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| 1 | Autoimmune hepatitis in childhood: The role of genetic and immune factors显示文摘Autoimmune hepatitis (AIH) is a rare chronic inflammatory disease of the liver, which affects a group of patients who lost their immunological tolerance to antigens of the liver. It is clinically characterized by hypergammaglobulinemia, elevated liver enzymes, presence of autoantibodies and histological changes. Although being rare in children, it represents a serious cause of chronic hepatic disease that can lead to cirrhosis and hepatic failure. Clinical findings, exclusion of more common liver disorders and the detection of antibodies antinuclear antibodies, smooth muscle antibodies and anti-LKM1 are usually enough for diagnosis on clinical practice. The pathogenic mechanisms that lead to AIH remain obscure, but some research findings suggest the participation of immunologic and genetic factors. It is not yet knew the triggering factor or factors that stimulate inflammatory response. Several mechanisms proposed partially explain the immunologic findings of AIH. The knowledge of immune factors evolved might result in better markers of prognosis and response to treatment. In this review, we aim to evaluate the findings of research about genetic and immune markers and their perspectives of application in clinical practice especially in pediatric population. | Priscila Menezes Ferri Liu Débora Marques de Miranda Eleonora Druve Tavares Fagundes Alexandre Rodrigues Ferreira Ana Cristina Simoes e Silva | 2013 | World Journal of Gastroenterology2013，19，28： | 3 |
| 2 | Diagnostic criteria for autoimmune hepatitis in children: A challenge for pediatric hepatologists显示文摘Autoimmune hepatitis (AIH) is a progressive inflammatory liver disorder that is rare in children and adolescents. AIH has a broad clinical spectrum and a quick response to treatment with corticosteroids and immunosuppressive medication. The available diagnosis criteria have limitations and should be evaluated in pediatric populations. Recently, some studies reported that the 2008 simplified diagnostic criteria for AIH could be used in children with high sensibility and specificity. In addition, the authors reported that globulin and immunoglobulin G levels can be used interchangeably for diagnostic purposes. They also demonstrated that the 2008 simplified criteria fail in identifying patients with fulminant hepatic failure. Here, we discuss the limitations of the use of these criteria in pediatric patients and the requirement of more studies to improve the diagnosis of AIH in children. | Priscila Menezes Ferri Alexandre Rodrigues Ferreira Débora Marques Miranda Ana Cristina Sim■es e Silva | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 3 | Relative contribution of acetylated cyclooxygenase (COX) -2 and 5- lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin显示文摘 | Fiorucci S Distrutti E Menezes de Lima O | 2003 | FASEB J2003，17，： | 2 |
| 4 | Pentaoxygenated xanthones from Bredemyera floribunda显示文摘 | SILVEIRA E R FALCAL A J C MENEZES Jr A | 1995 | Phytochemistry1995，39，6： | 1 |
| 5 | Analysis of the immunohistochemical expressions of p53, bel-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors 显示文摘 | Menezes H L Juc6 M J Gomes E G | 2010 | Arq Gastroenterol2010，47，2： | 1 |
| 6 | Null Controllability in Unbounded Domains for the Semilinear Heat Equation with Nonlinearities Involving Gradient Terms 显示文摘 | Cabanillas V Menezes S De Zuazua E | 2001 | J Optim Theory Applications2001，110，2： | 1 |
| 7 | Optimization of Alkaline Pretreatment of Coffee Pulp for Production of Bioethanol显示文摘 | Menezes E G T Carmo J R Alves J L F | 2014 | Biotechnol Prog2014，30，2： | 1 |
| 8 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 9 | Developments in Silk Finishing显示文摘 | Menezes E | 2003 | International Dyer2003，，4： | 1 |
| 10 | Intra -radicular dentin treatments and retention of fiber posts with self-adhesive resin cements显示文摘 | Faria -E -Silva AL Menezes MS Silva FP | 2013 | Braz Oral Res2013，27，1： | 1 |
| 11 | Emission quantum yield of europium (Ⅲ) mixed complexes with thenoyhriiluoroacetonate and some aromatic ligands 显示文摘 | Silva F R G E Menezes J F S Rocha G B Rocha G B Alves S Brito H F Longo R L Malta O L | 2000 | Journal of Alloys and Compounds2000，303，304： | 1 |
| 12 | Gene therapies for cancer: strategies, challenges and successes显示文摘 | Das S K Menezes M E Bhatia S | 2015 | J Cell Physiol2015，230，2： | 1 |
| 13 | Measurement and characterization of dietary starches显示文摘 | Rosin P M Lajolo F M Menezes E W | 2002 | Journal of Food Composition and Analysis2002，15，4： | 1 |
| 14 | Botulinum tox- in type a versus amitriptyline for the treatment of chronic daily migraine显示文摘 | Magalhaes E Menezes C Cardeal M | 2010 | Clin Neurol Neurosurg2010，112，6： | 1 |
| 15 | Bond-slip behavior of self-compacting concrete and vibrated concrete using pull-out and beam tests显示文摘 | ALMEIDA de F MENEZES F DEBS E | | 0，，06： | 1 |
| 16 | Intra - radicular dentin treatments and retention of fiberposts with self - adhesive resin cements 显示文摘 | Faria - e - Silva AL Menezes Mde S Silva FP | 2013 | Braz OralRes2013，27，1： | 1 |
| 17 | Effect of ethers and ether/ethanol additives on the physicochemical properties of diesel fuel and on engine tests 显示文摘 | de Menezes E W da Silva R Catalufia R | 2006 | Fuel2006，85，5： | 1 |
| 18 | Preventionof invasive cervical cancer in the United States:past, present, and future显示文摘 | Pierce Campbell C M Menezes L J Paskett E D | 2012 | Cancer Epidemiol Biomarkers Prey2012，21，9： | 1 |
| 19 | Pharmacokinetics of long-circulating liposomes 显示文摘 | ALLEN T M HANSEN C B DE MENEZES D E L | 1995 | Adv Drug Deliv Rev1995，16，23： | 1 |
| 20 | The in- fluence of dietary vitamin C and E supplementation on the physio- logical response of pirarucu, Arapaima gigas, in net culture 显示文摘 | MENEZES G C TRAVARES-DIAS M ONO E A | 2006 | Comp Bioehem Physiol A2006，145，2： | 1 |
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