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| 1 | Continuous quality improvement methodology: a case study on multidisciplinary collaboration to improve chlamydia screening显示文摘This article illustrates quality improvement(QI)methodology using an example intended to improve chlamydia screening in women.QI projects in healthcare provide great opportunities to improve patient quality and safety in a real-world healthcare setting,yet many academic centres lack training programmes on how to conduct QI projects.The choice of chlamydia screening was based on the significant health burden chlamydia poses despite simple ways to screen and treat.At the University of Michigan,we implemented a multidepartment process to improve the chlamydia screening rates using the plan-do-check-act model.Steps to guide QI projects include the following:(1)assemble a motivated team of stakeholders and leaders;(2)identify the problem that is considered a high priority;(3)prepare for the project including support and resources;(4)set a goal and ways to evaluate outcomes;(5)identify the root cause(s)of the problem and prioritise based on impact and effort to address;(6)develop a countermeasure that addresses the selected root cause effectively;(7)pilot a small-scale project to assess for possible modifications;(8)large-scale roll-out including education on how to implement the project;and(9)assess and modify the process with a feedback mechanism.Using this nine-step process,chlamydia screening rates increased from 29%to 60%.QI projects differ from most clinical research projects by allowing clinicians to directly improve patients’health while contributing to the medical science body.This may interest clinicians wishing to conduct relevant research that can be disseminated through academic channels. | Allison Ursu Grant Greenberg Michael McKee | 2019 | Family Medicine and Community Health2019，7，2： | 7 |
| 2 | Endocrine Regulation of Energy Metabolism by the Skeleton显示文摘 | Na Kyung Lee Hideaki Sowa Eiichi Hinoi Mathieu Ferron Jong Deok Ahn Cyrille Confavreux Romain Dacquin Patrick J. Mee Marc D. McKee Dae Young Jung Zhiyou Zhang Jason K. Kim Franck Mauvais-Jarvis Patricia Ducy Gerard Karsenty | 2007 | Cell2007，，3： | 5 |
| 3 | Blockchain technology in the future of business cyber security and accounting显示文摘This study looks into the current,and potential uses of Blockchain technology in business,specifically in Accounting and in cybersecurity.We relate Blockchain uses to current concerns within cybersecurity and accounting.We review the literature that includes topics such as Big Data in Accounting,blockchain’s use in financial security and cybersecurity,and its use in financial accounting though the use of ledger technology and also as a system of tracking financial misconduct.We also review the Department of Homeland Security plan for cybersecurity over the next few years to understand what the US Government plans because of the importance of cybersecurity development.We show that Blockchain impacts auditing in different ways that will change the profession drastically.We also find that blockchain should be effectively implemented into different aspects of cybersecurity,and accounting,such as Auditing and general accounting procedures. | Sebahattin Demirkan Irem Demirkan Andrew McKee | 2020 | Journal of Management Analytics2020，7，2： | 3 |
| 4 | Simplified three-dimensional culture system for long-term expansion of embryonic stem cells显示文摘AIM: To devise a simplified and efficient method for long-term culture and maintenance of embryonic stem cells requiring less frequent passaging. METHODS: Mouse embryonic stem cells(ESCs) labeled with enhanced yellow fluorescent protein were cultured in three-dimensional(3-D) self-assembling scaffolds and compared with traditional two-dimentional(2-D) culture techniques requiring mouse embryonic fibroblast feeder layers or leukemia inhibitory factor. 3-D scaffolds encapsulating ESCs were prepared by mixing ESCs with polyethylene glycol tetra-acrylate(PEG-4-Acr) and thiolfunctionalized dextran(Dex-SH). Distribution of ESCs in 3-D was monitored by confocal microscopy. Viability and proliferation of encapsulated cells during long-term culture were determined by propidium iodide as well as direct cell counts and PrestoB lue(PB) assays. Genetic expression of pluripotency markers(Oct4, Nanog, Klf4, and Sox2) in ESCs grown under 2-D and 3-D cultureconditions was examined by quantitative real-time polymerase chain reaction. Protein expression of selected stemness markers was determined by two different methods, immunofluorescence staining(Oct4 and Nanog) and western blot analysis(Oct4, Nanog, and Klf4). Pluripotency of 3-D scaffold grown ESCs was analyzed by in vivo teratoma assay and in vitro differentiation via embryoid bodies into cells of all three germ layers. RESULTS: Self-assembling scaffolds encapsulating ESCs for 3-D culture without the loss of cell viability were prepared by mixing PEG-4-Acr and Dex-SH(1:1 v/v) to a final concentration of 5%(w/v). Scaffold integrity was dependent on the degree of thiol substitution of Dex-SH and cell concentration. Scaffolds prepared using Dex-SH with 7.5% and 33% thiol substitution and incubated in culture medium maintained their integrity for 11 and 13 d without cells and 22 ± 5 d and 37 ± 5 d with cells, respectively. ESCs formed compact colonies, which progressively increased in size over time due to cell proliferation as determined by confocal microscopy and PB staining. 