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| 1 | Open label trial of granulocyte apheresis suggests therapeutic efficacy in chronically active steroid refractory ulcerative colitis显示文摘AIM:To study the efficacy, safety, and feasibility of a granulocyte adsorptive type apheresis system for the treatment of patients with chronically active ulcerative colitis despite standard therapy.METHODS: An open label multicenter study was carried out in 39 patients with active ulcerative colitis (CAI6-8) despite continuous use of steroids (a minimum total dose of 400 mg prednisone within the last 4 wk).Patients received a total of five aphereses using a granulocyte adsorptive technique (Adacolumn(R), Otsuka Pharmaceutical Europe, UK). Assessments at wk 6 and during follow-up until 4 mo comprised clinical (CAI) and endoscopic (EI) activity index, histology, quality of life(IBDQ), and laboratory tests.RESULTS: Thirty-five out of thirty-nine patients were qualified for intent-to-treat analysis. After the apheresis treatment at wk 6, 13/35 (37.1%) patients achieved clinical remission and 10/35 (28.6%) patients had endoscopic remission (CAI<4, EI<4). Quality of life (IBDQ) increased significantly (24 points, P<0.01)at wk 6. Apheresis could be performed in all but one patient. Aphereses were well tolerated, only one patient experienced anemia.CONCLUSION: In patients with steroid refractory ulcerative colitis, five aphereses with a granulocyte/monocyte depleting filter show potential short-term efficacy. Tolerability and technical feasibility of the procedure are excellent. | Wolfgang Kruis Axel Dignass Elisabeth Steinhagen-Thiessen Julia Morgenstern Joachim M(o|¨)ssner Stephan Schreiber Maurizio Vecchi Alberto Malesci Max Reinshagen Robert L(o|¨)fberg | 2005 | World Journal of Gastroenterology2005，11，44： | 4 |
| 2 | Wind-induced interference effects on two adjacent cooling towers 显示文摘 | Maurizio O | 2001 | Engineering Structures2001，23，： | 1 |
| 3 | Gastrointestinal histoplasmosis in the acquired immunodeficiency syndrome: report of 18 cases and literature review显示文摘 | Maha Assi David S. McKinsey Michael R. Driks Mary C. O’Connor Maurizio Bonacini Bruce Graham Farrin Manian | 2006 | Diagnostic Microbiology & Infectious Disease2006，，3： | 1 |
| 4 | Microemulsions and emulsions in DDAB/water/oil systems 显示文摘 | MAURIZIO O MAURA M and LUIGI A | 1999 | Colloids surfaces A: Physicochem Eng Aspects1999，160，1： | 1 |
| 5 | Sepsis-induced cholestasis, steatosis, hepatocellular injury,and impaired hepatocellular regeneration are enhanced in interlenkin-6-/- mice 显示文摘 | Clifford SD Maurizio CE Andrew O | 2006 | Crit Care Med2006，34，10： | 1 |
| 6 | Diffusion bonding of aluminum oxide to stainless steel using stress relief interlayers显示文摘 | DILERMANDO T MAURIZIO F GERT D O | 2002 | Materials Science and Engineering2002，337，12： | 1 |
| 7 | The effects of owner identity and external governance systems on R&D inves- tments: A study of Western European firms显示文摘 | Federico M Raffaele O Maurizio S | 2010 | Research Policy2010，39，： | 1 |
| 8 | Blue silver:A very sensitive colloidal Coomassie G-250 staining for proteome analysis显示文摘 | Giovanni C Maurizio Br Luca M Laura S Gian M G Barbara C Paola O Luciano Z and Pier G R | | 0，，09： | 1 |
| 9 | Wavelet Analysis for the Regional-Residual and Local Separation of Potential Field Anomalies 显示文摘 | Maurizio F Tatiana O | 1998 | Geophysical Prospecting1998，46，5： | 1 |
| 10 | Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida olbicans, Candida glabrata, and Candida krusei antimicrob显示文摘 | CHIATOGU O JILL R B MAURIZIO D P | 2003 | Agents Chemother2003，47，3： | 1 |
| 11 | Diffusion bonding of aluminium oxide to stainless steel using stress relief interlayers显示文摘 | Dilermando T Maurizio F Gert Den O | 2002 | Materials Science and Engineering2002，337，12： | 1 |
| 12 | Complex Inhibitory Effects of Nitric Oxide on Autophagy显示文摘 | Sovan Sarkar Viktor I. Korolchuk Maurizio Renna Sara Imarisio Angeleen Fleming Andrea Williams Moises Garcia-Arencibia Claudia Rose Shouqing Luo Benjamin R. Underwood Guido Kroemer Cahir J. O’Kane David C. Rubinsztein | 2011 | Molecular Cell2011，，1： | 1 |
| 13 | Computer-assisted discrimination of morphological units on north-central Crete (Greece) by applying multivariate statistics to local relief gradients显示文摘 | Ayodele O A Issaak P Maurizio P | 2004 | Geomorphology2004，58，： | 1 |
| 14 | Sepsis - induced cholestasis, steaflsis, hepaficellular injury, and impaired hepatocellular regeneration are enhanced in interleukin -6显示文摘 | Clifford SD Maurizio CE Andrew O | 2006 | Crit Care Med2006，34，10： | 1 |
| 15 | Diffusion bonding of aluminium oxide to stainless steel using stress relief interlayers显示文摘 | Dilermando T Maurizio F Gert D O | 2002 | Materials Science and Engineering2002，，337： | 1 |
| 16 | Photochemical synthesis of bithienyl derivatives显示文摘 | Maurizio D A Antonella D M Franco D O | 1987 | J Chem Soc Perkin Trans I1987，，： | 1 |
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