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| 1 | Waist Circumference Reference Values for Screening Cardiovascular Risk Factors in Chinese Children and Adolescents显示文摘Objectives To explore the optimal threshold values of waist circumference(WC)for detecting cardiovascular(CV)risk factors among Chinese children and adolescents.Methods Association of WC with CV risk factors was studied among 65 898 children aged 7-18 years whose data were pooled from nine previous studies in China.CV risk factors in this study included hypertension(blood pressure above 95 percentile levels),dyslipidemia(with one or more of the following three indexes:TG≥1.7 mmol/L,TC≥5.18 mmol/L,and HDL-C≤1.04 mmol/L)and elevated glucose level(fasting plasma glucose ≥5.6 mmol/L).Receive-operating characteristic analysis(ROC)and logistic regression were employed to derive optimal age-and sex-specific waist circumference references for predicting CV risk factors.Results A slight increasing trend of CV risk factors was observed starting from the 75th percentile of waist circumference in the study population,while a remarkable increasing trend occurred from the 90th percentile.The optimal waist circumference thresholds for predicting high blood pressures were at the 75th percentile for both boys and girls,which was at the 90th percentiles for detecting at least two of the above three CV risk factors.In comparison with children with waist circumference below the 75th percentile,the odds ratio of two CV risk factors doubled among children with waist circumference between the 75th and the 90th percentile,and increased by 6 times among children with waist circumference above the 90th percentile.The trend of high blood pressure increasing with waist circumference remained significant after having been stratified by BMI category.Conclusion The 75th and the 90th percentiles of WC are the optimal cut-off points for predicting an increased and a substantially increased risk of CV factors in Chinese children and adolescents,respectively. | GUAN-SHENG MA CHENG-YE JI JUN MA JIE MI R1TA YT SLING FENG XIONG WEI-LI YAN XIAO-QI HU YAN-PING LI SONG-M1NG DU HONG-YUN FANG AND J1NG-XIONG JIANG | 2010 | Biomedical and Environmental Sciences2010，23，1： | 25 |
| 2 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 3 | Impacts of Types and Degree of Obesity on Non-Alcoholic Fatty Liver Disease and Related Dyslipidemia in Chinese School-Age Children?显示文摘Objective To explore the impacts of types and degree of obesity on non‐alcoholic fatty liver disease (NAFLD) and related lipids disturbance in Chinese school‐age children. Methods A total of 1 452 school‐age Children of 7 to 17 years were recruited in Beijing with representative cluster sampling method. Data of anthropometric measurements including weight, height and waist circumference were collected from March to May of 2007. Body mass index(BMI)was calculated. Blood samples were obtained and lipid profiles including triglyceride (TG), total cholesterol (TC), high‐density lipoprotein cholesterol (HDL‐C) and low‐density lipoprotein cholesterol (LDL‐C) were measured, while glutamate‐pyruvate transaminase (ALT) and glutamic‐oxalacetic transaminase (AST) were determined to evaluate liver function. The liver was also scanned by sonography, and abnormal hepatic sonograms were documented. NAFLD was diagnosed according to the criteria recommended by the Fatty Liver and Alcoholic Liver Disease Study Group under the Chinese Liver Disease Association. Analysis of covariance (ANOVA), Chi‐square test for trend and binary logistic regression analysis were performed. Results The dyslipidemia and ultrasonographic fatty liver deteriorated with the degree of obesity defined either by BMI or waist circumference. Compared with BMI, waist circumference contributed more to the development of dyslipidemia, fatty liver and NAFLD. The highest levels of TG, TC, LDL‐C, and lowest level of HDL‐C were seen in the mixed obese group followed by abdominal obese, peripheral obese and non‐obese ones. Adjusted for gender and age, the odds ratios (ORs) and their 95% confidence intervals of peripheral obesity, abdominal obesity and mixed obesity were 0, 10.93 (0.98‐121.96) and 79.16 (10.95‐572.44) for