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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | The influence of magnesium on carbide characteristics and creep behavior of the MAR-M247 superalloy显示文摘 | BOR H Y CHAO C G MAC Y | 1998 | Scripta Materialia1998，38，2： | 1 |
| 3 | Pelvic floor muscle training versus no treatment, or inactive control treatments, for urinary incontinence in women 显示文摘 | Dumoulin C Hay - Smith EJ Mac Hab6e -S6guin G | 2014 | Cochrane Database Syst Rev2014，5，00： | 1 |
| 4 | Creating Evidence-Based Research in Adapted Physical Activity显示文摘 | Reid G Bouffard M Mac Donald C | 2012 | Adapted Physical Activity Quarterly2012，，2： | 1 |
| 5 | Development and evaluation of consensus-based sediment quality guidelines for freshwater ecosystems显示文摘 | Mac Donald D D Ingersoll C G Berger T A | 2000 | Archives of\sEnvironmental Contamination and Toxicology2000，39，1： | 1 |
| 6 | An improved technique for the in situ detection of DNA after polymerase chain reaction application显示文摘 | NUOVO G J GALLERY F MAC C P | 1991 | American Journal of Pathology1991，139，： | 1 |
| 7 | Polyaniline: interconversion of metallic and insulated forms 显示文摘 | MAC Diarmid A G CHIANG J C HALPERN M | 1985 | Molecular Crystals and Liquid Crystals1985，121，： | 1 |
| 8 | Poly- aniline: A new concept in conducting polymers 显示文摘 | MAC DIARMID A G CHIANG J C RICHTER A F | 1987 | Synth Met1987，18，13： | 1 |
| 9 | An improved bioassay for the detection of Bacillus thuringiensis β-exotoxin显示文摘 | Mac Innes T C Bouwer G | 2009 | J Invertebr Pathol2009，101，2： | 1 |
| 10 | A lipidomic screen of palmitate-treated MIN6β-cells links sphingolipid metabolites with endoplasmic reticulum(ER)stress and impaired protein trafficking显示文摘 | Boslem E Mac Intosh G Preston AM Bartley C Busch AK Fuller M | 2011 | Biochem J2011，435，1： | 1 |
| 11 | In situ fracture observation of a TiC/Ti MMC produced by combustion synthesis显示文摘 | TSANG H T CHAO C G MAC Y | 1996 | Scripta Materialia1996，35，8： | 1 |
| 12 | Elitists, risk-takers, and rugged ingdividualists? An exploratory analysis of cultural differences between entrepreneurs and non-entrepreneurs显示文摘 | MAC MILLAN I C SCHEINBERG S | 1992 | Journal of Business Venturing1992，7，2： | 1 |
| 13 | The Impact of Performance Distress on Aggressive Competitive Behavior:A Reconciliation of Conflicting Views显示文摘 | FERRIER W J MAC FHIONNLAOICH C SMITH K G | 2002 | Managerial and Decision Economics2002，23，4： | 1 |
| 14 | Long-term therapy with sulphasalazine protects against colorectal cancer in ulcerative colitis: a retrospective study of colorectal cancer risk and compliance with treatment in Leicestershire显示文摘 | G A Moody V Jayanthi C S J Probert H Mac Kay J F Mayberry | 1996 | European Journal of Gastroenterology & Hepatology1996，，12： | 1 |
| 15 | Endochondral and intramembranous fetal bone development:osteoblastic cell proliferation,and expression of alkaline phosphate,m-twist,and histone H显示文摘 | ALBORZI A MAC K G LACKIN C A | 1996 | Craniofac Genet Dev Biol1996，16，： | 1 |
| 16 | Where is VEGF in the body? A meta-analysis of VEGF distrbution in cancer显示文摘 | KUT C MAC G F POPEL A S | 2007 | Br J Cancer2007，97，7： | 1 |
| 17 | Lower back pain in physically demanding college academic programs: a questionnaire based study显示文摘 | Brennan G Shafat A Mac Donncha C | 2007 | BMC Musculoskelet Disord2007，8，1： | 1 |
| 18 | Arsenian pyrite from gold deposits;Au and As distribution investigated by SIMS and EMP,and color staining and surface oxidation by XPS and LIMS显示文摘 | Fleet M E Chryssoulis S L Mac Lean P J Davidson R Weisener C G | 1993 | Canadian Mineralogist1993，31，： | 1 |
| 19 | Electrochemical response of carbon aerogel electrodes in saline water显示文摘 | Rasines G Lavela P Mac as C | | 0，，671： | 1 |
| 20 | Definitional carbox ylic acid anions in oilfield waters 显示文摘 | MAC G D B SURDAM R C | 1988 | Organ Geo- chemical1988，12，3： | 1 |
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