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| 1 | Controlled attenuation parameter for non-invasive assessment of hepatic steatosis in Chinese patients显示文摘AIM:To evaluate the performance of a novel non-invasive controlled attenuation parameter(CAP)to assess liver steatosis.METHODS:This was a multi-center prospective cohort study.Consecutive patients(aged≥18 years)who had undergone percutaneous liver biopsy and CAP measurement were recruited from three Chinese liver centers.Steatosis was categorized as S0:<5%;S1:5%-33%;S2:34%-66%;or S3:≥67%,according to the nonalcoholic fatty liver disease(NAFLD)activity score.The FibroScan?502 equipped with the M probe(Echosens,Paris,France)was used to capture both CAP and liver stiffness measurement values simultaneously.Receiver operating characteristic curves were plotted,and the areas under the curves were calculated to determine the diagnostic efficacy.The accuracy of the CAP values at the optimal thresholds was defined by maximizing the sum of sensitivity and specificity(maximum Youden index).RESULTS:A total of 152 patients were recruited,including 52(34.2%)patients with NAFLD and 100(65.8%)with chronic hepatitis B(CHB)virus infection.After adjustment,the steatosis grade(OR=37.12;95%CI:21.63-52.60,P<0.001)and body mass index(BMI,OR=6.20;95%CI:2.92-9.48,P<0.001)were found independently associated with CAP by multivariate linear regression analysis.CAP was not influenced by inflammation,fibrosis or aetiology.The median CAP values and interquartile ranges among patients with S0,S1,S2 and S3 steatosis were 211(181-240)dB/m,270(253-305)dB/m,330(302-360)dB/m,and 346(313-363)dB/m,respectively.The cut-offs for the CAP values in all patients with steatosis≥5%,≥34%and≥67%were 253 dB/m,285 dB/m and 310 dB/m,respectively.The areas under the curves were 0.92,0.92and 0.88 for steatosis≥5%,≥34%and≥67%,respectively.No significant differences were found in the CAP values between the NAFLD group and the CHB group in each steatosis grade.CONCLUSION:CAP appears to be a promising tool for the non-invasive detection and quantification of hepatic steatosis,but is limited by BMI. | Feng Shen Rui-Dan Zheng Yu-Qiang Mi Xiao-Ying Wang Qin Pan Guang-Yu Chen Hai-Xia Cao Ming-Li Chen Liang Xu Jian-Neng Chen Yi Cao Rui-Nan Zhang Lei-Ming Xu Jian-Gao Fan | 2014 | World Journal of Gastroenterology2014，20，16： | 55 |
| 2 | Portosplenomesenteric vein thrombosis in patients with early-stage severe acute pancreatitis显示文摘AIM To investigate the incidence and risk factors of portosplenomesenteric vein thrombosis(PSMVT) in the early stage of severe acute pancreatitis(SAP).METHODS Patients with SAP in a tertiary care setting from January 2014 to December 2016 were retrospectively reviewed. All contrast-enhanced computed tomography(CT) studies were reassessed and reviewed. Clinical outcome measures were compared between SAP patients with and without PSMVT in the early stage of the disease. Univariate and multivariate logistic regression analyses were sequentially performed to assess potential risk factors for the development of PSMVT in SAP patients. A receiver operating characteristic(ROC) curve was generated for the qualifying independent risk factors.RESULTS Twenty-five of the one hundred and forty(17.86%) SAP patients developed PSMVT 6.19 ± 2.43 d after acute pancreatitis(AP) onset. PSMVT was confirmed by contrast-enhanced CT. Multivariate stepwise logistic regression analyses showed that Balthazar's CT severity index(CTSI) scores [odds ratio(OR): 2.742; 95% confidence interval(CI): 1.664-4.519; P = 0.000], hypoalbuminemia(serum albumin level < 25 g/L)(OR: 32.573; 95%CI: 2.711-391.353; P = 0.006) and gastrointestinal wall thickening(OR: 4.367, 95%CI: 1.218-15.658; P = 0.024) were independent risk factors for PSMVT developed in patients with SAP. The area under the ROC curve for Balthazar's CTSI scores was 0.777(P = 0.000), the sensitivity was 52%, and the specificity was 93% at a cut-off value of 5.5.CONCLUSION High Balthazar's CTSI scores, hypoalbuminemia and gastrointestinal wall thickening are independent risk factors for PSMVT developed in the early stage of SAP. | Ling Ding Feng Deng Chen Yu Wen-Hua He Liang Xia Mi Zhou Xin Huang Yu-Peng Lei Xiao-Jiang Zhou Yin Zhu Nong-Hua Lu | 2018 | World Journal of Gastroenterology2018，24，35： | 20 |
