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| 1 | Oxidative stress and male reproductive health显示文摘有缺点的精子功能的主要原因之一是氧化应力,它不仅破坏精子 DNA 的正直而且在精子血浆膜由于蛋白质和类脂化合物的并行的损坏限制这些房间的使肥沃的潜力。如此的氧化压力的起源看起来包含精子线粒体,它有一个趋势作为一篇序言产生 superoxide 阴离子的高水平到进入内在的 apoptotic 串联。不幸地,这些房间有很小的能力因为他们仅仅在基础切除修理(BER ) 拥有第一酶,对如此的攻击作出回应小径, 8-oxoguanine glycosylase 1 (OGG1 ) 。后者成功地创造一个 abasic 地点,而是精子因为他们缺乏下游的蛋白质,不能进一步处理氧化损害(APE1, XRCC1 ) 需要完成修理过程。在第一个有丝分裂的部门的 S 阶段的开始以前继续 BER 小径是卵母细胞的责任。如果一个错误被卵母细胞在开发的这个阶段犯,一个变化将被创造那将在身体在每个房间被代表。如此的机制可以在在作为年龄的后果在他们的细菌线承受了氧化应力的男性的后代观察的童年癌症和另外的疾病解释增加,环境或生活方式因素。在男不孕病人的精子的氧化 DNA 损坏的高流行可以为在 vitro 构思的孩子的健康有含意并且在细菌线为对免费激进的产生的起源的当前的研究担任一位司机。 | Robert J Aitken Tegan B Smith Matthew S Jobling Mark A Baker Geoffry N De Iuliis | 2014 | Asian Journal of Andrology2014，16，1： | 48 |
| 2 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 3 | Surveillance of colonic polyps:are we getting it right?显示文摘Colorectal cancer(CRC) is the third most commonly diagnosed cancer worldwide. The identification of colonic polyps can reduce CRC mortality through earlier diagnosis of cancers and the removal of polyps: the precursor lesion of CRC. Following the finding and removal of colonic polyps at an initial colonoscopy, some patients are at an increased risk of developing CRC in the future. This is the rationale for postpolypectomy surveillance colonoscopy. However, not all individuals found to have colonic adenomas have a risk of CRC higher than that of the general population. This review examines the literature on post-polypectomy surveillance including current international clinical guidelines. The potential benefits of surveillance procedures must be weighed against the burden of colonoscopy: resource use, the potential for patient discomfort, and the risk of complications. Therefore surveillance colonoscopy is best utilised in a selected group of individuals at a high risk of developing cancer. Further study is needed into the specific factors conferring higher risk as well as the efficacy of surveillance in mitigating this risk. Such evidence will better inform clinicians and patients of the relative benefits of colonoscopic surveillance for the individual. In addition, the decision to continue with surveillance must be informed by the changing profile of risks and benefits of further procedures with the patient's advancing age. | Stewart N Bonnington Matthew D Rutter | 2016 | World Journal of Gastroenterology2016，22，6： | 6 |
| 4 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 5 | Update on Cardiovascular Implantable Electronic Device Infections and Their Management: A Scientific Statement From the American Heart Association显示文摘 | Larry M. Baddour Andrew E. Epstein Christopher C. Erickson Bradley P. Knight Matthew E. Levison Peter B. Lockhart Frederick A. Masoudi Eric J. Okum Walter R. Wilson Lee B. Beerman Ann F. Bolger N A. Mark Estes Michael Gewitz Jane W. Newburger Eleanor B. S | 2010 | Circulation2010，，3： | 4 |
| 6 | Detection of flock movement and behaviour of broiler chickens at different feeders using image analysis显示文摘The behaviour of broiler chickens has been extensively studied as a function of stocking density and environmental conditions,but limited information was reported in the scientific literature about the effect of feeder type on birds’feeding process.The main objective of this study was to assess the effects of three different feeder types in relation to the birds’behaviour in its surroundings.The analysed feeders were:tube-type with partition grid(F1);tube-type without partition grid(F2);and automatic type with partition grid(F3).The considered variables were:occupied area(OA);activity