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| 1 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 2 | Microstructuralfeatures of quenching and partitioning:a new martensitic steelheat treatment显示文摘 | EDMONDS D V HE K MILLE M K | 2007 | Materials Science Furum2007，，： | 1 |
| 3 | 3'-minor groove binder-DNA probes increase sequence specificity at PCR extension temperatures 显示文摘 | KUTYAVIN I V AFONINA I A MILLS A | 2000 | Nucleic Acids Res2000，28，2： | 1 |
| 4 | Seagrass(Zostera muelleri)patch size and spatial location in fluence infaunal macroinverte- brate assemblages显示文摘 | MILLS V BERKENBUSCH K | 2009 | Estuarine Coastal and Shelf Science2009，81，1： | 1 |
| 5 | Effects of hypoxia on urinary organic acid and hypoxanthine excretion in fetal sheep显示文摘 | Walker V Bennet L Mills GA | 1996 | Pediatr Res1996，40，： | 1 |
| 6 | 3′-minor groove binder-DNA probes increase sequence specificity at PCR extension temperatures显示文摘 | Kutyavin I V Afonina I A Mills A | 2000 | Nucleic Acids Res2000，28，2： | 1 |
| 7 | Engraftment,differentiation,and functional benefits of autologous cardiospherederived cells in porcine ischemic cardiomyopathy显示文摘 | JOHNSTON P V SASANO T MILLS K | 2009 | Circulation2009，120，12： | 1 |
| 8 | 3-minor groove binding-DNA probes increase sequence specificity at PCR extension temperature显示文摘 | Kutyavin I V Afonina I A Mills A | 2000 | Nucleic Acids Res2000，28，2： | 1 |
| 9 | Progreesion of familial and non_familial dilated cardiomyopathy: long term follow up 显示文摘 | MICHELS V V DRISCOLL D J MILL F A | 2003 | Heart2003，89，： | 1 |
| 10 | Detailed observations of the phytoplankton spring bloom in the stratifying central North Sea 显示文摘 | Haren H V Mills D K Wetsteyn P M J | 1998 | Journal of Marine Research1998，56，： | 1 |
| 11 | Droplet vaporization: Effects of transients and variable propertites显示文摘 | HUBBARD G DENNY V MILLS A | 1975 | International Journal of Heat and Mass Transfer1975，18，： | 1 |
| 12 | The NIH human microbiome project显示文摘 | NIH HMP Working Group Peterson J Garges S Giovanni M McInnes P Wang L Schloss JA Bonazzi V McEwen JE Wetterstrand KA Deal C Baker CC Di Francesco V Howcroft TK Karp RW Lunsford RD Wellington CR Belachew T Wright M Giblin C David H Mills M Salomon R Mullins C Akolkar B Begg L Davis C Grandison L Humble M Khalsa J Little AR Peavy H Pontzer C Portnoy M Sayre MH Starke-Reed P Zakhari S Read J Watson B Guyer M | 2009 | Genome Res2009，19，12： | 1 |
| 13 | The mechanism of intein-mediated protein splicing: variations on a theme 显示文摘 | Mills K V Perler F B | 2005 | Protein Pept Lett2005，12，8： | 1 |
| 14 | The interaction between benthic diatom films and sediment transport 显示文摘 | Grant J Bathmann U V Mills E L | 1986 | Estuarine Coastal and Shelf Science1986，23，： | 1 |
| 15 | 3'-minor groove binder-DNA probes increase sequence specificity at PCR extension temperatures 显示文摘 | Kutyavin I V Monina I A Mills A | 2000 | Nucleic Acids Res2000，28，2： | 1 |
| 16 | Interaction of St John's wort with conventional drugs: systematic review of clinical trials显示文摘 | Mills E Montori V M Wu P | 2004 | BMJ2004，329，7456： | 1 |
| 17 | Effects of irrigation and plant density on cotton within-boll yield components显示文摘 | LU F Bufon V B Mills C 1 | 2010 | Agronomy Journal2010，102，： | 1 |
| 18 | Nonsimilar solutions for laminar film condensation on a vertical surface显示文摘 | Denny V Mills A | 1969 | International Journal of Heat and Mass Transfer1969，12，8： | 1 |
| 19 | A conceptual approach managingdesign resource显示文摘 | Wang F Mills JJ Devarajan V | 2002 | Computers inindustry2002，47，2： | 1 |
| 20 | 3-minor groove binder-DNA probes increase sequence specificity at PCR extension temperatures 显示文摘 | KUTYAVIN I V AFONINA I A MILLS A | 2000 | Nucleic Acids Res2000，28，： | 1 |
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