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| 1 | Mouse models of colorectal cancer: Past, present and future perspectives显示文摘Colorectal cancer(CRC)is the third most common diagnosed malignancy among both sexes in the United States as well as in the European Union.While the incidence and mortality rates in western,high developed countries are declining,reflecting the success of screening programs and improved treatment regimen,a rise of the overall global CRC burden can be observed due to lifestyle changes paralleling an increasing human development index.Despite a growing insight into the biology of CRC and many therapeutic improvements in the recent decades,preclinical in vivo models are still indispensable for the development of new treatment approaches.Since the development of carcinogen-induced rodent models for CRC more than 80 years ago,a plethora of animal models has been established to study colon cancer biology.Despite tenuous invasiveness and metastatic behavior,these models are useful for chemoprevention studies and to evaluate colitis-related carcinogenesis.Genetically engineered mouse models(GEMM)mirror the pathogenesis of sporadic as well as inherited CRC depending on the specific molecular pathways activated or inhibited.Although the vast majority of CRC GEMM lack invasiveness,metastasis and tumor heterogeneity,they still have proven useful for examination of the tumor microenvironment as well as systemic immune responses;thus,supporting development of new therapeutic avenues.Induction of metastatic disease by orthotopic injection of CRC cell lines is possible,but the so generated models lack genetic diversity and the number of suited cell lines is very limited.Patient-derived xenografts,in contrast,maintain the pathological and molecular characteristics of the individual patient's CRC after subcutaneous implantation into immunodeficient mice and are therefore most reliable for preclinical drug development–even in comparison to GEMM or cell line-based analyses.However,subcutaneous patient-derived xenograft models are less suitable for studying most aspects of the tumor microenvironment and anti-tumoral immune responses.The authors review the distinct mouse models of CRC with an emphasis on their clinical relevance and shed light on the latest developments in the field of preclinical CRC models. | Florian Bürtin Christina S Mullins Michael Linnebacher | 2020 | World Journal of Gastroenterology2020，26，13： | 9 |
| 2 | Genetic comparisons reveal the same unknown bacterial lineages in Atlantic and Pacific bacterioplankton communities 显示文摘 | MULLINS T D BRITSCHGI T B KREST R L | 1995 | Limnol Oceanogr1995，40，： | 1 |
| 3 | RAGE is the maJor receptor for the proinflammatory activity of HMGBI in rodent macrophages显示文摘 | Kokkola B Andersson A Mullins G | 2005 | Scand J Immunol2005，61，： | 1 |
| 4 | Insights from the fungus Fusarium oxysporum point to high affinity glucose transporters as targets for enhancing ethanol production from lignocellulose显示文摘 | ALI S S NUGENT B MULLINS E | 2013 | PLoS One2013，8，1： | 1 |
| 5 | Parenchymal abnormalities associated with cerebral venous sinus thrombosis:assessment with diffusion-weighted MR Imaging显示文摘 | Grant PE Wang B | 2004 | AJNR Am J Neuroradiol2004，25，： | 1 |
| 6 | Parenchymal abnormalities associated with cerebral venous sinus thrombosis:assessment with diffusion-weighted MR imaging显示文摘 | Mullins ME Grant PE Wang B | 2004 | AJNR2004，25，10： | 1 |
| 7 | High blood pressure in transgenic mice carrying the rat angiotensinogen gene 显示文摘 | Kimura S Mullins J J Bunnemann B | 1992 | EMBO J1992，11，3： | 1 |
| 8 | Assessment of hepatocytes and liver slices as in vitro test systems to predict in vivo gene expression 显示文摘 | Jessen B A Mullins J S De Peyster A | 2003 | Toxicol Sci2003，75，1： | 1 |
| 9 | Impaired hyaloidal circulation function and uncoordinated ocular growth patterns in experimental retinopathy of prematurity 显示文摘 | BERKOWITZ B A LUKASZEW R A MULLINS C M | 1998 | Invest Ophthalmol Vis Sci1998，39，2： | 1 |
| 10 | Agrobacterium-mediated genetic transformation of grapevines: transgenic plants of Vitis rupestris Scheele and buds of Vitis vinifera L显示文摘 | Mullins M G Tang F C A Faceiotti B | 1990 | Bio-Technol1990，8，： | 1 |
| 11 | Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA显示文摘 | Leslie A Kavanagh D Honeyborne I Pfafferott K Edwards C Pillay T Hilton L Thobakgale C Ramduth D Draenert R Le Gall S Luzzi G Edwards A Brander C Sewell A K Moore S Mullins J Moore C Mallal S Bhardwaj N Yusim K Phillips R Klenerman P Korber B Kiepiela P Walker B Goulder P | 2005 | J Exp Med2005，201，6： | 1 |
| 12 | The spectrophotometric deter- mination of nitrate in natural waters, with particular reference to sea-water 显示文摘 | Mullin J B Riley J P | 1955 | Analytica Chimica Acta1955，12，： | 1 |
| 13 | Polymorphism of the follistatin gene in polycystic ovary syndrome 显示文摘 | JONES M R WILSON S G MULLIN B H | 2007 | Mol Hum Reprod2007，13，4： | 1 |
| 14 | The NIH human microbiome project显示文摘 | NIH HMP Working Group Peterson J Garges S Giovanni M McInnes P Wang L Schloss JA Bonazzi V McEwen JE Wetterstrand KA Deal C Baker CC Di Francesco V Howcroft TK Karp RW Lunsford RD Wellington CR Belachew T Wright M Giblin C David H Mills M Salomon R Mullins C Akolkar B Begg L Davis C Grandison L Humble M Khalsa J Little AR Peavy H Pontzer C Portnoy M Sayre MH Starke-Reed P Zakhari S Read J Watson B Guyer M | 2009 | Genome Res2009，19，12： | 1 |
| 15 | Kinetic resolution of β-amino esters by acylation using immobilized penicillin amidohydrolase 显示文摘 | LANDIS B H M MULLINS K E WANG P T | 2002 | Org Process Res Dev2002，6，4： | 1 |
| 16 | Creation of highly aligned electrospun poly-L-lactic acid fibers for nerve regeneration applications显示文摘 | Wang H B Mullins M E Cregg J M | 2009 | J Neural Eng2009，6，01： | 1 |
| 17 | Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1infection显示文摘 | Crawford H Prado J G Leslie A HuéS Honeyborne I Reddy S van der Stok M Mncube Z Brander C Rousseau C Mullins J I Kaslow R Goepfert P Allen S Hunter E Mulenga J Kiepiela P Walker B D Goulder P J | 2007 | J Virol2007，81，15： | 1 |
| 18 | Creation of highly aligned electrospun poly-L-lactic acid fibers for nerve regeneration applications显示文摘 | Wang H B Mullins M E Cregg J M | 2009 | Journal of Neural Engineering2009，6，1： | 1 |
| 19 | Arching action in FRP reinforced concrete slabs 显示文摘 | TAYLOR S E MULLIN B | 2006 | Construction and Building Materials2006，20，12： | 1 |
| 20 | Deformation microstructures intitanium sheet metal显示文摘 | MULLINS S PATCHETT B M | 1981 | Metallurgical Transactions A1981，12，： | 1 |
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