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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017,17,15: | 37 |
| 2 | Rectal nitric oxide as biomarker in the treatment of inflammatory bowel disease: Responders versus nonresponders显示文摘瞄准:探索直肠的氮的氧化物(没有) 作为处理的简历标记,在 ulcerative (UC ) 和 Crohn 的反应是疾病(CD ) ,并且检验在之间的关系直肠没有,没有 synthases (NOS ) 的粘膜表示,和支持 inflammatory cytokines。方法:有 UC 的 22 个病人并且 24 在类固醇治疗期间与 CD 被监视。直肠没有层次被测量,临床的活动在天被估计 1, 3, 7 和 28。NOS 和支持 inflammatory cytokines 的粘膜存在被免疫组织化学和 RT-PCR 分析。结果:显著地显示的活跃 UC 和 CD 增加了直肠没有层次(10950 +/- 1280 每十亿分开的 7610 和 5040 +/-(ppb ) ,分别地) 作为与控制相比(154 +/- 71 ppb, P <
0.001 ) 。直肠不在 UC 和 CD 与疾病活动微弱地相关(r = 0.34 为 UC 和 r = 0.48 为 CD, P <
0.01 ) 。在 12 个病人,一堂类固醇倔强的功课导致了结肠切除术。仅仅稍微有的这些病人没增加层次(UC:620 +/- 270 ppb;CD:1260 +/- 550 ppb ) 与那些相比与治疗学的回答(UC:18860 +/- 530 ppb, P <
0.001;CD:10060 +/- 3200 ppb, P <
0.05 ) 。结论:直肠没有水平是在是的 IBD 的治疗反应的一个有用简历标记低没有层次预言差的临床的回答到类固醇治疗。 | Tryggve Ljung Sofie Lundberg Mark Varsanyi Catharina Johansson Peter T Schmidt Max Herulf Jon O Lundberg Per M Hellstr(o|¨)m | 2006 | World Journal of Gastroenterology2006,12,21: | 10 |
| 3 | Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study显示文摘 | William C Huang Andrew S Levey Angel M Serio Mark Snyder Andrew J Vickers Ganesh V Raj Peter T Scardino Paul Russo | 2006 | Lancet Oncology2006,,9: | 4 |
| 4 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017,20,11: | 2 |
| 5 | Large Molecular Hyperpolarizabilities. Quantitative Analysis of Aromaticity and Auxiliary Donor-Acceptor Effects显示文摘 | Albert I D L Marks T J Ratner M A | | 0,,: | 2 |
| 6 | Telangiectatic osteosarcoma:radiologic-pathologic comparison显示文摘 | Mark D M Suphanee wan Jaovisidha H Thomas T | 2003 | Radiology2003,229,: | 1 |
| 7 | Effect of yttrium and lanthanum on the final-stage sintering behavior of ultrahigh-purity alumina 显示文摘 | Fang Jinxin Mark T A Harmer M P | 1997 | Journal of the American Ceramic Society1997,80,8: | 1 |
| 8 | On the 'downward control'of the extratropical diabatic circulations by eddy-induced mean zonal forces显示文摘 | Haynes P H M E Marks T G Shepherd | 1991 | J Atmos Sci1991,48,: | 1 |
| 9 | Anisotropic effects on the strain rate dependence of a wrought magnesium alloy 显示文摘 | MATTHEW T T MARK F H PHILLIP M G HAITHAM E K WILBURN R W | 2009 | Scripta Materialia2009,60,: | 1 |
| 10 | A 4Ar/39 Ar and U/Pb isotopic study of the Ilimaussaq complex, South Green- land: Implications for the 40K decay constant and for the'dura- tion of magmatic activity in a peralkaline complex显示文摘 | Krumrei T V Villa I M Marks M A W | 2006 | Chemical Geology2006,227,: | 1 |
| 11 | Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase显示文摘 | Aino Soro-Paavonen Wei-Zeng Zhang Kylie Venardos Melinda T Coughlan Emma Harris David CK Tong Daniella Brasacchio Karri Paavonen Jaye Chin-Dusting Mark E Cooper David Kaye Merlin C Thomas Josephine M Forbes | 2010 | Journal of Hypertension2010,,4: | 1 |
| 12 | In situ intercalative polymerization of pyrrole in FeOCl: a new class of layered, conducting polymer-inorganic hybrid materials 显示文摘 | Kanatzidis M G Tonge L M Marks T J | 1987 | J Am Chem Soc1987,109,12: | 1 |
| 13 | Bis(oxazoline)-copper complexes as chiral catalysts for the enantioselective aziridination of olefins 显示文摘 | DAVID A EVANS MARGARET M MARK T | 1993 | J Am Chem Soc1993,115,12: | 1 |
| 14 | Process requirements for achieving full-flow disinfection of recirculating water using ozonation and UV irradiation 显示文摘 | STEVEN T S MARK J S SCOTT M T | 2009 | Aquacuhural Engineering2009,40,1: | 1 |
| 15 | The COP9 Complex, a Novel Multisubunit Nuclear Regulator Involved in Light Control of a Plant Developmental Switch显示文摘 | Daniel A Chamovitz Ning Wei Mark T Osterlund Albrecht G von Arnim Jeffrey M Staub Minami Matsui Xing-Wang Deng | 1996 | Cell1996,,1: | 1 |
| 16 | Commemorative:Francisco Varela (,1946 -,2001)显示文摘 | Marks - Tarlow T Martinez M | | 0,,02: | 1 |
| 17 | Threedimensional High-resolution Second-harmonic Generation Imaging of Endogenous Structural Proteins in Biological Tissues 显示文摘 | CAMPAGNOLA P J ANDREW C M MARK T | 2002 | Biophys J2002,81,1: | 1 |
| 18 | 显示文摘 | ALBERT D L MARKS T J RATNER M A | 1997 | J Am Chem Soc1997,119,28: | 1 |
| 19 | Step returns in threshold public goods: A meta -analysis and experimental analysis显示文摘 | Croson R T A M B Marks | 2000 | Experi- mental Economics2000,2,: | 1 |
| 20 | Using plasma transforming growth factor beta-1 during radiotherapy to select patients for dose escalation显示文摘 | Anscher M S Marks L B Shafman T D | | 0,,17: | 1 |