predicting NAFLD; 12.61 (1.24‐127.78), 19.39 (5.23‐71.85), and 93.21 (29.56‐293.90) for predicting ultrasonographic fatty liver; 1.78 (0.59‐5.44), 3.01 (1.91‐4.77), and 4.64 (3.52‐6.12) for predicting dyslipidemia, respectively compared with the non‐obese control group. The trend of hazards over groups was statistically significant (P<0.01). Conclusion The levels of lipid profile and the prevalence of NAFLD and dyslipidemia increased in parallel with the degree of obesity; As compared with the non‐obese control, the mixed obesity had the strongest association with NAFLD and dyslipidemia, followed by abdominal obesity and peripheral obesity in Chinese school‐age Children. | MENG LingHui LUO Na MI Jie | 2011 | Biomedical and Environmental Sciences2011，24，1： | 13 |
| 4 | China’s high-resolution optical remote sensing satellites and their mapping applications显示文摘Since the beginning of the twenty-first century,several countries have made great efforts to develop space remote sensing for building a high-resolution earth observation system.Under the great attention of the government and the guidance of the major scientific and technological project of the high-resolution earth observation system,China has made continuous breakthroughs and progress in high-resolution remote sensing imaging technology.The development of domestic high-resolution remote sensing satellites shows a vigorous trend,and consequently,a relatively stable and perfect high-resolution earth observation system has been formed.The development of high-resolution remote sensing satellites has greatly promoted and enriched modern mapping technologies and methods.In this paper,the development status,along with mapping modes and applications of China’s high-resolution remote sensing satellites are reviewed,and the development trend in high-resolution earth observation system for global and ground control-free mapping is discussed,providing a reference for the subsequent development of high-resolution remote sensing satellites in China. | Deren Li Mi Wang Jie Jiang | 2021 | Geo-Spatial Information Science2021，24，1： | 13 |
| 5 | Interaction of Hsp40 with influenza virus M2 protein: implications for PKR signaling pathway显示文摘Influenza virus contains three integral membrane proteins:haemagglutinin,neuraminidase,and matrix protein(M1 and M2).Among them,M2 protein functions as an ion channel,important for virus uncoating in endosomes of virus-infected cells and essential for virus replication.In an effort to explore potential new functions of M2 in the virus life cycle,we used yeast two-hybrid system to search for M2-associated cellular proteins.One of the positive clones was identified as human Hsp40/Hdj1,a DnaJ/Hsp40 family protein.Here,we report that both BM2(M2 of influenza B virus)and A/M2(M2 of influenza A virus)interacted with Hsp40 in vitro and in vivo.The region of M2-Hsp40 interaction has been mapped to the CTD1 domain of Hsp40.Hsp40 has been reported to be a regulator of PKR signaling pathway by interacting with p58^(IPK) that is a cellular inhibitor of PKR.PKR is a crucial component of the host defense response against virus infection.We therefore attempted to understand the relationship among M2,Hsp40 and p58^(IPK) by further experimentation.The results demonstrated that both A/M2 and BM2 are able to bind to p58^(IPK)in vitro and in vivo and enhance PKR autophosphorylation probably via forming a stable complex with Hsp40 and P58^(IPK),and consequently induce cell death.These results suggest that influenza virus M2 protein is involved in p58^(IPK)mediated PKR regulation during influenza virus infection,therefore affecting infected-cell life cycle and virus replication. | Zhenhong Guan Di Liu Shuofu Mi Jie Zhang Qinong Ye Ming Wang George F.Gao Jinghua Yan | 2010 | Protein & Cell2010，1，10： | 11 |
