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| 1 | Pm21 from Haynaldia villosa Encodes a CC-NBS- LRR Protein Conferring Powdery Mildew Resistance in Wheat显示文摘 | Liping Xing Ping Hu Jiaqian Liu Kamil Witek Shuang Zhou Jiefei Xu Weihao Zhou Li Gao Zhenpu Huang Ruiqi Zhang Xiue Wang Peidu Chen Haiyan Wang Jonathan D.G. Jones Miroslava Karafiatova Jan Vrana Jan Baros Jaroslav Dolezel Yuanchun Tian Yufeng Wu Aizhong Cao | 2018 | Molecular Plant2018，11，6： | 16 |
| 2 | A state-of-the-art review on passivation and biofouling of Ti and its alloys in marine environments显示文摘High strength-to-weight ratio, commendable biocompatibility and excellent corrosion resistance make Ti alloys widely applicable in aerospace, medical and marine industries. However, these alloys suffer from serious biofouling, and may become vulnerable to corrosion attack under some extreme marine conditions. The passivating and biofouling performance of Ti alloys can be attributed to their compact,stable and protective films. This paper comprehensively reviews the passivating and biofouling behavior,as well as their mechanisms, for typical Ti alloys in various marine environments. This review aims to help extend applications of Ti alloys in extremely harsh marine conditions. | Shaokun Yan Guang-Ling Song Zhengxian Li Haonan Wang Dajiang Zheng Fuyong Cao Miroslava Horynova Matthew S.Dargusch Lian Z-hou | 2018 | Journal of Materials Science & Technology2018，34，3： | 11 |
| 3 | Drain amylase value as an early predictor of pancreatic fistula after cephalic duodenopancreatectomy显示文摘AIM:To determine predictors of clinically relevant pancreatic fistulas(CRPF)by measuring drain fluid amylase(DFA)in the early postoperative period.METHODS:This prospective clinical study included382 patients with periampullary tumors that were surgically resected at our department between March 2005and October 2012.A cephalic duodenopancreatectomy (DP)was performed on all patients.Two closed suction drains were placed at the end of the surgery.The highest postoperative DFA value was recorded and analyzed during the first three postoperative days and on subsequent days if the drains were kept longer.Pancreatic fistula(PF)was classified according to the International Study Group of Pancreatic Fistula(ISGPF)criteria.Postoperative complications were defined according to the Dindo-Clavien classification.All data were statistically analyzed.The optimal thresholds of DFA levels on the first,second and third postoperative days were estimated by constructing receiver operating curves,generated by calculating the sensitivities and specificities of the DFA levels.The DFA level limits were used to differentiate between the group without PF and the groups with biochemical pancreatic fistula(BPF)and CRPF.RESULTS:Pylorus-preserving duodenopancreatectomy was performed on 289(75.6%)patients,while the remaining patients underwent a classic Whipple procedure(CW).The total incidence of PF was 37.7%(grade A22.8%,grade B 11.0%and grade C 3.9%).Soft pancreatic texture(SPT)was present in 58.3%of patients who developed PF.Mortality was 4.2%.The median DFA value on the first postoperative day(DFA1)in patients who developed PF was 4520 U/L(range 350-99000 U/L)for grade A fistula(BPF)with a SPT and a diameter of the main pancreatic duct(MPD)of≤3 mm.For grade B/C(CRPF),the median DFA1 value was 8501 U/L(range377-92060 U/L)with a SPT and MPD of≤3 mm.These values were significantly higher when compared to the patients who did not have PF(122;range 5-37875 U/L).The upper limit of DFA values for the first 3 postoperative days in the examined stages of PF were:DFA1 1200U/L for the BPF and CRPF;DFA3 350 U/L for BPF and DFA3 800 U/L for CRPF.The determined values were highly significant and demonstrated a reliable diagnostic test for both BPF and CRPF.CONCLUSION:DFA1≥1200 U/L is an important predictive factor for PF of any degree.The trend of DFA3(decrease of<50%)compared to DFA1 is a significant factor in the differentiation of CRPF from transient BPF. | Vladimir D Dugalic Djordje M Knezevic Vladan N Obradovic Miroslava G Gojnic-Dugalic Slavko V Matic Aleksandra R Pavlovic-Markovic Predrag D Dugalic Srbislav M Knezevic | 2014 | World Journal of Gastroenterology2014，20，26： | 7 |
