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| 1 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 2 | Human iPS Cells Loaded with MnO2-Based Nanoprobes for Photodynamic and Simultaneous Enhanced Immunotherapy Against Cancer显示文摘How to trigger strong anti-tumor immune responses has become a focus for tumor therapy.Here,we report the human-induced pluripotent stem cells(iPSs)to deliver MnO2@Ce6 nanoprobes into tumors for simultaneous photodynamic therapy(PDT)and enhanced immunotherapy.Ce6 photosensitizer was attached on manganese dioxide(MnO2)nanoparticles,and resultant MnO2@Ce6 nanoprobes were delivered into mitomycin-treated iPSs to form iPS-MnO2@Ce6 nanoprobes.The iPS-MnO2@Ce6 actively targeted in vivo tumors,the acidic microenvironment triggered interaction between MnO2 and H2O2,released large quantities of oxygen,alleviated hypoxia in tumor.Upon PDT,singlet oxygen formed,broken iPSs released tumor-shared antigens,which evoked an intensive innate and adaptive immune response against the tumor,improving dendritic cells matured,effector T cells,and natural killer cells were activated.Meanwhile,regulatory T cells were reduced,and then the immune response induced by iPS-MnO2@Ce6 was markedly stronger than the immune reaction induced by MnO2@Ce6(P<0.05).The iPS-MnO2@Ce6 markedly inhibited tumor growth and metastasis and reduced mortality in mice models with tumor.Human iPS s loaded with MnO2-based nanoprobes are a promising strategy for simultaneous PDT and enhanced immunotherapy against tumor and own clinical translational prospect. | Yanlei Liu Jingxing Yang Bin Liu Wen Cao Jingpu Zhang Yuming Yang Lijun Ma Jesus Martinez de la Fuente Jie Song Jian Ni Chunfu Zhang Daxiang Cui | 2020 | Nano-Micro Letters2020，12，10： | 2 |
| 3 | Primary cutaneous large B-cell lymphoma: the relation between morphology, clinical presentation, immunohistochemical markers,and survival显示文摘 | Fernandez-Vazquez A Rodriguez-Peralto JL Martinez MA | 2001 | Am J Surg Pathol2001，25，3： | 1 |
| 4 | Effect of natural and synthetic antioxidants on the oxidative stability of walnut oil under different storage conditions 显示文摘 | Marcela L Martinez Ma Cecilia Penci Vanesa Ixtaina | 2013 | LWT - Food Science and Technology2013，51，： | 1 |
| 5 | Prognostic value of bronchiectasis in patients with moderate - to - se- vere chronic obstructive pulmonary disease显示文摘 | Martinez - Garcia MA de la Rosa CD Soler - Cataluna JJ | 2013 | Am J Respir Crit Care Med2013，187，8： | 1 |
| 6 | Identification of P1 types and variants of Mycoplasma pneumoniae during an epidemic in Chile 显示文摘 | Martinez MA Ruiz M Zunino E | 2010 | J Med Microbiel2010，59，8： | 1 |
| 7 | Comparison of methods for evaluating stability and maturity of biosolids compost显示文摘 | Wu L Ma L Q Martinez G A | 2000 | Journal of Environmental Quality2000，29，2： | 1 |
| 8 | Bad bugs and beleagured bladders:Interplay between uropathogenic Escherichia coli and innate host defenses显示文摘 | Schilling JD Martinez JJ | 2000 | PNAS2000，97，： | 1 |
| 9 | Influence of endothelium on cultured vascular smooth muscle cell proliferation显示文摘 | Peiro C Redondo J Rodriguez - Martinez MA | 1995 | Hypertension1995，25，2： | 1 |
| 10 | Treatment of congenital obstruction of the lachrymal route, by means of ball catheter, intubation monoeanalieular, and endoscopic control显示文摘 | Alafi6n Ferndndez MA Alafi6n Fern6ndez F Martinez Ferndndez A | 2009 | Aeta Otorrinolaringol Esp2009，60，： | 1 |
| 11 | qPCR for quantitative detection of tyramine-producing bacteria in dairy products 显示文摘 | Ladero V Martinez N Martin MC Ferndndez M Alvarez MA | 2010 | Food Res Int2010，43，1： | 1 |
| 12 | Aggressive angiomyxoma:an ultrastructural study of four cases显示文摘 | Martinez MA Ballestin C Carabias E | 2003 | Ultrastruct Pathol2003，27，： | 1 |
| 13 | Aggressive angiomyxoma:an ultrastructural study of four cases显示文摘 | Martinez MA Ballestin C Carabias E | 2003 | Ultrastruct Pathol2003，27，4： | 1 |
| 14 | Prospective, randomized, comparative study of the efficacy, safety and cost of cefuroxime versus cephradine in acute infection 显示文摘 | Ovalle A Martinez MA Wolff M | 2000 | Rev Med Chi12000，128，7： | 1 |
| 15 | Aggressive angiomyxoma: an ultrastruetural study of four cases 显示文摘 | Martinez MA Ballestin C Carabias E | 2003 | Ultrastruct Pathol2003，27，4： | 1 |
| 16 | A three-dimensional finite elementanalysis of the combined behavior of ligaments and menisci inthe healthy human knee joint 显示文摘 | E Pena B Calvo Martinez MA et ai | 2005 | Journal of Biomchanics2005，39，9： | 1 |
| 17 | Mycoplasma hominis and ureaplasma urealyticum in pregnant and infertile women,differences in tubal pathology显示文摘 | Reid I Martinez MA Biron M | 2002 | Rev Chil Obstet Ginecol2002，58，： | 1 |
| 18 | Type 1 pilus-mediated bacterial invasion of bladder epithelial cells 显示文摘 | Martinez JJ Mulvey MA Schilling JD | 2000 | EMBO J2000，19，： | 1 |
| 19 | RNA interference of HIV replication显示文摘 | Martinez MA Cloter B Este JA | 2002 | Trends Immunol2002，23，12： | 1 |
| 20 | RNA interference of HIV replication显示文摘 | Martinez MA Clotet B Este JA | 2002 | Trends Immunol2002，23，： | 1 |
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