| 3 | The Intervention Effect of Rosiglitozone in Ovarian Fibrosis of PCOS Rats显示文摘Objective To explore the Intervention effect of Rosiglitozone in ovarian fibrosis of PCOS rats.Methods 60 female SD rats were randomly divided into 3 groups:control group,model group and treatment group.The model and treatment groups were established by subcutaneous injection of DHEA,while the treatment group was given RGZ.The serum hormone values,pathohistology of ovarian structure of rats,ovarian ultrastructure and the expressions of TGF-β 1 and CTGF were detected.Results The PCOS model was established successfully.The expression intensity of TGF-β 1 and CTGF in Oocytes of the PCOS groups was 9.545±2.954 and 9.665±2.400,respectively and was significantly higher than that of the control group 6.636±2.264 and 7.036±2.133;after treatment with rosiglitazone,the expression was significantly decreased 6.980±2.421 and 6.642±2.721 as compared with that of the model group (P<0.05,P<0.001).The values in serum of the PCOS groups were 3.749±2.054 and 0.265±0.129,and 1.914±1.801 and 0.096±0.088 in the control group which had statistically significant difference (P<0.05,P<0.001).After treatment with rosiglitazone,the values were 2.3100±1.825 and 0.112±0.187 and were significantly different with those of the model group (P<0.05,P<0.001).Conclusion TGF-β 1 and CTGF play an important role in the development of ovary fibrosis in PCOS.However,RGZ may postpone the development of fibrosis by decreasing the levels of TGF-β 1 and CTGF. | MIAO Zhu Lin GUO Liang WANG Yong Xia CUI Rong YANG Ning HUANG Mi Qiong QIN Wei Bing CHEN Jin LI Hong Mei WANG Zi Neng WEI Xiang Cai | 2012 | Biomedical and Environmental Sciences2012，25，1： | 14 |
| 4 | Correlation of Vascular Endothelial Growth Factor Production with Photochemical Reaction-induced Retinal Edema显示文摘 | Liang Shan Mi Zheng Yuan Zhang Yuan Qu Tian Niu Qing Gu Xin Xia | 2016 | Chinese Medical Journal2016，，24： | 9 |
| 5 | Pubertal Hypertension is a Strong Predictor for the Risk of Adult Hypertension显示文摘Objective To assess and compare the predictive effects of hypertension before puberty and during puberty on adult hypertension.Methods A total of 412 adults from the 'Beijing children and adolescents blood pressure (BP) study' cohort were followed up in a clinical examination in 2005.Systolic and diastolic BP,height,and weight in childhood were measured at a baseline survey in 1987.The participants were divided into pre‐puberty and puberty sub‐cohorts according to their pubertal development stage at baseline.Information on adult BP,anthropometric indices and life style were collected through questionnaire and physical examination.BP changes and the predictive effect on adult hypertension were compared between the two sub‐cohorts.Correlation of BP levels between 1987 and 2005 was examined through linear regression models.Results From childhood to adulthood,the regression coefficients of systolic BP were similar in the two sub‐cohorts (both β=0.34,P<0.001),while the coefficient of diastolic BP was larger in the pubertal cohort (β=0.31,P<0.001) compared with the pre‐pubertal cohort (β=0.12,P=0.017).Fifty percent of children with pubertal hypertension became hypertensive adults,while pre‐pubertal hypertension resulted in 34.3%.After adjustment for sex,age,family history of hypertension,obesity in childhood,and adulthood,pubertal hypertension predicted a higher risk of adult hypertension than pre‐pubertal hypertension,with odds ratios (95% confidence intervals) of 10.00 (3.03‐33.07) and 2.71 (0.83‐8.85),respectively.Conclusion Our results suggest that hypertension during pubertyis likely to result in adult hypertension. | LIANG YaJun MI Jie | 2011 | Biomedical and Environmental Sciences2011，24，5： | 9 |