| 6 | The Development of A Fluorescence Polarization Immunoassay for Aflatoxin Detection显示文摘A fluorescence polarization immunoassay(FPIA)was developed for the analysis ofaflatoxins(AFs)using an anti-aflatoxin B1(AFB1)monoclonal antibody and a novel fluorescein-labeled AFB1tracer.The FPIA showed an IC50 value of 23.33ng/mL with a limit of detection of 13.12 ng/mL for AFB1.The cross-reactivities of AFB1,AFB2,AFG1,AFG2,AFM1,and AFM2 with the antibody were100%,65.7%,143%,23.5%,111.4%,and 2%,respectively.The group-specificity of anti-AFB1mAb indicated that the FPIA could potentially be used in a screening method for the detection of total AFs,albeit not AFG2 and AFM2.The total time required for analyzing 96 samples in one microplate was less than 5 min.This study demonstrates the potential usefulness of the FPIA as a rapid and simple technique for monitoring AFs. | SHENG Ya Jie EREMIN Sergei MI Tie Jun ZHANG Su Xia SHEN Jian Zhong WANG Zhan Hui | 2014 | Biomedical and Environmental Sciences2014，27，2： | 10 |
| 7 | Pubertal Hypertension is a Strong Predictor for the Risk of Adult Hypertension显示文摘Objective To assess and compare the predictive effects of hypertension before puberty and during puberty on adult hypertension.Methods A total of 412 adults from the 'Beijing children and adolescents blood pressure (BP) study' cohort were followed up in a clinical examination in 2005.Systolic and diastolic BP,height,and weight in childhood were measured at a baseline survey in 1987.The participants were divided into pre‐puberty and puberty sub‐cohorts according to their pubertal development stage at baseline.Information on adult BP,anthropometric indices and life style were collected through questionnaire and physical examination.BP changes and the predictive effect on adult hypertension were compared between the two sub‐cohorts.Correlation of BP levels between 1987 and 2005 was examined through linear regression models.Results From childhood to adulthood,the regression coefficients of systolic BP were similar in the two sub‐cohorts (both β=0.34,P<0.001),while the coefficient of diastolic BP was larger in the pubertal cohort (β=0.31,P<0.001) compared with the pre‐pubertal cohort (β=0.12,P=0.017).Fifty percent of children with pubertal hypertension became hypertensive adults,while pre‐pubertal hypertension resulted in 34.3%.After adjustment for sex,age,family history of hypertension,obesity in childhood,and adulthood,pubertal hypertension predicted a higher risk of adult hypertension than pre‐pubertal hypertension,with odds ratios (95% confidence intervals) of 10.00 (3.03‐33.07) and 2.71 (0.83‐8.85),respectively.Conclusion Our results suggest that hypertension during pubertyis likely to result in adult hypertension. | LIANG YaJun MI Jie | 2011 | Biomedical and Environmental Sciences2011，24，5： | 9 |
| 8 | Role of the nucleus tractus solitarii in the protection of pre-moxibustion on gastric mucosal lesions显示文摘Previous studies have shown that somatic sensation by acupuncture and visceral nociceptive stimulation can converge in the nucleus tractus solitarii where neurons integrate signals impacting on the function of organs. To explore the role of the nucleus tractus solitarii in the protective mechanism of pre-moxibustion on gastric mucosa, nucleus tractus solitarii were damaged in rats and pre-moxibustion treatment at the Zusanli(ST36) point followed. The gastric mucosa was then damaged by the anhydrous ethanol lavage method. Morphological observations, enzyme linked immunosorbent assays, and western immunoblot analyses showed that gastric mucosa surface lesion and the infiltration of inflammatory cells were significantly ameliorated after pre-moxibustion treatment. Furthermore, the gastric mucosal damage index and somatostatin level were reduced, and epidermal growth factor content in the gastric mucosa and heat-shock protein-70 expression were increased. These results were reversed by damage to the nucleus tractus solitarii. These findings suggest that moxibustion pretreatment at the Zusanli point is protective against acute gastric mucosa injury, and nucleus tractus solitarii damage inhibits these responses. Therefore, the nucleus tractus solitarii may be an important area for regulating the signal transduction of the protective effect of pre-moxibustion on gastric mucosa. | Liang Peng Mi Liu Xiaorong Chang Zhou Yang Shouxiang Yi Jie Yan Yan Peng | 2014 | Neural Regeneration Research2014，9，2： | 9 |
