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| 1 | Endoscopic ultrasonography-guided fine needle aspiration:Relatively low sensitivity in the endosonographer population显示文摘AIM:To assess the characteristics and quality of endoscopic ultrasonography-guided fine needle aspiration(EUS-FNA) in a large panel of endosonographers.METHODS:A survey was conducted during the 13th annual live course of endoscopic ultrasonography(EUS) held in Amsterdam,Netherlands.A 2-page questionnaire was developed for the study.Content validity of the questionnaire was determined based on input by experts in the field and a review of the relevant literature.It contained 30 questions that pertained to demographics and the current practice for EUS-FNA of responders,including sampling technique,sample processing,cytopathological diagnosis and sensitivity of EUS-FNA for the diagnosis of solid mass lesions.One hundred and sixty-one endosonographers who attended the course were asked to answer the survey.This allowed assessing the current practice of EUS-FNA as well as the self-reported sensitivity of EUS-FNA for the diagnosis of solid mass lesions.We also examined which factors were associated with a self-reported sensitivity of EUS-FNA for the diagnosis of solid mass lesions > 80%.RESULTS:Completed surveys were collected from 92(57.1%) of 161 endosonographers who attended the conference.The endosonographers had been practicing endoscopy and EUS for 12.5 ± 7.8 years and 4.8 ± 4.1 years,respectively;one third of them worked in a hospital with an annual caseload > 100 EUS-FNA.Endoscopy practices were located in 29 countries,including 13 countries in Western Europe that totaled 75.3% of the responses.Only one third of endosonographers reported a sensitivity for the diagnosis of solid mass lesions > 80%(interquartile range of sensitivities,25.0%-75.0%).Factors independently associated with a sensitivity > 80% were(1) > 7 needle passes for pancreatic lesions or rapid on-site cytopathological evaluation(ROSE)(P < 0.0001),(2) a high annual hospital caseload(P = 0.024) and(3) routine isolation of microcores from EUS-FNA samples(P = 0.042).ROSE was routinely available to 27.9% of respondents.For lymph nodes and pancreatic masses,a maximum of three needle passes was performed by approximately two thirds of those who did not have ROSE.Microcores were routinely harvested from EUS-FNA samples by approximately one third(37.2%) of survey respondents.CONCLUSION:EUS-FNA sensitivity was considerably lower than reported in the literature.Low EUS-FNA sensitivity was associated with unavailability of ROSE,few needle passes,absence of microcore isolation and low hospital caseload. | Jean-Marc Dumonceau Thibaud Koessler Jeanin E van Hooft Paul Fockens | 2012 | World Journal of Gastroenterology2012，18，19： | 7 |
| 2 | Self-expandable metal stents for malignant gastric outlet obstruction: A pooled analysis of prospective literature显示文摘AIM: To provide an overview of the clinical outcomes of self-expandable metal stent(SEMS) placement for malignant gastric outlet obstruction(MGOO).METHODS: A systematic literature search was performed in Pub Med of the literature published between January 2009 and March 2015. Only prospective studies that reported on the clinical success of stent placement for MGOO were included. The primary endpoint was clinical success,defined according to the definition used in the original article. Data were pooled and analyzed using descriptive statistics. Subgroup analyses were performed for partially covered SEMSs(PCSEMSs) and uncovered SEMSs(UCSEMSs) using Fisher's exact test.RESULTS: A total of 19 studies,including 1281 patients,were included in the final analysis. Gastric(42%) and pancreatic(37%) cancer were the main causes of MGOO. UCSEMSs were used in 76% of patients and PCSEMSs in 24%. The overall pooled technical success rate was 97.3% and the clinical success rate was 85.7%. Stent dysfunction occurred in 19.6% of patients,mainly caused by re-obstruction(12.6%) and stent migration(4.3%),and was comparable between PCSEMSs and UCSEMSs(21.2% vs 19.1%,respectively,P = 0.412). Re-obstruction