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119篇 您的检索式：作者名="MULLIGAN P"

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	题名	作者	年代	出处	被引量
1	Targeting chronic lymphocytic leukemia cells in the tumor microenviroment: A review of the in vitro and clinical trials to date显示文摘Chronic lymphocytic leukemia(CLL) is the most common leukemia in the western world. Despite significantadvances in therapy over the last decade CLL remains incurable. Current front-line therapy often consists of chemoimmunotherapy-based regimens, most commonly the fludarabine, cyclophosphamide plus rituximab combination, but rates of relapse and refractory disease are high among these patients. Several key signaling pathways are now known to mediate the survival and proliferation of CLL cells in vivo, the most notable of which are the pathways mediated by the B-cell receptor(BCR) and cytokine receptors. A better understanding of the pathogenesis of the disease, the underlying biology of the CLL-cell and the roles of the tumour microenvironment has provided the rationale for trials of a range of novel, more targeted therapeutic agents. In particular, clinical trials of ibrutinib and idelalisib, which target the Brutons tyrosine kinase and the delta isoform of phosphoinositol-3 kinase components of the BCR signaling pathway respectively, have shown extremely promising results. Here we review the current literature on the key signaling pathways and interactions of CLL cells that mediate the survival and proliferation of the leukemic cells. For each we describe the results of the recent clinical trials and in vitro studies of novel therapeutic agents.	Kyle Crassini Stephen P Mulligan O Giles Best	2015	World Journal of Clinical Cases2015，3，8：	5
2	Recent developments in RF sputtered cadmium stannate films 显示文摘	Wu X Mulligan W P	1996	Thin Solid Films1996，289，：	2
3	CrN-Ag self-lubricating hard coatings显示文摘	Mulligan C P Gall D	2005	Surface & Coatings Technology2005，200，：	1
4	Review of thermo-mechanical cracking and wear mechanisms in largecaliber guns 显示文摘	Underwood J H Vigilante G N Mulligan C P	2007	Wear2007，263，712：	1
5	CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation显示文摘	Mulligan P Westbrook TF Ottinger M	2008	Mol Cell2008，32，5：	1
6	personality functioning: the influence of stature显示文摘	Ulph F Betts P Mulligan J	2004	Arch Dis Child2004，89，1：	1
7	Deformation and breakup of micro- and nanoparticle stabilized droplets in microfluidic extensional flows 显示文摘	MULLIGAN M K ROTHSTE1N J P	2011	Langmuir2011，27，16：	1
8	Microencapsulated phase change material suspensions for heat transfer in spacecraft thermal systems 显示文摘	Mulligan J C Colvin D P Bryant Y G	1996	Journal of Space and Rocket Reports1996，33，2：	1
9	TRAIL agonistson clinical trials for cancer therapy: the promises andthe challenges 显示文摘	Bellail AC Qi L Mulligan P	2009	Rev Recent Clin Trials2009，4，1：	1
10	Microeneap-sulated phase-change material suspensions for heat transfer in spacecraft thermal systems显示文摘	Mulligan J C Colvin D P Bryant Y G	1996	J Spacecraft Rockets1996，33，2：	1
11	Personality functioning:The influe-nce of stature显示文摘	Ulph F Betts P Mulligan J	2004	Arch Dis Child2004，89，1：	1
12	Thermomechanically controlled erosion in army cannons-A review显示文摘	Underwood H J Vigilante N G Mulligan P C Todaro E M	2006	Journal of Pressure Vessel Technology2006，128，：	1
13	Specification of A Capability - based IT Classification Framework 显示文摘	MULLIGAN P	2002	Information & Management2002，，39：	1
14	High-level JAG1 mRNA and protein predict poor outcome in breast cancer显示文摘	Dickson B C Mulligan A M Zhang H Lockwood G O' Malley F P Egan S E	2007	Mod Pathol2007，20，：	1
15	TRAIL agonists on clinical trials for cancer therapy:The promises and the challenges 显示文摘	BELLAIL A C QI L MULLIGAN P	2009	Rev Recent Clin Trials( Online)2009，4，1：	1
16	TRAIL agonists onclinical trials for Cancer therapy: The promises and thechallenges 显示文摘	Bellail AC Qi L Mulligan P	2009	Rev Recent Clin Trials: Online2009，23，4：	1
17	Microencapsulated phase change material suspensions for heat transfer in spacecraft thermal systems显示文摘	Mulligan J C Colvin D P	1996	Spacecraft and Rocket1996，33，2：	1
18	Microencapsulated phase- change material suspensions for heat transfer in spacecraft thermal systems 显示文摘	Mulligan J C Colvin D P Bryant Y G	1996	Journal of Spacecraft and Rockets1996，33，2：	1
19	Microencapsulated phase-change material suspensions for heat transfer in spacecraft thermal systems显示文摘	Mulligan J C Colvin D P Bryant Y G	1996	Journal of Spacecraft and Rockets1996，33，2：	1
20	An investigation of feeding level effects on digestibility in cattle for diets based on grass silage and high fibre concentrates at two forage: concentrate ratios显示文摘	Mulligan F J Caffrey P J Rath M	2002	Livestock Production Science2002，77，23：	1

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