|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals显示文摘AIM To determine steatosis and fibrosis prevalence in hepatitis C patients after a sustained virological response achieved with direct-acting antivirals.METHODS Transient elastography with controlled attenuation parameter(CAP) was used to assess hepatic steatosis post-sustained virological response(SVR);the CAP technology was not available in the United States at study initiation.Liver stiffness/fibrosis was measured before and 47 wk after treatment completion.Patients with genotype 3 and patients with cirrhosis were excluded.RESULTS One hundred and one patients were included in the study.Post-SVR there were decreases from baseline in alanine aminotransferase(ALT)(63.1 to 17.8 U/L),aspartate aminotransferase(51.8 to 21.5 U/L) and fibrosis score(7.4 to 6.1 k Pa)(P < 0.05).Post-SVR,48 patients(47.5%) had steatosis on CAP;of these,6.25% had advanced fibrosis.Patients with steatosis had higher body mass index(29.0 vs 26.1 kg/m2),glucose(107.8 vs 96.6 mg/d L),ALT(20.4 vs 15.3 mg/d L),CAP score(296.3 vs 212.4 d B/m) and fibrosis score(7.0 vs 5.3 k Pa);P < 0.05.Interestingly,compared to baseline,both patients with and without steatosis had change in fibrosis score post-SVR(7.7 k Pa vs 7.0 k Pa and 7.0 k Pa vs 5.3 k Pa);alternatively,(P < 0.05) and therefore patients with steatosis continued to have clinically significant stiffness(≥ 7 k Pa).CONCLUSION Fatty liver is very common in hepatitis C virus(HCV) patients post-SVR.These patients continue to have elevated mean fibrosis score(≥ 7 k Pa) compared to those without fatty liver;some have advanced fibrosis.Long term follow up is needed to assess steatosis and fibrosis in HCV patients post-SVR. | Mazen Noureddin Micaela M Wong Tsuyoshi Todo Shelly C Lu Arun J Sanyal Edward A Mena | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 2 | 体位性低血压的危险因素:老年男女存在差异显示文摘体位性低血压(orthostatic hypotension,OH)一般发生在站立后调节血压水平的机制发生变化以后。目前尚不清楚不同性别间OH的发生率和危险因素有何不同。本文旨在调查老年人OH患病率和危险因素的性别差异。方法:纳入来自委内瑞拉马拉开波老龄化研究的882名参与者。从仰卧位到站立位3 min后,收缩压持续下降≥20和(或)舒张压持续下降≥10 mm Hg(1 mm Hg=0.133 kPa)定义为OH。考虑到性别的交互作用和性别分层,研究者采用多因素Logistic回归模型评估男、女OH危险因素的相关性。 | Méndez AS Melgarejo JD Mena LJ Chávez CA González AC Boggia J Terwilliger JD Lee JH Maestre GE 陈云 叶鹏 | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 3 | Minimally invasive spleen-preserving distal pancreatectomy: Does splenic vessel preservation have better postoperative outcomes? A systematic review and meta-analysis显示文摘BACKGROUND: Minimally invasive spleen-preserving distal pancreatectomy(SPDP) can be performed with either splenic vessel preservation(SVP) or resection [Warshaw procedure(WP)]. The aim of this study was to evaluate the postoperative clinical outcomes of patients undergoing both methods.DATA SOURCES: Database search of PubM ed, Embase, Scopus,Cochrane, and Google Scholar was performed(2000-2014); key bibliographies were reviewed. Qualified studies comparing patients undergoing SPDP with either SVP or WP, and assessing postoperative complications were included. Calculated pooled risk ratio(RR) with the corresponding 95% confidence interval(CI) by random effects methods were used in the meta-analyses. RESULTS: The search yielded 215 studies, of which only 14 observational studies met our selection criteria. The studies included 943 patients in total; 652(69%) underwent SVP and 291(31%) underwent WP. Overall, there was a lower incidence of splenic infarction(RR=0.17; 95% CI: 0.09-0.33; P<0.001),gastric varices(RR=0.16; 95% CI: 0.05-0.51; P=0.002), and intra/postoperative splenectomy(RR=0.20; 95% CI: 0.08-0.49; P<0.001) in the SVP group. There was no difference in incidence of pancreatic fistula(WP vs SVP, 23.6% vs 22.9%;P=0.37), length of hospital stay, operative time or blood loss. There was moderate cross-study heterogeneity.CONCLUSIONS: SVP is a safe, efficient and feasible technique that may be used to preserve the spleen. WP may be more suitable for large tumors close to the splenic hilum or those associated with splenomegaly. Randomized clinical trials are justified to examine the long-term benefits of SVP-SPDP. | Fady Elabbasy Rahul Gadde Mena M Hanna Danny Sleeman Alan Livingstone Danny Yakoub | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，4： | 2 |