| 4 | Leveraging Metabolomics to Assess the Next Generation of Temozolomide-based Therapeutic Approaches for Glioblastomas显示文摘Glioblastoma multiforme(GBM) is the most common adult primary tumor of the central nervous system.The current standard of care for glioblastoma patients involves a combination of surgery,radiotherapy and chemotherapy with the alkylating agent temozolomide.Several mechanisms underlying the inherent and acquired temozolomide resistance have been identifed and contribute to treatment failure.Early identifcation of temozolomide-resistant GBM patients and improvement of the therapeutic strategies available to treat this malignancy are of uttermost importance.This review initially looks at the molecular pathways underlying GBM formation and development with a particular emphasis placed on recent therapeutic advances made in the feld.Our focus will next be directed toward the molecular mechanisms modulating temozolomide resistance in GBM patients and the strategies envisioned to circumvent this resistance.Finally,we highlight the diagnostic and prognostic value of metabolomics in cancers and assess its potential usefulness in improving the current standard of care for GBM patients. | Patrick-Denis St-Coeur Mohamed Touaibia Miroslava Cuperlovic-Culf Pier Jr Morin | 2013 | Genomics, Proteomics & Bioinformatics2013，11，4： | 5 |
| 5 | Effect of Osmotic Stress in Early Stages of Ontogenesis on Root Respiration, Growth, Sugar Content,and Cell Injury in Maize Seedlings Differing in Drought Sensitivity显示文摘有到干旱的不同敏感的玉米(Zea mays L.) 的栽培变种为 24 h 暴露于 0.3 mol/L 山梨糖醇(-1.4 MPa 水潜力) 。显著地浇缺乏的暴露减少了射击(coleoptile 和胚轴) 和根的生长。射击生长多于根的生长被禁止。渗透的应力提高了可溶的糖的累积。电解质漏,一个房间损害索引,稍微在 0.3 mol/L 山梨糖醇以后被增加。呼吸当面被测量并且 2,6-dichlorophenol indophenol 的缺席。2, 6-Dichlorophenol indophenol 没影响呼吸率,因为统计上相等的结果在两个条件下面被观察。全部的呼吸(vt ) 在 osmoticum 处理以后减少了。在在分析的栽培变种之中的 vt 没有重要差别。在 vt 的减少被衰落在细胞色素的活动和能力引起(vcyt, Vcyt ) 并且其他的小径(valt, Valt ) 呼吸。高剩余呼吸(vres ) 被观察,直到 27% 全部的不受禁令约束的呼吸。使用清楚地显示了那联合的 uncoupler 的结果在渗透的应力的 24 h 以后被维持。呼吸率的恢复与非强调的控制率的是可比较的。根据这些观察,没有可能的 mitochondrial 损坏被期望。水缺乏没导致其他的 oxidase 的刺激,因此我们假设其他的小径的刺激不与干旱压力抵抗有关;更确切地说,其他的小径的功能是在对变化环境的回答平衡碳新陈代谢和电子运输。 | Lukás, Kolarovic Miroslava Luxová Peter Valentovic | 2006 | Journal of Integrative Plant Biology2006，48，7： | 3 |
| 6 | Development of oligonucleotide probes for FISH karyotyping in Haynaldia villosa,a wild relative of common wheat显示文摘Haynaldia villosa is a wild relative of wheat and a valuable gene resource for wheat improvement.Owing to the limited number of probes available for fluorescence in situ hybridization(FISH),the resolution at which the karyotype of H.villosa can be characterized is poor,hampering accurate characterization of small segmental alien introgressions.We designed ten oligonucleotide probes using tandem repeats in DNA sequences derived from the short arm of H.villosa chromosome 6 V(6 VS).FISH with seven of them resulted in clear signals on H.villosa chromosomes.Using these,we constructed FISH karyotypes for H.villosa using oligo-6 VS-1 and oligo-6 VS-35 oligonucleotides and characterized the distribution of the two probes in five different H.villosa accessions.The new FISH probes can efficiently characterize H.villosa introgressions into wheat. | Jia Lei Jiawen Zhou Haojie Sun Wentao Wan Jin Xiao Chunxia Yuan Miroslava Karafiátová Jaroslav Dolezel Haiyan Wang Xiue Wang | 2020 | The Crop Journal2020，8，4： | 3 |
