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| 1 | The osmotic Potential of Polyethy --le- neglyel 6000 显示文摘 | MICHAEL BE KAUFAMAN MR | 1973 | Plant Physiol1973，51，： | 1 |
| 2 | Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial显示文摘 | Michael Henke Roland Laszig Christian Rübe Ulrich Sch?fer Klaus-Dieter Haase Burkhard Schilcher Stephan Mose Karl T Beer Ulrich Burger Chris Dougherty Hermann Frommhold | 2003 | The Lancet2003，，9392： | 1 |
| 3 | Distinct types of diffuse larger B-cell lymphoma identified by gene expression profiling显示文摘 | Alizadeh AA Michael BE Davis RE | 2000 | Nature2000，403，： | 1 |
| 4 | Molecular portraits of human breast tumors显示文摘 | Charles MP Therese S Michael BE | 2002 | Nature2002，406，6797： | 1 |
| 5 | Lipoatrophic diabetes in Irsl ( -/- )/Its3( -/- ) double knockout mice显示文摘 | Laustsen PC Michael MD Crute BE | 2002 | Genes Dev2002，16，： | 1 |
| 6 | The osmotic potential of polyethy- lene glycol 6000 显示文摘 | Michael BE Kaufaman MR | 1973 | Plant Physiology1973，51，5： | 1 |
| 7 | Shock Efficacy of Subcutaneous Implantable Cardioverter-Defibrillator for Prevention of Sudden Cardiac Death: Initial Multicenter Experience显示文摘 | Ali Aydin Friederike Hartel Michael Schlüter Christian Butter Julia K?be Martin Seifert Nils Gosau Boris Hoffmann Matthias Hoffmann Eik Vettorazzi Iris Wilke Karl Wegscheider Hermann Reichenspurner Lars Eckardt Daniel Steven Stephan Willems | 2012 | Circulation: Arrhythmia and Electrophysiology2012，，5： | 1 |
| 8 | Phase 3 clinical trial investigating the effect of selenium supplementation in men at high-risk for prostate cancer显示文摘 | Atnit MAlgotar M Suzanne Stmtton Frederick R Ahmann James Ranger- Moore iqaytltond B Nagle Patrieia A Thompson Elizabeth Slate Chiu i4 Hsu Be L Dalkin Puneet Sindhwani Michael A Holmes John A Tuckey lt/td L Graham Howard L Parnes Lawrence C Clark Steven P Stratton | 2013 | The Prostate2013，73，3： | 1 |
| 9 | Molecular portraits of human breast tumors 显示文摘 | Charles MP Therese S Michael BE | 2002 | Nature2002，406，6797： | 1 |
| 10 | Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial显示文摘 | Michael Henke Roland Laszig Christian Rübe Ulrich Sch?fer Klaus-Dieter Haase Burkhard Schilcher Stephan Mose Karl T Beer Ulrich Burger Chris Dougherty Hermann Frommhold | 2003 | The Lancet2003，，9392： | 1 |
| 11 | Lipoatrophic diabetes in Irs1(-/-)/ Irs3 (-/-) double knockout mice显示文摘 | Laustsen PG Michael MD Crute BE | 2002 | Genes Dev2002，16，24： | 1 |
| 12 | Mutations in the Fumarate Hydratase Gene Cause Hereditary Leiomyomatosis and Renal Cell Cancer in Families in North America显示文摘 | Jorge R. Toro Michael L. Nickerson Ming-Hui Wei Michelle B. Warren Gladys M. Glenn Maria L. Turner Laveta Stewart Paul Duray Ousman Tourre Nirmala Sharma Peter Choyke Pamela Stratton Maria Merino McClellan M. Walther W. Marston Linehan Laura S. Schmidt Be | 2003 | The American Journal of Human Genetics2003，，： | 1 |
| 13 | CGR3: A Golgi-Localized Protein Influencing Homogalacturonan Methylesterification显示文摘植物房间墙是提供结构、机械的支持种房间的复杂结构并且为植物建筑学和形式最终负责。果胶是在 Golgi 被做并且藏匿了到墙的植物房间墙的复杂多糖的一个大组。果胶的 methylesterification 被相信是为房间墙的动态性质的一个重要因素。这里,我们在用棉花 Golgi 的广泛的 proteomics 分析发现的未知功能的蛋白质上报导。通过生物信息的分析,我们识别了如此的蛋白质的 ortholog,这里命名的棉花 Golgi 相关 3 (CGR3 ) 在 Arabidopsis 并且发现它与 S-adenosylmethionine methyltransferases 分享保存残余。我们证实 CGR3 在 Golgi 仪器是局部性的并且 CGR3 基因的表示与几房间墙 biosynthetic 基因的被相关,建议在果胶修正的蛋白质的一个可能的角色。与这个假设一致,有为 homogalacturonan 果胶(HG ) 的抗体的 immunofluorescence 显微镜学分别地在 HG methylesterification 显示房间 cgr3 大美人异种围,植物 overexpressing CGR3 被减少并且增加。我们的结果建议 CGR3 在 Arabidopsis 在 homogalacturonan 的 methylesterification 起一个作用。 | Michael A. Held Evan Be Starla Zemelis Saunia Withers Curtis Wilkerson Federica Brandizzi | 2011 | Molecular Plant2011，4，5： | 0 |
| 14 | Biodiversity and belowground interactions mediate community invasion resistance against a tall herb invader显示文摘Aims Species-rich plant communities are hypothesized to be more resistant against plant invasions because they use resources in a more efficient way.However,the relative contributions of aboveground competition and belowground interactions for invasion resistance are still poorly understood.Methods We compared the performance of Knautia arvensis transplants growing in plots differing in plant diversity both under full competition and with shoots of neighbors tied back to determine the relative strength of aboveground competition in suppressing this test invader without the confounding effect of shading.In addition,we assessed the effects of belowground competition and