|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cardiac remodeling and physical training post myocardial infarction显示文摘After myocardial infarction(MI), the heart undergoes extensive myocardial remodeling through the accumulation of fibrous tissue in both the infarcted and noninfarcted myocardium, which distorts tissue structure, increases tissue stiffness, and accounts for ventricular dysfunction. There is growing clinical consensus that exercise training may beneficially alter the course of post-MI myocardial remodeling and improve cardiac function. This review summarizes the present state of knowledge regarding the effect of post-MI exercise training on infarcted hearts. Due to the degree of difficulty to study a viable human heart at both protein and molecular levels, most of the detailed studies have been performed by using animal models. Although there are some negative reports indicating that post-MI exercise may further cause deterioration of the wounded hearts, a growing body of research from both human and animal experiments demonstrates that post-MI exercise may beneficially alter the course of wound healing and improve cardiac function. Furthermore, the improved function is likely due to exercise training-induced mitigation of reninangiotensin-aldosterone system, improved balance between matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1, favorable myosin heavy chain isoform switch, diminished oxidative stress, enhanced antioxidant capacity, improved mitochondrial calcium handling, and boosted myocardial angiogenesis. Additionally, meta-analyses revealed that exercise-based cardiac rehabilitation has proven to be effective, and remains one of the least expensive therapies for both the prevention and treatment of cardiovascular disease, and prevents re-infarction. | Michael A Garza Emily A Wason John Q Zhang | 2015 | World Journal of Cardiology2015，7，2： | 28 |
| 2 | Super-resolution dipole orientation mapping via polarization demodulation显示文摘Fluorescence polarization microscopy(FPM)aims to detect the dipole orientation of fluorophores and to resolve structural information for labeled organelles via wide-field or confocal microscopy.Conventional FPM often suffers from the presence of a large number of molecules within the diffraction-limited volume,with averaged fluorescence polarization collected from a group of dipoles with different orientations.Here,we apply sparse deconvolution and least-squares estimation to fluorescence polarization modulation data and demonstrate a super-resolution dipole orientation mapping(SDOM)method that resolves the effective dipole orientation from a much smaller number of fluorescent molecules within a sub-diffraction focal area.We further apply this method to resolve structural details in both fixed and live cells.For the first time,we show that different borders of a dendritic spine neck exhibit a heterogeneous distribution of dipole orientation.Furthermore,we illustrate that the dipole is always perpendicular to the direction of actin filaments in mammalian kidney cells and radially distributed in the hourglass structure of the septin protein under specific labelling.The accuracy of the dipole orientation can be further mapped using the orientation uniform factor,which shows the superiority of SDOM compared with its wide-field counterpart as the number of molecules is decreased within the smaller focal area.Using the inherent feature of the orientation dipole,the SDOM technique,with its fast imaging speed(at sub-second scale),can be applied to a broad range of fluorescently labeled biological systems to simultaneously resolve the valuable dipole orientation information with super-resolution imaging. | Karl Zhanghao Long Chen Xu-San Yang Miao-Yan Wang Zhen-Li Jing Hong-Bin Han Michael Q Zhang Dayong Jin Jun-Tao Gao Peng Xi | 2016 | Light(Science & Applications)2016，5，1： | 11 |