| 6 | Role of the nucleus tractus solitarii in the protection of pre-moxibustion on gastric mucosal lesions显示文摘Previous studies have shown that somatic sensation by acupuncture and visceral nociceptive stimulation can converge in the nucleus tractus solitarii where neurons integrate signals impacting on the function of organs. To explore the role of the nucleus tractus solitarii in the protective mechanism of pre-moxibustion on gastric mucosa, nucleus tractus solitarii were damaged in rats and pre-moxibustion treatment at the Zusanli(ST36) point followed. The gastric mucosa was then damaged by the anhydrous ethanol lavage method. Morphological observations, enzyme linked immunosorbent assays, and western immunoblot analyses showed that gastric mucosa surface lesion and the infiltration of inflammatory cells were significantly ameliorated after pre-moxibustion treatment. Furthermore, the gastric mucosal damage index and somatostatin level were reduced, and epidermal growth factor content in the gastric mucosa and heat-shock protein-70 expression were increased. These results were reversed by damage to the nucleus tractus solitarii. These findings suggest that moxibustion pretreatment at the Zusanli point is protective against acute gastric mucosa injury, and nucleus tractus solitarii damage inhibits these responses. Therefore, the nucleus tractus solitarii may be an important area for regulating the signal transduction of the protective effect of pre-moxibustion on gastric mucosa. | Liang Peng Mi Liu Xiaorong Chang Zhou Yang Shouxiang Yi Jie Yan Yan Peng | 2014 | Neural Regeneration Research2014，9，2： | 9 |
| 7 | An-Luo-Hua-Xian Pill Improves the Regression of Liver Fibrosis in Chronic Hepatitis B Patients Treated with Entecavir显示文摘Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and cancer.As the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-Hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,2020.Demographic,laboratory,and liver histology data before and after 78 weeks of treatment were collected.The Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after treatment.Results:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX group.After 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=0.035.The percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=0.056.Logistic regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients. | Yi-Qi Liu Chi Zhang Jia-Wen Li Li-Hua Cao Zhan-Qing Zhang Wei-Feng Zhao Qing-Hua Shang Da-Zhi Zhang An-Lin Ma Qing Xie Hong-Lian Gui Guo Zhang Ying-Xia Liu Jia Shang Shi-Bin Xie Jun Li Xu-Qing Zhang Zhi-Qiang Zou Yu-Ping Chen Zong Zhang Ming-Xiang Zhang Jun Cheng Fu-Chun Zhang Li-Hua Huang Jia-Bin Li Qing-Hua Meng Hai-Bin Yu Yu-Qiang Mi Yan-Zhong Peng Zhi-Jin Wang Li-Ming Chen Fan-Ping Meng Wan-Hua Ren Lang Bai Yi-Lan Zeng Rong Fan Xian-Zhi Lou Wei-Feng Liang Hui Liu Hui Zhuang Hong Zhao Gui-Qiang Wang | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 7 |
| 8 | A Comprehensive Review of Isogeometric Topology Optimization:Methods,Applications and Prospects显示文摘Topology Optimization(TO)is a powerful numerical technique to determine the optimal material layout in a design domain,which has accepted considerable developments in recent years.The classic Finite Element Method(FEM)is applied to compute the unknown structural responses in TO.However,several numerical deficiencies of the FEM significantly influence the effectiveness and efficiency of TO.In order to eliminate the negative influence of the FEM on TO,IsoGeometric Analysis(IGA)has become a promising alternative due to its unique feature that the Computer-Aided Design(CAD)model and Computer-Aided Engineering(CAE)model can be unified into a same mathematical model.In the paper,the main intention is to provide a comprehensive overview for the developments of Isogeometric Topology Optimization(ITO)in methods and applications.Finally,some prospects for the developments of ITO in the future are also presented. | Jie Gao Mi Xiao Yan Zhang Liang Gao | 2020 | Chinese Journal of Mechanical Engineering2020，33，6： | 6 |
