|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | 肿瘤浸润髓系细胞上表达的共抑制分子B7S1抑制抗肿瘤CD8 T细胞的功能显示文摘文章简介近年来,肿瘤免疫治疗蓬勃发展,为人类战胜癌症带来了一线曙光。阻断PD-1/PD-L1通路的抗体药物可以提高CD8 T细胞的抗肿瘤活性,疗效显著优于传统治疗手段。然而,只有小部分实体瘤病人可以对PD-1/PD-L1免疫治疗产生应答. | 黎静 Younghee Lee Yanjian Li Yu Jiang Huiping Lu Wenjuan Zang Xiaohong Zhao Liguo Liu Yang Chen Haidong Tan 杨志英 Michael Q Zhang Tak W.Mak Ling Ni 董晨 | 2019 | 科学新闻2019，0，2： | 6 |
| 3 | Visibility, air quality and daily mortality in Shanghai, China显示文摘 | Wei Huang Jianguo Tan Haidong Kan Ni Zhao Weimin Song Guixiang Song Guohai Chen Lili Jiang Cheng Jiang Renjie Chen Bingheng Chen | 2009 | Science of the Total Environment2009，，10： | 1 |
| 4 | The impact of the 2008 cold spell on mortality in Shanghai, China显示文摘 | Wenjuan Ma Chunxue Yang Chen Chu Tiantian Li Jianguo Tan Haidong Kan | 2013 | International Journal of Biometeorology2013，，1： | 1 |
| 5 | The impact of the 2008 cold spell on mortality in Shanghai, China显示文摘 | Wenjuan Ma Chunxue Yang Chen Chu Tiantian Li Jianguo Tan Haidong Kan | 2013 | International Journal of Biometeorology2013，，1： | 1 |
| 6 | Backstepping controller design for the trajectory tracking control of work platform of folding-boom aerial platform vehicle显示文摘 | Haidong Hu En Li Xiaoguang Zhao Min Tan Wensheng Yu | 2010 | International Conference on Robotics and Biomimetics (ROBIO)2010，，： | 1 |
| 7 | Visibility, air quality and daily mortality in Shanghai, China 显示文摘 | HUANG Wei TAN Jianguo KAN Haidong | 2009 | Science of the Total Environment2009，407，10： | 1 |
| 8 | Characterization of domain distributions by second harmonic generation in ferroelectrics显示文摘Domain orientations and their volume ratios in ferroelectrics are recognized as a compelling topic recently for domain switching dynamics and domain stability in devices application.Here,an optimized second harmonic generation method has been explored for ferroelectric domain characterization.Combing a unique theoretical model with azimuth-polarization-dependent second harmonic generation response,the complex domain components and their distributions can be rigidly determined in ferroelectric thin films.Using the proposed model,the domain structures of rhombohedral BiFeO_(3) films with 71°and 109°domain wall,and,tetragonal BiFeO_(3),Pb(Zr_(0.2)Ti_(0.8))O_(3),and BaTiO_(3) ferroelectric thin films are analyzed and the corresponding polarization variants are determined.This work could provide a powerful and all-optical method to track and evaluate the evolution of ferroelectric domains in the ferroelectric-based devices. | Yuan Zhang Yi Zhang Quan Guo Xiangli Zhong Yinghao Chu Haidong Lu Gaokuo Zhong Jie Jiang Congbing Tan Min Liao Zhihui Lu Dongwen Zhang Jinbin Wang Jianmin Yuan Yichun Zhou | 2018 | npj Computational Materials2018，，1： | 1 |
| 9 | Visibility, air quality and daily mortality in Shanghai, China 显示文摘 | HUANG Wei TAN Jianguo KAN Haidong | 2009 | Sei Total Environ2009，407，10： | 1 |
| 10 | Recombinant human bone morphogenetic protein-7 expressed from CHO cells possessing the activity of bone-induced in vitro显示文摘Objective To express the recombinant human bone morphogenetic protein-7 (rhBMP-7) in Chinese hamster ovary (CHO) cells and to establish the in vitro biological activity assay of rhBMP-7. Methods Human BMP-7 cDNA was subcloned into pcDNA3.1 mammalian expression vector and transfected to CHO cells by using the lipofectin transfection method. BMP-7 expression cell culture supernatants were