index(AI)(flock movement);total birds presented in the area(TB);and birds effectively eating(EE).OA and AI were calculated by computational image analysis while TB and EE were manually measured.The results indicated that the feeder type could have influenced the birds’behaviour regarding to OA(R2=0.56),TB(R2=0.48),and EE(R2=0.40),but AI(R2=0.01)was not found to be directly influenced by the feeder type.A higher percentage of birds effectively eating were found in F2(86.4%),which was the one with the largest free area to access the feed.Similar average number of total birds was found in F1,but with a lower percentage of individuals effectively eating(63.3%),which means that birds were nearby this feeder performing other behaviours.Since the assessed feeders were in the same house under the same conditions,it can be suggested that not only the free area to access the feed but potentially the design of feeders could have influenced the birds’feeding preference.The real beneficial effect of the adoption of partition grid on feed trays is still uncertain,and it is also unclear whether the financial value of reduced wastage would compensate the possible reduction in feed intake. | Diego Pereira Neves Saman Abdanan Mehdizadeh Matthew Tscharke Irenilza de Alencar Nääs Thomas Michael Banhazi | 2015 | Information Processing in Agriculture2015，2，3： | 4 |
| 7 | 多年生黑麦草、雀麦根系形态和生长对土壤干旱的适应性显示文摘为了研究牧草根系对干旱环境的适应性,选择多年生黑麦草(Lolium perenne)和雀麦(Bromus valdivianus)进行盆栽试验,给予80%~85%有效水(PAW)充分供水和20%~25%PAW极端干旱两种水分模式,通过对两种牧草的根系外形、干物质积累和根系形态学分析,探求两牧草在极干旱胁迫下的有效生产策略。研究表明,两种牧草的根尖外形略有不同。雀麦根毛长而密,分生区细胞致密,伸长区较长;多年生黑麦草根毛稀疏,伸长区短。20%~25%PAW极干旱胁迫使黑麦草根系粗细不匀,出现畸形;而雀麦根系未见明显受害。两种牧草生物量在茎叶和根的积累无显著的种间差异和水分处理间的组间差异。雀麦和多年生黑麦草单株根系的总长度、根面积、根平均直径、根尖数和分叉数存在极显著差异。多年生黑麦草根量显著高于雀麦(至少P≤0.01),根长和面积是雀麦的1.5倍左右,根尖数和分叉数是雀麦的2倍以上。雀麦根系末端侧根分枝密度高,短且粗;多年生黑麦草侧根细而长。干旱胁迫显著减少了两种牧草的总根长度,促进了雀麦根的径向生长。总之,雀麦根毛区较多年生黑麦草发达,多年生黑麦草根量显著多于雀麦。黑麦草主要以根数量(量)取胜,采取广泛吸水的适应策略;雀麦以根毛发达,侧根分枝密度高(质)为主,采用确保有效吸水的适应策略。 | 张咏梅 胡海英 白小明 Matthew Cory García-Favre Javier Ordóñez Iván P | 2022 | 中国生态农业学报(中英文)2022，30，11： | 3 |
| 8 | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack显示文摘 | S Claiborne Johnston Peter M Rothwell Mai N Nguyen-Huynh Matthew F Giles Jacob S Elkins Allan L Bernstein Stephen Sidney | 2007 | 2007 (9558)2007，，9558： | 3 |
| 9 | Langerhans cell histiocytosis masquerading as acute appendicitis: Case report and review显示文摘Langerhans cell histiocytosis(LCH) is a rare syndrome characterized by unifocal,multifocal unisystem,or disseminated/multi-system disease that commonly involves the bone,skin,lymph nodes,pituitary,or sometimes lung(almost exclusively in smokers) causing a variety of symptoms from rashes and bone lesions to diabetes insipidus or pulmonary infiltrates.We present a previously unreported case of gastrointestinal LCH as well as a novel characteristic lesion affecting the colon of a young woman who presented with signs and symptoms mimicking acute on chronic appendicitis.Immunohistochemical analysis of appendectomy specimen and nodular specimens on colonoscopy demonstrated S-100,CD1a,and langerin reactivity.The patient underwent systemic chemotherapy with cytarabine and demonstrated excellent response to therapy. | Mohammad M Karimzada Michele N Matthews Samuel W French Daniel De Ugarte Dennis Y Kim | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，3： | 3 |
| 10 | Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity显示文摘 | Matthew N Meriggioli Donald B Sanders | 2009 | Lancet Neurology2009，，5： | 2 |
| 11 | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack显示文摘 | S Claiborne Johnston Peter M Rothwell Mai N Nguyen-Huynh Matthew F Giles Jacob S Elkins Allan L Bernstein Stephen Sidney | 2007 | The Lancet . 2007 (9558)2007，，9558： | 2 |
