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| 1 | Prognostic factors in patients with advanced cholangiocarcinoma: Role of surgery, chemotherapy and body mass index显示文摘AIM: To study the factors that may affect survival of cholangiocarcinoma in Lebanon. METHODS: A retrospective review of the medical records of 55 patients diagnosed with cholangio- carcinoma at the American University of Beirut between 1990 and 2005 was conducted. Univariate and multivariate analyses were performed to determine the impact of surgery, chemotherapy, body mass index, bilirubin level and other factors on survival. RESULTS: The median survival of all patients was 8.57 mo (0.03-105.2). Univariate analysis showed that low bilirubin level (< 10 mg/dL), radical surgery and chemotherapy administration were significantly associated with better survival (P = 0.012, 0.038 and 0.038, respectively). In subgroup analysis on patients who had no surgery, chemotherapy administration prolonged median survival significantly (17.0 mo vs 3.5 mo, P = 0.001). Multivariate analysis identifiedonly low bilirubin level < 10 mg/dL and chemotherapy administration as independent predictors associated with better survival (P < 0.05). CONCLUSION: Our data show that palliative and postoperative chemotherapy as well as a bilirubin level < 10 mg/dL are independent predictors of a significant increase in survival in patients with cholangiocarcinoma. | Mirna H Farhat Ali I Shamseddine Ayman N Tawil Ghina Berjawi Charif Sidani Wael Shamseddeen Kassem A Barada | 2008 | World Journal of Gastroenterology2008，14，20： | 9 |
| 2 | Effect of mucin production on survival in colorectal cancer:A case-control study显示文摘AIM: To investigate the impact of mucin production on prognosis in colorectal cancer, in terms of overall survival (OS) and time to disease progression (TTP) in patients with mucinous compared to those with non-mucinous colorectal cancer (NMCRC), matched for age, gender, and tumor stage.METHODS: Thirty five patients with mucinous colorectal cancer (MCRC) were matched for age, gender, and tumor stage with 35 controls having NMCRC. OS and TTP were compared among 4 groups divided according to mucin content: group A (50%-75% mucin), group B (75%-100% mucin), group C or controls (< 50% mucin). Group D consisted of all patients with tumors having < 75% mucin (controls and groups A together).RESULTS: Median survival in MCRC and NMCRC groups was 46.2 and 112.9 mo, respectively (P = 0.26). OS in groups A and B was 70.1 and 32.8 mo (P = 0.46), and in groups B and D was 32.8 and 70.1 mo, respectively (P = 0.143). TTP in MCRC and NMCRC was 50.17 and 44.77 mo, respectively (P = 0.795). TTP in groups A, B, and D was 70.1, 24.8, and 65.5 mo, respectively. Twenty-eight percent of patients with MCRC had poorly differentiated adenocarcinoma versus 8.6% in NMCRC patients (P = 0.028).CONCLUSION: MCRC is associated with a non-significant decrease in median survival and TTP, particularlywhen mucin content is > 75% of tumor volume. However, it tends to be more poorly differentiated. A larger study matching for stage and grade is needed. | Mirna H Farhat Kassem A Barada Ayman N Tawil Doha M Itani Hassan A Hatoum Ali I Shamseddine | 2008 | World Journal of Gastroenterology2008，14，45： | 6 |
| 3 | Eosinophilic esophagitis: Updated consensus recommendations for children and adults显示文摘 | Chris A. Liacouras Glenn T. Furuta Ikuo Hirano Dan Atkins Stephen E. Attwood Peter A. Bonis A. Wesley Burks Mirna Chehade Margaret H. Collins Evan S. Dellon Ranjan Dohil Gary W. Falk Nirmala Gonsalves Sandeep K. Gupta David A. Katzka Alfredo J. Lucendo Jo | 2011 | The Journal of Allergy and Clinical Immunology2011，，1： | 3 |
| 4 | SARS-CoV-2 involvement in central nervous system tissue damage显示文摘As the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to spread globally,it became evident that the SARS-CoV-2 virus infects multiple organs including the brain.Several clinical studies revealed that patients with COVID-19 infection experience an array of neurological signs ranging in severity from headaches to life-threatening strokes.Although the exact mechanism by which the SARS-CoV-2 virus directly impacts the brain is not fully understood,several theories have been suggested including direct and indirect pathways induced by the virus.One possible theory is the invasion of SARS-CoV-2 to the brain occurs either through the bloodstream or via the nerve endings which is considered