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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Nutrients and other abiothic factors af fecting bacterial communities in an Ohi River(USA)显示文摘 | Melissa A R Laura G L | 2007 | Microbi al Ecology2007，54，2： | 1 |
| 4 | Post-cesarean related infection and vaginal preparation with povidone-iodine revisited显示文摘 | Melissa A G Samuel D P | 2002 | Prim Care Update Ob/Gyns2002，9，6： | 1 |
| 5 | Starch structure and digestibility of rice high in resistant starch显示文摘 | Shu X L Jiao G A Melissa et oi | 2006 | Starch2006，58，： | 1 |
| 6 | Pediatric cardiomyopathies: causes, epidemiology, clinical course, preventive strategies and therapies显示文摘 | Steven E Lipshultz Thomas R Cochran David A Briston Stefanie R Brown Peter J Sambatakos Tracie L Miller Adriana A Carrillo Liat Corcia Janine E Sanchez Melissa B Diamond Michael Freundlich Danielle Harake Tamara Gayle William G Harmon Paolo G Rusconi Sati | 2013 | Future Cardiol2013，，6： | 1 |
| 7 | Lateral line receptors: where do they come from developmentally and where is out research going显示文摘 | Melissa A G | 2004 | Brain Behavior and Evolution2004，64，3： | 1 |
| 8 | The Role of Hyaluronic Acid Fillers(Restylane) in Facial Cosmetic Surgery: Review and Technical Considerations 显示文摘 | ROD J R ASHKAN G MELISSA A C | 2007 | Plast Reconstr Surg2007，120，6： | 1 |
| 9 | Predicating pressure gradients in heavy oil-water pipelines 显示文摘 | Melissa J M Randall G G Clifton A S | 2000 | The Canadian Journal of Chemical Engineering2000，8，8： | 1 |
| 10 | Lateral line receptors: where do they come from developmentally and where is out research going, Brain显示文摘 | Melissa A G | 2004 | Behavior and Evolution2004，64，： | 1 |
| 11 | Predicting pressure gradients in heavy oil-water pipelines显示文摘 | Melissa J McKibben Randall G Gillies Clifton A Shook | 2000 | The Candian Journal of Chemical engineering2000，，78： | 1 |
| 12 | 查看详情显示文摘 | Lu D H Truong T N Melissas V S Lynch G C Liu Y P Grarrett B C Steckler R Issacson A D Rai S N Hancock G C Lauderdale J G Joseph T Truhlar D G | | 0，，： | 1 |
| 13 | 查看详情显示文摘 | Lu D H Truong T N Melissas V S Lynch G C Liu Y P Grarrett B C StecklerR Issacson A D Rai S N Hancock G C Lauderdale J G Joseph T Truhlar D G | | 0，，： | 1 |
| 14 | Nutrients and other abiothic factors affecting bacterial communities in an Ohi River (usa) 显示文摘 | Melissa A R Laura G L | 2007 | Microbial Ecology2007，54，2： | 1 |
| 15 | Melatonin and breast cancer:cellular mechanisms,clinical studies and future perspectives显示文摘 | Stephen G Melissa A Jean J | | 0，，5： | 1 |
| 16 | Gait dynamics in trisomic mice:quantitative neurological traits of down syndrome 显示文摘 | Hamptona Thomas G Staskob Melissa R Kalec A j it | 2004 | Physiol Behav2004，82，23： | 1 |
| 17 | OSAS in chicdrencorrelation between endoscopic and poly somnographic finfings显示文摘 | FABIANA C P MELISSA A G MARCIA B P | 2005 | Otolaryngol Head Neck Surg2005，132，： | 1 |
| 18 | Ab initio and density functional theory studies for the explanation of the antioxidant activity of certain phenolic acids显示文摘 | Bakalbassis E G Chatzopoulou A Melissas V S Tsimidou M Tsolaki M Vafiadis A | 2001 | Lipids2001，36，： | 1 |
| 19 | OSAS in children:correlation between endoscopic and polysomnographic findings 显示文摘 | FABIANA C P MELISSA A G MARCIA B P | 2005 | Otolaryngol Head Neck Surg2005，132，： | 1 |
| 20 | A comparison of directed evolution approaches using the β-Glucuronidase model system显示文摘 | Rowe L A Melissa L G Omar B A | 2003 | Journal of Molecular Biology2003，332，： | 1 |
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