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| 1 | Multiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics显示文摘Multiple myeloma is a hematological malignancy inwhich clonal plasma cells proliferate and accumulate within the bone marrow. The presence of osteolytic le-sions due to increased osteoclast(OC) activity and sup-pressed osteoblast(OB) function is characteristic of the disease. The bone marrow mesenchymal stromal cells(MSCs) play a critical role in multiple myeloma patho-physiology, greatly promoting the growth, survival, drug resistance and migration of myeloma cells. Here, we specifically discuss on the relative contribution of MSCs to the pathophysiology of osteolytic lesions in light of the current knowledge of the biology of my-eloma bone disease(MBD), together with the reported genomic, functional and gene expression differences between MSCs derived from myeloma patients(pMSCs) and their healthy counterparts(dMSCs). Being MSCs the progenitors of OBs, pMSCs primarily contribute to the pathogenesis of MBD because of their reduced osteogenic potential consequence of multiple OB inhibi-tory factors and direct interactions with myeloma cells in the bone marrow. Importantly, pMSCs also readily contribute to MBD by promoting OC formation and ac-tivity at various levels(i.e., increasing RANKL to OPG expression, augmenting secretion of activin A, uncou-pling ephrinB2-EphB4 signaling, and through augment-ed production of Wnt5a), thus further contributing to OB/OC uncoupling in osteolytic lesions. In this review, we also look over main signaling pathways involved in the osteogenic differentiation of MSCs and/or OB activity, highlighting amenable therapeutic targets; in parallel, the reported activity of bone-anabolic agents(at preclinical or clinical stage) targeting those signaling pathways is commented. | Antonio Garcia-Gomez Fermin Sanchez-Guijo M Consuelo del Caizo Jesus F San Miguel Mercedes Garayoa | 2014 | World Journal of Stem Cells2014，6，3： | 5 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Application of predictive sliding mode controllers to a solar plant 显示文摘 | Mercedes P P Cristina M C Eduardo F C | 2008 | IEEE Transactions on Control System Technology2008，16，4： | 1 |
| 4 | Differential distribution of non-structural proteins of foot-and-mouth disease virus in BHK-21 cells显示文摘 | Mercedes G B Maria F R Monica G M | 2006 | Virology2006，349，： | 1 |
| 5 | Analysis of Acetamiprid in Vegetables Using Gas Chromatography-Tandem Mass Spectrometry显示文摘 | MANUEL M-S MERCEDES M F JAVIER A | 2003 | Analytical Sciences2003，19，5： | 1 |
| 6 | Differential distribution of non-structural proteins of foot-and-mouth disease virus in BHK-21 cells 显示文摘 | Mercedes G B Maria F R Monica G M | 2006 | Viology2006，349，： | 1 |
| 7 | Analysis of acetamiprid in vegetables using gas chromalography-tandem mass spectrometry显示文摘 | Mannel M S mercedes M Arrebola F J | 2003 | AnalyticalSciences2003，19，5： | 1 |
| 8 | Differential distri- bution of non-structural proteins of foot-and-mouth disease virus in BHK- 21 cells 显示文摘 | MERCEDES G B MARIA F R MONICA G M | 2006 | Virology2006，349，： | 1 |
| 9 | Exposure of maize seeds to stationary magnetic fields:Effects on germination and early growth 显示文摘 | Mercedes F Carbonell M V Martinez E | 2007 | Environmental and Experimental Botany2007，59，： | 1 |
| 10 | Analysis of acetamiprid in vegetables using gas chromatography - tandem mass spectrometry显示文摘 | Manuel M S Mercedes M Javier F A | 2003 | Analytical Sciences2003，19，5： | 1 |
| 11 | Differential Improvement among Countries in Child Stunting Is Associated with Long-Term Development and Specific Interventions 显示文摘 | ANNA M EDWARD A F MERCEDES DE ONIS | 2005 | Am Soci Nutr Scien2005，1，135： | 1 |
| 12 | Optics filters with fracal transmission spectra based on diffractive optics显示文摘 | OMEL MENDOZA Y GLADYS M V MERCEDES F A | 2009 | Optics Letters2009，34，5： | 1 |
| 13 | Differential distribution of non-structural proteins of foot-and- mouth disease virus in BHK-21 cells 显示文摘 | Mercedes G B Maria F R Monica G M | 2006 | Viology2006，349，： | 1 |
| 14 | Feasibility study of the cut and weld operations by RH on the cooling pipes of ITER NB components显示文摘 | Oscar P Carlos F Mercedes M | | 0，，7： | 1 |
| 15 | Differential distribution of non-structural proteins of foot-and-mouth disease virus in BHK-21 cells显示文摘 | Mercedes G B Maria F R Monica G M | 2006 | Virology2006，349，： | 1 |
| 16 | The phenotype of soluble starch synthase IV defective mutants of Arabidopsis thaliana suggests a novel function of elongation enzymes in the control of starch granule formantion显示文摘 | Roldan I Wattebled F Mercedes M | 2007 | The Plant Journal2007，49，3： | 1 |
| 17 | Analysis of acetamiprid in vegetables using gas chromatography-tandem mass spectrometry显示文摘 | MANUEL M S MERCEDES M ARREBOLA F J | 2003 | Analytical Sciences2003，19，5： | 1 |
| 18 | Analysis of acetamiprid in vegetables using gas chromatography-tandem mass spectrometry显示文摘 | MANUEL M S MERCEDES M ARREBOLA F J | 2003 | Analytical Sciences2003，19，5： | 1 |
| 19 | Hepatitis C: Problems to extinction and residual hepatic and extrahepatic lesions after sustained virological response显示文摘Loss of follow-up or reinfections hinder the expectations of hepatitis C eradicationdespite the existence of highly effective treatments. Moreover, the elimination ofthe infection does not imply the reversion of those chronic alterations derivedfrom the previous infection by hepatitis C virus (HCV). This review analyzes therisk factors associated with loss to follow-up in diagnosis or treatment, and thepossibility of reinfection. Likewise, it assesses the residual alterations induced bychronic HCV infection considering the liver alterations (inflammation, fibrosis,risk of decompensation, hepatocellular carcinoma, liver transplantation) and, onthe other hand, the comorbidities and extrahepatic manifestations (cryoglobulinemia,non-Hodgkin lymphoma, peripheral insulin resistance, and lipid, boneand cognitive alterations). Peculiarities present in subjects coinfected with humanimmunodeficiency virus are analyzed in each section. | Sara Cuesta-Sancho Mercedes Márquez-Coello Francisco Illanes-Álvarez Denisse Márquez-Ruiz Ana Arizcorreta Fátima Galán-Sánchez Natalia Montiel Manuel Rodriguez-Iglesias José-Antonio Girón-González | 2022 | World Journal of Hepatology2022，14，1： | 0 |
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