3-D scaffold cultured ESCs expressed significantly higher levels(P < 0.01) of Oct4, Nanog, and Kl4, showing a 2.8, 3.0 and 1.8 fold increase, respectively, in comparison to 2-D grown cells. A similar increase in the protein expression levels of Oct4, Nanog, and Klf4 was observed in 3-D grown ESCs. However, when 3-D cultured ESCs were subsequently passaged in 2-D culture conditions, the level of these pluripotent markers was reduced to normal levels. 3-D grown ESCs produced teratomas and yielded cells of all three germ layers, expressing brachyury(mesoderm), NCAM(ectoderm), and GATA4(endoderm) markers. Furthermore, these cells differentiated into osteogenic, chondrogenic, myogenic, and neural lineages expressing Col1, Col2, Myog, and Nestin, respectively. CONCLUSION: This novel 3-D culture system demonstrated long-term maintenance of mouse ESCs without the routine passaging and manipulation necessary for traditional 2-D cell propagation. | Christina McKee Mick Perez-Cruet Ferman Chavez G Rasul Chaudhry | 2015 | World Journal of Stem Cells2015，7，7： | 2 |
| 5 | Using MODIS Terra 250 m imagery to map concentrations of total suspended matter in coastal waters显示文摘 | Richard L. Miller Brent A. McKee | 2004 | Remote Sensing of Environment2004，，1： | 2 |
| 6 | Weighted stationary phase of higher orders显示文摘这份报纸的主题是有由 g 加权的阶段 f (x) 的指数的摆动的积分有限间隔上的(x)[] :当阶段 f (x) 在() 有一个单个静止的点时,这的第 n 顺序的 asymptotic 扩大积分为 n 被证明 2:这 asymptotic 扩大削尖 n = 的古典结果 1 由 M.N. 赫克斯利。类似的 asymptotic 扩大被 V 证明。Blomer, R。中亚细亚并且在 f (x) 和 g (x) 是光滑的假设和 g (x) 下面年轻的 M. 简洁地在 R 上被支持:在现在的纸,然而,这些功能仅仅被假定连续地可辨在上[] 2n + 3 并且 2n + 1 次分别地。因为在端点 g (x) 和它的衍生物消失上没有要求并且,现在的 asymptotic 扩大总体上包含明确的边界术语并且错误术语。在这份报纸的 asymptotic 扩大对在分析,分析数字理论,和另外的地的问题的一个更宽的班因此适用。 | Mark MCKEE Haiwei SUN Yangbo YE | 2017 | Frontiers of Mathematics in China2017，12，3： | 2 |
| 7 | Methods of Operative Fixation of the Acromio-Clavicular Joint: A Biomechanical Comparison显示文摘 | Alison J McConnell Daniel J Yoo Rad Zdero Emil H Schemitsch Michael D McKee | 2007 | Journal of Orthopaedic Trauma2007，，4： | 2 |
| 8 | 低可得性环境下的金融消费者保护监管——发展负责任金融的契机(一)显示文摘2010年2月美国及其它成熟市场上,不负责任的金融活动和金融产品的危害持续发酵,继续影响全球金融,此时,负责任金融一词在新闻中频繁出现1。很明显,监管失败是金融系统崩溃的重要原因2。全球金融危机也带来了一线光明,这就是金融消费者保护受到了更多关注。在拥有发达金融市场的国家, | Laura Brix Kathatine Mckee 杨岚 赵煊 孙天琦 | 2011 | 西部金融2011，，11： | 2 |
| 9 | Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages显示文摘 | McKee CM Penno MB Cowman M | | Journal of Clinical Investigation0，，： | 2 |
| 10 | The 'terrible triad' of the elbow显示文摘 | Pugh DM McKee MD | 2002 | Teeh Hand Upper Extrem Surg2002，6，： | 1 |
| 11 | Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorr hage显示文摘 | Borel C O McKee A Parra A | 2003 | Stroke2003，34，2： | 1 |
| 12 | Neural mechanisms underlying amblyopia显示文摘 | McKee SP | 1999 | Curr Opinion Neurobiol1999，9，： | 1 |
| 13 | Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein显示文摘 | Ducy P Mckee MD | 1997 | Nature1997，386，： | 1 |
| 14 | The inhibition of grahite oxidation by phosphorus additives 显示文摘 | Spiro C L Lamby E J | 1984 | Carbon1984，22，3： | 1 |
| 15 | Functional outcome of ipsilateral intertrochanteric and femoral shaft fractures 显示文摘 | Peskun C McKee M Kreder H | 2008 | J Orthop Trauma2008，2，： | 1 |
| 16 | Estimating the determinants of taxpayer compliance with experimental data显示文摘 | Alm J Jackson B McKee M | 1992 | National Tax Journal1992，45，： | 1 |
| 17 | Hitting the Memory Wall: Implications of the Obvious显示文摘 | Wulf W A McKee S A | 1995 | Computer Architecture News1995，23，1： | 1 |
| 18 | The use of a blade plate autogenous cancellous bone graft in the treatment of ununited fractures of the proximal humerus显示文摘 | Ring D McKee MD Perey BH | 2001 | Shoulder Elbow Surg2001，10，6： | 1 |
| 19 | The Impact of Polygraphy on Admissions of Victims and offenses in Adult Sexual Offenders显示文摘 | Ahlmeyer S Heil P Mckee B | 2000 | Sex Abuse2000，12，2： | 1 |
| 20 | Equity in access to exercise tolerance testing,coronary angiography,and coronary artery bypass grafting by age,sex and clinical indications显示文摘 | Bowling A Bond M Mckee D | 2001 | Heart2001，85，6： | 1 |
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