soil-borne pathogens on transplant performance.Important Findings Both aboveground competition and plant species richness strongly and independently affected invader performance.Aboveground biomass,height,leaf mass per area and flowering of transplanted individuals of K.arvensis decreased with increasing species richness of the host community.Species-rich and species-poor communities both imposed equally strong aboveground competition on K.arvensis.However,belowground interactions(especially belowground root competition)had strong negative effects on transplant performance.In addition,the presence of grasses in a plant community further reduced the performance of K.arvensis.Our results suggest that belowground competition can render species-rich host communities more suppressive to newly arriving species,thus enhancing community invasion resistance. | Christoph Scherber Peter NMwangi Martin Schmitz Michael Scherer-Lorenzen Holger Beßler Christof Engels Nico Eisenhauer Varvara DMigunova Stefan Scheu Wolfgang WWeisser Ernst-Detlef Schulze Bernhard Schmid | 2010 | Journal of Plant Ecology2010，3，2： | 0 |
| 15 | Long-term clinical outcomes of lipiodol marking using standard gastroscopy for image-guided radiotherapy of upper gastrointestinal cancers显示文摘BACKGROUND Image-guided radiotherapy(IGRT)has significantly improved the precision in which radiotherapy is delivered in cancer treatment.Typically,IGRT uses bony landmarks and key anatomical structures to locate the tumor.Recent studies have demonstrated the feasibility of peri-tumor fiducials in enabling even more accurate delineation of target and normal tissue.The use of gold coils as fiducials in gastrointestinal tumors has been extensively studied.However,placement requires expertise and specialized endoscopic ultrasound equipment.This article reports the long-term outcomes of using a standard gastroscopy to inject liquid fiducials for the treatment of oesophageal and gastric tumors with IGRT.AIM To assess the long-term outcomes of liquid fiducial-guided IGRT in a cohort of oesophageal and gastric cancer patients.METHODS A retrospective cohort study of consecutive adults with Oesophagogastric cancers referred for liquid fiducial placement before definitive/neo-adjuvant or palliative IGRT between 2013 and 2021 at a tertiary hospital in Melbourne,Australia was conducted.Up to four liquid fiducials were inserted per patient,each injection consisting of 0.2-0.5mL of a 1:1 mixture of iodized oil(Lipiodol;Aspen Pharmacare)and n-butyl 2-cyanoacrylate(Histoacryl®;B.Braun).A 23-gauge injector(Cook Medical)was used for the injection.All procedures were performed by or under the supervision of a gastroenterologist.Liquid fiducial-based IGRT(LF-IGRT)consisted of computer-assisted direct matching of the fiducial region on cone-beam computerised tomography at the time of radiotherapy.Patients received standard-IGRT(S-IGRT)if fiducial visibility was insufficient,consisting of bone match as a surrogate for tumor position.Radiotherapy was delivered to 54Gy in 30 fractions for curative patients and up to 45Gy in 15 fractions for palliative treatments.RESULTS 52 patients were referred for liquid fiducial placement within the study period.A total of 51 patients underwent liquid fiducial implantation.Of these a total of 31 patients received radiotherapy.Among these,the median age was 77.4 years with a range between 57.5 and 88.8,and 64.5%were male.Twenty-seven out of the 31 patients were able to have LF-IGRT while four had S-IGRT.There were no complications after endoscopic implantation of liquid fiducials in our cohort.The cohort overall survival(OS)post-radiotherapy was 19 mo(range 0 to 87 mo).Whilst the progression-free survival(PFS)post-radiotherapy was 13 mo(range 0 to 74 mo).For those treated with curative intent,the median OS was 22.0 mo(range 0 to 87 mo)with a PFS median of 14.0 mo(range 0 to 74 mo).Grade 3 complication rate post-radiotherapy was 29%.CONCLUSION LF-IGRT is feasible in 87.1%of patients undergoing liquid fiducial placement through standard gastroscopy injection technique.Our cohort has an overall survival of 19 mo and PFS of 13 mo.Further studies are warranted to determine the long-term outcomes of liquid-fiducial based IGRT. | Kim Hay Be Richard Khor Daryl Lim Joon Ben Starvaggi Michael Chao Sweet Ping Ng Michael Ng Leonardo Zorron Cheng Tao Pu Marios Efthymiou Rhys Vaughan Sujievvan Chandran | 2021 | World Journal of Gastroenterology2021，27，42： | 0 |
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