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| 1 | Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies显示文摘在地岬基因的 Oncogenic 变化在人的癌症是很普通的,导致有描绘得好的选择优点,而且不太听说得好的危险的房间。我们执行了一幅大规模 loss-of-function 屏幕识别被转变 KRAS 的结肠癌房间,然而并非由缺乏这 oncogene 的衍生物要求的基因。最高得分的基因然后在 KRAS 变异、野类型的癌症房间的一块更大的面板被测试。表示 oncogenic KRAS 的癌症房间被发现高度依赖于抄写因素 GATA2 和 DNA 复制开始管理者 CDC6。与已知的目标用许多药扩大这分析,我们发现有变异的 KRAS 的癌症房间与 topoisomerase 抑制显示出选择嗜好到 proteasome 功能,以及合成致命性。联合指向引起的这些功能改善了相对野类型的房间 KRAS 变异的房间杀死。这些观察建议新奇目标和在地岬变异的癌症为最佳的效果联合存在治疗的新方法,它传统地被看作对治疗高度倔强。 | Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock | 2012 | Cell Research2012，22，8： | 5 |
| 2 | Genome sequence and analysis of the soil cellulolytic actinomyeete Thermobifidafusca YX 显示文摘 | Athanasios L Konstantinos M Natalia I lain A Miriam L Genevieve D Michele M Alia L Susan L Alex C Paul R David BW Nikos K | 2007 | J Bacteriol2007，189，6： | 1 |
| 3 | A Statistical Method for Predicting Automobile Driving Posture显示文摘 | Reed Matthew R Manary Miriam A Flannagan Carol A C | | 0，，04： | 1 |
| 4 | Array biosensor for detection of oehratoxin A in cereals and beverages 显示文摘 | Miriam M N Lias C S Martin H M | 2005 | Analytical Chemistry2005，77，1： | 1 |
| 5 | Effects of agro- chemical treatments on the occurrence of Fusariurn ear rot andfumonisin contamination of maize in Southern Italy 显示文摘 | Filippo D C Vincenzo D C Miriam H | 2011 | Field Crops Research2011，123，2： | 1 |
| 6 | Structural and functional properties of soy protein isolate and Cod gelatin blend films 显示文摘 | Gabriela A Denavi Miriam Perez-Mateos Mara C Anon | 2009 | Food Hydrocolloids2009，23，： | 1 |
| 7 | Factors influencing the decision to seek treatment for symptoms of acute myocardial infarction an evaluation of the self- regulatory model of illness behaviour显示文摘 | Jane C Walsh Miriam Lynch | 2004 | Journal of Psychosomatic Research2004，56，： | 1 |
| 8 | Mutagenic activity promoted by amentoflavone and methanolic extract of Byrsonima crassa Niedenzu显示文摘 | Cássia Regina Primila Cardoso Ilce Mara de Syllos Cólus Caroline Cristiane Bernardi Miriam Sannomiya Wagner Vilegas Eliana Aparecida Varanda | 2006 | Toxicology2006，，1： | 1 |
| 9 | Differences in the pheno- lic composition and sensory profile between red wines aged in oak barrels and wines aged with oak chips显示文摘 | Miriam O H Silvia P M Estela C M | 2010 | LWT-Food Science and Technology2010，，43： | 1 |
| 10 | Effect of prolonged exposure to disel engine exhaust on proinflam- matory markers in different regions of the rat brain 显示文摘 | Miriam E C erlofs-Nijland Damien van Berlo Felmming R Cassee | 2010 | Particle and fibre toxicology2010，7，： | 1 |
| 11 | New molecular targeted therapies for advanced non-small-cell lung cancer显示文摘 | Miriam M Ana C Mariano P | | 0，，03： | 1 |
| 12 | Effect of procalcitonin-guded treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trail 显示文摘 | Miriam C Dalana J Roland B | 2004 | Lancet2004，363，： | 1 |
| 13 | Cathepsins F and S block HDL3-induced cholesterol efflux from macrophage foam cells 显示文摘 | Leena L Miriam L Katariin C | 2003 | Biochem Biophys Res Commun2003，312，4： | 1 |
| 14 | Lack of association between intussusception and oral polio vaccine in Cuban children显示文摘 | Miguel A. Galindo Sardi?as Andrés Zambrano Cárdenas Gisele Coutin Marie Manuel Santin Pe?a Miriam Ali?o Santiago Marlen Valcárcel Sanchez C.P. Farrington | 2001 | European Journal of Epidemiology2001，，8： | 1 |
| 15 | Transition Metal Complexes of Boron-synthesis,Structure and Reactivity显示文摘 | HOLGER B MIRIAM C | 2001 | Coordination Chemistry Reviews2001，223，1： | 1 |
| 16 | Determination of menthol in plasma and urine of rats and humans by headspace solid phase microextraction and gas chromatography-mass spectrometry显示文摘 | Miriam Spichiger Roman C Mühlbauer | 2004 | J of Chromatogr B2004，799，： | 1 |
| 17 | Aerosol deposition in turbulent channel flow on a regular array of three-dimensional roughness elements 显示文摘 | Alvin C K Lai Miriam A Byme Anthony J H Goddard | 2001 | Aerosol Science2001，32，： | 1 |
| 18 | Influence of sub-lethal antiox- idant doses, water potential and temperature on growth, sclero- tia, aflatoxins and aflD( = nor-1 ) expression by Aspergillus fla- vus RCP08108显示文摘 | Maria A P Laura C R Miriam E | 2012 | Microbiol Res2012，167，8： | 1 |
| 19 | Enhanced particle loss in ventilation duct with ribbed surface 显示文摘 | Alvin C K Lai Miriam A Byrne Anthony J H Goddard | 2000 | Building and Environment2000，35，： | 1 |
| 20 | Decreased interleukin-2 production in murine acute pancreatitis:potential for immunomodulation显示文摘 | Curley P Miriam N Kathryn C | 1996 | Gastroenterology1996，110，4： | 1 |
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