to be the direct route.Such findings are based on studies reporting the presence of viral material in the cerebrospinal fluid and brain cells.Nevertheless,the indirect mechanisms,including blood-clotting abnormalities and prolonged activation of the immune system,can result in further tissue and organ damages seen during the course of the disease.This overview attempts to give a thorough insight into SARS-CoV-2 coronavirus neurological infection and highlights the possible mechanisms leading to the neurological manifestations observed in infected patients. | Muhammad Ali Haidar Zaynab Shakkour Mohammad Amine Reslan Nadine Al-Haj Perla Chamoun Karl Habashy Hasan Kaafarani Shima Shahjouei Sarah HFarran Abdullah Shaito Esber SSaba Bassam Badran Mirna Sabra Firas Kobeissy Maya Bizri | 2022 | Neural Regeneration Research2022，17，6： | 2 |
| 5 | Esophageal Subepithelial Fibrosis in Children With Eosinophilic Esophagitis显示文摘 | Mirna Chehade Hugh A Sampson Raffaella A Morotti Margret S Magid | 2007 | Journal of Pediatric Gastroenterology and Nutrition2007，，3： | 2 |
| 6 | Identifica their target genes in develop by deep sequencing 显示文摘 | Song Q X Liu Y F tion of miRNAs and ing soybean seeds Hu X Y | 2011 | BMC Plant Biology2011，11，： | 1 |
| 7 | Eosinophilic esophagitis: Updated consensus recommendations for children and adults显示文摘 | Chris A. Liacouras Glenn T. Furuta Ikuo Hirano Dan Atkins Stephen E. Attwood Peter A. Bonis A. Wesley Burks Mirna Chehade Margaret H. Collins Evan S. Dellon Ranjan Dohil Gary W. Falk Nirmala Gonsalves Sandeep K. Gupta David A. Katzka Alfredo J. Lucendo Jo | 2011 | The Journal of Allergy and Clinical Immunology2011，，1： | 1 |
| 8 | Improved prediction of decreased creatinine clearance by serum cystatin C: use in cancer patients before and during chemotherapy显示文摘 | Borut S Levin V Mirna S | 2000 | Clin Chem2000，46，： | 1 |
| 9 | Rapamycin Reverses Pulmonary Artery Smooth Muscle Cell Proliferation in Pulmonary Hypertension显示文摘 | Houssaini Amal Abid Shariq Mouraret Nathalie Wan Feng Rideau Dominique Saker Mirna Marcos Elisabeth Tissot Claire-Marie Dubois-Rand? Jean-Luc Amsellem Val?rie Adnot Serge | 2013 | American Journal of Respiratory Cell and Molecular Biology2013，，： | 1 |
| 10 | Effect of TixAly catalysts on hydrogen storage properties of LiAlH4 and NaAlH4显示文摘 | Mirna Resan Michael D Hampton Janice K Lomness | 2005 | Int J Hydrogen Energy2005，30，： | 1 |
| 11 | Expression pattern of Pax3 and Pax6 genes during human embryogenesis 显示文摘 | Janos Terzc Mirna Saraga-Babic | 1999 | Int J Dev Biol1999，43，： | 1 |
| 12 | Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons显示文摘 | Deshpande A Mirna E Glabe C | 2006 | J Neurosci2006，26，： | 1 |
| 13 | Bacterial communities as-sociated with the production of artisanal Istrian cheese 显示文摘 | MIRNA MF MARION E ANDREA S | 2010 | Int J FoodMicrobiol2010，142，1： | 1 |
| 14 | Effects of various catalysts on hydrogen release and uptake characteristics of LiAlH4 显示文摘 | Mirna Resana | 2005 | Int J Hydrogen Energy2005，30，： | 1 |
| 15 | Effects of relativistic binary collisions on PIC simulation of laser plasmas显示文摘 | Sentoku Y Mirna K Kishimoto Y | 1998 | J Phys Soc Jpn1998，67，12： | 1 |
| 16 | Forensic Applications of Laser Capture Microdissection: Use in DNA-Based Parentage Testing and Platform Validation显示文摘 | Zoran M Budimlija Mirna Lechpammer Dorota Popiolek | 2005 | Croat Med J2005，46，4： | 1 |
| 17 | The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer显示文摘 | Edgard Graner Dan Tang Sabrina Rossi Antonella Baron Toshiro Migita Lisa J Weinstein Mirna Lechpammer Dieter Huesken Johann Zimmermann Sabina Signoretti Massimo Loda | 2004 | Cancer Cell2004，，3： | 1 |
| 18 | Colloidalaggregation Phenomena: Spatial Structuring of TEOS-derived Silica Aerogels显示文摘 | Ekaterina Vinogradova Mirna Estrada AbelMoreno | 2006 | Colloid and Interface Science2006，19，1： | 1 |
| 19 | Theoretical and experimental insights on the true impact of C 12 TAC cationic surfactant in enhanced oil recovery for heavy oil carbonate reservoirs显示文摘 | Mirna Pons-Jiménez Rocío Cartas-Rosado José Manuel Martínez-Magadán Raúl Oviedo-Roa Rodolfo Cisneros-Dévora Hiram I. Beltrán Luis S. Zamudio-Rivera | 2014 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2014，，： | 1 |
| 20 | Lithium/water system-primary batteries显示文摘 | Mirna Urquidi-Macdonald Jose' R Flores Digby D Macdonald | 1998 | Electrochim Acta1998，43，： | 1 |
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