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| 1 | Glucocorticosteroid therapy in inflammatory bowel diseases: From clinical practice to molecular biology显示文摘Inflammatory bowel diseases(IBDs),such as ulcerative colitis and Crohn's disease,are chronic pathologies associated with a deregulated immune response in the intestinal mucosa,and they are triggered by environmental factors in genetically susceptible individuals.Exogenous glucocorticoids(GCs)are widely used as anti-inflammatory therapy in IBDs.In the past,patients with moderate or severe states of inflammation received GCs as a first line therapy with an important effectiveness in terms of reduction of the disease activity and the induction of remission.However,this treatment often results in detrimental side effects.This downside drove the development of second generation GCs and more precise(non-systemic)drugdelivery methods.Recent clinical trials show that most of these new treatments have similar effectiveness to first generation GCs with fewer adverse effects.The remaining challenge in successful treatment of IBDs concerns the refractoriness and dependency that some patients encounter during GCs treatment.A deeper understanding of the molecular mechanisms underlying GC response is key to personalizing drug choice for IBDs patients to optimize their response to treatment.In this review,we examine the clinical characteristics of treatment with GCs,followed by an in depth analysis of the proposed molecular mechanisms involved in its resistance and dependence associated with IBDs.This thorough analysis of current clinical and biomedical literature may help guide physicians in determining a course of treatment for IBDs patients and identifies important areas needing further study. | Karen Dubois-Camacho Payton A Ottum Daniel Franco-Munoz Marjorie De la Fuente Alejandro Torres-Riquelme David Díaz-Jiménez Mauricio Olivares-Morales Gonzalo Astudillo Rodrigo Quera Marcela A Hermoso | 2017 | World Journal of Gastroenterology2017，23，36： | 6 |
| 2 | Circulating ghrelin in thyroid dysfunction is related to in- sulin resistance and not to hunger, food intake or anthropo- metric changes显示文摘 | Gime'nez-Palop O Gimenez-Perez G Mauricio D | 2005 | Eur J Endocrinol2005，153，1： | 1 |
| 3 | Diabetic neuropathy is associated with activation of the TNF-α system in subjects with type 1 diabetes mellitus 显示文摘 | Gonzalez-Clemente JM Mauricio D Richart C | 2005 | Clin Endocrinol ( Oxf)2005，63，5： | 1 |
| 4 | A brief discussion on (pure mode I ) fatigue crack growth rate data in 5HS weave fabric composites: evaluation of empirical relations显示文摘 | MARCOS Y S REYNDERT C A MAURICIO V D | 2015 | International Journal of Fatigue2015，84，： | 1 |
| 5 | PTEN promoter methylation in sporadic thyroid carcinomas 显示文摘 | Alvarez-Nunez F Bussaglia E Mauricio D | 2006 | Thyroid2006，16，1： | 1 |
| 6 | Vitamin D analogues in insulin-dependent diabetes mellitus and other autoimmune diseases: a therapeutic perspective 显示文摘 | Mauricio D Mandrup-Poulsen T Nerup J | 1996 | Diabetes Metab Rev1996，12，1： | 1 |
| 7 | PTEN promoter methylation in sporadic thyroid carcinomas显示文摘 | Francisco AN Bussaglia E Mauricio D | 2006 | Thyroid2006，16，7： | 1 |
| 8 | Minimum Entro Pydeconvolution with Frequency-domain Constraints显示文摘 | Mauricio D S Danilo R V Alberta H C | 1994 | Geophysics1994，59，6： | 1 |
| 9 | Three-phase transformer modeling using a vector hysteresis model and including the eddy current and the anomalous losses显示文摘 | Mauricio V Ferreira D L Jean V L | 2010 | IEEE Transactions on Magnetics2010，46，8： | 1 |
| 10 | Impact of dietary fibersmethyl cellulose,chitosan,and pectin on digestion of lipids under simulated gastrointestinal conditions显示文摘 | Mauricio E R Fabian P A Mcclements D J | 2014 | Food & Function2014，5，12： | 1 |
| 11 | Clarification of fruit juices by fungal pectinases显示文摘 | Ivana Greice Sandri Roselei Claudete Fontana Débora Menim Barfknecht Mauricio Moura da Silveira | 2011 | LWT - Food Science and Technology2011，，10： | 1 |
