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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Aspects of the surface and bulk ni- tration of cellulose in nitric acid, nitric acid/water, and ni- tric acid/dichloromethane mixes 显示文摘 | Short R D Munro H S | 1990 | Journal of Applied Polymer Science1990，39，： | 1 |
| 3 | Three cases of myocarditis in childhood associated with Human Parvovirus(B19 virus)显示文摘 | Munro K Croxson MC Thomas S | 2003 | Pediatr Cardiol2003，24，5： | 1 |
| 4 | Evening Primrose Oil and Treatment of Premenstrual Syndrome显示文摘 | Khoo S K Munro C Battistutta D | 1990 | The Medical Journal of Australia1990，153，4： | 1 |
| 5 | Two-stage Fowler-Stephens Orchidopexy Preserving the Gobernacular Vessels and a Purely Laparoscopic Second Stage显示文摘 | Robertson S A Munro F D Mackinlay G A | 2007 | J Laparoendosc Adv Surg Tech A2007，17，1： | 1 |
| 6 | An Hsp70-like protein in the ER:identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein显示文摘 | MUNRO S PELHAM H R | 1986 | Cell1986，46，： | 1 |
| 7 | Commerlcal Manila clam( Tapes philippinarum) culture in British Columbia, Canada: The effects of predator netting on intertidal sediment characteristics 显示文摘 | Munroe D McKinley R S | 2007 | Estuarine Coastal and Shelf Science2007，72，： | 1 |
| 8 | 显示文摘 | PALMER J BURGI D S MUNRO N J | 2001 | Anal Chem2001，73，： | 1 |
| 9 | The Sources, Fate, and Toxicity of Chemical Warfare Agent Degradation Products 显示文摘 | Nancy Munro Sylvia S TalmageGuy D | 1999 | Environmental Health Perspectives1999，107，12： | 1 |
| 10 | Molecular characteriza- tion of a peripheral receptor for cannabinoids显示文摘 | Munro S Thomas K L Abu-Shaar M | 1993 | Nature1993，365，6441： | 1 |
| 11 | The role of transar- terial embolization in the treatment of renal cell carcinoma 显示文摘 | Munro NP Woodhams S Nawrocki JD | 2003 | BJU Int2003，92，3： | 1 |
| 12 | UV Studies of Tetrahedral Bonding in Diamondlike Amorphous Carbon显示文摘 | Merkulov V I Lannin J S Munro C H | 1997 | Physical Review Letters1997，78，25： | 1 |
| 13 | Anteroposterior radiographs of the osteoathritic knee 显示文摘 | Messieh S Fowler PJ Munro T | 1990 | J Bone Joint Surg( Br)1990，72，： | 1 |
| 14 | Re-examinationof the psychometric characteristics of the La Monica-Oberst Patient Satisfaction Scale显示文摘 | Munro B H Jacobsen B S Brooten D A | 1994 | Res Nurs Health1994，17，2： | 1 |
| 15 | 查看详情显示文摘 | Landen O L Boehly T R Bradley D K Braun D G Callahan D A Celliers P M Collins G W Dewald E L Divol L Glenzer S H Hamza A Hicks D G Hoffman N Izumi N Jones O S Kirkwood R K Kyrala G A Michel P Milovich J Munro D H Nikroo A Olson R E Robey H F Spears B K Th | | 0，，： | 1 |
| 16 | Information Technology Assessment and Ddoption:A Field Study显示文摘 | Huff S L Munro M C | 1985 | MIS Quarterly1985，9，4： | 1 |
| 17 | Fire retardant mechanism of aliphatic bromine compounds in polystyrene and polypropylene显示文摘 | Kaspersma J Doumen C Munro S | 2002 | Polym Degrad Stab2002，77，2： | 1 |
| 18 | Possible pathogenetic role new cytokines in posemenopaisal osteoporosis and changes during alcitonin plus caleiumtherapy显示文摘 | Stebbings S Munro K Simon MA | 2002 | Rheumatology(Oxford)2002，41，12： | 1 |
| 19 | Genome-Wide Analysis of Blood Pressure Variability and Ischemic Stroke显示文摘 | Yadav S Cotlarciuc I Munroe PB | 2013 | Stroke2013，44，： | 1 |
| 20 | Molecular characterization of a peripheral receptor for cannabinoids 显示文摘 | Munro S Thomas KL Abu-Shaar M | 1993 | Nature1993，365，6441： | 1 |
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