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| 1 | Chlorinated paraffins in the technosphere:A review of available information and data gaps demonstrating the need to support the Stockholm Convention implementation显示文摘Chlorinated paraffins(CPs)have been produced for a wide range of applications,mostly in open uses,such as metalworking fluids,lubricants,coolants or additives in consumer goods.The production volume is more than one million tonnes requiring control of the lifecycle of these persistent and bioaccumulative chemicals.In May 2017,the Stockholm Convention amended its Annex A to list short chain chlorinated paraffins(SCCPs)as a Persistent Organic Pollutant(POP).Additionally,a limit for the presence of SCCPs in other CP mixtures was set at 1%by weight.CPs can be released to the environment throughout their lifecycle.Therefore,the major objective of this review was to assess and compile information on SCCPs and other CPs regarding their lifecycle in the technosphere to support the Stockholm Convention implementation.A few studies have assessed CP production plants and contamination in the surrounding environments.However,there was no systematic investigation of release routes from production and no assessment of associated landfills,even though these are known major pollution sources at other organochlorine production sites.Some studies have reported that industrial areas,where CPs have likely been used,have elevated levels of CPs in sediments and soil.However,although CPs are largely released when used as metalworking fluids or lubricants,no systematic assessment of releases has been conducted at the thousands of sites where CPs are used in high volumes.Many CPs,mainly medium chain chlorinated paraffins(MCCPs)and SCCPs,are used as additives in the production of consumer goods,resulting in exposure risks.Levels above the European Union regulation for SCCPs of 1500 mg kg^-1 and up to approx.20%are frequently found.The end-of-life management of CP-containing products is difficult since no labelling requirement exists even for products containing SCCPs.The Stockholm Convention prohibits the recycling of SCCP-containing products,which will result in challenges recycling the impacted waste categories.The activities under the Stockholm Convention related to SCCPs,such as the inventory,phase-out,and management of impacted products,provide opportunities to address existing data gaps and challenges.Special attention needs to be given to developing countries with lacking analytical capacity as well as waste management and destruction capacity. | Yago Guida Raquel Capella Roland Weber | 2020 | Emerging Contaminants2020，6，1： | 4 |
| 2 | Small intestinal bacterial overgrowth in inactive Crohn's disease:Influence of thiopurine and biological treatment显示文摘AIM:To investigate the influence of thiopurines and biological drugs on the presence of small intestinal bacterial overgrowth(SIBO) in patients with inactive Crohn's disease(CD).METHODS:This was a prospective study in patients with CD in remission and without corticosteroid treatment,included consecutively from 2004 to 2010.SIBO was investigated using the hydrogen glucose breath test.RESULTS:One hundred and seven patients with CD in remission were included.Almost 58%of patients used maintenance immunosuppressant therapy and 19.6%used biological therapy.The prevalence of SIBO was16.8%.No association was observed between SIBO and the use of thiopurine Immunosuppressant(12/62patients),administration of biological drugs(2/21 patients),or with double treatment with an anti-tumor necrosis factor drugs plus thiopurine(1/13 patients).Half of the patients had symptoms that were suggestive of SIBO,though meteorism was the only symptom that was significantly associated with the presence of SIBO on univariate analysis(P<0.05).Multivariate analysis revealed that the presence of meteorism and a fistulizing pattern were associated with the presence of SIBO(P<0.05).CONCLUSION:Immunosuppressants and/or biological drugs do not induce SIBO in inactive CD.Fistulizing disease pattern and meteorism are associated with SIBO. | Cristina Sánchez-Montes Vicente Ortiz Guillermo Bastida Ester Rodríguez María Yago Belén Beltrán Mariam Aguas Marisa Iborra Vicente Garrigues Julio Ponce Pilar Nos | 2014 | World Journal of Gastroenterology2014，20，38： | 4 |
