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| 1 | Long-term antifibrotic action of interferon-γ treatment in patients with chronic hepatitis B virus infection显示文摘BACKGROUND:The first priority in treating fibrosis is to eliminate the causes that result in liver injury,e.g.,hepatitis B and C virus.However,in many liver diseases the cause is either unknown or untreatable.The present study was designed to investigate the long-term antifibrotic effect of interferon-gamma(IFN-γ)treatment in patients chronically infected with hepatitis B virus. METHODS:A total of 42 patients,30 treated with IFN-γand 12 controls,were enrolled from an original clinical trial(Clin Gastroenterol Hepatol 2005;3:819.).Three serial liver biopsies that were obtained at the initiation and end of IFN-γtreatment as well as 4 to 6 years after treatment discontinuation were assessed according to the modified Chevallier scoring system. RESULTS:Twenty-five out of 30 IFN-γ-treated patients were followed up until 4 to 6 years after the treatment was stopped. However,all controls were excluded from follow-up due to death,loss and elevated virus level within 2 years.Twenty-five IFN-γ-treated patients had stable serum liver function and liver fibrosis indices without any further antiviral or anti-fibrotic treatment.Improved inflammatory and fibrotic scores were found after nine months of IFN-γtreatment according to the modified Chevallier scoring system(inflammation:11.8±6.5 at the beginning of IFN-γtreatment vs.9.2±4.1 after 9 months, P<0.05;fibrosis:15.0±7.3 at baseline vs.12.6±6.8 after 9 months, P<0.05).Among them,14 patients accepted a third serial liver biopsy 4 to 6 years after treatment discontinuation,and the fibrotic score was increased(14.2±8.3 vs.11.9±7.6 after 9 months, P<0.05). CONCLUSIONS:Nine-month IFN-γtreatment significantly improves the fibrosis score in patients with chronic HBV infection.The majority of patients demonstrate stable serum biochemical indices and quality of life.However,they do not show a long-term benefit according to histological criteria. Given the limited sample size,long-term IFN-γtreatment regimens should be assessed in further clinical trials. | Peter R Mertens Steven Dooley | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，2： | 6 |
| 2 | Diagnosis and stagerelated treatment of disseminated intravascular coagulation in meningococcal infections显示文摘 | Mertens R Peschgens T Granzen B | 1999 | Klin Padiatr1999，211，2： | 1 |
| 3 | Practical applications of hydrogenase I from Pyrococcus furiosus for NADPH generation and regeneration 显示文摘 | Mertens R Greiner L | 2003 | J Mol Catal B : Enzymatic2003，24，5： | 1 |
| 4 | Simian rotaviruses possess divergent gene constellations that originated from interspecies transmission and reas- sortment 显示文摘 | Matthijnssens J Taraporewala Z F Yang H Rao S Yuan L Cao D Hoshino Y Mertens P P Carner G R McNeal M Sestak K Van Ranst M Patton J T | 2010 | J Virol2010，84，4： | 1 |
| 5 | Nasopharyngeal carcinoma in childhood and adolescence: concept and preliminary results of the cooperative GPOH study NPC-91 显示文摘 | Mertens R Granzen B Lassay L | 1997 | Cancer1997，80，5： | 1 |
| 6 | Creating a System for Meeting the Fiber Requirements of Dairy Cows显示文摘 | Mertens D R | 1997 | J Dairy Sci1997，80，： | 1 |
| 7 | Formation of intermetallie cobalt phases in the near surface region of cemented carbides for improved diamond layer deposition显示文摘 | Cremera R Mertens R Neuschutitz D | 1999 | Thin Solid Films1999，，： | 1 |
| 8 | 显示文摘 | D R J R Loften | 1980 | J Dairy Sci1980，63，9： | 1 |
| 9 | Synergism and antagonism in mild steel corrosion inhibition by sodium dodecylbenzenesulphonate and hexamethylenetetnunine显示文摘 | Hosseini M Mertens S F L Arshadi M R | 2003 | Corrosion Science2003，45，7： | 1 |
| 10 | Value of Islet 1 and PAX8 in identifying metastatic neuroendocrine tumors of pancreatic origin 显示文摘 | Koo J Mertens R B Mirocha J M | 2012 | Mod Pathol2012，25，6： | 1 |
| 11 | From pathogenesis to treat-ment of chronic lymphocytic leukaemia 显示文摘 | Zenz T Mertens D Kuppers R | 2010 | Nat Rev Cancer2010，10，1： | 1 |
| 12 | The role of psychophysiology in fo- rensic assessments: Deception detection, ERPs, and vir- tual reality mock crime scenarios 显示文摘 | Mertens R Allen JJB | 2008 | Psychophysiology2008，45，2： | 1 |
| 13 | Comparison by computerized numeric modeling of energy losses in different Fontan connections显示文摘 | VAN HAESDONCK J M MERTENS L SIZAIRE R | 1995 | Circulation1995，92，9： | 1 |
| 14 | Creating a system for meeting the fiber requirements of dairy cows显示文摘 | MERTENS D R | 1997 | Journal of Dairy Science1997，80，7： | 1 |
| 15 | Platelet mi- croparticles promote platelet interaction with subendo- thelial matrix in a glycoprotein IIb/IIIa-dependent mechanism显示文摘 | Merten M Pakala R Thiagarajan P | 1999 | Circulation1999，99，： | 1 |
| 16 | Short-term alcohol and drug treatment outcomes predict long-term outcome显示文摘 | Constance Weisner G Thomas Ray Jennifer R Mertens Derek D Satre Charles Moore | 2003 | Drug and Alcohol Dependence2003，，3： | 1 |
| 17 | Vascular extracellular superoxide dismutase activity in patients with coronary artery disease: relation to endothelium dependent vasodilation 显示文摘 | Landmesser U Merten R S Iekermann S | 2000 | Circulation2000，101，： | 1 |
| 18 | FIBEX-treated rice straw as a feed ingredient for lactating dairy cows显示文摘 | Weimer P J Mertens D R Severin B F | 2003 | Animal Feed Science and Technology2003，103，： | 1 |
| 19 | Effect of an- nealing atmosphere on the galvanizing behavior of a dual- phase steel 显示文摘 | Khondker R Mertens A Mc Dermid J R | 2007 | Materials Science and Engineering A2007，463，12： | 1 |
| 20 | Creating a system for meeting the fiber re?quirements of dairy cows显示文摘 | Mertens D R | 1997 | Journal of Dairy Science1997，80，7： | 1 |
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