| 7 | Evidence for a Role of Second Pathophysiological Stress in Prevention of Delayed Neuronal Death in the Hippocampal CA1 Region显示文摘 | Jozef Burda Milina Matia?ová Miroslav Gottlieb Viera Danielisová Miroslava Némethová Lidia Garcia Matilde Salinas Rastislav Burda | 2005 | Neurochemical Research2005，，11： | 2 |
| 8 | Relevance of low viral load in haemodialysed patients with chronic hepatitis C virus infection显示文摘AIM: To identify predictors of sustained virological response in hemodialysed patients treated by PEGinterferon α for chronic hepatitis C, genotype 1.METHODS: The sustained virological response(SVR) rate, IL28 B genotype, IFNL4 genotype, initial viral load(IVL) and other pretreatment variables in 39 endstage renal disease patients(ESRD) on maintenance haemodialysis(HD) infected with hepatitis C virus(HCV), genotype 1b, were compared with a control group of 109 patients with normal kidney function treated within the same period. All the patients were treatment nave and had well compensated liver disease. The ESRD patients received 135 μg of PEGylated interferon α-2a(Peg IFN-α) weekly and a reduced dose of ribavirin(RBV) was administered to 23/39 patients with an initial haemoglobin level > 10 g/d L. Control group patients were given standard doses of Peg IFN-α and RBV. SVR was assessed as HCV RNA negativity 24 wk post-treatment. A t-test or ANOVA were used for comparisons of the means and a χ2 testcompared the frequencies.Logistic regression was used to determine significant predictors of SVR.Cutoff values for continuous variables were obtained from Receiver Operating Characteristic analysis.RESULTS:The distribution of IL28B rs12979860 CC,CT and TT genotypes in the ESRD group was 28.2%,64.1%and 7.7%,respectively,and 19.3%,62.4%and18.3%in the controls.The IFNL4 genotype was in almost absolute linkage disequlibrium with IL28B.The proportion of patients with a low IVL(<600000 IU/m L)was significantly higher in the ESRD group than in the controls(28/39,71.8%vs 51/109,46.8%,P=0.009),as was the proportion of patients with low IVL in IL28B CC carriers compared with non-CC carriers in the ESRD group(10/11,90.9%vs 18/28,64.3%,P=0.0035).This difference was not found in the controls(7/22,31.8%vs 44/87,50.6%,P=0.9).The overall SVR rate was 64.1%(25/39)in the ESRD group and 50.5%(55/109)in the control group(P=0.19).11/11(100%)and 19/22(86.4%)IL28B CC patients achieved SVR in the ESRD and control groups,respectively.A statistically significant association between SVR and IL28B and IFNL4 variants was found in both groups.The ESRD patients who achieved SVR showed the lowest IVL[median 21000,interquartile range(IQR):6000-23000IU/m L],compared with ESRD individuals without SVR(1680000,IQR:481000-6880000,P=0.001),controls with SVR(387000,IQR:111000-1253000)and controls without SVR(905000,IQR:451000-3020000).In ESRD,an IVL<600000 IU/m L was strongly associated with SVR:24/28(85.7%)patients who achieved SVR had viraemia below this threshold.CONCLUSION:Haemodialysis decreases the viral load,especially in IL28B CC genotype carriers.A low IVL was the strongest predictor of SVR in ESRD patients identified in multivariate analysis. | Jan Sperl Sona Frankova Renata Senkerikova Magdalena Neroldova Vaclav Hejda Miroslava Volfova Dusan Merta Ondrej Viklicky Julius Spicak Milan Jirsa | 2015 | World Journal of Gastroenterology2015，21，18： | 2 |