| 9 | Recombinant tissue plasminogen activator plus heparin compared with heparin alone for patients with acute submassive pulmonary embolism: one-year outcome显示文摘OBJECTIVE: To evaluate the long-term effects of thrombolysis on patients with submassive pulmonary embolism (PE)。 METHODS: Data of 136 patients with acute submassive PE and low risk of bleeding were prospectively collected from January 2005 to October 2011 in a single medical center。 Patients received recombinant tissue plasminogen activator (r-tPA) plus low molecular weight heparin (LMWH, TT group, n = 79) or LMWH alone (AT group, n = 57), depending on treating physician's recommendation and patient's preference。 Echocardiography was performed at admission, 24 h, 6 and 12 months to evaluate right ventricular function。 Computed tomography pulmonary angiography (CTPA) and lung perfusion scan were performed on admission, at 7 days, 6 and 12 months to evaluate clot burden。 RESULTS: Seventy-nine patients received r-tPA plus LMWH (TT group) while 57 received LMWH alone (AT group)。 The baseline characteristics and risk factors did not differ between the two groups。 Respiratory rate, heart rate, and systolic blood pressure improved within two hours in both groups。 Systolic pulmonary arterial pressure and tricuspid regurgitation improved to a greater extent in the TT group at 24 h, and at 12 months (P < 0。001), as compared to those in the AT group。 At one week, and 12 months, clot burden decreased more in AT group, as compared to that in AT group (P < 0.001)。 There was no death due to bleeding in both groups。 Recurrent PE were similar in both groups (2.5% in TT vs。 1.8% in AT)。 The rates of minor hemorrhages were 6.3% in TT group and 1.8% in AT group (P < 0.05)。 In submassive PE patient who has low risk of bleeding, thrombolysis plus anticoagulation can lead to greater improvement of right ventricular dysfunction and clot burden reduction as compared to anticoagulation therapy alone。 | Yu-Hong Mi Ying Liang Yan-Hui Lu Ya-Min Li Wen-Xu Liu Wang Qian | 2013 | Journal of Geriatric Cardiology2013，10，4： | 6 |
| 10 | Effects of pre-moxibustion at Zusanli (ST36) on heat shock protein 70 expression in rats with gastric mucosal lesions after neurotomy显示文摘Studies have shown that pre-moxibustion protects the gastric mucosa by up-regulating the expres- sion of heat shock protein 70. However, the signaling pathway underlying this effect remains unclear. Rats were intragastrically administered absolute alcohol, causing obvious lesion of the gastric mucosa. Following pre-moxibustion at Zusanli (ST36) for 8 days, the ulcer index decreased to different degrees. The results of an enzyme linked immunosorbent assay and western blotting showed significant upregulation of heat shock protein 70 expression in the gastric mucosa and serum. None out of transection of the spinal cord, damage to the nucleus of the solitary tract, neurotomy of the vagal nerve and neurotomy of the common peroneal nerve affected the decrease in ulcer index or the increase in heat shock protein 70 expression in serum after pre-moxibustion at Zusanli, and heat shock protein 70 expression was obviously decreased in the gastric mucosa. These findings suggest that pre-moxibustion at Zusanli can protect the gastric mucosa against lesioning, and that the mechanism underlying this effect involves its induction of heat shock protein 70 expression. Neural pathways participate in the regulatory effects of moxibustion on heat shock protein 70 expression in the gastric mucosa. | Liang Peng Mi Liu Xiaorong Chang Zhou Yang Shouxiang Yi Jie Yan Yan Peng | 2012 | Neural Regeneration Research2012，7，30： | 5 |
