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1A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11  916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou 2016Journal of Systematics and Evolution2016,54,6:44
2Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer显示文摘AIM: To investigate the expression levels of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular endothelial growth factor receptor-3 (VEGFR-3) and CD44 genes and the relationship between their lev- els and clinicopathological parameters in gastric cancer.METHODS: Tissue samples were obtained from 33 patients (8 females) with gastric cancer. mRNA levels of LYVE-1, VEGFR-3 and CD44 in normal and tumor tissues were quantitatively measured using real time polymerase chain reaction. The results were correlated with lymph node metastasis, histological type and differentiation of the tumor, T-stage, and presence of vascular, perineural and lymphatic invasions. The distribution of molecules in the tissue was evaluated using immunohistochemistry. RESULTS: LYVE-1, CD44 and VEGFR-3 gene expression levels were significantly higher in gastric cancer than in normal tissue. While there was no correlation between gene expressions and clinicopathologic fea- tures such as histologic type, differentiation and stage, gene expression levels were found to be increased in conjunction with positive lymph node/total lymph node ratio and the presence of perineural invasion. A significant correlation was also found between LYVE-1 and CD44 over-expressions and perineural invasion and lymph node positivity in gastric cancers. When the dis- tribution of LYVE-1 antibody-stained lymphatic vessels in tissue was evaluated, lymphatic vessels were located intra-tumorally in 13% and peri-tumorally in 27% of the patients. Moreover, lymph node metastases were also positive in all patients with LYVE-1-staining. CONCLUSION: LYVE-1, VEGFR-3 and CD44 all play an important role in lymphangiogenesis, invasion and metastasis. LYVE-1 is a perfectly reliable lymphatic vessel marker and useful for immunohistochemistry.Fusun Ozmen M Mahir Ozmen Evren Ozdemir Munevver Moran Selda Sekin Dicle Guc Ergun Karaagaoglu Emin Kansu 2011World Journal of Gastroenterology2011,17,27:27
3A comparison of optimization theories for energy conservation in heat exchanger groups显示文摘In general,thermal processes can be classified into two categories: heat-work conversion processes and heat transfer processes. Correspondingly,the optimization of thermal processes has to have two different criteria:the well known entropy generation minimization method and the recently proposed entransy dissipation maximization method. This study analyzes the thermal issues in a heat exchanger group,and optimizes the unit arrangements under different constraints based on a suitable optimization crite-rion. The result indicates that the principle of minimum entropy generation rate is valid for optimizing heat exchangers in a ther-modynamic cycle with given boundary temperatures. In contrast,the entransy dissipation maximization is more suitable in heat exchanger optimizations involving only heat transfer processes. Furthermore,the entropy generation rate induced by dumping used streams into ambient surroundings has to be taken into account,except for that originating from the hot and cold-ends of heat exchangers,when using the entropy generation minimization to optimize heat exchangers undergoing a thermodynamic cycle.CHEN Qun WU Jing WANG MoRan PAN Ning GUO ZengYuan 2011Chinese Science Bulletin2011,56,4:20