was more common with UCSEMSs(14.9% vs 5.1%,P < 0.001) and stent migration was more frequent after PCSEMS placement(10.9% vs 2.2%,P < 0.001). The overall perforation rate was 1.2%. Bleeding was reported in 4.1% of patients,including major bleeding in 0.8%. The median stent patency ranged from 68 to 307 d in five studies. The median overall survival ranged from 49 to 183 d in 13 studies.CONCLUSION: The clinical outcomes in this large population showed that enteral stent placement was feasible,effective and safe. Therefore,stent placement is a valid treatment option for the palliation of MGOO. | Emo E van Halsema Erik AJ Rauws Paul Fockens Jeanin E van Hooft | 2015 | World Journal of Gastroenterology2015，21，43： | 5 |
| 3 | Adherence to surveillance guidelines for dysplasia and colorectal carcinoma in ulcerative and Crohn's colitis patients in the Netherlands显示文摘AIM: To study adherence to the widely accepted surveillance guidelines for patients with long-standing colitis in the Netherlands. METHODS: A questionnaire was sent to all 244 gastroenterologists in the Netherlands. RESULTS: The response rate was 63%. Of all gastroenterologists, 95% performed endoscopic surveillance in ulcerative colitis (UC) patients and 65% in patients with Crohn's colitis. The American Gastroenterological Association (AGA) guidelines were followed by 27%, while 27% and 46% followed their local hospital protocol or no specific protocol, respectively. The surveillance was correctly initiated in cases of pancolitis by 53%, and in cases of left-sided colitis by 44% of the gastroenterologists. Although guidelines recommend 4 biopsies every 10 cm, less than 30 biopsies per colonoscopy were taken by 73% of the responders. Only 31%, 68% and 58% of the gastroenterologists referred patients for colectomy when low-grade dysplasia, high-grade dysplasia (HGD) or Dysplasia Associated Lesion or Mass (DALM) was present, respectively. CONCLUSION: Most Dutch gastroenterologists performendoscopic surveillance without following international recommended guidelines. This practice potentially leads to a decreased sensitivity for dysplasia, rendering screening for colorectal cancer in this population highly ineffective. | Anne F van Rijn Paul Fockens Peter D Siersema Bas Oldenburg | 2009 | World Journal of Gastroenterology2009，15，2： | 4 |
| 4 | Diagnosis and management of iatrogenic endoscopic perforations: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement显示文摘 | Gregorios Paspatis Jean-Marc Dumonceau Marc Barthet S?ren Meisner Alessandro Repici Brian Saunders Antonios Vezakis Jean Gonzalez Stine Turino Zacharias Tsiamoulos Paul Fockens Cesare Hassan | 2014 | Endoscopy2014，，： | 4 |
| 5 | Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicentre randomised trial显示文摘 | Jeanin E van Hooft Willem A Bemelman Bas Oldenburg Andreas W Marinelli Martijn F Lutke Holzik Marina J Grubben Mirjam A Sprangers Marcel G Dijkgraaf Paul Fockens | 2011 | Lancet Oncology2011，，4： | 3 |
| 6 | Adenoma detection with cap-assisted colonoscopy versus regular colonoscopy: a randomised controlled trial显示文摘 | Thomas R de Wijkerslooth Esther M Stoop Patrick M Bossuyt Elisabeth M H Mathus-Vliegen Jan Dees Kristien M A J Tytgat Monique E van Leerdam Paul Fockens Ernst J Kuipers Evelien Dekker | 2012 | Gut2012，，10： | 3 |
| 7 | Efficacy and safety of the new WallFlex enteral stent in palliative treatment of malignant gastric outlet obstruction (DUOFLEX study): a prospective multicenter study显示文摘 | Jeanin E. van Hooft Madeleen J. Uitdehaag Marco J. Bruno Robin Timmer Peter D. Siersema Marcel G.W. Dijkgraaf Paul Fockens | 2009 | Gastrointestinal Endoscopy2009，，6： | 2 |
| 8 | Efficacy of Endoscopic Closure of Acute Perforations of the Gastrointestinal Tract显示文摘 | Rogier P. Voermans Olivier Le Moine Daniel von Renteln Thierry Ponchon Marc Giovannini Marco Bruno Bas Weusten Stefan Seewald Guido Costamagna Pierre Deprez Paul Fockens | 2012 | Clinical Gastroenterology and Hepatology2012，，6： | 2 |
| 9 | Effect of peroral endoscopic myotomy on esophagogastric junction physiology in patients with achalasia显示文摘 | Tessa Verlaan Wout O. Rohof Albert J. Bredenoord Susanne Eberl Thomas R?sch Paul Fockens | 2013 | Gastrointestinal Endoscopy2013，，1： | 2 |