| 11 | In situ generation of Li_(3)N concentration gradient in 3D carbon-based lithium anodes towards highly-stable lithium metal batteries显示文摘The uncontrolled dendrite growth of lithium metal anodes(LMAs)caused by unstable anode/electrolyte interface and uneven lithium deposition have impeded the practical applications of lithium metal batteries(LMBs).Constructing a robust artificial solid electrolyte interphase(SEI)and regulating the lithium deposition behavior is an effective strategy to address these issues.Herein,a three-dimensional(3D)lithium anode with gradient Li_(3)N has been in-situ fabricated on carbon-based framework by thermal diffusion method(denoted as CC/Li/Li_(3)N).Density functional theory(DFT)calculations reveal that Li_(3)N can effectively promote the transport of Li^(+)due to the low energy barrier of Li^(+)diffusion.As expected,the Li_(3)N-rich conformal artificial SEI film can not only effectively stabilize the interface and avoid parasitic reactions,but also facilitate fast Li^(+)transport across the SEI layer.The anode matrix with uniformly distributed Li3N can enable homogenous deposition of Li,thus preventing Li dendrite propagation.Benefiting from these merits,the CC/Li/Li_(3)N anode achieves ultralong-term cycling for>1000 h at a current density of 2 m A cm^(-2)and dendrite-free Li deposition at an ultrahigh rate of 20 m A cm^(-2).Moreover,the full cells coupled with LiFePO4cathodes show extraordinary cycling stability for>300 cycles in liquidelectrolyte-based batteries and display a high-capacity retention of 96.7%after 100 cycles in solid-state cells,demonstrating the promising prospects for the practical applications of LMBs. | Wenzhu Cao Weimin Chen Mi Lu Cheng Zhang Du Tian Liang Wang Faquan Yu | 2023 | Journal of Energy Chemistry2023，，1： | 4 |
| 12 | A Comprehensive Approach for the Clustering of Similar-Performance Cells for the Design of a Lithium-Ion Battery Module for Electric Vehicles显示文摘An energy-storage system comprised of lithium-ion battery modules is considered to be a core component of new energy vehicles,as it provides the main power source for the transmission system.However,manufacturing defects in battery modules lead to variations in performance among the cells used in series or parallel configuration.This variation results in incomplete charge and discharge of batteries and non-uniform temperature distribution,which further lead to reduction of cycle life and battery capacity over time.To solve this problem,this work uses experimental and numerical methods to conduct a comprehensive investigation on the clustering of battery cells with similar performance in order to produce a battery module with improved electrochemical performance.Experiments were first performed by dismantling battery modules for the measurement of performance parameters.The kmeans clustering and support vector clustering(SVC)algorithms were then employed to produce battery modules composed of 12 cells each.Experimental verification of the results obtained from the clustering analysis was performed by measuring the temperature rise in the cells over a certain period,while air cooling was provided.It was found that the SVC-clustered battery module in Category 3 exhibited the best performance,with a maximum observed temperature of 32℃.By contrast,the maximum observed temperatures of the other battery modules were higher,at 40℃for Category 1(manufacturer),36℃for Category 2(manufacturer),and 35℃for Category 4(k-means-clustered battery module). | Wei Li Siqi Chen Xiongbin Peng Mi Xiao Liang Gao Akhil Garg Nengsheng Bao | 2019 | Engineering2019，5，4： | 4 |
| 13 | Epidemiological Features of Severe Acute Respiratory Syndrome in Beijing Urban and Suburb Areas in 2003显示文摘Objective To describe the epidemiologic features of an outbreak of severe acute respiratory syndrome (SARS) in urban and suburb areas in Beijing and to explore their differences between these two areas. Methods Data of SARS cases were collected from daily notification of China Ministry of Health and a database of infectious diseases was established by the Beijing Municipal Center for Disease Prevention and Control (BCDC). All the data were put into dataset files by Microsoft Excel-2000 and analyzed with SPSS