4A survey of remote sensing-based aboveground biomass estimation methods in forest ecosystems显示文摘Remote sensing-based methods of aboveground biomass(AGB)estimation in forest ecosystems have gained increased attention,and substantial research has been conducted in the past three decades.This paper provides a survey of current biomass estimation methods using remote sensing data and discusses four critical issues–collection of field-based biomass reference data,extraction and selection of suitable variables from remote sensing data,identification of proper algorithms to develop biomass estimation models,and uncertainty analysis to refine the estimation procedure.Additionally,we discuss the impacts of scales on biomass estimation performance and describe a general biomass estimation procedure.Although optical sensor and radar data have been primary sources for AGB estimation,data saturation is an important factor resulting in estimation uncertainty.LIght Detection and Ranging(lidar)can remove data saturation,but limited availability of lidar data prevents its extensive application.This literature survey has indicated the limitations of using single-sensor data for biomass estimation and the importance of integrating multi-sensor/scale remote sensing data to produce accurate estimates over large areas.More research is needed to extract a vertical vegetation structure(e.g.canopy height)from interferometry synthetic aperture radar(InSAR)or optical stereo images to incorporate it into horizontal structures(e.g.canopy cover)in biomass estimation modeling.Dengsheng Lu Qi Chen Guangxing Wang Lijuan Liu Guiying Li Emilio Moran 2016International Journal of Digital Earth2016,9,1:17
5众筹的力量显示文摘聚集众人的力量已经是很多行业内的热门生意手段,所以它成为企业募集资金的渠道,是早晚的事情。如今,众筹(Crowdfunding)网站风起云涌,为小企业、艺术家等提供必要的资金援助。Pro Founder.com、Kickstarter.com和Peerbackers.com这三个众筹网站,都给予企业家及艺术家为自身的项目筹集资金的机会。通常情况下,投资人无条件地捐献一定的资金,受助方并无义务或者鲜有义务给予回报或者返还资金。Gwen Moran 寒雨 2011创业邦2011,,2:12
6Long-term follow-up of distal intestinal obstruction syndrome in cystic fibrosis显示文摘AIM: To investigate the long-term follow-up of distal intestinal obstruction syndrome(DIOS) in Israeli cystic fibrosis(CF) patients.METHODS: This is a multi-center,comparative,retrospective study in which we reviewed the medical records of all CF patients from three major CF centers in Israel who were treated in the period from 1980 to 2012.Patients diagnosed with DIOS were defined as the study group.The patients were diagnosed with DIOS based on their clinical presentation and typical findings on either abdominal X-ray or computerized tomography scan.For the control group,CF patients with no DIOS were matched to the patients in the study group for age,sex,and cystic fibrosis transmembrane conductance regulator(CFTR) mutations.For both groups,the collected data included age,sex,CFTR genotype,weight,height,and body mass index.Clinical data included respiratory function tests in the last five years prior to the study,respiratory function test immediately before and after the DIOS event,number of hospitalizations,sputum culture results,and CFrelated conditions diagnosed according to the CF clinical practice guidelines.In the study group,data on the DIOS treatment and tendency for DIOS recurrence were also analyzed.RESULTS: The medical charts for a total of 350 CF patients were reviewed.Of the 350 CF patients,26(7.4%) were diagnosed with DIOS.The control group included 31 CF patients with no DIOS diagnosis.The mean follow-up period was 21.6 ± 8.2 years.The total of DIOS episodes in the follow-up period was 60.The distribution of DIOS episodes was as follows: 6/26(23.1%) study patients had one episode of DIOS intheir lifetime,7/26(26.9%) had two episodes,7/26(26.9%) had three episodes,and 6/26(23.1%) had four or more episodes.Compared to the control group,DIOS patients had a significantly higher incidence of meconium ileus in the past(65.4% vs 0%,respectively,P < 0.02),more Aspergillus spp.colonization(34.6% vs 3.2%,respectively,P < 0.02),and a higher