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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Frailty is independently associated with increased hospitalisation days in patients on the liver transplant waitlist显示文摘AIM To investigate the impact of physical frailty on risk of hospitalisation in cirrhotic patients on the liver transplant waitlist.METHODS Cirrhotics listed for liver transplantation at a single centre underwent frailty assessments using the Fried Frailty Index, consisting of grip strength, gait speed, exhaustion, weight loss, and physical activity. Clinical and biochemical data including MELD score as collected at the time of assessment. The primary outcome was number of hospitalised days per year; secondary outcomes included incidence of infection. Univariable and multivariable analysis was performed using negative binomial regression to associate baseline parameters including frailty with clinical outcomes and estimated incidence rate ratios(IRR). RESULTS Of 587 cirrhotics, 64% were male, median age(interquartile range) was 60(53-64) years and MELD score was 15(12-18). Median Fried Frailty Index was 2(1-3); 31.6% were classified as frail(fried frailty ≥ 3). During 12 mo of follow-up, 43% required at least 1hospitalisation; 38% of which involved major infection.107/184(58%) frail and 142/399(36%) non-frail patients were hospitalised at least once(P < 0.001). In univariable analysis, Fried Frailty Index was associated with total hospitalisation days per year(IRR = 1.51,95%CI: 1.28-1.77; P ≤ 0.001), which remained significant on multivariable analysis after adjustment for MELD, albumin, and gender(IRR for frailty of 1.21,95%CI: 1.02-1.44; P = 0.03). Incidence of infection was not influenced by frailty.CONCLUSION In cirrhotics on the liver transplant waitlist, physical frailty is a significant predictor of hospitalisation and total hospitalised days per year, independent of liver disease severity. | Marie Sinclair Eduard Poltavskiy Jennifer L Dodge Jennifer C Lai | 2017 | World Journal of Gastroenterology2017，23，5： | 11 |
| 3 | Therapeutic efficiency of everolimus and lapatinib in xenograft model of human colorectal carcinoma with KRAS mutation显示文摘 | Céline Chu Marie‐Sophie No?l‐Hudson Valérie Boige Diane Goéré Sylvie Marion Mélanie Polrot Ludovic Bigot Patrick Gonin Robert Farinotti Laurence Bonhomme‐Faivre | 2013 | Fundamental & Clinical Pharmacology2013，，4： | 2 |
| 4 | 在 7T 的多原子的磁性的回声光谱学的应用显示文摘 AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.made at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies. | Mary C Stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed William Vennart Susan T Francis Peter G Morris | 2011 | World Journal of Radiology2011，3，4： | 2 |
| 5 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 6 | The relation of diabetes to the severity of acute myocardial infarction and post-myocardial infarction survival in Mexica-Americans and non-Hispanic Whites显示文摘 | David C Mary L | 1994 | Diabetes1994，43，： | 1 |
| 7 | Experimental characterization of thermo-oxidation-induced shrinkage and damage in polymer-matrix composites显示文摘 | Dinh Q V Marco G Marie C L | 2012 | Composites : Part A2012，43，4： | 1 |
| 8 | Pneumocystis jirovecii pneumonia显示文摘 | Emilie C Fanny L Marie EB | 2010 | Infect Dis Clin N Am2010，24，10： | 1 |
| 9 | Sex steroids and insulin resistance显示文摘 | Callum L Mary C | 2009 | Clin Sci2009，20，1： | 1 |
| 10 | Critical Role of Acidic Sphingomyelinase in Murine Hepatic Ischemia-Reperfusion Injury显示文摘 | LLACUNA L MARI M GARCIA-RUIZ C | 2006 | Hepatology2006，44，3： | 1 |
| 11 | The Dioscorea genus: a review of bioactive steroid saponins显示文摘 | Marc S Anne C M Marie A L | 2007 | J Nat Med2007，，61： | 1 |
| 12 | A Dyadic Study of Interpersonal Informa-tion Search显示文摘 | Gilly Mary C John L | | 0，，02： | 1 |
| 13 | Solvent-free microwave extraction of essential oil from aromatic herbs: comparison with conventional hydro-distillation 显示文摘 | Marie E L Farid C Jacqueline S | 2004 | J Chromatogr A2004，，1043： | 1 |
| 14 | Effect of phenol-CNSL formaldehyde on the thermal aging of elastomers-Ⅰ显示文摘 | Mary L C Thachil E T | 2008 | International Journal of Polymeric Materials2008，57，1： | 1 |
| 15 | Carbon dioxide emulsion assisted loading of polymer mierospheres toward sustained release materials 显示文摘 | GARY A B MARY L C MATTHEW Z Y | 2005 | Langmuir2005，21，9： | 1 |
| 16 | Bone consolidation is enhanced by rhBMP-2 in a rabbit model of distraction osteogenesis显示文摘 | Gang Li Mary L Bouxsein Luppen C | 2002 | J Orthop Res2002，20，4： | 1 |
| 17 | Managing irrigation and nitrogen fertility of hard spring wheats for optimum bread and noodle quality显示文摘 | MARY J G REUBEN M L JEFFREY C S | 2005 | Crop Science2005，45，5： | 1 |
| 18 | CATIⅢ chlorampheni- col resistance in Pasteurella haemolytica and Pasteu- rella multocida isolated from calves显示文摘 | Ceclev B Marie C Jean L etal | 1996 | Journal of Anti Chem1996，38，： | 1 |
| 19 | Aspartate aminotransferase in synaptic and nonsynaptic mitochondria: Differential effect of compounds that influ-ence transient hetero-enzyme complex (metabolon) format-ion 显示文摘 | Mary C Mckenna Irene B Hopkins Steven L | 2006 | Neurochemistry International2006，48，62： | 1 |
| 20 | Increased risk of adverse neurological development for late preterol infants 显示文摘 | Joann R Marie C Maria L | 2009 | J Pediatr2009，154，2： | 1 |
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