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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | New oxidation catalysts based on iron(III) porphyrins immobilized on Mg-Al layered double hydroxides modified with triethanolamine 显示文摘 | CASTRO K A D F BAIL A GROSZEWICZ P B MACHADO G S SCHREINER W H WYPYCH F NAKAGAKI S | 2010 | Appl Catal A: Gen2010，386，： | 1 |
| 4 | Mitochondrial distribution and adenosine triphosphate content of bovine ooctyes before and after in vitro maturation:correlation with morphological criteria and developmental capacity after in vitro fertilization and culture 显示文摘 | STOJKOVIC M MACHADO S A STOJKOVIC P | 2001 | Biol Reprod2001，64，3： | 1 |
| 5 | InterleukinlB and InterleukinlRN polymorphism are associated with increased risk of gastric carcinoma显示文摘 | Machado JC Pharoah P Sousa S | 2001 | Gastroenterology2001，121，4： | 1 |
| 6 | The ribosomal protein L10/QM-like protein is a component of the NIK-mediated antiviral signa- ling 显示文摘 | Rocha C S Santos A A Machado J P | 2008 | Virology2008，380，2： | 1 |
| 7 | Source,level and age differences in fat utilization in broilers 显示文摘 | Machado L P Vieira S L Quadros R V | 2003 | Poul Sci2003，82，： | 1 |
| 8 | 1Aminoguanidine and metformin prevent the reduced rate of HDL-mediated cell cholesterol efflux induced by formation of advanced glycation end products显示文摘 | MACHADO A P PINTO R S MOYSES Z P | 2006 | Int J Biochem Cell Biol2006，38，： | 1 |
| 9 | Uhrasound promoted syn- thesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors显示文摘 | Gabriela D S Anna S Machado P | 2009 | Bio Org Med Chem2009，19，2： | 1 |
| 10 | Recovery of nicotine-free proteins from tobacco leaves using phosphate buffer system under controlled conditions显示文摘 | FU H MACHADO P A HAHM T S | 2009 | Bioresource Technology2009，，10： | 1 |
| 11 | Structural and magnetic characterization of Ni nanoparticles synthesized in ionic liquids 显示文摘 | Migowski P Teixeira S R Machado G | 2007 | Journal of Electron Spectroscopy and Related Phenomena2007，，： | 1 |
| 12 | Non-linear buckling and postbuckling behavior of thin-walled beams considering shear deformation 显示文摘 | Machado S P | 2008 | International Journal of Non-Linear Mechanics2008，43，5： | 1 |
| 13 | Mitochondrial distribution and adenosine triphosphate content of bovine ooctyes before and after in vitro maturation:correlation with morphological criteria and developmental capacity after in vitro fertilization and culture显示文摘 | STOJKOVIC M MACHADO S A STOJKOVIC P | 2001 | Biol Reprod2001，64，： | 1 |
| 14 | Non--linear Buckling and Post--buck- ling Behavior of Thin--wailed Beams Considering Shear Deformation显示文摘 | Machado S P | 2008 | International Journal of Non--Linear Mechanics2008，43，5： | 1 |
| 15 | Hybrid Atom Transfer Radical Polymerization System for Balanced Polymerization Rate and Polymer Molecular Weight Control显示文摘 | Machado M Faucher S Zhu S P | 2010 | J Polym Sci Part A2010，48，： | 1 |
| 16 | Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxi- dase inhibitors显示文摘 | GABRIELA D S ANNA S MACHADO P | 2009 | Bioorg IVied Chem Lett2009，19，2： | 1 |
| 17 | Membrane formation mechanism based on precipitation kinetics and membrane morphology: flat and hollow fiber polysulfone membranes显示文摘 | Habert A C Borges C P 1999 | 1999 | J Membr Sci1999，155，： | 1 |
| 18 | Aminoguanidine and metformin prevent the reduced rate of HDL-mediated cell cholesterol efflux induced by formation of advanced glycation end products显示文摘 | MACHADO A P PINTO R S MOYSES Z P | 2006 | Int J Biochem CellBiol2006，38，3： | 1 |
| 19 | Interleukin 1B and interleukin 1RN polymorphisms are associated with in- creased risk of gastric carcinoma显示文摘 | Machado JC Pharoah P Sousa S | 2001 | Gastroenterology2001，121，4： | 1 |
| 20 | Membrane formation mechanism based on precipitation kinetics and membrane morphology:Flat and hollow fiber polysulfone membranes显示文摘 | Machado P S T Habert A C Borges C P | 1999 | JMembr Sci1999，155，： | 1 |
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