| 9 | Regulation of transforming growth factor-β signaling as a therapeutic approach to treating colorectal cancer显示文摘According to data from 2020,Slovakia has long been among the top five countries with the highest incidence rate of colorectal cancer(CRC)worldwide,and the rate is continuing to rise every year.In approximately 80%of CRC cases,allelic loss(loss of heterozygosity,LOH)occurs in the long arm of chromosome 18q.The most important genes that can be silenced by 18q LOH or mutations are small mothers against decapentaplegic homolog(SMAD)2 and SMAD4,which are intracellular mediators of transforming growth factor(TGF)-βsuperfamily signals.TGF-βplays an important role in the pro-oncogenic processes,including such properties as invasion,epithelial-mesenchymal transition(commonly known as EMT),promotion of angiogenesis,and immunomodulatory effects.Several recent studies have reported that activation of TGF-βsignaling is related to drug resistance in CRC.Because the mechanisms of drug resistance are different between patients in different stages of CRC,personalized treatment is more effective.Therefore,knowledge of the activation and inhibition of factors that affect the TGF-βsignaling pathway is very important. | Jana Maslankova Ivana Vecurkovska Miroslava Rabajdova Jana Katuchova Milos Kicka Michala Gayova Vladimir Katuch | 2022 | World Journal of Gastroenterology2022，28，33： | 2 |
| 10 | Results of National Colorectal Cancer Screening Program in Croatia(2007-2011)显示文摘AIM:To study the epidemiologic indicators of uptake and characteristic colonoscopic findings in the Croatian National Colorectal Cancer Screening Program.METHODS:Colorectal cancer(CRC) was the second leading cause of cancer mortality in men(n = 1063,49.77/100 000),as well as women(n = 803,34.89/100 000) in Croatia in 2009.The Croatian National CRC Screening Program was established by the Ministry of Health and Social Welfare,and its implementation started in September,2007.The coordinators were recruited in each county institute of public health with an obligation to provide fecal occult blood testing(FOBT) to the participants,followed by colonoscopy in all positive cases.The FOBT was performed by hypersensitive guaiac-based Hemognost card test(Biognost,Zagreb).The test and short questionnaire were delivered to the home addresses of all citizens aged 50-74 years consecutively during a 3-year period.Each participant was required to complete the questionnaire and send it together with the stool specimen on three test cards back to the institute for further analysis.About 4% FOBT positive cases are expected in normal risk populations.A descriptive analysis was performed.RESULTS:A total of 1 056 694 individuals(born between 1933-1945 and 1952-1957) were invited to screening by the end of September 2011.In total,210 239(19.9%) persons returned the envelope with a completed questionnaire,and 181 102 of them returned it with a correctly placed stool specimen on FOBT cards.Until now,12 477(6.9%),FOBT-positive patients have been found,which is at the upper limit of the expected values in European Guidelines for Quality Assurance in CRC Screening and Diagnosis [European Union(EU) Guidelines].Colonoscopy was performed in 8541 cases(uptake 66%).Screening has identified CRC in 472 patients(5.5% of colonoscopied,3.8% of FOBT-positive,and 0.26% of all screened individuals).This is also in the expected range according to EU Guidelines.Polyps were found and removed in 3329(39% of colonoscopied) patients.The largest number of polyps were found in the left half of the colon:64%(19%,37% and 8% in the rectum,sigma,and descendens,respectively).The other 36% were detected in the proximal part(17% in the transverse colon and 19% in ceco-ascending colon).Small polyps in the rectum(5-10 mm in diameter),sigmoid and descending colon were histologically found to be tubular adenomas in 60% of cases,with a low degree of dysplasia,and 40% were classified as hyperplastic.Polyps of this size in the transverse or ceco-ascending colon in almost 20% had a histologically villous component,but still had a low degree of dysplasia.Polyps sized 10-20 mm in diameter were in 43% cases tubulovillous,and among them,32% had areas with a high degree of dysplasia,especially those polyps in the cecoascending or transverse part.The characteristics of the Croatian CRC Screening National Program