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| 1 | Opposite Interplay Between the Canonical WNT/β-Catenin Pathway and PPAR Gamma: A Potential Therapeutic Target in Gliomas显示文摘In gliomas, the canonical Wingless/Int(WNT)/b-catenin pathway is increased while peroxisome proliferator-activated receptor gamma(PPAR-c) is downregulated.The two systems act in an opposite manner. This review focuses on the interplay between WNT/b-catenin signaling and PPAR-c and their metabolic implications as potential therapeutic target in gliomas. Activation of the WNT/bcatenin pathway stimulates the transcription of genes involved in proliferation, invasion, nucleotide synthesis,tumor growth, and angiogenesis. Activation of PPAR-c agonists inhibits various signaling pathways such as the JAK/STAT, WNT/b-catenin, and PI3 K/Akt pathways,which reduces tumor growth, cell proliferation, cell invasiveness, and angiogenesis. Nonsteroidal anti-inflammatory drugs, curcumin, antipsychotic drugs, adiponectin,and sulforaphane downregulate the WNT/b-catenin pathway through the upregulation of PPAR-c and thus appear to provide an interesting therapeutic approach for gliomas.Temozolomide(TMZ) is an antiangiogenic agent. The downstream action of this opposite interplay may explain the TMZ-resistance often reported in gliomas. | AlexANDre Vallée Yves Lecarpentier Rémy Guillevin Jean-Noёl Vallée | 2018 | Neuroscience Bulletin2018，34，3： | 7 |
| 2 | 通过业余时间运动的中老年的运动心电图:100次运动试验足以确定一个无症状心肌缺血的心脏事件风险显示文摘运动心电图在预防运动员心脏事件方面的重要性一直存在争议。为了确定运动心电图中无症状心肌缺血(silent myocardial ischemia,SMI)的频率及运动心电图与冠状动脉造影评估结果和潜在可预防的心脏事件的关系。Hupin等纳入2011-2014年就诊于Saint-Etienne大学医院运动医学科年龄≥35岁的无症状业余运动员,进行前瞻性队列研究。 | 刘青 叶鹏 Hupin D Edouard P Oriol M Laukkanen J Abraham P Doutreleau S Guy JM CarréF Barthélémy JC Roche F Chatard JC | 2018 | 中华高血压杂志2018，26，4： | 6 |
| 3 | 原位合成由硒纳米颗粒修饰的细菌纤维素/明胶水凝胶具有增强的抗菌抗氧化及抗炎性能促进皮肤创面的修复显示文摘与细菌相关的创面感染及抗生素耐药给患者和医疗保健体系带来了沉重的负担。因此,迫切需要开发一种既能有效预防创面感染,又能促进创面愈合且无抗生素的多功能创面敷料来解决这一难题。该研究基于细菌纤维素(BC)、明胶和硒纳米颗粒(SeNP)等材料,构建了一系列具有显著抗菌、抗氧化和抗炎能力的多功能纳米复合水凝胶用于修复创面。该BC/明胶/SeNP纳米复合水凝胶具有优越的机械性能,良好的溶胀性、柔韧性、生物可降解性及生物相容性,并且可以缓慢、持久地释放SeNP。SeNP的加入赋予了该水凝胶优越的抗氧化和抗炎能力,并对常见的细菌(大肠埃希菌和金黄色葡萄球菌)及多重耐药菌具有优异的抗菌活性。此外,BC/明胶/SeNP纳米复合水凝胶在大鼠全层皮肤缺损模型中表现出较好的促进创面愈合能力,创面具体表现为明显的炎症减轻、创面闭合、肉芽组织形成、胶原沉积、血管生成以及Fb的活化和分化。该研究表明,该多功能BC/明胶/SeNP纳米复合水凝胶作为创面敷料在预防创面感染和促进皮肤再生方面具有巨大的临床应用前景。 | Mao L Wang L Zhang MY 张清荣(编译) | 2021 | 中华烧伤杂志2021，37，11： | 5 |
| 4 | 限制卡路里摄入可抑制大鼠促进动脉衰老的炎症反应,保持年轻的表型显示文摘老化呈指数性增加典型心血管病的发病率和死亡率,这主要是由于动脉壁内分子、细胞和组织水平的动脉促炎变化。动物实验中,大鼠的卡路里限制(calorie restriction,CR)改善了动脉功能并延长了健康跨度和寿命。然而,CR如何影响大鼠动脉壁内分子,细胞和组织表型促炎变化仍有待阐明。该文选取随意喂食的344只年轻(6个月大)和老(24个月大)的Fischer大鼠,获取主动脉;另外选取1组在1个月大时开始只维持40%CR。 | 刘青 叶鹏 Wang MY Zhang L Zhu WQ Zhang J Kim SH Wang YS Ni L Telljohann R Monticone RE McGraw K Liu LJ Rafael de Cabo Lakatta EG | 2018 | 中华高血压杂志2018，26，11： | 3 |
| 5 | Dual Peroxisome Proliferator–Activated Receptor α/δ Agonist GFT505 Improves Hepatic and Peripheral Insulin Sensitivity in Abdominally Obese Subjects显示文摘 | Bertrand Cariou Rémy Hanf Stéphanie Lambert-Porcheron Yassine Za?r Valérie Sauvinet Benoit No?l Laurent Flet Hubert Vidal Bart Staels Martine Laville | 2013 | Diabetes Care2013，，10： | 2 |
| 6 | Miss rate for colorectal neoplastic polyps: a prospective multicenter study of back-to-back video colonoscopies显示文摘 | D. Heresbach T. Barrioz M. Lapalus D. Coumaros P. Bauret P. Potier D. Sautereau C. Boustière J. Grimaud C. Barthélémy J. Sée I. Serraj P. D’Halluin B. Branger T. Ponchon | 2008 | Endoscopy2008，，04： | 2 |