version 10.0 software. Results The respective urban incidence and mortality rate were 29.06 and 2.21 per 100 000, while the case fatality rate was 7.62%. In contrast, the respective suburb incidence and mortality rate were 10.61 and 0.78 per 100 000, and the case fatality rate was 7.32%. No significant differences were found in demographic characteristics between the urban and suburb areas. Conclusion Beijing urban area suffered a more serious SARS epidemic than the suburb area in 2003. | MIN LIU WAN-NIAN LIANG HONG DU QI CHEN JIE MI ZE-JUN LIU | 2005 | Biomedical and Environmental Sciences2005，18，4： | 4 |
| 14 | Effects of electrode configuration on electroslag remelting process of M2 high-speed steel ingot显示文摘The electrode configuration determines the thermophysical field during the electroslag remelting(ESR) process and affects the final microstructure of the ingot. In this work, ingot with a diameter of 400 mm was prepared with two electrode configuration modes of single power ESR process, namely one electrode(OE) and two series-connected electrodes(TSCE). Finite element simulation was employed to calculate the electromagnetic field, flow field and temperature field of the ESR system. The results show that the temperature of the slag pool and the metal pool of the TSCE process is lower and more uniform than that of the OE process.The calculated temperature distribution of the ingot could be indirectly verified from the shape of the metal pool by the experiment. The experimental results show that the depth of the metal pool in the OE ingot is about 160 mm, while the depth of the TSCE ingot is nearly 40 mm shallower than that of the OE ingot. Microstructural comparisons indicate that coarse eutectic carbides are formed in the center of the OE ingot, whereas more even eutectic carbides appear in the center of the TSCE ingot. In general, compared with the OE process, the TSCE process is preferred to remelt high speed steel ingots. | Fu-xing Yin Yu Liang Zhi-xia Xiao Jian-hang Feng Zhi-bin Xie Yong-wang Mi | 2019 | China Foundry2019，16，2： | 3 |
| 15 | Adenoma of the posterior urethra:131 case report显示文摘A case-report on adenoma of the posterior urethra. Methods: In 131 cases of adenoma of the posterior urethra, aged 17- 79 (mean: 36.4) years, a detailed medical history was taken and urinalysis, urethroscopy, and prostatic specific antigen (PSA) immunohistochemical staining were performed. They were then treated with transurethral resection (TUR) or transurethral electric coagulation (TUEC). Results: Hemospermia occurred in 51% of the cases, hematuria in 38 %, bood overflow from the urethral orifice in 6 %, and dysuria in 5 %. The position of the tumor was at or around the verurumontanum. The appearance of the rumor was similar to those of a papilla, a villus, a dactyl or polyp, or simply an engorgement. The tumor contained glandular alveoli and adeno-epithelial cells. PSA immunohistochemistry was positive in the cytoplasm and nucleus of the adeno-epithelial cell. One hundred and tweenty-nine cases were cured after TUR or TUEC, while 2 patients recurred and were operated again. Conclusion: Adenoma of the posterior urethra is a common cause of hemospermia and hematuria in young men. Urethroscopic examination and biopsy are the principal diagnostic measures. TUR or TUEC are believed to be the treatment of choice with a short-term recurrence rate of around 1.5%. | Zhen-Guo MI Xiao-Feng YANG Xue-Zhi LIANG Hong-Yao LIU Shang-Yin LIU Hong ZHANG Dong-Wen WANG Chum LIU Department of Urology,The First Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China | 2001 | Asian Journal of Andrology2001，3，1： | 3 |
