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| 1 | Tumor targeted mesoporous silica-coated gold nanorods facilitate detection of pancreatic tumors using Multispectral optoacoustic tomography显示文摘Multispectral optoacoustic 断层摄影术(MSOT ) 是在传统的形式上提供几个优点的一种新兴的成像技术,特别地处于它解决在显微镜的规模上的深度的光对比的能力。当潜在的应用包括临床的阀值由当前的技术设置了的下面的肿瘤的早察觉时,肿瘤特定的对比代理人的缺乏限制 MSOT 成像的使用。因此,我们与 polyacrylic 酸(泛美航空公司) 或 aminefunctionalized mesoporous 硅石(MS ) 由涂层金牌 nanorods (GNR ) 构造了高度稳定的 nano 对比代理人。Syndecan-1,被显示了指向像胰岛素的生长因素 1 受体(IGF1-R )( 在胰腺的肿瘤的 upregulated ) ,在泛美航空公司涂的 GNR (PAA-GNRs ) 或 MS 涂的 GNR (MS-GNRs ) 的表面上被结合创造指向肿瘤的 nanoparticles。在 vitro, nanoparticles 指向的肿瘤与流动 cytometry 被估计。在 S2VP10L 房间(为 IGF1-R 积极) , syndecan-1 MS-GNRs (Syndecan-MS-GNRs ) 在 OA 信号表明了增加, 10x,与 syndecan-1 PAAGNR (Syndecan-PAA-GNRs ) 相比。最小的绑定在 MiaPaca-2 房间被观察(为 IGF1-R 否定) 。在 vivo,肿瘤 Syndecan-MS-GNRs 的特定的指向用鼠科的 orthotopic 被评估胰腺的癌症模型。Syndecan- MS-GNRs 比在象肝那样的离开目标机关在胰腺的肿瘤以内表明了显著地更大的累积。与 IGF1-R 否定 MiaPaca-2 房间植入的老鼠没表明指向的特定的肿瘤。在摘要,我们报导指向的 nano 对比代理人(Syndecan-MS-GNRs ) 能成功地检测 orthotopic 有在用 MSOT 的 vivo 有约束力的最小的离开目标的胰腺的肿瘤。 | Anil Khanal Christopher Ullum Charles W Kimbrough Nichola C. Garbett Joseph A. Burlison Molly W. McNally Phillip Chuong Ayman S. EI-Baz Jacek B. Jasinski Lacey R. McNally | 2015 | Nano Research2015，8，12： | 2 |
| 2 | Results of the Medications At Transi- tions and Clinical Handoffs (MATCH) Study: An Analysis of Medication Reconciliation Errors and Risk Factors at Hospital Admission显示文摘 | Kristine M Molly R David W | 2010 | J Gen Intern Med2010，25，5： | 1 |
| 3 | Why Should I Share? Examining Social Capital and Knowledge Contribution in Electronic Networks of Practice显示文摘 | Molly W M Faraj S | 2005 | MIS Quarterly2005，29，1： | 1 |
| 4 | Impact of menopause on collagen subtypes in thearcus tendineous faseiapetvis 显示文摘 | MOLLI P A TALARICO L C SUNG V W | 2005 | J Urol2005，174，41： | 1 |
| 5 | Diminishing riskfor age-related macular degeneration with nutrition : a cur-rent view显示文摘 | MOLLY S KAREN W CAREN G ALLEN T | 2013 | Nutrients2013，5，7： | 1 |
| 6 | Measurement system for end face mechanical seal performance显示文摘 | Williams Molly W Pilletteri Vincent J | 1996 | Sealing Technology1996，，： | 1 |
| 7 | Effect of a dalteparin prophylaxis protocol using anti-factor Xa concentrations on venous thromboembolism in high-risk trauma patients显示文摘 | Molly E Droege Eric W Mueller Kelly M | 2014 | The Journal of Trauma and Acute Care Surgery2014，76，2： | 1 |
| 8 | Development of a 5-step multi-chamber reactor as a simulation of the human intestinal microbial ecosystem显示文摘 | Molly K Vande Woestyne M Verstracate W | 1993 | Appl Microbid Biotechnol1993，39，2： | 1 |
| 9 | Development of a 5-step multi-chamber reactor as a simulation of the human intestinal microbial ecosystem 显示文摘 | Molly K Woestyne M V Verstraete W | 1993 | Applied Microbiology and Biotechnology1993，，39： | 1 |
| 10 | Dysnatremias and Survival in Adult Burn Patients: A Retrospective Analysis显示文摘 | Stewart Ian J Morrow Benjamin D Tilley Molly A Snow Brian D Gisler Christopher Kramer Keith W Aden James K Renz Evan M Chung Kevin K | 2013 | American Journal of Nephrology2013，，1： | 1 |
| 11 | Development of 5-step multi-chamber reactor as a simulation of the humam intestinal microbial ecosystem显示文摘 | Molly K Vancle Woestyne M Verstrate W | 1993 | Appl Microbiol Biotechnol1993，39，2： | 1 |
| 12 | Five-year follow-up of routine outpatient test turnaround time: a college of American pathologists Q-Probes study 显示文摘 | Paul V Molly W | 2003 | Areh Pathol Lab Med2003，127，11： | 1 |
| 13 | PAK signaling in oncogenesis 显示文摘 | MOLLI P R LID Q MURRAY B W | 2009 | Oncogene2009，28，28： | 1 |
| 14 | PAK signaling inoncogenesis显示文摘 | MOLLI P R LI D Q MURRAY B W | 2009 | Oncogene2009，28，28： | 1 |
| 15 | Five-year fillow-up of routine outpatient test turna- round time: a College of American Pathologists Q-Probes study显示文摘 | Paul V Molly W | 2003 | Arch Pathol Lab Med2003，127，11： | 1 |
| 16 | Why Should I Share? Examining Social Capital and Knowledge Contribution in Electronic Networks of Practice 显示文摘 | Molly M W Samer F | 2005 | MIS Quarterly2005，29，1： | 1 |
| 17 | Confronting and changing middle school teacher’perceptions of scientific methodology显示文摘 | MOLLY W | 2003 | school science and Mathematics2003，103，50： | 1 |
| 18 | Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development 显示文摘 | MOLLY W JONATHAN M Y DUNN R N | 1999 | Development1999，126，： | 1 |
| 19 | Five-year follow-up of routine outpatient test turnaround time:a college of American pathologists Q-probes study显示文摘 | Paul V Molly W | | 0，，11： | 1 |
| 20 | Five-yearfollow-upofroutineoutpa-tienttestturnaroundtime:acollegeofAmericanPatholo-gistsQ-probesstudy显示文摘 | PaulV Molly W | 2003 | ArchPatholLabMed2003，127，11： | 1 |
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