| 4 | Toxic effects of L-DOPA on mesencephalic cell cultures: protection with antioxidants 显示文摘 | Mena MA Casarejos M J | 1995 | Brain Res1995，682，： | 1 |
| 5 | Role for the DOF transcription factor BPBF in the regulation of gibber- ellin responsive genes in barley aleurone 显示文摘 | Mena M Cejudo F J Isabel-Lamoneda I | 2002 | Plant Physi- o12002，130，： | 1 |
| 6 | Effect of solids on homogeneous-heterogeneous flow regime transition in bubble cohimns 显示文摘 | Mena P C Ruzicka M C Rocha F A | 2005 | Chemical Engineering Science2005，60，22： | 1 |
| 7 | A new role for reticulon-4B/NOGO- B in the intestinal epithelial barrier function and inflammatory bowel disease显示文摘 | Rodriguez-Feo JA Puerto M Fernandez- Mena C | 2015 | Am J Physiol Gastrointest Liver Physiol2015，308，2： | 1 |
| 8 | Diversification of C-function activity in maize flower development 显示文摘 | MENA M AMBROSE BA MEELEY RB | 1996 | Science1996，274，： | 1 |
| 9 | Using image analy- sis in the study of multiphase gas absorption 显示文摘 | Mena P C Pons M N Teixeira J A | 2005 | Chemi- cal Engineering Science2005，60，18： | 1 |
| 10 | Development of a tyrosinase biosensor based on gold nanoparticles-modified glassy car- bon electrodes: Application to the measurement of a bioelectrochemical polyphenols index in wines显示文摘 | SANZ V C MENA M L GONZ LEZ-CORT S A | 2005 | Anal Claim Aeta2005，528，1： | 1 |
| 11 | Development of a tyrosinase biosensor based on gold nanoparticles-modified glassy carbon electrodes application to the measurement of a bioelectroehemical polyphenols index in wines显示文摘 | SANZ V C MENA M L CORTES A G | 2005 | Anal China Acts2005，528，： | 1 |
| 12 | Differential expression of pathogen-responsive genes encoding two types of glycine-rich proteins in barley 显示文摘 | Molina A Mena M Carbonero P | 1997 | Plant Mol Biol1997，33，： | 1 |
| 13 | Down-regulation of adhesion molecules and other inflammatory biomarkers after moderate wine consumption in healthy women: a randomized trial 显示文摘 | Sacanella E Vazquez-Agell M Mena MP | 2007 | Am J Clin Nutr2007，86，： | 1 |
| 14 | Spinal cord malignant astrncytomas - Cliuicopathologic features in 36 cases显示文摘 | Santi M Mena H Wong K | 2003 | Cancer2003，98，： | 1 |
| 15 | Intracranial hemangiopericytomas: MR and CT features 显示文摘 | Chiechi M Smirniotopoulos J G Mena H | 1996 | AJNR Am J Neuroradiol1996，17，7： | 1 |
| 16 | Review of functional/anatomical imaging in oncology 显示文摘 | HISTED S N LINDENBERG M L MENA E | 2012 | Nucl Med Commun2012，33，4： | 1 |
| 17 | Comprehensive analysis of gluten in processed foods using a new extraction method and a competitive ELISA based on the R5 antibody显示文摘 | Mena M C Lombardia M Hemando A | | 0，，15： | 1 |
| 18 | Down-regulation of adhesionmolecules and other inflammatory biomarkers after moderate wine consumptionin healthy women:a randomized trial显示文摘 | Sacanella E V(a)zquez-Agell M Mena MP | 2007 | Am J Clin Nutr2007，86，5： | 1 |
| 19 | Role of Kinet- ics in Acute Lethality of Nonreactive Volatile Organic Com- pounds(VOCs)显示文摘 | DeJongh J Velhaar H J M He r' mena J L M | 1998 | Toxicological Science1998，45，： | 1 |
| 20 | Effects of calcium antagonists on the dopamine system 显示文摘 | Mena M A Garcla de Y6benes M J Tabernero C | 1995 | Clin Neuropharmacol1995，18，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员