| 16 | Solid-phase Synthesis of Thymopentin Derivative and Its Immune Regulatory Activity显示文摘Thymopentin derivative(septapeptide) was prepared by means of the solid-phase peptide synthesis method in which stepwise and segment condensations were involved. The structures of the key intermediate and target molecule were confirmed by ESI-MS, elementary analysis, IR, 1H NMR and 13C NMR spectrometries in our experiments. In this study, the authors found that both thymopentin derivetive(septapeptide) and thymopentin could promote T cell proliferation and increase of E-rose fomation cells. | LIANG Yong-tao MI Hao-yu WANG Ming-zhe YU Li-ya LIU Zhong-hui WANG En-si | 2009 | Chemical Research in Chinese Universities2009，25，2： | 3 |
| 17 | CO2 geological storage into a lateral aquifer of an offshore gas field in the South China Sea: storage safety and project design显示文摘DF1-1 煤气的领域,在西方的华南海定位了,这样包含公司2,的高集中关于需要有大担心减少许多选择在最近的年里被考虑了在这研究在海南岛上与天然气溪流分开的 CO 2处理的 CO 2排出物,在 DF1-1 煤气的地的侧面的盐的含水土层的公司2存储的可行性被估计,包括含水土层选择和地质的评价,公司2迁居和存储安全,工程设计,并且经济分析六近海含水土层为公司2被调查了地质的存储因为它封上能力证明, DF1-1 煤气的地的侧面的含水土层为公司2注射和存储作为最好的目标被选择了,并且联合含水土层和烃水库的大存储能力地质的结构分开的公司2将在海南岛上被使脱水并且为压力调整在 supercritical 或液体状态由一条长途的 subsea 管道搬运了到 DF1-1 煤气的地的中央站台公司2然后将被注射进经由通过一座水平井水库的一个 subsea 水源的侧面的含水土层,模拟建议没有扰乱 scoping 经济分析显示出的天然气生产,注射公司2将在含水土层向上慢慢地移居联合起来的存储工程花费了,这是近似有 subsea 管道的 US$26-31/ton 公司2作为主要贡献者到大写的开销( CAPEX ),和是的脱水系统操作开销( OPEX )的主要因素。 | Liang ZHANG Dexiang LI Justin EZEKIEL Weidong ZHANG Honggang MI Shaoran REN | 2015 | Frontiers of Earth Science2015，9，2： | 2 |
| 18 | Synthesis and Immunosuppressive Activity of New Amino Alcohol Derivatives(Ⅰ)显示文摘A series of new amino alcohol derivatives was synthesized and evaluated for their immunosuppressive activity on mouse peripheral blood lymphocytes.The structures were confirmed by means of 1H NMR,13C NMR,IR and MS.Most of the compounds display moderate to potent inhibitory activity.Compound 9d shows the most activity among them that are expected as a powerful candidate for safer immunosuppressant for organ transplantations and the treatment of autoimmune diseases. | MI Hao-yu CUI Lin-lin ZHANG Qun-li LI Fang JIANG Tao LIANG Yong-tao WANG En-si | 2011 | Chemical Research in Chinese Universities2011，27，4： | 2 |
| 19 | Luteolin delays photoreceptor degeneration in a mouse model of retinitis pigmentosa显示文摘Luteolin is neuroprotective for retinal ganglion cells and retinal pigment epithelial cells after oxidative injury,whereby it can inhibit microglial neurotoxicity.Therefore,luteolin holds the potential to be useful for treatment of retinal diseases.The purpose of this study was to investigate whether luteolin exhibits neuroprotective effects on rod cells in rd10 mice,a slow photoreceptor-degenerative model of retinitis pigmentosa.Luteolin(100 mg/kg)intraperitoneally injected daily from postnatal day 14(P14)to P25 significantly enhanced the visual performance and retinal light responses of rd10 mice at P25.Moreover,it increased the survival of photoreceptors and improved retinal structure.Mechanistically,luteolin treatment attenuated increases in reactive oxygen species,photoreceptor apoptosis,and reactive gliosis;increased mRNA levels of anti-inflammatory cytokines while lowering that of pro-inflammatory and chemoattractant cytokines;and lowered the ratio of phospho-JNK/JNK.Application of the JNK inhibitor SP600125 exerted a similar protective effect to luteolin,suggesting that luteolin delays photoreceptor degeneration and functional deterioration in rd10 mice through regulation of retinal oxidation and inflammation by inhibiting the JNK pathway.Therefore,luteolin may be useful as a supplementary treatment for retinitis pigmentosa.This study was approved by the Qualified Ethics Committee of Jinan University,China(approval No.IACUC-20181217-02)on December 17,2018. | Xiao-Bin Liu Feng Liu Yi-Yao Liang Gang Yin Hui-Jun Zhang Xue-Song Mi Zai-Jun Zhang Kwok-Fai So Ang Li Ying Xu | 2021 | Neural Regeneration Research2021，16，10： | 2 |
| 20 | Multivalued Solutions of an Iterative Equation with Variable Coefficients显示文摘In this paper, we consider a second order multivalued iterative equation with variable coefficients and the results on increasing solution and decreasing solution are obtained. | MI Yu-zhen LIANG Ying | 2013 | Chinese Quarterly Journal of Mathematics2013，28，1： | 2 |
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