| 9 | Integrating landscape ecological principles and land evaluation for sustainable land use显示文摘1IntroductionRisingpopulationscompetingforlimitedlandresourceshavefocusedatentionontheneedforincreasingfoodproduction,whilepr... | Fu Bo jie, Chen Li ding Research Centre for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China He Chan sheng Department of Geography, Western Michigan University, Kalamazoo, MI 49008, USA | 1999 | Journal of Environmental Sciences1999，11，2： | 8 |
| 10 | Acellular ostrich corneal stroma used as scaffold for construction of tissue-engineered cornea显示文摘AIM:To assess acellular ostrich corneal matrix used as a scaffold to reconstruct a damaged cornea.· METHODS:A hypertonic saline solution combined with a digestion method was used to decellularize the ostrich cornea.The microstructure of the acellular corneal matrix was observed by transmission electron microscopy(TEM) and hematoxylin and eosin(H&E) staining.The mechanical properties were detected by a rheometer and a tension machine.The acellular corneal matrix was also transplanted into a rabbit cornea and cytokeratin 3 was used to check the immune phenotype.·RESULTS:The microstructure and mechanical properties of the ostrich cornea were well preserved after the decellularization process.In vitro,the methyl thiazolyl tetrazolium results revealed that extracts of the acellular ostrich corneas(AOCs) had no inhibitory effects on the proliferation of the corneal epithelial or endothelial cells or on the keratocytes.The rabbit lamellar keratoplasty showed that the transplanted AOCs were transparent and completely incorporated into the host cornea while corneal turbidity and graft dissolution occurred in the acellular porcine cornea(APC) transplantation.The phenotype of the reconstructed cornea was similar to a normal rabbit cornea with a high expression of cytokeratin 3 in the superficial epithelial cell layer.· CONCLUSION:We first used AOCs as scaffolds to reconstruct damaged corneas.Compared with porcine corneas,the anatomical structures of ostrich corneas are closer to those of human corneas.In accordance with the principle that structure determines function,a xenograft lamellar keratoplasty also confirmed that the AOC transplantation generated a superior outcome compared to that of the APC graft. | Xian-Ning Liu Xiu-Ping Zhu Jie Wu Zheng-Jie Wu Yong Yin Xiang-HuaXiao Xin Su Bin Kong Shi-Yin Pan Hua Yang Yan Cheng Na An Sheng-Li Mi | 2016 | International Journal of Ophthalmology(English edition)2016，9，3： | 6 |
| 11 | A Comprehensive Review of Isogeometric Topology Optimization:Methods,Applications and Prospects显示文摘Topology Optimization(TO)is a powerful numerical technique to determine the optimal material layout in a design domain,which has accepted considerable developments in recent years.The classic Finite Element Method(FEM)is applied to compute the unknown structural responses in TO.However,several numerical deficiencies of the FEM significantly influence the effectiveness and efficiency of TO.In order to eliminate the negative influence of the FEM on TO,IsoGeometric Analysis(IGA)has become a promising alternative due to its unique feature that the Computer-Aided Design(CAD)model and Computer-Aided Engineering(CAE)model can be unified into a same mathematical model.In the paper,the main intention is to provide a comprehensive overview for the developments of Isogeometric Topology Optimization(ITO)in methods and applications.Finally,some prospects for the developments of ITO in the future are also presented. | Jie Gao Mi Xiao Yan Zhang Liang Gao | 2020 | Chinese Journal of Mechanical Engineering2020，33，6： | 6 |
| 12 | Agricultural Heritage Systems Tourism: definition,characteristics and development framework显示文摘Architectural heritage comprises one o the most important elements of mountain settlements in Greece. It holds high cultural value, represents the tangible continuation of the past and forms the unique character and identity of each mountain region. Yet, controversy regarding funding for its preservation often arises. In this paper, we used two Contingent Valuation surveys to estimate the socia benefit deriving from protecting the traditiona architecture in the mountainous village of Sirako and through it, to examine perceptions and attitudes o local residents and visitors. Research findings revealed a strong social will in favor of the good's protection followed by high