number of hospitalizations due to respiratory exacerbations(8.6 vs 6.2 mean total hospitalizations per follow-up period,respectively,P < 0.02).No other significant differences were found between the control and study groups.The conservative treatment of DIOS,which mainly includes hydration and stool softeners,was successful in 82% of the episodes.The survival rate was similar for both groups.CONCLUSION: CF patients with DIOS suffer from recurrent hospitalizations and airway pathogen acquisition.Although recurrence of DIOS is common,conservative treatment is successful in most patients.Moran Lavie Tzipora Manovitz Daphna Vilozni Sarina Levy-Mendelovich Ifat Sarouk Ilana Weintraubv David Shoseyov Malena Cohen-Cymberknoh Joseph Rivlin Ori Efrati 2015World Journal of Gastroenterology2015,21,1:10
7加拿大“海王星”海底观测网络系统显示文摘海底观测科学正朝着多元、立体、实时、长期、持续的趋势发展。加拿大'海王星'海底观测网(NEPTUNE Canada)是世界上第一个区域性海底电缆观测网络,位于加拿大西海岸20万km2的胡安·德富卡板块的北部,拥有全长800 km的主干网,5个海底观测站,自2009年12月业务运行以来为海洋学界的科学家们源源不断地提供着各种宝贵数据。首先对该系统工程的建设规模等基本构架进行简要介绍,然后从科学与机遇、关键技术、安全措施、业务运行与管理等方面阐述了该网络工程在设计、建造和运行整个过程中的几个主要关键问题,希望以此为我国海底观测工程的建设提供参考。李彦 Kate Moran Benot Pirenne 2013海洋技术2013,32,4:9
8Necroptosis of tumor cells leads to tumor necrosis and promotes tumor metastasis显示文摘Delong Jiao Zhenyu Cai Swati Choksi Dan Ma Moran Choe Hyung-Joon Kwon Jin Young Balk Brian G. Rowan Chengyu Liu Zheng-gang Liu 2018Cell Research2018,28,8:9
9A comparative study on serologic profiles of virus hepatitis B显示文摘INTRODUCTIONHepatitis B viral infection, one of the most-prevalent liver disorders in China and Korea, is aserious infectious disease as it has the potential ofprogressing into liver cirrhosis and primary hepaticcarcinoma. China and Korea both belong to high-risk endemic regions of viral hepatitis[1]. TheHBsAg positive rates in China ranged from 6.9% -17.9% by age, race and test methods[2-5].BoYOUl Cho Moran Ki Hung Bae Park 2001World Journal of Gastroenterology2001,7,1:6
10Cytoreductive surgery and intraperitoneal chemotherapy for colorectal peritoneal metastases显示文摘AIM:To systematically review the available evidence regarding cytoreductive surgery(CRS) and intraperitoneal chemotherapy(IPC) for colorectal peritoneal metastases(CPM).METHODS:An electronic literature search was carried out to identify publications reporting oncological outcome data(overall survival and/or disease free survival and/or recurrence rates)following CRS and IPC for treatment of CPM.Studies reporting outcomes following CRS and IPC for cancer subtypes other than colorectal were only included if data were reported independently for colorectal cancer-associated cases;in addition studies reporting outcomes for peritoneal carcinomatosis of appendiceal origin were excluded.RESULTS:Twenty seven studies,published between1999 and 2013 with a combined population of 2838patients met the predefined inclusion criteria.Included studies comprised 21 case series,5 case-control studies and 1 randomised controlled trial.Four studies provided comparative oncological outcome data for patients undergoing CRS in combination with IPC vs systemic chemotherapy alone.The primary indication for treatment was CPM in 96%of cases(2714/2838)and recurrent CPM(rCPM)in the remaining 4%(124/2838).In the majority of included studies(20/27)CRS was combined with hyperthermic intraperitoneal chemotherapy(HIPEC).In 3 studies HIPEC was used in combination with early post-operative intraperitoneal chemotherapy(EPIC),and 2 studies used EPIC only,following CRS.Two studies evaluated comparative outcomes with CRS+HIPEC vs CRS+EPIC for treatment of CPM.The delivery of IPC was performed using an'open'or'closed'abdomen approach in the included studies.CONCLUSION:The available evidence presented in this review indicates that enhanced survival times can be achieved for CPM after combined treatment with CRS and IPC.Reza Mirnezami Brendan J Moran Kate Harvey Tom Cecil Kandiah Chandrakumaran Norman Carr Faheez Mohamed Alexander H Mirnezami 2014World Journal of Gastroenterology2014,20,38:6
