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| 1 | C-reactive protein levels during a relapse of Crohn’s disease are associated with the clinical course of the disease显示文摘AIM: To explore if C-reactive protein (CRP) levels might serve as a prognostic factor with respect to the clinical course of Crohn's disease and might be useful for classification.METHODS: In this retrospective cohort study we enrolled 94 patients from the inflammatory bowel disease (IBD) database of the University Medical Centre Utrecht. CRP levels during relapse were correlated with the number of relapses per year. Severity of relapses was based on endoscopic reports and prednisone use. Furthermore, patients were categorized in a low or high CRP group based on their CRP response during relapse and demographic and clinical features were compared.RESULTS: Overall, a positive correlation between CRP levels, number of relapses, and severity of relapse was found (respectively rs = 0.31, P < 0.01 and rs = 0.50, P < 0.001). Employing a cut-off level of 15 mg/L, the index CRP level was found to discriminate patients with respect to the number of relapses per year, as well as for severity of relapses (respectively 0.25 ± 0.16 vs 0.36 ± 0.24, P < 0.05 and 4.4 ± 1.2 vs 3.2 ± 1.1 on a 10-point visual analogue scale, P < 0.001 for the high CRP and low CRP groups respectively). In addition, the high CRP group showed more cumulative days of prednisone use per year (107 ± 95 vs 58 ± 48, P < 0.05), as well as a better response to infliximab (93 % vs 33 %, P = 0.06).CONCLUSION: A higher CRP level during relapse seems to be associated with a more severe clinical course of disease. | Chantal L Koelewijn Matthijs P Schwartz Melvin Samsom Bas Oldenburg | 2008 | World Journal of Gastroenterology2008，14，1： | 4 |
| 2 | FoxMl is required for execution of the mitotic programme and chromosome stability 显示文摘 | Jamila L Matthijs R H Alexandra B | 2005 | Cell Biology2005，7，2： | 1 |
| 3 | HapX-mediated iron homeostasis is essential forrhizosphere competence and virulence of the soilbornepathogen Fusarium oxysporum显示文摘 | López-Berges MS Capilla J Turrà D Schafferer L Matthijs S J?chl C Cornelis P Guarro J Haas H PietroAD | 2012 | Plant Cell2012，24，38： | 1 |
| 4 | Inhibition of lipolysis in bovine adipose tissue by buturate and 13 hydroxybutyrate显示文摘 | Stef H M M Matthijs L C Simon G V B | 1974 | FEBS Lett1974，47，1： | 1 |
| 5 | Description-driven community detection 显示文摘 | Simon P Franeesco B Matthijs V L | 2014 | ACM Transation on Intelligent Systems Technology2014，5，2： | 1 |
| 6 | Erythromycin is a motilin receptor agonist显示文摘 | PEETERS T L MATTHIJS G DEPOORTERE I | 1989 | Am J Physiol1989，257，： | 1 |
| 7 | Epidemiology,diagnosis,and an-timicrobial treatment of acute bacterial meningitis 显示文摘 | Matthijs C Brouwer L Allan R el al | 2010 | Clin Microbiol2010，23，3： | 1 |
| 8 | The role of water retaining substrata on the photosynthetic response of threedrought tolerant phototrophic micro-organisms isolated from a terrestrial habitat显示文摘 | De Winder B Matthijs H C P Mur L R | 1989 | Archives of Microbiology1989，152，： | 1 |
| 9 | Rapid NK- cell activation in chicken after infection with infectious bronchitis virus M41 显示文摘 | Vervelde L Matthijs M G van Haarlem D A | 2013 | Vet Immunol Immunopathol2013，151，34： | 1 |
| 10 | Trajectory planning and feed forward design for electromechanical motion systems 显示文摘 | Paul L Matthijs B Maarten S | 2005 | Control Engineering Practice2005，13，2： | 1 |
| 11 | The effect of raltegravir on the glucuronidation of lamotrigine显示文摘 | MATTHIJS L ANGELA C VERWEY-VAN | 2009 | J Clin Pharmacol2009，49，10： | 1 |
| 12 | 较大直肠腺瘤中经肛门内镜显微手术与内镜下黏膜切除术的随机对照试验(TREND研究)显示文摘摘要 目的 非随机研究表明内镜下黏膜切除术(endoscopic mucosal resection,EMR)在切除直肠较大腺瘤时与经肛门内镜显微手术(transanal endoscopic microsurgery,TEM)同样有效,但EMR可能更具成本效益且相对安全。本试验旨在对比摘除较大直肠腺瘤时EMR与TEM的临床结局与成本效益。 | Renee M Barendse Gijsbert D Musters Eelco J R de Graaf Frank J C van den Broek Esther C J Consten Pascal G Doornebosch James C Hardwick Ignace H J T de Hingh Chrisiaan Hoft Jeroen M Jansen A W Marc van Milligen de Wit George P van der Schelling Erik J Schoon Matthijs P Schwartz Bas L A M Weusten Marcel G Dijkgraaf Paul Fockens Willem A Bemelman Evelien Dekker TREND研究小组 李佳宁(译) 吴东(校) | 2018 | 英国医学杂志中文版2018，21，11： | 0 |
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