| 3 | 4种天然气基汽车燃料的生命周期3E评价显示文摘 以天然气基汽车代用燃料系统为研究对象,运用生命周期评价方法,评估用天然气生产压缩天然气、甲醇、二甲醚、柴油四种代用燃料系统的生命周期指标,从能源、环境和经济(3E)三方面评价天然气基汽车代用燃料系统;为推广能耗少,对生态环境友好,经济上可接受的能源及能源政策的制定提供依据. | 吴锐 任玉珑 雍静 韩唯健 WANG Michael Q | 2004 | 系统工程理论与实践2004，24，9： | 7 |
| 4 | 肿瘤浸润髓系细胞上表达的共抑制分子B7S1抑制抗肿瘤CD8 T细胞的功能显示文摘文章简介近年来,肿瘤免疫治疗蓬勃发展,为人类战胜癌症带来了一线曙光。阻断PD-1/PD-L1通路的抗体药物可以提高CD8 T细胞的抗肿瘤活性,疗效显著优于传统治疗手段。然而,只有小部分实体瘤病人可以对PD-1/PD-L1免疫治疗产生应答. | 黎静 Younghee Lee Yanjian Li Yu Jiang Huiping Lu Wenjuan Zang Xiaohong Zhao Liguo Liu Yang Chen Haidong Tan 杨志英 Michael Q Zhang Tak W.Mak Ling Ni 董晨 | 2019 | 科学新闻2019，0，2： | 6 |
| 5 | Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade显示文摘 | Clifford R Jack David S Knopman William J Jagust Leslie M Shaw Paul S Aisen Michael W Weiner Ronald C Petersen John Q Trojanowski | 2010 | Lancet Neurology2010，，1： | 4 |
| 6 | 生物炭在柑橘皮厌氧发酵中作用机理研究显示文摘该研究主要调查柑橘皮废料厌氧消化能力在不同类型的生物炭和不同比率下的影响。柑橘皮对厌氧消化有抑制作用。生物炭的存在有两种影响:相对于只有柑橘皮废料的培养来说,它减少了迟滞期的长度,并且使甲烷的产量更高。微生物迟滞期随着柑橘皮与生物炭比例的增加而降低,在比例为2∶1时停滞期最长,为9.4 d,在比例为1∶3时迟滞期最短,为7.5 d。生物炭和柑橘皮培养中累积的甲烷产量在163.9到186.8 mLCH4 ·g^-1VS之间变动,而只有柑橘皮培养中的甲烷产量只有165.9 mLCH4 ·g^-1VS。在检测生物炭材料时发现了推测的产甲烷菌群。D-柠檬烯吸附和微生物固定化的协同作用在生物炭的影响下会提高厌氧消化的性能。 | Michael O Fagbohungbe Ben M J Herbert Lois Hurst Hong Li Shams Q Usmani Kirk T Semple 张冀川(译) | 2019 | 中国沼气2019，37，5： | 2 |
| 7 | Network - based global inference of human disease gehes 显示文摘 | Xuebing Wu Rui Jiang Michael Q Zhang Shao Li | 2008 | Molecular Systems Biology2008，4，： | 1 |
| 8 | The GRASP multiple micro-UAV testbed 显示文摘 | MICHAEL N MELLINGER D LINDSEY Q | 2010 | IEEE Robotics and Automation Magazine2010，17，3： | 1 |
| 9 | The Missing Mechanical Circuit Element显示文摘 | CHEN Michael Z Q Papageorgiou Christos Scheibe Frank | 2009 | IEEE Circuits and Systems Magazine2009，9，1： | 1 |
| 10 | The grasp multiple micro-UAV test bed experimental evaluation of multirobot aerial control algorithms显示文摘 | Michael N Mellinger D Lindsey Q | 2010 | IEEE Robotics & Automation Magazine2010，17，3： | 1 |
| 11 | Prevalence of Salmonella on Retail Chicken Meat in Russian Federation显示文摘 | Alali Walid Q Gaydashov Roman Petrova Elena Panin Alexander Tugarinov Oleg Kulikovskii Alexander Mamleeva Dzhemile Walls Isabel Doyle Michael P | 2012 | EN2012，，8： | 1 |
| 12 | Efficient tumour formation by single human melanoma cells显示文摘 | Elsa Q Mark S Michael S | 2008 | Nature2008，456，： | 1 |
| 13 | Versatile suicide vectors which allow direct selection for gene replacement in gram-negative bacteria 显示文摘 | Jurgen Q Michael FH | 1993 | Gene1993，127，1： | 1 |
| 14 | Homo-cysteinyl peptide inhibitors of the L1 metallo-β-1actamase and SAR as determined by combinatorial library synthesis显示文摘 | Sun Q Andy L Michael WC | 2006 | Bioorg & Med Chem2006，16，： | 1 |
| 15 | Atorvastatin causes insulin resistance and increases ambient glycemia in hypercholesterolemic patients显示文摘 | KWANG K K MICHAEL J Q SEUNG H H | 2010 | J Am Coll Cardiol2010，55，： | 1 |
| 16 | Souble recombinant endostat in purified from escherichia coli:antiangiogenic activity and antit umor effect 显示文摘 | Huang XJ Michael KKW Zhao Q | 2001 | Cancer Research2001，15，61： | 1 |
| 17 | High-difinition optical coherence tomography features in vitellifonn macular dystrophy 显示文摘 | Guiseppe Q Michael R Claudia Q | 2008 | Am J Ophthalmol2008，146，10： | 1 |
| 18 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 19 | High-accuracy,compact database of narrow-band k-distributions for water vapor and carbon dioxide显示文摘 | WANG A Q Michael F M | 2005 | Journal of Quantitative Spectroscopy & Radiative Transfer2005，93，13： | 1 |
| 20 | A view of cloud computing显示文摘 | MICHAEL A ARMANDO F REAN Q ANTHONY D J RANDY K ANDY K GUNHO L DAVID P ARIEL R ION S MATEI Z | 2010 | Communications of the ACM2010，53，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员