | Maccon M Kane Seth A Ertenberg Marion M Nau | 1999 | Cancer Research1999，59，3： | 1 |
| 10 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding 显示文摘 | Marion M Bradford | 1976 | Analytical Biochemis- try1976，72，12： | 1 |
| 11 | Search for variations of fun- damental constants using atomic tountain clocks显示文摘 | Marion H Pereira D S F Abgrall M | 2003 | Physical Review Letters2003，90，15： | 1 |
| 12 | Bedside fluoroscopic flexion and extension cervical spine radiographs for clearance of the cervi cal spine in comatose trauma patients 显示文摘 | Bolinger B Shartz M Marion D | 2004 | J Trauma2004，56，1： | 1 |
| 13 | 显示文摘 | Marion M Bradford | 1976 | Analytical Biochemistry1976，72，： | 1 |
| 14 | Current and future role of ther- apeutic hypothermia 显示文摘 | Marion D Bullock M R | 2009 | J Neurotrauma2009，26，3： | 1 |
| 15 | A betaarrestin 2 signaling complex mediates lithium action on behavior显示文摘 | Beaulieu J M Marion S Rodriguiz R M | 2008 | Cell2008，132，1： | 1 |
| 16 | Real-time reverse transcription PCR analysis of expression of atrazine catabolism genes in two bacterial strains isolated from soil 显示文摘 | Marion D Guy S Fabrice M L | 2004 | Journal of Microbiological Methods2004，56，1： | 1 |
| 17 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding 显示文摘 | Marion M Bradford | 1976 | Analytical Biochem- istry1976，72，12： | 1 |
| 18 | A rapid sentative method for the quantitiation of microgram quantities of protein utilizing the principle of protein-dye binding显示文摘 | Marion M Bradford | 1976 | Analytical Biochemistry1976，72，： | 1 |
| 19 | Studies on the ignitionand burning of levitated aluminum particles 显示文摘 | Marion M Chauveau C Gokalp I | 1996 | Combustion Science and Technology1996，115，456： | 1 |
| 20 | Histopathology of profound sensorineural deafness 显示文摘 | Hinojosa R Marion M | 1983 | Ann New York Acad of Sci1983，405，： | 1 |
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