| 10 | Random Comparison of Guaiac and Immunochemical Fecal Occult Blood Tests for Colorectal Cancer in a Screening Population显示文摘 | Leo G. van Rossum Anne F. van Rijn Robert J. Laheij Martijn G. van Oijen Paul Fockens Han H. van Krieken Andre L. Verbeek Jan B. Jansen Evelien Dekker | 2008 | Gastroenterology2008，，1： | 2 |
| 11 | Endoscopic Trimodal Imaging Detects Colonic Neoplasia as Well as Standard Video Endoscopy显示文摘 | Teaco Kuiper Frank J.C. van den Broek Anton H. Naber Ellert J. van Soest Pieter Scholten Rosalie Ch. Mallant–Hent Jan van den Brande Jeroen M. Jansen Arnoud H.A.M. van Oijen Willem A. Marsman Jacques J.G.H.M. Bergman Paul Fockens Evelien Dekker | 2011 | Gastroenterology2011，，7： | 2 |
| 12 | EUS-guided fiducial markers placement with a 22-gauge needle for image-guided radiation therapy in pancreatic cancer显示文摘 | Raquel Dávila Fajardo Selma J. Lekkerkerker Astrid van der Horst Eelco Lens Jacques J. Bergman Paul Fockens Arjan Bel Jeanin E. van Hooft | 2013 | Gastrointestinal Endoscopy2013，，： | 2 |
| 13 | Peroral Endoscopic Myotomy for the Treatment of Achalasia: An International Prospective Multicenter Study显示文摘 | Daniel Von Renteln Karl–Hermann Fuchs Paul Fockens Peter Bauerfeind Melina C. Vassiliou Yuki B. Werner Gerald Fried Wolfram Breithaupt Henriette Heinrich Albert J. Bredenoord Jan F. Kersten Tessa Verlaan Michael Trevisonno Thomas R?sch | 2013 | Gastroenterology2013，，2： | 2 |
| 14 | Endoscopic features of sessile serrated adenomas: validation by international experts using high-resolution white-light endoscopy and narrow-band imaging显示文摘 | Yark Hazewinkel Maria López-Cerón James E. East Amit Rastogi Maria Pellisé Takeshi Nakajima Susanne van Eeden Kristien M.A.J. Tytgat Paul Fockens Evelien Dekker | 2013 | Gastrointestinal Endoscopy2013，，6： | 2 |
| 15 | Extended Transthoracic Resection Compared With Limited Transhiatal Resection for Adenocarcinoma of the Mid/Distal Esophagus: Five-Year Survival of a Randomized Clinical Trial显示文摘 | Jikke M. T. Omloo Sjoerd M. Lagarde Jan B. F. Hulscher Johannes B. Reitsma Paul Fockens Herman van Dekken Fiebo J. W. ten Kate Huug Obertop Hugo W. Tilanus J Jan B. van Lanschot | 2007 | Annals of Surgery2007，，6： | 2 |
| 16 | Adalimumab for Crohn’s disease: Long-term sustained benefit in a population-based cohort of 438 patients显示文摘 | Charlotte P. Peters Emma J. Eshuis Florien M. Toxopeüs Merel E. Hellemons Jeroen M. Jansen Geert R.A.M. D’Haens Paul Fockens Pieter C.F. Stokkers Hans A.R.E. Tuynman Adriaan A. van Bodegraven Cyriel Y. Ponsioen | 2014 | Journal of Crohn’s and Colitis2014，，： | 2 |
| 17 | Efficacy of Radiofrequency Ablation Combined With Endoscopic Resection for Barrett’s Esophagus With Early Neoplasia显示文摘 | Roos E. Pouw Katja Wirths Pierre Eisendrath Carine M. Sondermeijer Fiebo J. Ten Kate Paul Fockens Jacques Devière Horst Neuhaus Jacques J. Bergman | 2010 | Clinical Gastroenterology and Hepatology2010，，： | 2 |
| 18 | Endoscopic transluminal necrosectomy in necrotising pancreatitis: a systematic review显示文摘 | Sandra Brunschot Paul Fockens Olaf J. Bakker Marc G. Besselink Rogier P. Voermans Jan-Werner Poley Hein G. Gooszen Marco Bruno Hjalmar C. Santvoort | 2014 | Surgical Endoscopy2014，，5： | 2 |
| 19 | A randomized trial of endoscopic balloon dilation and endoscopic sphincterotomy for removal of bile duct stones in patients with a prior Billroth II gastrectomy显示文摘 | Jacques J.G.H.M Bergman Anne-Marie van Berkel Marco J Bruno Paul Fockens Erik A.J Rauws Jan G.P Tijssen Guido N.J Tytgat Kees Huibregtse | 2001 | Gastrointestinal Endoscopy2001，，1： | 2 |
| 20 | Endoscopic radiofrequency ablation combined with endoscopic resection for early neoplasia in Barrett’s esophagus longer than 10 cm显示文摘 | Lorenza Alvarez Herrero Frederike G.I. van Vilsteren Roos E. Pouw Fiebo J.W. ten Kate Mike Visser Cornelis A. Seldenrijk Mark I. van Berge Henegouwen Paul Fockens Bas L.A.M. Weusten Jaques J.G.H.M. Bergman | 2011 | Gastrointestinal Endoscopy2011，，4： | 1 |
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