| 7 | The oxidative stress status in diabetes mellitus and diabetic nephropathy显示文摘 | Pan HZ Zhang L Guo MY | 2010 | Acta Diabetol2010，47，1： | 1 |
| 8 | Hepatic insig-1 or-2 overexpressionreduces lipogenesis in obese Zucker diabetic fatty rats and in fas-ted/ refed normal rats 显示文摘 | Taish K Aplomb L Wang MY | 2004 | Proc Natl Acad Sci U S A2004，101，18： | 1 |
| 9 | Simultaneous control of acid gases and P AHs using a spray dryer combined with a fabric filter using different additives 显示文摘 | LIU Z S WEI MY LIN C L | 2002 | Journal of Hazardous Materials2002，91，13： | 1 |
| 10 | Evaluation of diffusion parameters as early biomarkers of disease progression in glioblastoma multiforme显示文摘 | Khayal IS Polley MY Jalbert L | 2010 | Neuro On- eol2010，12，9： | 1 |
| 11 | Management of hypogammaglobulinaemia occurring in patients with systemic lupus erythematosus显示文摘 | Yong PF Aslam L Karim MY | 2008 | Rheumalology ( Oxford)2008，47，9： | 1 |
| 12 | Inhaled nitric oxide in preterm and term neonates with hypoxemic respiratory failure and persistent pulmonary hypertension显示文摘 | Du LZ Sun MY Shi L P | 2002 | Acta Pharmacol Sin2002，，： | 1 |
| 13 | Hepatic insig-1or-2 overexpression reduces lipogenesis in obese Zuckerdiabetic fatty rats and in fasted/refed normal rats显示文摘 | Takaishi K Duplomb L Wang MY | 2004 | ProcNatl Acad Sci USA2004，101，18： | 1 |
| 14 | An epididymis-specific beta-defensin is important for the initiation of sperm maturation显示文摘 | Zhou CX Zhang YL Xiao L Zheng M Leung KM Chan MY Lo PS Tsang LL Wong HY Ho LS | | 0，，05： | 1 |
| 15 | The high Nrf2 exp- ression in human acute myeloid leukemia is driven by NF-KB a- nd underlies its chemoesistanee 显示文摘 | Rushworth SA Zaitseva L Murray MY | 2012 | Blood2012，120，260： | 1 |
| 16 | Prediction of blue,red and green aurorae at Mars显示文摘 | Lilensten J Bernard D Barthélémy M | 2015 | Planetary and Space Science2015，115，： | 1 |
| 17 | Identification of a fourth subunit of mammalian DNA polymerase delta显示文摘 | Liu L Mo J Lee MY | 2000 | J Biol Chem2000，275，18： | 1 |
| 18 | Society of obstetri- cians and Gynecologist of Canada, rubella in pregnancy显示文摘 | Dontigny L Arsenauh MY Martel MJ | 2008 | J Ob- stet Gynaecol Can2008，30，2： | 1 |
| 19 | Poor ovarian response to gonadotropin stimulation is associated with low expres- sion of tollicle- slimulating hormone receptor in granulosa cells显示文摘 | Cai J l~u HY Dong MY | 2007 | Fertil Sterii2007，87，6： | 1 |
| 20 | Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE) 显示文摘 | Raaschou-Nielsen 0 Andersen ZJ Beelen R Samoli E Stafoggia M Weinmayr G Hoffmann B Fischer P Nieuwenhuijsen MJ Brunekreef B Xun WW Katsouyanni K Dimakopoulou K Sommar J Forsberg B Modig L Oudin A Oftedal B Schwarze PE Nafstad p De Faire U Pedersen NL Ostenson CG Fratiglioni L Penell J Korek M Pershagen G Eriksen KT Serensen M Tjenneland A Ellermann T Eeftens M Peeters PH Meliefste K Wang M Bueno-de-Mesquita B Key TJ de Hoogh K Concin H Nagel G Yilier A Grioni S Krogh y Tsai MY Ricceri F Sacerdote C Galassi C Migliore E Ranzi A Cesaroni G Badaloni C Forastiere F Tamayo I Amiano P Dorronsoro M Trichopoulou A Bamia C Yineis p Hoek G | 2013 | Lancet Oncol2013，14，9： | 1 |
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