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| 1 | Hypoglycemic and anti-hyperglycemic study of Gynura procumbens leaf extracts显示文摘Objective:To study the antidiabetic activity of Gynura procumbens(G.procumbens)used in the traditional management of diabetes in Southern Asia.Methods:G.procumbens leaves were extracted sequentially with graded percentage of ethanol in water(95%,75%,50%,25%and 0%),and the extracts were tested for antidiabetic activity using acute(7 h),subcutaneous glucose tolerance test and sub-chronic(14 d)test in non-diabetic and streptozotocin-induced diabetic rats.The extracts were further subjected to phytochemical studies.Results:In acute dose(1 g/kg),the extracts significantly lowered fasting blood glucose(FBG)in streptozotocin-induced diabetic rats(P<0.05).However,the FBG-lowering effect of the 25%extract compared to the other extracts,was rapid(47%after 2 h)and the highest:53%,53%and 60%in the 3rd,5th,and 7th h,respectively(P<0.05),comparable only to the effect of metformin.Furthermore,the extracts suppressed peak FBG in subcutaneous glucose tolerance test,but only the 0%and 25%extracts,and metformin sustained the decrease until the 90th min(P<0.05).Moreover,in the 14 days study,the 25%extract exerted the highest FBG-lowering effect,namely 49.38%and 65.43%on days 7 and 14,respectively(P<0.05),similar to the effect of metformin(46.26%and 65.42%).Total flavanoid and phenolic contents in the extracts were found to decrease with increase in polarity of extraction solvents.The composition of reference compounds(chlorogenic acid,rutin,astragalin and kaempferol-3-O-nrtinoside)followed a similar trend.Conclusions:G.procumbens contains antidiabetic principles,most extracted in 25%ethanol.Interaction among active components appears to determine the antidiabetic efficacy,achieved likely by a metformin-like mechanism. | Khalid Algariri Kuong Y Meng Item J Atangwho Mohd Z Asmawi Amirin Sadikun Vikneswaran Murugaiyah Norhyati Ismail | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，5： | 4 |
| 2 | Development of solid-based paper strips for rapid diagnosis of Pseudorabies infection显示文摘 | Joon Tam Y Mohd Lila M A Bahaman A R | 2004 | Trop Biomed2004，21，2： | 1 |
| 3 | Comparison of the Mechanical Properties and Interracial Interactions Between Talc, Kaolin, and Calcium Carbonate Filled Polypropylene Composites显示文摘 | Leong Y W Bakar M B Mohd Z A | 2004 | Journal of Applied Polymer Science2004，91，5： | 1 |
| 4 | Development of solid-based paper strips for rapid diagnosis of Pseudorabies infection显示文摘 | Joon Tam Y Mohd Lila M A Bahaman A R | 2004 | Trop Biomed2004，21，2： | 1 |
| 5 | Effects of Filler Treatments on the Mechanical, Flow, Thermal, and Morphological Properties of Talc and Calcium Carbonate Filled Polypropylene Hybrid Composites 显示文摘 | Leong Y W Bakar M B Mohd Z A | 2005 | Journal of Applied Polymer Science2005，98，1： | 1 |
| 6 | Bacteriological qualityand safetyo frawmilkinmalaysia显示文摘 | Fook Y C Aminah A Mohd K A | | Food Microbiology2 0040，21，： | 1 |
| 7 | Development of solid- based papers trips for rapid diagnosis of pseudorabies infection 显示文摘 | Joon Tam Y Mohd Lila M A Bahaman A R | 2004 | Trop Biomed2004，21，2： | 1 |
| 8 | The fabrication of lead dioxide layers on a titanium substrate显示文摘 | MOHD Y PLETCHER D | 2006 | Electrochiinica Acta2006，52，3： | 1 |
| 9 | A new design of piezoelectric driven compliant-based microgripper for micromanipulation显示文摘 | MOHD N M Z SHIRINZADEH B TIAN Y L | 2009 | Mechanism and Machine Theory2009，44，12： | 1 |
| 10 | Total qualityman- agement and theory of constraints implementation in malaysian automotive suppliers: a survey result 显示文摘 | RAIMONA Z H MOHD Y S | 2006 | Total Quality Management & Business Excellence2006，17，8： | 1 |
| 11 | Mechanical and thermal properties of talc and calcium carbonate filled polypropylene hybrid composites显示文摘 | Leong Y Mohd Ishak | 2004 | Journal of Applied Polymer Science2004，91，5： | 1 |
| 12 | Sediment traps from synthetic construction site stormwater runoff by grassed filter strip显示文摘 | Mohamad A F Mohd H K Badronnisa Y | 2013 | Journal of Hydrology2013，502，34： | 1 |
| 13 | Characterization of talc/calcium carbonate filled polypropylene hybrid composites weathered in a natural environment 显示文摘 | Y W Leong M B Abu Bakar Z A Mohd Ishak | 2004 | Polymer Degradation and Stability2004，83，3： | 1 |
| 14 | The promising future of chia,Salvia hispanica L显示文摘 | MOHD Al N YEAP S K HO W Y | 2012 | Journal of Biomedicine and Biotechnology2012，2012，17： | 1 |
| 15 | Extraction of 13 - carotenes from palm oil mesocarp using sub-critical R134a 显示文摘 | Mustapa A N Manana Z A Mohd Azizi C Y | 2011 | Food Chemistry2011，125，1： | 1 |
| 16 | Effects of parameters on yield for sub-critical R134a extraction of palm oil 显示文摘 | Mustapa A N Manana Z A Mohd Azizi C Y | 2009 | Journal of Food Engineering2009，95，4： | 1 |
| 17 | Investiga- tion of Curing Kinetics of Diglycidyl Ether of Bisphenol A and Zinc (Ⅱ) Complexes Using Dynamic DSC Technique显示文摘 | KHADIJEHBEIGOM G MOHD A Y NILOFAR A | 2015 | J Polym Res2015，22，： | 1 |
| 18 | Review of modification of activated carbon for enhancing contaminant uptake from aqueous solutions 显示文摘 | Yin C Y Mohd K A Wan M A W D | 2007 | Separation and Purification Technology2007，52，3： | 1 |
| 19 | Ion exchange study of carbonate,nitrate and dioctyl sulfosuccinate with anthraquinone-2-sulphonate encapsulated in inorganic layered structures显示文摘 | ASMAH H Y MOHD Z B H WONG S S | 2003 | J Phys Chem Solid2003，64，： | 1 |
| 20 | Dependence of the wake on inclination of a stationary cylinder显示文摘 | Zhou T Mohd Razali S F Zhou Y | 2009 | Exp Fluids2009，46，： | 1 |
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