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| 1 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 2 | Routine day-case laparoscopic cholecystectomy显示文摘 | Leeder PC Matthews T Krzeminska K | 2004 | Br J Surg2004，91，3： | 1 |
| 3 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 4 | Application of chitosanbased polysaccharide biomaterials in cartilage tissue engineering: A review显示文摘 | Francis Suh J K Matthew H W T | 2000 | Biomaterials2000，21，24： | 1 |
| 5 | Ink4a/Arf expression is a biomarker of aging显示文摘 | Janakiraman K Chad T Matthew R | 2004 | J Clin Invest2004，114，9： | 1 |
| 6 | Anisotropic effects on the strain rate dependence of a wrought magnesium alloy 显示文摘 | MATTHEW T T MARK F H PHILLIP M G HAITHAM E K WILBURN R W | 2009 | Scripta Materialia2009，60，： | 1 |
| 7 | Application of chitosan-based polysaccharide biomateri',ds in cartilage tissue engineering: a review显示文摘 | Suh J K Matthew H W T | 2000 | Biomaterials2000，21，24： | 1 |
| 8 | Ink4a/Arf expression is a biomarker of aging 显示文摘 | Janakiraman K Chad T Matthew R | 2004 | J Clin Invest2004，114，9： | 1 |
| 9 | Application of chitosanbased polysaccharide biomaterials in cartilage tissue engineering:A review显示文摘 | Francis S J K Matthew H W T | | 0，，24： | 1 |
| 10 | The biology of Toll-like receptors 显示文摘 | Means T K Douglas T Matthew J | 2000 | Cytokine Growth Factor Rev2000，11，3： | 1 |
| 11 | Application of chitosan - based polysaccharide biomaterials in cartilage tissue engineering, a review显示文摘 | Suh J K F Matthew H W T | | 0，，： | 1 |
| 12 | Depressive symptoms during the menopausal transition : the Study of Women's Health Across the Nation (SWAN)显示文摘 | BROMBERGER J T MATTHEWS K A SCHOTT L L | 2007 | J Affect Disord2007，103，13： | 1 |
| 13 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 14 | Predictors of first lifetime episodes of major depression in midlife women显示文摘 | BROMBERGER J T KRAVITZ H M MATTHEW S K | 2009 | Psychol Med2009，39，1： | 1 |
| 15 | Neighborhood Street Layout and Property Value: The Interaction of Accessibility and Land Use Mix显示文摘 | John W Matthews G K T | 2007 | Journal of Real Estate Finance and Economics2007，，35： | 1 |
| 16 | Application of chitosan- based polysaccharide biomatefials in cartilage tissue engineering:a review 显示文摘 | Francis Suh J K Matthew H W T | 2000 | Biomaterials2000，21，24： | 1 |
| 17 | Epstein-Barr virus and cancer 显示文摘 | Matthew P T Razelle K | 2004 | Clin Cancer Res2004，10，1： | 1 |
| 18 | Effects of spatial variability in light use efficiency on satellite-based NPP monitoring显示文摘 | David P Turner Stith T Gower Warren B Cohen Matthew Gregory Tom K Maiersperger | 2002 | Remote Sensing of Environment2002，，3： | 1 |
| 19 | A Bayesian framework for saliency using natural statistics显示文摘 | ZHANG Ling-yun MATTHEW H T TIM K M | 2012 | Journal of Vision2012，14，1： | 1 |
| 20 | Hydrogenation of polynuclear aromatic hydrocarbons 2: structure/reactivity quantitative correlations显示文摘 | Styliani C K Matthew N Michael T K | 1994 | Chemical Engineering Science1994，49，24： | 1 |
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