| 3 | Effect of Calcineurin Inhibitors in the Outcome of Liver Transplantation in Hepatitis C Virus-Positive Recipients显示文摘 | Marina Berenguer Victoria Aguilera Fernando San Juan Salvador Benlloch Angel Rubin Rafael López-Andujar Angel Moya Eugenia Pareja Eva Montalva Maria Yago Manuel de Juan José Mir Martín Prieto | 2010 | Transplantation2010，，11： | 3 |
| 4 | E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin al- phaLbeta2-mediated slow leukocyte rolling显示文摘 | Yago T Shao B Miner JJ | 2010 | Blood2010，116，3： | 1 |
| 5 | Tacrolimus po- tently inhibits human osteoclastogenesis induced by IL-17 from human monocytes alone and suppresses human Thl7 differentiation 显示文摘 | Yago T Nanke Y Kawamoto M | 2012 | Cytokine2012，59，2： | 1 |
| 6 | E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrinalpha Lbeta2-mediated slow leukocyte rolling显示文摘 | Yago T Shao B Miner JJ | 2010 | Blood2010，116，3： | 1 |
| 7 | Investigation and threshold of optimum blood concentration of voriconazole : a descriptive statistical meta-analysis显示文摘 | HAMADA Y SETO Y YAGO K | 2012 | J Infect Chemother2012，18，4： | 1 |
| 8 | How-enhanced adhesion regulated by a selectin interdomain hinge显示文摘 | LOU J YAGO T KLOPOCKI A G | 2006 | J Cell Biol2006，174，： | 1 |
| 9 | IL-23 induces human osteoclasto- genesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-in- duced arthritis in rats显示文摘 | Yago T Nanke Y Kawamoto M | 2007 | Arthritis Res Ther2007，9，： | 1 |
| 10 | Role of osteoclastsand interleukin -17 in the pathogenesis of rheumatoidarthritis: crucial iiuman osteoclastology' 显示文摘 | Kotake S Yago T Kawamoto M | 2012 | J Bone MinerMetab2012，30，2： | 1 |
| 11 | Distribution of nitric oxide synthase and secretory role of exogenous nitric oxide in the isolated rat pancreas显示文摘 | Zsolt Ember MD Maria Dolores Yago Jaipaul Singh | 2001 | International Journal of Pancreatology2001，，2： | 1 |
| 12 | Catch bonds govern adhesion through L-selectin at threshold shear显示文摘 | Yago T Wu JH Wey CD | 2004 | J Cell Biol2004，166，： | 1 |
| 13 | ILl7 induces osteoclasto- genesis from human monocytes alone in the absence of osteo- blasts, which is potently inhibited by anti TNF-alpha antibody: anovel mechanism of osteoclastogenesis hy IL-17显示文摘 | Yago T Nanke Y Ichikawa N | 2009 | J Cell Bio- ehem2009，108，5： | 1 |
| 14 | Kinematic parameter estimation technique for calibration and repeatability improvement of articulated arm coordinate measuring machines显示文摘 | SANTOLARIA J AGUILAR J J YAGOE J A | 2008 | Precision Engineering2008，32，4： | 1 |
| 15 | Role of osteoclastsand interleukin-17 in the pathogenesis of rheumatoidarthritis: crucial Iiuman osteoclastology' 显示文摘 | Kotake S Yago T Kawamoto M | 2012 | J Bone MinerMetab2012，30，2： | 1 |
| 16 | Blood pressure, electroencephalogram, sleep wakefulness rhythm and defecation in rads exposed to the electric field generated by the high voltage electro potential therapy apparatur显示文摘 | NAGASUMI YAGO TAGUCHI S HARA A | 1999 | Good Laboratory Practice Guidelines Wednesday1999，10，： | 1 |
| 17 | Piezoelectric modeling using a time domain finite element program显示文摘 | Yago Gomez-Ullate Ricon Francisco Montero de Espinosa Freijo | | 0，，： | 1 |
| 18 | Activation of brain mechanisms of attention switching as a function of auditory frequency change显示文摘 | YAGO E CORRAL M J ESCERA C | 2001 | Neuroreport2001，12，： | 1 |
| 19 | Detecting anti-SSA and anti-SSB antibodies in routine analysis:a comparison between double immunodiffusion and immunoblotting显示文摘 | Yago M Belmonte M A Olmos M J | 1999 | Ann Clin Biochem1999，36，3： | 1 |
| 20 | Teriparatide therapy for bi- sphosphonate-associated osteoneerosis of the jaw in an elderly Japa- nese woman with severe osteoporosis 显示文摘 | Iwamoto J Yago K Sato Y | 2012 | Clin Drug Investig2012，32，8： | 1 |
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