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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | 中阿40m射电望远镜选址与电磁环境监测显示文摘优良站址的选择是射电望远镜完成既定科学目标并实现高效运行的重要保障。影响射电望远镜选址的主要因素包括电磁环境、水文、气象、地质条件、隔离性与可及性等。对于射电天文观测而言,来自宇宙天体的射电信号往往极其微弱,对望远镜系统及设备的灵敏度要求极高。然而,随着人类活动的不断加强,人们日常工作和生活中使用的电子通讯设备越来越多,无线电干扰源呈爆炸式涌现。在射电望远镜选址工作中,进行电磁环境监测,选择一个电磁环境良好的站址,对于射电望远镜实现常规观测运行、获取有效数据资料至关重要。同时,电磁环境监测结果也是射电望远镜接收机系统研制、站址电磁环境及无线电宁静区立法保护的重要依据。中阿天文学者和技术人员历时1年半完成了16个候选站址的初步勘察,并对优选出的3个主要候选站址进行了深入细致的电磁环境监测工作,获得了大量可靠数据。中阿双方依据电磁环境监测结果并结合各主要候选站址的水文、气象、地质及道路等条件,最终将位于Talacasto戈壁的3号候选站址确定为中阿CART射电望远镜的建设站点。 | 赵卫普 李建斌 李金增 孙建民 齐力 罗滔 马晓耘 莫铠玮 李鹏程 夏跃兵 MALLAMACI C C PODESTA R C PACHECO A M ACTIS E CASTRO J I ALVIS R H LOPEZ C E FRANCILE C PODESTA F PEREZ J | 2014 | 天文学进展2014，32，3： | 4 |
| 3 | Successful operation of a cooperative SLR station of China and Argentina in San Juan显示文摘We introduced the observations and researches using a Satellite Laser Ranging (SLR) system with high precision, which was designed and made in China and installed in the Observatory of San Juan Uni- versity, Argentina, the capability of the system and the achievement of the cooperative procedure be- tween China and Argentina. The SLR station in San Juan, set up by China and Argentina, is quite sig- nificant for improving the distribution of SLR stations and enhancing the orbital coverage of the whole earth. Since the SLR system started to work in the Observatory of San Juan University in the beginning of 2006, the operation is rather good, and rich data with high precision have been obtained. Further plan of the cooperation for the near future is also presented. | HAN YanBen LIU WeiDong E ACTIS R PODESTA WANG TanQiang GUO TangYong QU Feng A M PACHECO A A GONZALEZ E ALONSO XIANG QingGe HUANG DongPing YIN ZhiQiang | 2008 | Chinese Science Bulletin2008，53，16： | 2 |
| 4 | Active linking in evolutionary games显示文摘 | Traulsen A Nowak M A | 2006 | Journal of Theoretical Biology2006，243，3： | 1 |
| 5 | Selenium and aflatoxin levels in raw Brazil nuts from the Amazon basin 显示文摘 | PACHECO A M SCUSSEL1 V M | 2007 | J Agrle Food Chem2007，55，11： | 1 |
| 6 | Preparation of palladium and silver alloy membrane on a porous or-alumina tube via simultaneous electroless plating 显示文摘 | PACHECO TANAKA D A LLOSA TANCO M A NIWA S | 2005 | J Membr Sci2005，247，12： | 1 |
| 7 | Characterization of entertoxigenic Escherichia coli by random amplication of polymorphic DNA 显示文摘 | A B F Pacheco B E C Guth D F | 1996 | Res Microbiol1996，，147： | 1 |
| 8 | Ability of commercially available dairy ration programs to predict duodenal flows of protein and essential amino acids in dairy cows显示文摘 | PACHECO D PATTON R A PARYS C | 2012 | Journal of Dairy Science2012，95，2： | 1 |
| 9 | Impacts of land use conflicts on riverine ecosystems 显示文摘 | Renato F Valle Junior Simone G P Varandas Femando A L Pacheco | 2014 | Land Use Policy2014，43，： | 1 |
| 10 | Holocarboxylas esyn- thetase is an obligate participant in biotin mediated regulation of its own ex- pression and of biotin dependent carboxylases mP,_NA levels in human cells显示文摘 | Solorzano V R S Pacheco A D Leon-Del-P io A | 2002 | Proc Nail Acad Sci USA2002，99，53： | 1 |
| 11 | An investigation of the dependent of atmospheric corrosion rate on temperature using printed-circuit iron cells 显示文摘 | A M G Pacheco M G S Ferreira | 1994 | Corrosion Science1994，36，5： | 1 |
| 12 | Elevated MMP - 12 protein levels in induced sputum from patients with COPD 显示文摘 | Demedts I K Morel - Montero A Lebecque S Pacheco Y Cataldo D Joos G F Pauwels R A Brusselle G G | 2006 | Thorax2006，61，6： | 1 |
| 13 | Review of dimethyl carbonate (DMC) manufacture and its characteristics as a fuel additive 显示文摘 | Pacheco Michael A Marshall Christopher L | 1997 | Energy & Fuels1997，11，： | 1 |
| 14 | Review of dimethyl carbonate(DMC)manufacture and its characteristics as a fuel additive显示文摘 | Michael A Pacheco Christopher L Marshall | 1997 | Energy & Fuels1997，11，1： | 1 |
| 15 | Coevolution of strategy and structure in complex networks with dynamic linking 显示文摘 | Pacheco J M Traulsen A Nowak M A | 2006 | Phys Rev Lett2006，97，25： | 1 |
| 16 | Estudo do Efeito da Adicao de PP Reciclado nas Propriedades Mecanicas e de Escoamento de Misturas de PP/EPDM显示文摘 | Pacheco E B A V da Silva A L N | 2013 | Polimeros2013，23，3： | 1 |
| 17 | Social and clinical comparison between schizophrenia and bipolar disorder type I with psychosis in costa rica显示文摘 | Pacheco A Barguil M Contreras J | 2009 | Soc Psychiatry Psychiatr Epidemiol2009，30，8： | 1 |
| 18 | Adhesion of water stressed Helicobacter pylori to abiotic surfaces 显示文摘 | Azevedo N F Pacheco A P Keevil C W | 2006 | J Appl Microbiol2006，101，： | 1 |
| 19 | Elemental levels in tree-bark and epiphytic-lichen transplantsat a mixed environment in mainland Portugal, and compari- sons with an in situ lichen显示文摘 | PACHECO A M G FREITAS M C BAPTISTA M S | 2008 | Environmental Pollution2008，151，2： | 1 |
| 20 | Estimation curve for modal damping in stay cable with viscous damper显示文摘 | PACHECO B M FUJINO Y SULEKH A | 1993 | Journal of Structural Engineering1993，119，9： | 1 |
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