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| 1 | Preliminary studies of acute and sub-chronic toxicity of the aqueous extract of Guibourtia tessmannii(Harms) J.Leonard stem barks (Caesalpiniaceae) in mice and rats显示文摘Objective: To investigate the toxicity of aqueous extract of Guibourtia tessmannii(Harms) J. Leonard(G. tessmannii) and evaluate its safety.Methods: NMRI mice were used to determine the acute toxicity of G. tessmannii.Increasing concentrations of the plant extracts were administered intraperitoneally or by force-feeding. General behavior and death were monitored and recorded daily for 7 days.In order to determine the sub-acute toxicity of the extract, several doses were administered by oral gavage daily for 28 days in adult Wistar rats. Different parameters were assessed including body weight, food and water intake, biochemical parameters and several vital organ weights.Results: LD50 of 328.78 mg/kg was obtained by i.p. route and more than 5 000 mg/kg was obtained in acute toxicity by oral route. In sub-acute toxicity, no significant alteration was observed in body weight or vital organs, food and water intake, and biochemical parameters.Conclusions: The results showed that the aqueous extract of G. tessmannii has low toxicity intraperitoneally and no sub-acute toxicity via oral intake. | Noreen Orianna Koumba Madingou Aristide Traore Alain Souza Marlaine Michelle Boukandou Mounanga Raissa Reine Aworet Samseny Sylvin Ouedraogo Alfred Sababenedyo Traore | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，6： | 2 |
| 2 | Establishment and characterization of cell sublines with high and low metastatic potential derived from human osteosarcoma显示文摘The most frequent cause of death of patients with osteosarcoma is the metastasis of tumour cells. In spite of successful control of the primary tumour, the mortality of the patients due to metastatic spread is more than 30% within 5 years. 1 Recent studies about osteosarcoma metastatic mechanism are based on osteosarcoma matrilineal cell lines. 2 For further studies of metastatic mechanism of osteosarcoma the establishment of a better metastatic experimental model of osteosarcoma is needed. We isolated and established two cell sublines, with high and low metastatic potentials, respectively, derived from human osteosarcoma MG-63 cell line by cloning in vitro and transplantation in vivo , then analysed and identified their biological characteristics. | SHIXiao-bing CHENAn-ming CAIXian-hua GUOFen-jing LIAOGuo-ning MADing | 2005 | Chinese Medical Journal2005，，8： | 2 |
| 3 | BioMagResBank显示文摘 | Ulrich E L Akutsu H Doreleijers J F Harano Y Ioannidis Y E Lin J Livny M Mading S Maziuk D Miller Z Nakatani E Schulte C F Tolmie D E Kent Wenger R Yao H Markley J L | | 0，，1： | 1 |
| 4 | The effect of carbon source on the secretome of Kluyveromyces lactis显示文摘 | MADINGER C L SHARMA S S ANTON B P | 2009 | Proteomics2009，9，20： | 1 |
| 5 | Transplantation of ex vivo expanded cord blood显示文摘 | Elizabeth J Shpall Ralph Quinones Roger Giller Chan Zeng Anna E Baron Roy B Jones Scott I Bearman Yago Nieto Brian Freed Nancy Madinger Christopher J Hogan Vicki Slat-Vasquez Peggy Russell Betsy Blunk Deborah Schissel Elaine Hild Janet Malcolm William War | 2002 | Biology of Blood and Marrow Transplantation2002，，： | 1 |
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