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| 1 | Beneficial effects of adenosine triphosphate-sensitive K^+ channel opener on liver ischemia/reperfusion injury显示文摘AIM:To investigate the effect of diazoxide administration on liver ischemia/reperfusion injury.METHODS:Wistar male rats underwent partial liver ischemia performed by clamping the pedicle from the medium and left anterior lateral segments for 1 h under mechanical ventilation.They were divided into 3 groups:Control Group,rats submitted to liver manipulation,Saline Group,rats received saline,and Diazoxide Group,rats received intravenous injection diazoxide(3.5 mg/kg) 15 min before liver reperfusion.4 h and 24 h after reperfusion,blood was collected for determination of aspartate transaminase(AST),alanine transaminase(ALT),tumor necrosis factor(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10),nitrite/nitrate,creatinine and tumor growth factor-β1(TGF-β1).Liver tissues were assembled for mitochondrial oxidation and phosphorylation,malondialdehyde(MDA) content,and histologic analysis.Pulmonary vascular permeability and myeloperoxidase(MPO) were also determined.RESULTS:Four hours after reperfusion the diazoxide group presented with significant reduction of AST(2009 ± 257 U/L vs 3523 ± 424 U/L,P = 0.005); ALT(1794 ± 295 U/L vs 3316 ± 413 U/L,P = 0.005); TNF-α(17 ± 9 pg/mL vs 152 ± 43 pg/mL,P = 0.013; IL-6(62 ± 18 pg/mL vs 281 ± 92 pg/mL); IL-10(40 ± 9 pg/mL vs 78 ± 10 pg/mL P = 0.03),and nitrite/nitrate(3.8 ± 0.9 μmol/L vs 10.2 ± 2.4 μmol/L,P = 0.025) when compared to the saline group.A significant reduction in liver mitochondrial dysfunction was observed in the diazoxide group compared to the saline group(P < 0.05).No differences in liver MDA content,serum creatinine,pulmonary vascular permeability and MPO activity were observed between groups.Twenty four hours after reperfusion the diazoxide group showed a reduction of AST(495 ± 78 U/L vs 978 ± 192 U/L,P = 0.032); ALT(335 ± 59 U/L vs 742 ± 182 U/L,P = 0.048),and TGF-β1(11 ± 1 ng/mL vs 17 ± 0.5 ng/mL,P = 0.004) serum levels when compared to the saline group.The control group did not present alterations when compared to the diazoxide and saline groups.CONCLUSION:Diazoxide maintains liver mitochondrial function,increases liver tolerance to ischemia/reperfusion injury,and reduces the systemic inflammatory response.These effects require further evaluation for using in a clinical setting. | Mateus Antunes Nogueira Ana Maria Mendona Coelho Sandra Nassa Sampietre Rosely Antunes Patzina Fabiano Pinheiro da Silva Luiz Augusto Carneiro D'Albuquerque Marcel Cerqueira Cesar Machado | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 2 | Studies of rapid solft tooling with conformal cooling channels for plastic injection moulding显示文摘 | Ferrira J C Mateus A | 2003 | Journal of Materials Processing Technology2003，142，5： | 1 |
| 3 | Synthesis of wurtzite Zn S nanoparticles using the microwave assisted solvothermal method显示文摘 | FELIPE A L MATEUS M F | 2013 | J Alloy Compd2013，556，： | 1 |
| 4 | Chemical characterization and antioxidant activities of oligomeric and polymeric procyanidin fractions from grape seods显示文摘 | Spranger I Sun B Mateus A M | 2008 | Food Chemish-y2008，108，2： | 1 |
| 5 | Antigenic heterogeneity of foot-and-mouth disease virus serotype in the eld is mediated by very limited sequence variation at several antigenic sites显示文摘 | Mateu M G Hernandez J Martinez M A | 1994 | J Virol1994，68，3： | 1 |
| 6 | Removal of organic contaminants from soils by an electrokinetic process:the case of atrazine显示文摘 | RIBEIRO A B RODRIGUEZ-MAROTO J M MATEUS E P | 2005 | Chemosphere2005，59，： | 1 |
| 7 | Studies of rapid soft tooling with conformal cooling channels for plastic injection moulding显示文摘 | FERREIRA JC MATEUS A | 2003 | Journal of Materials Processing Technology2003，142，： | 1 |
| 8 | Direct evaluation of the immunodominance of a major immunogenic site on foot and mouth disease virus in a natural host 显示文摘 | Mateu M G Camarero J A Giralt E | 1995 | Virology1995，206，1： | 1 |
| 9 | Biomarkers of exposure and effect as indicators of the interference of selenomethionine on methylmercury toxicity 显示文摘 | DOS SANTOS A P MATEUS M L CARVALHO C M | 2007 | Toxicol Lett2007，169，2： | 1 |
| 10 | 显示文摘 | Tadeu A Antonio J Mateus D | 2004 | Applied Acoustics2004，65，1： | 1 |
| 11 | Enhanced myeloid specificity of CD117 compared with CD13 and CD33显示文摘 | Nomdedeu JF Mateu R Altes A | 1999 | Leuk Res1999，23，4： | 1 |
| 12 | Use of the modified BCR three-step sequential extraction procedure for the study of trace element dynamics in contaminated soils显示文摘 | Pueyo M Mateu J Rigol A | 2008 | Environmental Pollution2008，152，2： | 1 |
| 13 | Interempping soybean and palisade grass for enhanced land use efficiency and revenue in a no till system显示文摘 | CRUSCIOL C A C NASCENTE A S MATEUS G P | 2014 | European Journal of Agronomy2014，，58： | 1 |
| 14 | Rituximab therapy for HIV-associated Castleman disease 显示文摘 | Marcelin A Aaron L Mateus C | 2003 | Blood2003，102，8： | 1 |
| 15 | A parametric study of the post - buckling behavior of steel plates 显示文摘 | Antonio F Mateus Joel A Witz | 2001 | Engineering Structure2001，23，： | 1 |
| 16 | Enhanced myeloid spe- cificity of CDl17 compared with CD13 and CD33 显示文摘 | Nomdedeu JF Mateu R Altis A | 1999 | Leuk Res1999，23，4： | 1 |
| 17 | Probabilistic situation calculus 显示文摘 | Mateus P Pacheco A Pinto J Sernadas A Sernadas C | 2001 | Annals of Mathematics and Artificial Intelligence2001，32，14： | 1 |
| 18 | Studies of rapid soft tooling with conformal cooling channels for plastic injection moulding显示文摘 | FERREIRA J C MATEUS A | 2003 | Journal of Materials Processing Technology2003，142，： | 1 |
| 19 | Inmaunological features of the non-structural proteins of porcine reproductive and respiratory syndrome virus 显示文摘 | Rascon-Casteio E Burgara-Estrella A Mateu E | 2015 | Viruses2015，7，3： | 1 |
| 20 | Use of the modified BCR three-step sequential extraction procedure for the study of trace element dynamics in contaminated soils 显示文摘 | PUEYO M MATEU J RIGOL A | 2008 | Environmental Pollution2008，152，： | 1 |
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