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	题名	作者	年代	出处	被引量
1	Free DNA and carcinoembryonic antigen serum levels: an important combination for diagnosis ofcolorectal cancer显示文摘	Flamini E Mercatali L Nanni O	2006	Clin Cancer Res2006，12，23：	1
2	Bone and cancer:the osteon-cology显示文摘	Ibrahim T Mercatali L Amadori D		0，，02：	1
3	RT-PCR determination of maspin and mammaglobin B in peripheral blood of healthy donors and breast cancer patients显示文摘	Mercatali L Valenti V Calistri D		0，，04：	1
4	A new emergency in oncology : Bone metastases in breast cancer patients ( Re- view) 显示文摘	Ibrahim T Mercatali L Amadori D	2013	Oncol Lett2013，6，2：	1
5	Pathogenesis of osteoblastic bone metastases from prostate cancer 显示文摘	Ibrahim T Flamin E i Mercatali L	2009	Cancer2009，11，6：	1
6	Tumor-Induced Osteoclast miRNA Changes as Regulators and Biomarkers of Osteolytic Bone Metastasis显示文摘	Brian Ell Laura Mercatali Toni Ibrahim Neil Campbell Heidi Schwarzenbach Klaus Pantel Dino Amadori Yibin Kang	2013	Cancer Cell2013，，4：	1
7	Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis显示文摘	Ell B Mercatali L Ibrahim T	2013	Cancer Cell2013，24，：	1
8	Multiple marker de- tection in peripheral blood for NSCLC diagnosis 显示文摘	Ulivi P Mercatali L Casoni GL	2013	PLoS One2013，8，57：	1
9	Bone metastases detection by circulating biomarkers:OPG and RANK-L显示文摘	Mercatali L Ibrahim T Sacanna E		0，，01：	1
10	Increased levels of free circulating DNA in patients with idiopathic pulmonary fibrosis 显示文摘	Casoni GL Ulivi P Mercatali L	2010	Int J Biol Markers2010，25，4：	1
11	Three-dimensional collagen-based scaffold model to study the microenvironment and drug-resistance mechanisms of oropharyngeal squamous cell carcinomas显示文摘Objective:Squamous cell carcinoma(SCC)represents the most common histotype of all head and neck malignancies and includes oropharyngeal squamous cell carcinoma(OSCC),a tumor associated with different clinical outcomes and linked to human papilloma virus(HPV)status.Translational research has few available in vitro models with which to study the different pathophysiological behavior of OSCCs.The present study proposes a 3-dimensional(3 D)biomimetic collagen-based scaffold to mimic the tumor microenvironment and the crosstalk between the extracellular matrix(ECM)and cancer cells.Methods:We compared the phenotypic and genetic features of HPV-positive and HPV-negative OSCC cell lines cultured on common monolayer supports and on scaffolds.We also explored cancer cell adaptation to the 3 D microenvironment and its impact on the efficacy of drugs tested on cell lines and primary cultures.Results:HPV-positive and HPV-negative cell lines were successfully grown in the 3 D model and displayed different collagen fiber organization.The 3 D cultures induced an increased expression of markers related to epithelial–mesenchymal transition(EMT)and to matrix interactions and showed different migration behavior,as confirmed by zebrafish embryo xenografts.The expression of hypoxia-inducible factor 1α(1α)and glycolysis markers were indicative of the development of a hypoxic microenvironment inside the scaffold area.Furthermore,the 3 D cultures activated drug-resistance signaling pathways in both cell lines and primary cultures.Conclusions:Our results suggest that collagen-based scaffolds could be a suitable model for the reproduction of the pathophysiological features of OSCCs.Moreover,3 D architecture appears capable of inducing drug-resistance processes that can be studied to better our understanding of the different clinical outcomes of HPV-positive and HPV-negative patients with OSCCs.	Giacomo Miserocchi Claudia Cocchi Alessandro De Vita Chiara Liverani Chiara Spadazzi Sebastiano Calpona Giandomenico Di Menna Massimo Bassi Giuseppe Meccariello Giovanni De Luca Angelo Campobassi Maria Maddalena Tumedei Alberto Bongiovanni Valentina Fausti Franco Cotelli Toni Ibrahim Laura Mercatali	2021	Cancer Biology & Medicine2021，18，2：	1
12	Pathogenesis of osteoblastic bone metastases from prostate cancer显示文摘	Ibrahim T Flamini E Mercatali L	2010	Cancer2010，116，6：	1
13	Effects of maricul-ture on macrobenthic assemblages in a western mediterra-nean site显示文摘	Tomassetti P Persia E Mercatali I	2009	Mar Poll Bull2009，58，4：	1
14	Pathogenesis of osteoblastic bone metastases from prostate cancer显示文摘	IBRAHIM T FLAMINI E MERCATALI L		0，，06：	1
15	RT-PCR determination of maspin and mammaglobin B in peripheral blood of healthy donors and breast cancer patients 显示文摘	Mercatali L Valenti V Calistri D	2006	Ann Oncol2006，17，3：	1
16	Bone metastases detec- tionby circulating biomarkers:OPG and RANK - L显示文摘	Mercatali L Ibrahim T Sacanna E	2011	Int J On- col2011，39，1：	1
17	SCALE modeling of selected neutronies test problems within the OECD UAM LWR's bench- mark显示文摘	MERCATALI L IVANOV K SANCHEZ V H	2013	Science and Technology of Nuclear In- stallations2013，2013，：	1
18	Effects of maricuhure on macrobenthic assemblages in a western mediterranean site 显示文摘	TOMASSETFI P PERSIA E MERCATALI I	2009	Marine Pollution Bulletin2009，58，4：	1
19	RT-PCR determination of maspin and mammaglobin B in peripheral blood of healthy donors and breast cancer patients显示文摘	Mercatali L Valenti V Calistri D	2006	Ann Oncol2006，17，3：	1
20	Tumor-induced osteo- clast miRNA changes as regulators and biomarkers of oste- olytic bone metastasis显示文摘	Ell B Mercatali L Ibrahim T	2013	Cancer Cell2013，24，4：	1

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