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| 1 | 从髓鞘脱失到髓鞘再生:脊髓损伤的治疗之路显示文摘髓鞘完整性是维持中枢神经系统的生理功能的重要因素,脊髓损伤后髓鞘完整性的保存和再生对于脊髓功能的恢复有关键性的作用。脊髓损伤后,郎飞氏结等结构破坏,轴索暴露,髓鞘脱失处的神经传导受阻。之后出现少突胶质细胞丢失及髓鞘溶解等进一步的损伤。本文对少突胶质细胞丢失及髓鞘溶解的主要生物学事件及机制进行综述,并探讨抑制这些过程的方法。促进内源性的髓鞘再生是脊髓损伤后修复另外一个重要方面。最近研究发现在髓鞘再生过程中,先天性免疫和自适应免疫具有多重作用,胶质疤痕也可能具有潜在的免疫调节作用。神经元活化、少突胶质细胞生成及髓鞘形成间的紧密联系提示髓鞘恢复对脊髓功能的修复有重要意义。在临床应用中,已有几种治疗方案将脊髓损伤的病理生理作为修复目标,包括基因调控、小分子治疗、免疫调节、调控胶质疤痕以及细胞移植。一些新技术也已经开始尝试用于脊髓损伤的治疗,如通过细胞编程将一种细胞转变为另一种细胞、纳米或组织工程技术等。脊髓损伤后脊髓组织的损伤情况是复杂多样的,因此在治疗中需要使用综合性的手段,在损伤后早期尽快修复少突胶质细胞和髓鞘,促进髓鞘再生,为临床应用打基础。 | Florentia Papastefanaki Rebecca Matsas 唐颖馨 | 2015 | 神经损伤与功能重建2015，10，3： | 11 |
| 2 | Cell Stem Cell:利用干细胞制造出的心肌细胞有助精准心血管医疗取得进展显示文摘在一项新的研究中。来自美国斯坦福大学医学院的研究人员发现利用人诱导性多能干细胞(iPS细胞)制造的心肌细胞忠实地反映供者天然的心脏组织中关键基因的表达模式。因此,这些细胞能够被用来预测病人是否可能经历药物相关的心脏损伤。相关研究结果在线发表在Cell Stem Cell期刊上。论文标题为"Transcriptome Profiling of Patient -Specific Human iPSC - ardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro". | Elena Matsa Paul W. Burridge Kun-Hsing Yu John H. Ahrens Vittavat Termglinchan Haodi Wu Chun Liu Praveen Shukla Nazish Sayed Jared M. Churko Ningyi Shao Nicole A. Woo Alexander S. Chao Joseph D. Gold Ioannis Karakikes Michael P. Snyder Joseph C. Wu | 2016 | 现代生物医学进展2016，0，32： | 4 |
| 3 | Accurate nanoelectrode recording of human pluripotent stem cell-derived cardiomyocytes for assaying drugs and modeling disease显示文摘The measurement of the electrophysiology of human pluripotent stem cell-derived cardiomyocytes is critical for their biomedical applications,from disease modeling to drug screening.Yet,a method that enables the high-throughput intracellular electrophysiology measurement of single cardiomyocytes in adherent culture is not available.To address this area,we have fabricated vertical nanopillar electrodes that can record intracellular action potentials from up to 60 single beating cardiomyocytes.Intracellular access is achieved by highly localized electroporation,which allows for low impedance electrical access to the intracellular voltage.Herein,we demonstrate that this method provides the accurate measurement of the shape and duration of intracellular action potentials,validated by patch clamp,and can facilitate cellular drug screening and disease modeling using human pluripotent stem cells.This study validates the use of nanopillar electrodes for myriad further applications of human pluripotent stem cell-derived cardiomyocytes such as cardiomyocyte maturation monitoring and electrophysiology-contractile force correlation. | Ziliang Carter Lin Allister F.McGuire Paul W.Burridge Elena Matsa Hsin-Ya Lou Joseph C.Wu Bianxiao Cui | 2017 | Microsystems & Nanoengineering2017，3，1： | 2 |
| 4 | Feeder - free culture of human embryonic stem cells in conditioned medium for efficient genetic mod- ification 显示文摘 | Braam SR Denning C Matsa E | 2008 | Nat Protoc2008，3，9： | 1 |