11Methods to extract impervious surface areas from satellite images显示文摘Impervious surface area(ISA)is an important parameter for many environmental or socioeconomic relevant studies.The unique characteristics of remote sensing data made it the primary data source for ISA mapping at various scales.This paper summarizes general ISA mapping procedure and major techniques and discusses impacts of scale issues on selection of remote sensing data and corresponding algorithms.Previous studies have indicated that ISA mapping remains a challenge,especially in urban–rural frontiers and in covering a large area.Effectively employing rich spatial information in high spatial resolution imagery through texture and objectbased methods is valuable.Data fusion of multi-resolution images and spectral mixture analysis are common approaches to reduce the mixed pixel problem in medium spatial resolution images such as Landsat.Coarse spatial resolution images such as MODIS and DMSP-OLS are valuable for national and global ISA mapping but more research is needed to effectively integrate multisource/scale data for improving mapping performance.Development of an optimal procedure corresponding to specific study areas and purposes is required to generate accurate ISA mapping results.Dengsheng Lu Guiying Li Wenhui Kuang Emilio Moran 2014International Journal of Digital Earth2014,7,2:5
12Current approach to treatment of minimal hepatic encephalopathy in patients with liver cirrhosis显示文摘Minimal hepatic encephalopathy(MHE)corresponds to the earliest stage of hepatic encephalopathy(HE).MHE does not present clinically detectable neurological-psychiatric abnormalities but is characterized by imperceptible neurocognitive alterations detected during routine clinical examination via neuropsychological or psychometrical tests.MHE may affect daily activities and reduce job performance and quality of life.MHE can increase the risk of accidents and may develop into overt encephalopathy,worsening the prognosis of patients with liver cirrhosis.Despite a lack of consensus on the therapeutic indication,interest in finding novel strategies for prevention or reversion has led to numerous clinical trials;their results are the main objective of this review.Many studies address the treatment of MHE,which is mainly based on the strategies and previous management of overt HE.Current alternatives for the management of MHE include measures to maintain nutritional status while avoiding sarcopenia,and manipulation of intestinal microbiota with non-absorbable disaccharides such as lactulose,antibiotics such as rifaximin,and administration of different probiotics.This review analyzes the results of clinical studies that evaluated the effects of different treatments for MHE.Segundo Moran Marlene López-Sánchez María del Pilar Milke-García Gustavo Rodríguez-Leal 2021World Journal of Gastroenterology2021,27,22:5
13胸腺恶性肿瘤Masaoka-Koga分期相关术语的说明与定义显示文摘目前,胸腺恶性肿瘤尚无国际抗癌联盟(International Union Against Cancer, UICC)和美国癌症联合委员会(American Joint Committeeon Cancer, AJCC)的官方分期。在2017年新版国际肿瘤分期提出较为广泛接受的分期之前,国际胸腺肿瘤协作组织(International Thymic Malignancy Interest Group, ITMIG)仍然建议选用经Koga等修订的Masaoka分期[1-3]。然而, Masaoka和Koga分期都存在一些模糊的术语定义,尤其是对某些细节未作出明确的定义,造成学术界的许多混乱。为此,ITMIG首先由核心工作组起草推荐定义,再交由扩展工作组提炼,并于2010年11月16日ITMIG举办的定义和术语研讨会上进行了进一步修订,最终经ITMIG全体成员讨论后于2011年2月经ITMIG批准并被采用。其灵魂内容是ITMIG对Masaoka-Koga分期系统的许多细节问题给出了较明确定义与解释,旨在使得大家在应用Masaoka-Koga分期的过程中更加一致,以利于相互合作、资源共享,同时便于前瞻性数据的正确收集,最终提出更合理的分期系统供临床使用。本文就此作一综述。付浩 中国胸腺瘤协作组全体成员 Frank C.Detterbeck Andrew G.Nicholson Kazuya Kondo Paul Van Schil Cesar Moran 2014中国肺癌杂志2014,17,2:5