| 12 | Diabetic neuropathy is associated with activation of the TNF-alpha system in subjects with type 1 diabetes mellitus显示文摘 | Gonzalez-Clemente J M Mauricio D Richart C | 2005 | Clin Endocrinol (Oxf)2005，63，5： | 1 |
| 13 | Time toinsulin initiation cannot be used in defining latent autoimmune dia-betes in adults显示文摘 | BROPHY S YDERSTRAEDE K MAURICIO D | 2008 | Diabetes Care2008，31，3： | 1 |
| 14 | Time to insulin initiation cannot be used in defining latent autoimmune diabetes in adults显示文摘 | Brophy S Yderstraede K Mauricio D | 2008 | Diabets Care2008，31，2： | 1 |
| 15 | Changes in aminoacidergic and monoaminergic neurotransmission in the hippocampus and amygdala of rats after ayahuasca ingestion显示文摘AIM: To evaluate changes in neurotransmission induced by a psychoactive beverage ayahuasca in the hippocampus and amygdala of naive rats. METHODS: The level of monoamines, their main metabolites and amino acid neurotransmitters concentrations were quantified using high performance liquid chromatography(HPLC). Four groups of rats were employed: saline-treated and rats receiving 250, 500 and 800 mg/kg of ayahuasca infusion(gavage). Animals were killed 40 min after drug ingestion and the structures stored at-80 ℃ until HPLC assay. The data from all groups were compared using Analysis of variance and Scheffé as post test and P < 0.05 was accepted as significant. RESULTS: The results showed decreased concentrations of glycine(GLY)(0.13 ± 0.03 vs 0.29 ± 0.07, P < 0.001) and γ-aminobutyric acid(GABA)(1.07 ± 0.14 vs 1.73 ± 0.25, P < 0.001) in the amygdala of rats that received 500 of ayahuasca. Animals that ingested 800 mg/kg of ayahuasca also showed a reduction of GLY level(0.11 ± 0.01 vs 0.29 ± 0.07, P < 0.001) and GABA(0.98 ± 0.06 vs 1.73 ± 0.25, P < 0.001). In the hippocampus, increased GABA levels were found in rats that received all ayahuasca doses: 250 mg/kg(1.29 ± 0.19 vs 0.84 ± 0.21, P < 0.05); 500 mg/kg(2.23 ± 038 vs 084 ± 0.21, P < 0.05) and 800 mg/kg(1.98 ± 0.92 vs 0.84 ± 0.21, P < 0.05). In addition, an increased utilization rate of all monoamines was found in the amygdala after ayahuasca administration in doses: 250 mg/kg(noradrenaline: 0.16 ± 0.02 vs 0.36 ± 0.06, P < 0.01; dopamine: 0.39 ± 0.012 vs 2.39 ± 0.84, P < 0.001; serotonin: 1.02 ± 0.22 vs 4.04 ± 0.91, P < 0.001), 500 mg/kg(noradrenaline: 0.08 ± 0.02 vs 0.36 ± 0.06, P < 0.001; dopamine: 0.33 ± 0.19 vs 2.39 ± 0.84, P < 0.001; serotonin: 0.59 ± 0.08 vs 4.04 ± 0.91, P < 0.001) and 800 mg/kg(noradrenaline: 0.16 ± 0.04 vs 0.36 ± 0.06, P < 0.001; dopamine: 0.84 ± 0.65 vs2.39 ± 0.84, P < 0.05; serotonin: 0.36 ± 0.02 vs 4.04 ± 0.91, P < 0.001). CONCLUSION: Our data suggest increased release of inhibitory amino acids by the hippocampus and an increased utilization rate of monoamines by the amygdala after different doses of ayahuasca ingestion. | Eduardo Ferreira de Castro-Neto Rafael Henrique da Cunha Dartiu Xavier da Silveira Mauricio Yonamine Telma Luciana Furtado Gouveia Esper Abr o Cavalheiro Débora Amado Maria da Gra a Naffah-Mazzacoratti | 2013 | World Journal of Biological Chemistry2013，4，4： | 1 |
| 16 | Early diagnosis of subependymal giant cell astrocytoma in patients with tuberous sclerosis 显示文摘 | Orlando A T Roach E S Mauricio R D | 1998 | J Child Neurol1998，13，4： | 1 |
| 17 | Apoptosis and the pathogenesis of IDDM:a question of life and death显示文摘 | Mauricio D Mandrup - Poulsen T | 1998 | Diabetes1998，47，10： | 1 |
| 18 | Channel estimation using implicit training显示文摘 | Orozco-Lugo A G Mauricio L M McLernon D C | 2004 | IEEE Transactions on Signal Processing2004，52，1： | 1 |
| 19 | Dimethoate accel- erates the extinction of eyeblink conditioning in mice 显示文摘 | Mauricio V H Irene C Corin D | 2012 | NeuroToxicology2012，33，1： | 1 |
| 20 | Nurse-driven, protocol-di- rected weaning from mechanical ventilation improves clinical outcomes and is well accepted by intensive care unit physicians 显示文摘 | Mauricio D Horiana G Raymonde J | 2013 | Journal of Critical Care2013，28，4： | 1 |
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