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| 1 | Platelet count/spleen diameter ratio to predict esophageal varices in Mexican patients with hepatic cirrhosis显示文摘AIM:To validate whether the platelet count/spleen size ratio can be used to predict the presence of esophageal varices in Mexican patients with hepatic cirrhosis.METHODS:This was an analytical cross-sectional study to validate the diagnostic test for hepatic cirrhosis and was performed between February 2010 and December 2011.Patients with a diagnosis of hepatic cirrhosis were included and stratified using their ChildPugh score.Biochemical parameters were evaluated,and ultrasound was used to measure the longest diameter of the spleen.The platelet count/spleen diameter ratio was calculated and analyzed to determine whether it can predict the presence of esophageal varices.Upper gastrointestinal endoscopy was used as the gold standard.Sensitivity and specificity,positive and negative predictive values,and positive and negative likelihood ratios were determined,with the cutoff points determined by receiver-operating characteristic curves.RESULTS:A total of 91 patients were included.The mean age was 53.75±12 years;50(54.9%)were men,and 41(45.0%)women.The etiology of cirrhosis included alcohol in 48(52.7%),virally induced in24(26.3%),alcoholism plus hepatitis C virus in three(3.2%),cryptogenic in nine(9.8%),and primary biliary cirrhosis in seven(7.6%).Esophageal varices were present in 73(80.2%)patients.Child-Pugh classification,17(18.6%)patients were classified as class A,37(40.6%)as class B,and 37(40.6%)as class C.The platelet count/spleen diameter ratio to detect esophageal varices independent of the grade showed using a cutoff value of≤884.3,had 84%sensitivity,70%specificity,and positive and negative predictive values of 94%and 40%,respectively.CONCLUSION:Our results suggest that the platelet count/spleen diameter ratio may be a useful tool for detecting esophageal varices in patients with hepatic cirrhosis. | Alejandro González-Ojeda Gabino Cervantes-Guevara Manuela Chávez-Sánchez Carlos Dávalos-Cobián Susana Ornelas-Cázares Michel Dassaejv Macías-Amezcua Mariana Chávez-Tostado Kenia Militzi Ramírez-Campos Anaís del Rocío Ramírez-Arce Clotilde Fuentes-Orozco | 2014 | World Journal of Gastroenterology2014，20，8： | 18 |
| 2 | Early dynamic transcriptomic changes during preoperative radiotherapy in patients with rectal cancer: A feasibility study显示文摘AIM: To develop novel biomarkers of rectal radiotherapy, we measured gene expression profiles on biopsies taken before and during preoperative radiotherapy. METHODS: Six patients presenting with a locally advanced rectal cancer (T>T2, N0/Nx, M0) eligible for preoperative radiotherapy (45 Gy in 25 fractions) were selected in a pilot study. Six tumor and 3 normal tissues biopsies were taken before and during radiotherapy,after a dose of 7.2 Gy at a median time of 1 h following irradiation (0:27-2:12). Tumor or normal tissue purity was assessed by a pathologist prior to RNA extraction. Mean RNA content was 23 μg/biopsy (14-37) before radiotherapy and 22.7 μg/biopsy (12-35) during radiotherapy. After RNA amplification, biopsies were analysed with 54K HG-U133A Plus 2.0 Affymetrix expression micro-arrays. Data were normalized according to MAS5 algorithm. A gene expression ratio was calculated as: (gene expression during radiotherapy-gene expression before radiotherapy)/gene expression before radiotherapy. Were selected genes that showed a ratio higher than ± 0.5 in all 6 patients. RESULTS: Microarray analysis showed that preoperative radiotherapy significantly up-regulated 31 genes and down-regulated 6 genes. According to the Gene Ontology project classification, these genes are involved in protein metabolism (ADAMDEC1 ; AKAP7 ; CAPN5 ; CLIC5 ; CPE ; CREB3L1 ; NEDD4L ; RAB27A), ion transport (AKAP7 ; ATP2A3 ; CCL28 ; CLIC5 ; F2RL2 ; NEDD4L ; SLC6A8), transcription (AKAP7 ; CREB3L1 ; ISX ; PAB-PC1L ; TXNIP), signal transduction (CAPN5 ; F2RL2 ; RA- B27A ; TNFRSF11A), cell adhesion (ADAMDEC1 ; PXDN ; SPON1 ; S100A2), immune response (CCL28 ; PXDN ; TNFRSF11A) and apoptosis (ITM2C ; PDCD4 ; PVT1). Up-regulation of 3 genes (CCL28 ; CLIC5 ; PDCD4) was detected by 2 different probes and up-regulation of 2 genes (RAB27A ; TXNIP) by 3 probes. CONCLUSION: Micro-arrays can efficiently assess early transcriptomic changes during preoperative radiotherapy for rectal cancer, and may help better understand tumor radioresistance. | Stephane Supiot Wilfried Gouraud Loc Campion Pascal Jezéquel Bruno Buecher Josiane Charrier Marie-Francoise Heymann Marc-Andre Mahé Emmanuel Rio Michel Chérel | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 3 | New promising molecular targets in head and neck squamous cell carcinoma显示文摘 | Bauman JE Michel LS Chung CH | 2012 | Curt Opin Oneol2012，，3： | 1 |
| 4 | Nmda receptor structures reveal subunit arrangement and pore architecture 显示文摘 | Lee CH Lu W Michel JC et a/ | 2014 | Na- ture2014，511，7508： | 1 |
| 5 | Double immunohistochemical labeling technique applied to different types of cytokeratins in epithelial proliferations of the breast显示文摘 | Denoux Y Lebeau CH Michels JJ | 2003 | Biotech Histochem2003，78，1： | 1 |
| 6 | New promising molecular targets in head and neck squamous cell carcinoma显示文摘 | Bauman JE Michel LS Chung CH | 2012 | Curr Opin Oncol2012，24，3： | 1 |
| 7 | Ranpirnase(frog RNase)targeted with a humanized,internalizing,anti- Trop-2 antibody has potent cytotoxicity against diverse epi- thelial cancer cells显示文摘 | Chang CH Gupta P Michel R | 2010 | Mol Cancer Ther2010，9，： | 1 |
| 8 | Differences in nitric oxide product by superficial and deep human articular chondrocytes: implications for proteoglycan turnover in inflammatory joint disease显示文摘 | Hauselmann HJ Evans CH Michel DA | 1998 | J Immunol1998，160，： | 1 |
| 9 | Dissolution and forming of cellulose with ionic liquids显示文摘 | Kosan B Michels Ch Meister F | 2008 | Cellulose2008，15，： | 1 |
| 10 | Lyocell process-material and technological restrictions显示文摘 | Michels Ch Kosan B | 2000 | Chem Fibers Int2000，50，： | 1 |
| 11 | , New space geodetic constraints on the distribution of deformation in Central Asia显示文摘 | Reigber Ch Michel G W Galas R | 2001 | Earth and planetary Science Letters2001，191，12： | 1 |
| 12 | Head and neck manifestation and prognosis of Langerhans’ cell histiocytosis in children显示文摘 | R. Nicollas A. Rome H. Bela?ch S. Roman M. Volk J.C. Gentet G. Michel J.M. Triglia | 2010 | International Journal of Pediatric Otorhinolaryngology2010，，6： | 1 |
| 13 | Lyocell Products with Built-in Functional Properties显示文摘 | MEISTER F VORBACH D MICHELS Ch | 1998 | Chemical Fibers International1998，48，2： | 1 |
| 14 | An in vitro mouth model to test antiplaque agents: Preliminary studies using a toothpaste containing chlorhexidine 显示文摘 | Roques CH Michel G | 1994 | Caries Res1994，28，1： | 1 |
| 15 | Cancer stem cells in solid tumors显示文摘 | Patrick CH Sonu B Michele C | 2010 | Semin Cancer Biol2010，20，2： | 1 |
| 16 | Characteristics Developed at the Turning Institute of Textile and Plastics 显示文摘 | MICHELS Ch MAROND R of the Amine Oxide Process TEAGER E | 1996 | Fiber Chemistry1996，28，1： | 1 |
| 17 | Spontaneous rupture of extensor tendons in Madelung' s deformity显示文摘 | Goodwin DR Michels CH Weissman SL | 1979 | Hand1979，11，1： | 1 |
| 18 | Guideline for Prevention of surgical site infection,1999显示文摘 | Mangram AJ Teresa CH Michele LP | | 0，，02： | 1 |
| 19 | A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease显示文摘 | Frank Jessen Rebecca E. Amariglio Martin van Boxtel Monique Breteler Mathieu Ceccaldi Ga?l Chételat Bruno Dubois Carole Dufouil Kathryn A. Ellis Wiesje M. van der Flier Lidia Glodzik Argonde C. van Harten Mony J. de Leon Pauline McHugh Michelle M. Mielke | 2014 | Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association2014，，： | 1 |
| 20 | Histopathological effects of the Yen- Tc toxin complex from Yersinia entomophaga MH96 (Enterobacteriaceae) on the Costelytra zealandica (Coleoptera: Scarabaeidae) larval midgut 显示文摘 | Sean DGM Michelle CH Sandra AJ | 2012 | Applied and Environmental Microbiology2012，78，14： | 1 |
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