percentages of positive willingness to pay(WTP). However, WTP is significantly higher among residents. Cultura heritage value, of the good, appears to prevail, along with the environmental one. However, both residents and visitors pointed out that local heritage, if wellpreserved, will boost tourism development. Residents appeared to better recognize the true level o architectural decay, expressed higher apprehension for its protection and were willing to pay higher amount of money. Tourists, on the other side expressed high satisfaction for their visit, appreciated the beauty and serenity emerging from local built and natural environment and spent several days visiting the surrounding area. The longer they stayed and gotfamiliar with the village, the more willing they were to contribute to local heritage's protection. Percentages reflecting indifference for protecting architecture were extremely low. Yet, they were higher among tourists. Traditional architecture is considered as public good; an opinion resulting in an important percentage of visitors stating that national government should provide the necessary funding. In addition, the architecture appears to hold a high level of topicality. Those descending from Sirako or emotionally connected to it, of both social groups,turned out to be more concerned about the good and with a stronger sense of responsibility for it. Usevalue of the good holds high economic value, as well,while higher percentages of zero WTP appeared among non-users. Research findings revealed social attitudes and perceptions on what constitutes architectural heritage, in its cultural and economic frame. If taken under consideration, they may form useful drivers for local, heritage-based, | TIAN Mi MIN Qing-wen JIAO Wen-jun YUAN Zheng Anthony M.FULLER YANG Lun ZHANG Yong-xun ZHOU Jie CHENG Bing | 2016 | Journal of Mountain Science2016，13，3： | 6 |
| 13 | PCDD/Fs in soil around a hospital waste incinerator:comparison after three years of operation显示文摘Polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/Fs) can be formed during the cooling of flue gases in waste incinerator.These pollutants are either in the gas phase or attached to the fine particles,escaping dust collection.After stack emission,they are slowly oxidized photochemically(gas phase),or eventually are deposited(dry and wet deposition of particulate) in earth surface.In 2007 and 2010,11 soil samples were collected in the vicinity of a hospital waste incinerator(HWI),prior and after its startup.In order to find out any variation of PCDD/Fs in soil,in brief dioxins,their concentrations were analyzed by high-resolution gas chromatography with high-resolution mass spectrometry(HRGC/HRMS).Compared to the baseline survey(2007),PCDD/Fs in soil significantly increased,by average,+81.6% in total PCDD/Fs and +132.7% in international toxic equivalency(I-TEQ) unit.By principal component analysis(PCA),both the PCDD/Fs homologue and the HxCDF isomer profile in soil were found to become more similar with fly ash.Generally,this incinerator influences the soil only in a limited area.More comprehensive supervision,stricter management and more advanced technology should be implemented in this plant to reduce pollutants emission,even though the level of PCDD/Fs in soil is quite low at present. | Xiaodong Li Mi Yan Jie Yang Tong Chen Shengyong Lu Jianhua Yan | 2012 | Journal of Environmental Sciences2012，24，4： | 6 |
| 14 | RIP3/MLKL-mediated neuronal necroptosis induced by methamphetamine at 39℃显示文摘Methamphetamine is one of the most prevalent drugs abused in the world.Methamphetamine abusers usually present with hyperpyrexia (39℃),hallucination and other psychiatric symptoms.However,the detailed mechanism underlying its neurotoxic action remains elusive.This study investigated the effects of methamphetamine + 39℃ on primary cortical neurons from the cortex of embryonic Sprague-Dawley rats.Primary cortex neurons were exposed to 1 mM methamphetamine + 39℃.Propidium iodide staining and lactate dehydrogenase release detection showed that methamphetamine + 39℃ triggered obvious necrosis-like death in cultured primary cortical neurons,which could be partially inhibited by receptor-interacting protein-1 (RIP1) inhibitor Necrostatin-1 partially.Western blot assay results showed that there were increases in the expressions of receptor-interacting protein-3 (RIP3) and mixed lineage kinase domain-like protein (MLKL) in the primary cortical neurons treated with 1 mM methamphetamine + 39℃ for 3 hours.After pre-treatment with RIP3 inhibitor GSK’872,propidium iodide staining and lactate dehydrogenase release detection showed that neuronal necrosis rate was significantly decreased;RIP3 and MLKL protein expression significantly decreased.Immunohistochemistry staining results also showed that the expressions of RIP3 and MLKL were up-regulated in brain specimens from humans who had died of methamphetamine abuse.Taken together,the above results suggest that methamphetamine + 39℃ can induce RIP3/MLKL regulated necroptosis,thereby resulting in neurotoxicity.The study protocol was approved by the Medical Ethics Committee of the Third Xiangya Hospital of Central South University,China (approval numbers: 2017-S026 and 2017-S033) on March 7,2017. | Li-Min Guo Zhen Wang Shi-Ping Li Mi Wang Wei-Tao Yan Feng-Xia Liu Chu-Dong Wang Xu-Dong Zhang Dan Chen Jie Yan Kun Xiong | 2020 | Neural Regeneration Research2020，15，5： | 5 |
| 15 | Effects of pre-moxibustion at Zusanli (ST36) on heat shock protein 70 expression in rats with gastric mucosal lesions after neurotomy显示文摘Studies have shown that pre-moxibustion protects the gastric mucosa by up-regulating the expres- sion of heat shock protein 70. However, the signaling pathway underlying this effect remains unclear. Rats were intragastrically administered absolute alcohol, causing obvious lesion of the gastric mucosa. Following pre-moxibustion at Zusanli (ST36) for 8 days, the ulcer index decreased to different degrees. The results of an enzyme linked immunosorbent assay and western blotting showed significant upregulation of heat shock protein 70 expression in the gastric mucosa and serum. None out of transection of the spinal cord, damage to the nucleus of the solitary tract, neurotomy of the vagal nerve and neurotomy of the common peroneal nerve affected the decrease in ulcer index or the increase in heat shock protein 70 expression in serum after pre-moxibustion at Zusanli, and heat shock protein 70 expression was obviously decreased in the gastric mucosa. These findings suggest that pre-moxibustion at Zusanli can protect the gastric mucosa against lesioning, and that the mechanism underlying this effect involves its induction of heat shock protein 70 expression. Neural pathways participate in the regulatory effects of moxibustion on heat shock protein 70 expression in the gastric mucosa. | Liang Peng Mi Liu Xiaorong Chang Zhou Yang Shouxiang Yi Jie Yan Yan Peng | 2012 | Neural Regeneration Research2012，7，30： | 5 |
| 16 | Childhood BMI and Adult Obesity in a Chinese Sample:A 13-Year Follow-up Study显示文摘Objective Obesity is recognized as a significant risk factor for diabetes and hypertension. The present study aimed to examine the associations between adults' obesity risk and childhood and parental obesity. Methods A total of 204 children aged 6-17 years were recruited in 2002 with an average follow-up period of 13.2 years. Height and body weight were measured by trained staffs. Overweight and obesity were defined based on the Chinese standard for children and adults. T-test, analysis of variance, and Chi-square analysis were used for single factor analysis. Multiple linear and logistic regression analyses were used to perform multifactor analysis. Results The percentage of non-obese children who grew up to be non-obese adults was 62.6%, and that of obese children who grew up to be obese adults was 80.0%. There was a significant association between childhood body mass index(BMI) and adulthood BMI with a β regression coefficient of 3.76 [95% confidence interval(CI): 1.36-6.16], and between childhood obesity and adulthood obesity with an odds ratio of 5.76(95% CI: 1.37-24.34). There was no statistical difference between parental obesity at baseline and children's adulthood obesity, after adjustment of confounders. Male participants and those aged 10.0-13.0 years had a higher risk of adulthood obesity with odds ratios of 2.50(95% CI: 1.12-5.26) and 3.62(95% CI: 1.17-11.24), respectively. Conclusion Childhood obesity is an important predictor of adulthood obesity. | LIU Dan HAO Yun Xia ZHAO Ting Zhi SONG Peng Kun ZHAI Yi PANG Shao Jie ZHAO Yan Fang ZHANG Mei WANG Zhuo Qun MI Sheng Quan WANG Yu Ying ZHANG Jian ZHAO Wen Hua | 2019 | Biomedical and Environmental Sciences2019，32，3： | 5 |