| 12 | Bulbocavernosus muscle area measurement: a novel method to assess androgenic activity显示文摘浆液睾丸激素不与雄激素织物活动相关,并且优化工具在男性评估如此的活动是批评的。bulbocavernosus 肌肉(BCM ) 的超声测量被用来在雄激素受体(AR ) 和 BCM 尺寸估计在 CAG 重复(CAGn ) 的数字之间的关系;在 CAGn 超龄的数字的变化也被评估。BCM 的 Transperineal 超声测量也被执行。AR CAGn 被高效液体层析,和早上荷尔蒙决定层次用免疫分析被决定。48 个人让 CAG 重复分析。25 是 < 30 岁,平均数 23.7 年(s.d = 3.24 ) 并且 23 是 > 45 岁,平均数 53 年(s.d = 5.58 ) 。中部的 CAGn 是 21 (13-29 ) 。当 CAGn 的数字是 < 时, BCM 区域更大; 18 作为与 CAGn > 的数字相比; 24 (P = 0.04 ) 。在 CAGn 和 BCM 区域 R 2= 的数字之间有线性关联 16%(P = 0.01 ) 。在 45 到 65-years-old 组,强壮得多的否定关联(R 2=29% , P = 0.01 ) 被注意。在 19,到 29-years-old 组,,没有如此的关联被发现(R 2=4% , P = 0.36 ) 。在老人, CAGn 的数字与年龄增加了(R 2=32% , P = 0.01 ) 。在 AR 的 CAGn 的数字与 BCM 的区域相关。对 BCM 的超声评价是一个有效代理人评估雄激素的结束器官活动。CAGn 的数字可以与年龄增加。 | Ali A Dabaja Matthew S Wosnitzer Anna Mielnik Alexander Bolyakov Peter N Schlegel Darius A Paduch | 2014 | Asian Journal of Andrology2014，16，4： | 2 |
| 13 | How location and cellular signaling combine to activate the NLRP3 inflammasome显示文摘NOD-,LRR-,and pyrin domain-containing 3(NLRP3)is a cytosolic innate immune sensor of cellular stress signals,triggered by infection and sterile inflammation.Upon detection of an activating stimulus,NLRP3 transitions from an inactive homo-oligomeric multimer into an active multimeric inflammasome,which promotes the helical oligomeric assembly of the adaptor molecule ASC.ASC oligomers provide a platform for caspase-1 activation,leading to the proteolytic cleavage and activation of proinflammatory cytokines in the IL-1 family and gasdermin D,which can induce a lytic form of cell death.Recent studies investigating both the cellular requirement for NLRP3 activation and the structure of NLRP3 have revealed the complex regulation of NLRP3 and the multiple steps involved in its activation.This review presents a perspective on the biochemical and cellular processes controlling the assembly of the NLRP3 inflammasome with particular emphasis on structural regulation and the role of organelles.We also highlight the latest research on metabolic control of this inflammatory pathway and discuss promising clinical targets for intervention. | Anil Akbal Alesja Dernst Marta Lovotti Matthew S.J.Mangan Róisín M.McManus Eicke Latz | 2022 | Cellular & Molecular Immunology2022，19，11： | 2 |
| 14 | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack显示文摘 | S Claiborne Johnston Peter M Rothwell Mai N Nguyen-Huynh Matthew F Giles Jacob S Elkins Allan L Bernstein Stephen Sidney | 2007 | The Lancet2007，，9558： | 2 |
| 15 | Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort显示文摘 | Ian Jacobs Aleksandra Gentry-Maharaj Matthew Burnell Ranjit Manchanda Naveena Singh Aarti Sharma Andy Ryan Mourad W Seif Nazar N Amso Gillian Turner Carol Brunell Gwendolen Fletcher Rani Rangar Kathy Ford Keith Godfrey Alberto Lopes David Oram Jonathan He | 2011 | Lancet Oncology2011，，1： | 2 |
| 16 | Crystal doping aided by rapid expansion of supercritical solutions 显示文摘 | Chandra V Matthew J M Thomas E N | 2002 | AAPS Pharm-SciTech2002，3，4： | 1 |
| 17 | SPARC Inhibits LPA-Mediated Mesothelial-Ovarian Cancer Cell Crosstalk 显示文摘 | Neveen AS Ida N Matthew JS | 2007 | Neoplasia2007，9，1： | 1 |
| 18 | The hot workability of Cromanite,a high nitrogen austenitic stainless steel显示文摘 | TARBOTON J N MATTHEWS L M SUTCLIFFE A | | 0，，： | 1 |
| 19 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 20 | Volume estimation of prefrontal cortical sub?elds using MRI and stereology显示文摘 | Matthew A Howard Roberts N | 2003 | Brain Research Protocols2003，10，： | 1 |
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