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| 1 | A rare case of primary choriocarcinoma in the sigmoid colon显示文摘Primary colorectal choriocarcinoma is an extremely rare neoplasm and is usually associated with a poor prognosis.Only 13 cases of colorectal choriocarcinoma have previously been reported.There is no standard chemotherapeutic regimen for this tumor type.A 68-year-old man presented with melena and was diagnosed with sigmoid colonic adenocarcinoma with multiple liver metastases.He underwent a laparoscopic sigmoidectomy.Pathology revealed choriocarcinoma with a focal component of moderately differentiated adenocarcinoma of colon origin.Based on the collagen gel droplet-embedded culture drug sensitivity test(CD-DST)results,mFOLFOX6 and bevacizumab were administered,which suppressed aggressive tumor growth for 4 mo.The patient died 9 mo after the initial diagnosis.Our study results suggest that the standard chemotherapy regimen for colorectal cancer might have suppressive effects against primary colorectal choriocarcinoma.Moreover,CD-DST may provide,at least in part,therapeutic insight for the selection of appropriate antitumor agents for such patients. | Hiromitsu Maehira Tomoharu Shimizu Hiromichi Sonoda Eiji Mekata Tomoharo Yamaguchi Tohru Miyake Mitsuaki Ishida Tohru Tani | 2013 | World Journal of Gastroenterology2013，19，39： | 6 |
| 2 | Age-related changes in the oxidation-reduction characteristics and the 8-OHdG accumulation in liver, lung, brain of SAM R1 and SAM RI显示文摘 | Fusako Maehira Yoshio Nakama Norio Ohmine | 2004 | International congress series2004，1260，： | 1 |
| 3 | Anti-diabetic effects including diabetic nephropathy of anti-osteoporotic trace minerals on diabetic mice显示文摘 | Maehira F Ishimine N Miyagi I | 2011 | Nutrition2011，27，4： | 1 |
| 4 | Selenium regulates transcription factor NF-kB activation during the acute phase reaction显示文摘 | Maehira F Miyagi I Eguchi Y | 2003 | Clinica Chimica Acta2003，334，： | 1 |
| 5 | Alterations of protein kinase C, 8-hydroxydeoxyguanosine, and K-ras oncogene in rat lungs exposed to passive smoking显示文摘 | Maehira F Miyagi I Asato T etal | 1999 | Clin Chim Acta1999，289，12： | 1 |
| 6 | Coronary microvaseular abnormality in the reversible systolic dysfunction observed after noncar- diac disease 显示文摘 | Sadamatsu K Tashiro H Maehira N | 2000 | Jpn Cite J2000，64，： | 1 |
| 7 | Alterations of protein kinase C ,8-hydroxydeoxyguanosine,and K-ras oncogene in rat lungs exposed to passive smoking 显示文摘 | Maehira F Miyagi I Asato T | 1999 | Clin Chim Acta1999，289，12： | 1 |
| 8 | Effects of passive smoking on the regulation of rat aortic cholesteryl ester hydrolases by signal transduction显示文摘 | MAEHIRA F ZAHA F MIYAGI I | 2000 | Lipids2000，35，5： | 1 |
| 9 | Effects of passive smoking onthe regulation of rat aortic cholesteryl ester hydrolases by signal transduction显示文摘 | Zaha F Miyagi I | 2000 | Lipids2000，35，5： | 1 |
| 10 | Coronary microvascular abnormali- ty in the reversible systolic dysfunction observed after noneardiac disease 显示文摘 | Sadamatsu K Tashiro H Maehira N | 2000 | Jpn Circ J2000，64，： | 1 |
| 11 | Selenium regulates transcription factor NF-kappa B activation during the acute phase reaction显示文摘 | Maehira F Miyagi I Eguchi Y | 2003 | Clin Chim Acta2003，334，12： | 1 |
| 12 | Journal of Physics- Condensed Matter显示文摘 | Maehira T Higuchi M Hasegawa A | 2003 | 15(28): $22372003，15，28： | 1 |
| 13 | Anti-diabetic effects in- cluding diabetic nephropathy of anti-osteoporotic trace minerals on diabetic mice显示文摘 | Maehira F Ishimine N Miyagi I | 2011 | Nutrition2011，27，4： | 1 |
| 14 | Physica B-CondensedMatter显示文摘 | Maehira T Higuchi M Hasegawa A | 2003 | 329:5742003，329，： | 1 |
| 15 | Coronary microvascular abnonnality in the reversible systolic dysfunction observed after noncardiac disease显示文摘 | Sadamatsu K Tashiro H Maehira N | 2000 | Jpn Circ J2000，64，10： | 1 |
| 16 | Selenium regulates transcriptionfactor NF-kappaB activation during the acute phase reaction显示文摘 | Maehira F Luyo GA Miyagi I | 2003 | Clin Chim Acta2003，334，： | 1 |
| 17 | Alterations of protein kinase C, 8- hydroxyguanosine, and K -ras oncogene in rat lungs exposed to passive smoking 显示文摘 | Maehira F Miyagi I Asato T | 1999 | Clin Chim Acta1999，289，12： | 1 |
| 18 | Alterations of protein ki- nase C, 8-hydroxyguanosine, and K-ras oneogene in rat lungs exposed to passive smoking 显示文摘 | Maehira F MiyagiI Asato T | 1999 | Clin Chim Acta1999，289，12： | 1 |
| 19 | Anti-diabetic effects including diabetic nephropathy of anti-osteoporotic trace minerals on diabetic mice显示文摘 | Fusako Maehira Nau Ishimine Ikuko Miyagi Yukinori Eguchi Katsumasa Shimada Daisuke Kawaguchi Yoshihide Oshiro | 2011 | Nutrition2011，，4： | 1 |
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