in the first 3 years were as follows:relatively low percentage of returned FOBT,higher number of FOBT-positive persons but still in the range for population-based programs,and higher number of pathologic findings(polyps and cancers).CONCLUSION:These results suggest a need for intervention strategies that include organizational changes and educational activities to improve awareness of CRC screening usefulness and increase participation rates. | Miroslava Katii Nataa Antoljak Milan Kujundzi Valerija Stameni Dunja Skoko Poljak Danica Kramari Davor timac Marija Strnad Peikan Mirko amija Zdravko Ebling | 2012 | World Journal of Gastroenterology2012，18，32： | 2 |
| 11 | 基于纤毛鹅观草特异的卫星重复序列开发寡核苷酸探针显示文摘[目的]本文旨在开发纤毛鹅观草特异的寡核苷酸(oligonucleotide,oligo)探针,进一步完善纤毛鹅观草染色体鉴定技术。[方法]利用前期选育的普通小麦-纤毛鹅观草异附加系DA2S^(c)L和DA6S^(c),通过流式分拣和基因组二代测序获得纤毛鹅观草染色体6S^(c)和染色体臂2S^(c)长臂的基因组序列,利用Repeatexplorer2/TAREAN软件从中鉴定出卫星重复序列并设计成oligo探针,通过荧光原位杂交(fluorescence in situ hybridization,FISH)分析所开发oligo探针的应用价值。[结果]从6S^(c)和2S^(c)L基因组序列中共鉴定出11个卫星重复序列并开发成11个oligo探针,oligo-FISH结果表明,其中6个探针可以在纤毛鹅观草染色体上产生明显杂交信号,而在小麦染色体上未产生明显杂交信号,可用于特异鉴定小麦背景中的纤毛鹅观草染色体或片段。对1套普通小麦-纤毛鹅观草异附加系oligo-FISH分析发现,oligo-2S^(c)L^(-1)63和oligo-6S^(c)-111仅在S^(c)基因组染色体上产生明显信号,可作为纤毛鹅观草S^(c)组特异探针;将oligo-2S^(c)L-161和oligo-2S^(c)L-163组合,对1整套二体异附加系进行双色oligo-FISH,构建了纤毛鹅观草染色体的oligo-FISH核型。[结论]本研究提供了纤毛鹅观草重复序列组成的初步信息,开发的探针能特异鉴定纤毛鹅观草染色体,阐明纤毛鹅观草2个基因组的来源和分化,对推动纤毛鹅观草优异基因的转移和利用有重要意义。 | 程梦豪 Miroslava Karafiatova 孙昊杰 Kate Arina Holušva Jaroslav Dolezel 宋新颖 王海燕 王秀娥 | 2022 | 南京农业大学学报2022，45，3： | 2 |
| 12 | Photodynamic inactivation of Escherichia coli by methylene blue incorporated in ZSM-5 zeolite channels under red LED light 显示文摘 | Miroslava S Petra O Daniela H | 2010 | Acta Chimica Slovaca2010，3，1： | 1 |
| 13 | Effect of a keto acidamino acid supplement on the metabolism and renal emilination of branched-chain amino acids in patients with chronic renal insufficiency on a low protein diet显示文摘 | Vladimi T Otto S Miroslava | 2000 | Middle Eur J Med2000，112，87： | 1 |
| 14 | Diminished thrombus formation and alleviation of myocardial infarction and reperfusion injury through antibody-or small-molecule-mediated inhibition of selectin-dependent platelet functions 显示文摘 | Gertie JO Miroslava P Ralf JL | 2007 | Haematologica2007，92，4： | 1 |
| 15 | Evaluation of contaminant removal of reverse osmosis and advanced oxidation in full-scale operation by combi- ning passive sampling with chemical analysis and bioana- lytical tools 显示文摘 | Beate I Escher Michael Lawrence Miroslava Macova | 2011 | Environ Sci Teehnol2011，45，12： | 1 |
| 16 | Natalizumab for the Treatment of Active Crohn’s Disease: Results of the ENCORE Trial显示文摘 | Stephan R. Targan Brian G. Feagan Richard N. Fedorak Bret A. Lashner Remo Panaccione Daniel H. Present Martina E. Spehlmann Paul J. Rutgeerts Zsolt Tulassay Miroslava Volfova Douglas C. Wolf Chito Hernandez Jeffrey Bornstein William J. Sandborn | 2007 | Gastroenterology2007，，： | 1 |
| 17 | Electroanalyti- cal techniques for determination of flavonoids 显示文摘 | Miroslava Beklova Ondrej Zitka Zbynek Gazdik | 2008 | Toxicology Letters2008，180，： | 1 |
| 18 | Polyaniline - coated silver nanowires 显示文摘 | Patrycja Bober Jaroslav Stejskal Miroslava Trchov6 | 2010 | Reactive & Functional Polymers2010，70，： | 1 |
| 19 | In vitro and In vivo antimicrobial activity of propolis on the microbiota from gastrointestinal tract of chickens显示文摘 | Miroslava Ka?ániová Katarína Rovná Henrieta Arpá?ová Juraj ?uboň Luká? Hleba Jaroslav Pochop Simona Kunová Peter Ha??ík | 2012 | Journal of Environmental Science and Health Part A2012，，11： | 1 |
| 20 | Nutritional evaluation of genetically modified maize corn performed on rats显示文摘 | M dria Chrenkovd A Sommer Zuzana Ceresn 6kovd Sona Nitrayovd Miroslava Prostrednd | 2002 | Archiv fur Tierern hrung2002，56，3： | 1 |
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