| 17 | Abnormal Adipokines Associated with Various Types of Obesity in Chinese Children and Adolescents显示文摘Objective To explore the role of adipokines including insulin, resistin, leptin, adiponectin, acylation stimulating protein (ASP) and complement C3 (C3) in various types of obesity (peripheral obesity, abdominal obesity and mixed obesity) in Chinese children and adolescents, and their relationships with body size and pubertal development. Methods Children and adolescents (n=3 508) aged 6 to 18 years, with 1 788 boys and 1 720 girls were assessed for body mass index, waist circumference, pubertal development, blood insulin, resistin, leptin, adiponectin, ASP and C3 levels. Three types of obesity [peripheral obesity (n=43), abdominal obesity (n=473), mixed obesity (n=1 187)] and non‐obese control (n=1 805) were defined with combined use of Chinese body mass index and waist circumference criteria. Results Serum resistin, leptin and adiponectin levels were higher in girls than those in boys (all P<0.01). Insulin and leptin increased and adiponectin decreased across five Tanner stages in both girls and boys (all P<0.001), while ASP changed only in girls (P<0.001) and C3 only in boys (P<0.001). Insulin, leptin and ASP were higher, but adiponectin was lower in all three types of obesity vs. the non‐obese control (all P<0.05). The greatest abnormalities of all six adipokines were found in the mixed obesity group. With inclusion of body mass index and waist circumference in simultaneous regression analyses, both body size indices were independently and significantly correlated with insulin, leptin and adiponectin after age and gender adjustment. Compared with waist circumference, the body mass index was stronger in interpreting insulin, leptin, adiponectin and ASP levels, whereas it was weaker in explaining variance of plasma C3. Conclusions Obese children have a worse metabolic profile with high insulin, resistin, leptin, ASP and C3, and low adiponectin levels. The adipokine profile in mixed obesity is worse than that in peripheral or abdominal obesity. Identification of obese subjects with a malignant adipokine profile using a combination of body mass index and waist circumference is important for the prevention of obesity‐related disease. | ZHANG MeiXian ZHAO XiaoYuan LIMing CHENG Hong HOU DongQing WEN Yu Katherine CIANFLONE MI Jie | 2011 | Biomedical and Environmental Sciences2011，24，1： | 4 |
| 18 | Effect of Alpinia officinarum Hance alcohol extracts on primary dysmenorrheal显示文摘Objective:To study the effect of Alpinia officinarum Hance(A.officinarum) 80% alcohol extract on the primary dysmenorrhea.Methods:A.officinarum 80% alcohol extract were enriched by macroporous adsorption resins.Female mice of primary dysmenorrhea model were established by oxytocin induction; the effects of A.officinarum 80% alcohol extract on primary dysmenorrhea were observed by body twist method; and the homogenate level of prostaglandin F_(2α)(PGF_(2α)),prostaglandin E_2(PGE_2) and Ca^(2+) in the uterus were observed in oxytocin-induced female mice.Results:The writhing frequency of primary dysmenorrhea mice was significantly decreased after treatment of A.officinarum 80% alcohol extract and the level of PGF_(2α),PGE_2 and Ca^(2+) in mice uterus was significantly decreased(P<0.05,P<0.01) in groups of mice treated with middle and high dosage of A.officinarum 80% alcohol extract compared with that of model group.Conclusions:These findings suggest that A.Officinarum 80% alcohol extract can significantly relieve primary dysmenorrhea. | Ling Huang Jun-Qing Zhang You-Bin Li Mi Liu Hui-Ming Deng Yu-Chao Luo Yin-Feng Tan Jie Hou Gui-Wei Yao Wei-Wei Guan | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，9： | 4 |