14Development of a Low-cost Hardware-in-the-loop Simulation System as a Test Bench for Anti-lock Braking System显示文摘Nowadays validation of anti-lock braking systems(ABS) relies mainly on a large amount of road tests.An alternative means with higher efficiency is employing the hardware-in-the-loop simulation(HILS) system to substitute part of road tests for designing,testing,and tuning electronic control units(ECUs) of ABS.Most HILS systems for ABS use expensive digital signal processor hardware and special purpose software,and some fail-safe functions with regard to wheel speeds cannot be evaluated since artificial wheel speed signals are usually provided.In this paper,a low-cost ABS HILS test bench is developed and used for validating the anti-lock braking performance and tuning control parameters of ABS controllers.Another important merit of the proposed test bench is that it can comprehensively evaluate the fail-safe functions with regard to wheel speed signals since real tone rings and sensors are integrated in the bench.A 5-DOF vehicle model with consideration of longitudinal load transfer is used to calculate tire forces,wheel speeds and vehicle speed.Each of the four real-time wheel speed signal generators consists of a servo motor plus a ring gear,which has sufficient dynamic response ability to emulate the rapid changes of the wheel speeds under strict braking conditions of very slippery roads.The simulation of braking tests under different road adhesion coefficients using the HILS test bench is run,and results show that it can evaluate the anti-lock braking performance of ABS and partly the fail-safe functions.This HILS system can also be used in such applications as durability test,benchmarking and comparison between different ECUs.The test bench developed not only has a relatively low cost,but also can be used to validate the wheel speed-related ECU design and all its fail-safe functions,and a rapid testing and proving platform with a high efficiency for research and development of the automotive ABS is therefore provided.ZHANG Wei DING Nenggen CHEN Moran YU Guizhen XU Xiangyang 2011Chinese Journal of Mechanical Engineering2011,24,1:5
15Impact of Helicobacter pylori on the healing process of the gastric barrier显示文摘AIM To determine the impact of selected well defined Helicobacter pylori(H. pylori) antigens on gastric barrier cell turnover.METHODS In this study,using two cellular models of gastric epithelial cells and fibroblasts,we have focused on exploring the effects of well defined H. pylori soluble components such as glycine acid extract antigenic complex(GE),subunit A of urease(Ure A),cytotoxin associated gene A protein(Cag A) and lipopolysaccharide(LPS) on cell turnover by comparing the wound healing capacity of the cells in terms of their proliferative and metabolic activity as well as cell cycle distribution. Toxic effects of H. pylori components have been assessed in an association with damage to cell nuclei and inhibition of signal transducer and activator of transcription 3(STAT3) phosphorylation. RESULTS We showed that H. pylori GE,Cag A and Ure A promoted regeneration of epithelial cells and fibroblasts,which is necessary for effective tissue healing. However,in vivo increased proliferative activity of these cells may constitute an increased risk of gastric neoplasia. In contrast,H. pylori LPS showed a dose-dependent influence on the process of wound healing. At a low concentration(1 ng/m L) H. pylori LPS accelerated of healing epithelial cells,which was linked to significantly enhanced cell proliferation and MTT reduction as well as lack of alterations in cell cycle and downregulation of epidermal growth factor(EGF) production as well as cell nuclei destruction. By