| 5 | One-dimensional Order in Atactic Polyacrylates Containing Aromatic Side Groups显示文摘 | Marchetti A Matsa F | 1974 | Eur Polym J1974，10，7： | 1 |
| 6 | Haplotypes of NOS3 gene polymorphisms in dilated cardiomyopathy 显示文摘 | Matsa LS Rangaraju A Vengaldas V | 2013 | PloS One2013，8，70： | 1 |
| 7 | Feeder-free culture of human embryonic stem cells in conditioned medium for efficient genetic modification显示文摘 | Braam SR Denning C Matsa E | 2008 | Nat Protoc2008，3，9： | 1 |
| 8 | Washing as a Remediation Technology Applicable in Soils Heavily Polluted by Mining-Metallurgical Activities 显示文摘 | MOUTSATSOU A GREGOU M MATSAS D | 2006 | Chemosphere2006，63，10： | 1 |
| 9 | Washing as a re- mediation technology applicable in soils heavily polluted by mining- metallurgical activities显示文摘 | MOUTSATSOU A GREGOU M MATSAS D | 2006 | Chemosphere2006，63，10： | 1 |
| 10 | Drug evaluation in cardiomyocytes de- rived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation 显示文摘 | Matsa E Rajamohan D Dick E | 2011 | Eur Heart J2011，32，： | 1 |
| 11 | Washing as a remediation technology applicable in soils heavily polluted by mining-metallurgical activities显示文摘 | MOUTSATSOU A GREGOU M MATSAS D | 2006 | Chemosphere2006，63，10： | 1 |
| 12 | Cardiac stem cell biology:glimpse of the past,present,and future显示文摘 | Matsa E Sallam K Wu JC | 2014 | Circ Res2014，114，1： | 1 |
| 13 | Self-starting passively mode-locked fiber ring soliton laser exploiting nonlinear polarisation rotation显示文摘 | | 1992 | Electron1992，28，15： | 1 |
| 14 | Selfstarting passively mode-locked fiber ring soliton laser exploration nonlinear polarization rotation显示文摘 | Matsas V J Newson T P Richardson D J | 1992 | IEEE Electron Lett1992，28，15： | 1 |
| 15 | Knee joint kine- matics from familiarised treadmill walking can be generalised to overground walking in young unimpaired subjects显示文摘 | MATSAS A TAYLOR N MCBURNEY H | 2000 | Gait Pos- ture2000，11，1： | 1 |
| 16 | Selfstarting passively mode locked fibre ring soliton laser exploiting nonlinear polarisation rotation 显示文摘 | Matsas V J Newson T P Richardson D J | 1992 | Electron Lett1992，28，15： | 1 |
| 17 | Knee joint kinematics from familiarised treadmill walking can be generalised to overground walking in young unimpaired subjects 显示文摘 | Matsas A Taylor N McBurney H | 2000 | Gait Posture2000，11，1： | 1 |
| 18 | CEO Compensation and Corporate Risk: Evidence From a Natural Experiment显示文摘 | Gormley T A Matsa D A Milbourn T | 2013 | Journal of Accounting and Economics2013，56，2： | 1 |
| 19 | Faster generation of hiPSCs by coupling high-titer lentivirus and column-based positive selection显示文摘 | Dick E Matsa E Young LE | | 0，，06： | 1 |
| 20 | Self- starting passively mode-locked fibre ring soliton laser ex- ploiting nonlinear polarisation rotation 显示文摘 | Matsas V J Newson T P Richardson D J | 1992 | Electronics Letters1992，28，15： | 1 |
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