| 19 | Differences in atheroma between Caucasian and Asian subjects with anterior stroke:A vessel wall MRI study显示文摘Background and purpose While extracranial carotid artery stenosis is more common among Caucasians and intracranial artery stenosis is more common among Asians,the differences in atherosclerotic plaque characteristics have not yet been extensively examined.We sought to investigate plaque location and characteristics within extracranial carotid and intracranial arteries in symptomatic Caucasians and Chinese using vessel wall MRI.Methods Subjects with recent anterior circulation ischaemic stroke were recruited and imaged at two sites in the USA and China using similar protocols.Both extracranial carotid and intracranial arteries were reviewed to determine plaque location and characteristics.Results The prevalence of extracranial carotid plaque in Caucasians and Chinese was 73.1%and 49.1%,respectively(p=0.055).Prevalence of intracranial plaque was 38.5%and 69.1%in Caucasians and Chinese,respectively(p=0.02).Furthermore,42% of Caucasians and 16%of Chinese had high-risk plaque(HRP)features(intraplaque haemorrhage,luminal surface disruption)in the extracranial carotid artery(p=0.03).The prevalence of HRP features in intracranial arteries was not significantly different between the two cohorts(4%vs 11%;p=0.42).Conclusions Differences in the location and characteristics of cerebrovascular atherosclerosis were identified by vessel wall MRI in US Caucasian and Chinese subjects with recent anterior circulation ischaemic stroke.Extracranial carotid plaques with HRP features were more common in Caucasians.Intracranial plaques were more common in Chinese subjects,but no significant difference between the two cohorts in intracranial HRP prevalence was found.Larger studies using vessel wall imaging to investigate racial differences in cerebrovascular disease may inform underlying mechanisms of HRP development and may ultimately help guide appropriate therapy. | Hiroko Watase Mi Shen Binbin Sui Peiyi Gao Dong Zhang Jie Sun Niranjan Balu Daniel S Hippe Gail P Jarvik Xihai Zhao Rui Li Shuo Chen Chun Yuan Thomas S Hatsukami | 2021 | Stroke & Vascular Neurology2021，6，1： | 4 |
| 20 | Cytokines predict virological response in chronic hepatitis B patients receiving peginterferon alfa-2a therapy显示文摘BACKGROUND Chronic hepatitis B virus infection remains a major global public health problem.Peginterferon-alpha-2a(PEG-IFN)has direct antiviral and immunoregulatory effects,and it has become one of the first choice drugs for the treatment of chronic hepatitis B(CHB).Cytokines play an important role in immunity,and they directly inhibit viral replication and indirectly determine the predominant pattern of the host immune response.AIM To determine the correlation between cytokine/chemokine expression levels and response to PEG-IFN treatment in patients with CHB.METHODS Forty-six kinds of cytokines were analyzed before PEG-IFN therapy and at 24 wk during therapy in 26 CHB patients.RESULTS The monokine induced by INF-γ(CXCL9)and serum interferon-inducible protein 10(IP-10)levels at baseline were higher in virological responders than in nonvirological responders(NRs)and decreased during treatment,whereas the NRs did not exhibit significant changes.The macrophage inflammatory protein 1d(MIP-1d)levels at baseline and during treatment were significantly higher in the virological responders than in the NRs,while thymus and activation-regulated chemokine(TARC)levels at baseline and during treatment were significantly lower in the virological responders than in the NRs.The CXCL9,IP-10,MIP-1d,and TARC baseline levels exhibited the expected effects for interferon treatment.The area under the receiver operating characteristic curve values of CXCL9,IP-10,MIP-1d,and TARC for predicting virological responses were 0.787,0.799,0.787,and 0.77(P=0.01,0.013,0.01,and 0.021),respectively.CONCLUSION We found that cytokine levels before and during treatment may represent potential biomarkers to select CHB patients who can respond to PEG-IFN.Therefore,cytokines can be used as an indicator of antiviral drug selection before CHB treatment. | Wen-Kang Fu Jie Cao Ning-Ning Mi Chong-Fei Huang Long Gao Jin-Duo Zhang Ping Yue Bing Bai Yan-Yan Lin Wen-Bo Meng | 2020 | World Journal of Clinical Cases2020，8，11： | 4 |
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