harvested and purified for target protein. To analyze the bioactivity of the secreted rhBMP-7, a novel in vitro assay was established by measuring its alkaline phosphatase (ALP) stimulating of osteoblast cell line, W-20-17. Results BMP-7 stably expressing cell clone was selected, which secreted mature disulfide-linked homodimer form of hBMP-7 and had an apparent molecular weight of 36kDa. rhBMP-7 with >95% purity was obtained using 3 step chromatography method. Bioactivity assay showed that the purified protein specifically stimulated W-20-17 cell producing ALP, with a 4-fold increase of ALP activity at 100ng/ml or more, and the EC50 of 15.6ng/ml. Conclusion Purified rhBMP-7 from this CHO expression system has significant biological activity in induction of osteoblast phenotype, which demonstrates potential bone regeneration activity. | LI Xiaoyan WANG Hao YANG Yang TAN Min XUE Jingya NI Haidong GUO Yajun | 2006 | 脊柱外科杂志2006，4，3： | 1 |
| 11 | Stress sensitivity of carbonate gas reservoirs and its microscopic mechanism显示文摘In order to evaluate the stress sensitivity of carbonate reservoirs,a series of rock stress sensitivity tests were carried out under in-situ formation temperature and stress condition.Based on the calibration of capillary pressure curve,the variable fractal dimension was introduced to establish the conversion formula between relaxation time and pore size.By using the nuclear magnetic resonance(NMR)method,the pore volume loss caused by stress sensitivity within different scales of pore throat was quantitatively analyzed,and the microscopic mechanism of stress sensitivity of carbonate gas reservoirs was clarified.The results show that fractures can significantly affect the stress sensitivity of carbonate reservoirs.With the increase of initial permeability,the stress sensitivity coefficient decreases and then increases for porous reservoirs,but increases monotonously for fractured-porous reservoirs.The pore volume loss caused by stress sensitivity mainly occurs for mesopores(0.02–0.50μm),contributing more than 50%of the total volume loss.Single high-angle fracture contributes 9.6%of the stress sensitivity and 15.7%of the irreversible damage.The microscopic mechanism of the stress sensitivity of carbonate gas reservoirs can be concluded as fracture closure,elastic contraction of pores and plastic deformation of rock skeleton. | CHENG Youyou GUO Chunqiu CHEN Pengyu SHI Haidong TAN Chengqian CHENG Muwei XING Yuzhong LUO Xiang | 2023 | Petroleum Exploration and Development2023，50，1： | 0 |
| 12 | Author Correction: Characterization of domain distributions by second harmonic generation in ferroelectrics显示文摘Correction to:npj Computational Materials http://gffzzd3cc09b8251d45dfsuwqwwp6cvpv66uuf.ffgz.tsg.suse.edu.cn/10.1038/s41524-018-0095-6,published online 24 July 2018 In this article the affiliation details for author Yinghao Chu were incorrectly given as‘Department of Materials Science and Engineering,National Chiao Tung University,30010 Hsinchu,Taiwan’but should have been‘Department of Materials Science and Engineering,National Chiao Tung University,30010 Hsinchu,Taiwan,China’.The original article has been corrected. | Yuan Zhang Yi Zhang Quan Guo Xiangli Zhong Yinghao Chu Haidong Lu Gaokuo Zhong Jie Jiang Congbing Tan Min Liao Zhihui Lu Dongwen Zhang Jinbin Wang Jianmin Yuan Yichun Zhou | 2023 | npj Computational Materials2023，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员