comparison,H. pylori LPS at a high concentration(25 ng/m L) inhibited the process of wound repair,which was related to diminished proliferative activity of the cells,cell cycle arrest,destruction of cell nuclei and downregulation of the EGF/STAT3 signalling pathway.CONCLUSION In vivo H. pylori LPS driven effects might lead to the maintenance of chronic inflammatory response and pathological disorders on the level of the gastric mucosal barrier.Eliza Mnich Magdalena Kowalewicz-Kulbat Paulina Sicińska Krzysztof Hinc Michal Obuchowski Adrian Gajewski Anthony P Moran Magdalena Chmiela 2016World Journal of Gastroenterology2016,22,33:4
16Pseudomyxoma peritonei显示文摘Pseudomyxoma peritonei (PMP) is an uncommon 'bor-derline malignancy' generally arising from a perforated appendiceal epithelial tumour. Optimal treatment involves a combination of cytoreductive surgery (CRS) with heated intraperitoneal chemotherapy (HIPEC). Controversy persists regarding the pathological classification and its prognostic value. Computed tomography scanning is the optimal preoperative staging technique. Tumour marker elevations correlate with worse prognosis and increased recurrence rates. Following CRS with HIPEC, 5-year survival ranges from 62.5% to 100% for low grade, and 0%-65% for high grade disease. Treat-ment related morbidity and mortality ranges from 12 to 67.6%, and 0 to 9%, respectively. Surgery and HIPEC are the optimal treatment for PMP which is at best a 'borderline' peritoneal malignancy.Katharine E Bevan Faheez Mohamed Brendan J Moran 2010World Journal of Gastrointestinal Oncology2010,2,1:4
17动脉瘤性蛛网膜下腔出血患者出血后脑血管痉挛的介入治疗显示文摘本临床实践标准述及动脉瘤性蛛网膜下腔出血患者出血后脑血管痉挛(post—hemorrhagiccerebralvasospasm,PHCV)的介入治疗。这些结论基于神经介入外科学学会的标准委员会的评估,包括使用由美国心脏协会卒中委员会和牛津大学循证医学中心提出的循证医学指南进行的文献回顾。特别关注现有介入治疗方法的安全性和有效性,包括腔内球囊血管成形术(transluminalballoonangioplasty,TBA)和动脉内血管扩张药物输注治疗(intra-arterialvasodilatorinfusiontherapy,IAVT)。评估结果显示,这些侵袭性介入治疗可能有益,并可考虑用于PHCV,如伴有脑缺血症状和最佳的药物治疗无效的患者的治疗。概括起来,IAVT对累及近端和(或)远端颅内脑循环的PHCV可能有益,而TBA则可能对累及近端颅内脑循环的PHCV有益。评估结果显示,对于上述适应证,根据美国心脏协会指南可将TBA和IAVT归为IIb级推荐和B级证据,根据牛津大学循证医学中心指南则可归为4级推荐和C级证据。Todd Abruzzo Christopher Moran Kristine A Blacldaam Clifford J Eskey Raisa Lev Philip Meyers Sandra Narayanan Charles Joseph Prestigjacol~ 黄凯滨(译) 吴永明(译) 2013国际脑血管病杂志2013,21,1:4
18阻塞性睡眠呼吸暂停的手术治疗显示文摘介绍阳塞性睡眠呼吸暂停(OSA)的手术治疗,讨论了悬雍垂腭咽成形术(uvulopalatopharyng-oplasty,uPPP)不同术式的适应症和手术前后的注意事项。Koopmann CF Moran WB 罗勇 1991国外医学(耳鼻咽喉科学分册)1991,15,5:3
19The Treatment-Naive Microbiome in New-Onset Crohn’s Disease显示文摘Dirk Gevers Subra Kugathasan Lee A. Denson Yoshiki Vázquez-Baeza Will Van Treuren Boyu Ren Emma Schwager Dan Knights Se Jin Song Moran Yassour Xochitl C. Morgan Aleksandar D. Kostic Chengwei Luo Antonio González Daniel McDonald Yael Haberman Thomas Walter 2014Cell Host & Microbe2014,,:3
20Endoscopic evaluation in diagnosis and management of inflammatory bowel disease显示文摘Endoscopy is a keystone in the management of patients with inflammatory bowel disease(IBD).It is the fundamental diagnostic tool for IBD,and can help discern between ulcerative colitis and Crohn's disease.Endoscopic assessment provides an objective end point in clinical trials,and identifies patients in clinical practice who may benefit from treatment escalation and may assist risk stratification in patients seeking to discontinue therapy.Recent advances in endoscopic assessment of patients with IBD include video capsule endoscopy,and chromoendoscopy.Technological advances enable improved visualization and focused biopsy sampling.Endoscopic resection and close surveillance of dysplastic lesions where feasible is recommended instead of prophylactic colectomy.Carthage P Moran Barra Neary Glen A Doherty 2016World Journal of Gastrointestinal Endoscopy2016,8,20:3
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