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| 1 | Prognosis of metastatic splenic hilum lymph node in patients with gastric cancer after total gastrectomy and splenectomy显示文摘AIM:To clarify the significance of combined resection of the spleen to dissect the No.10 lymph node(LN). METHODS:We studied 191 patients who had undergone total gastrectomy with splenectomy,excluding non-curative cases,resection of multiple gastric cancer, and those with remnant stomach cancer.Various clinico-pathological factors were evaluated for any independent contributions to No.10 LN metastasis,usingχ 2 test. Significant factors were extracted for further analysis, carried out using a logistic regression method.Furthermore,lymph node metastasis was evaluated for any independent contribution to No.10 LN metastasis,using the same methods.The cumulative survival rate was calculated using the Kaplan-Meier method.The significance of any difference between the survival curves was determined using the Cox-Mantel test,and any difference was considered significant at the 5%level. RESULTS:From the variables considered to be potentially associated with No.10 LN metastasis,age, depth,invasion of lymph vessel,N factor,the numberof lymph node metastasis,Stage,the number of sites, and location were found to differ significantly between those with metastasis(the Positive Group)and those without(the Negative Group).A logistic regression analysis showed that the localization and Stage were significant parameters for No.10 LN metastasis.There was no case located on the lesser curvature in the Posi-tive Group.The numbers of No.2,No.3,No.4sa,No. 4sb,No.4d,No.7,and No.11 LN metastasis were each found to differ significantly between the Positive Group and the Negative Group.A logistic regression analysis showed that No.4sa,No.4sb,and No.11 LN metastasis were each a significant parameter for No.10 LN metastasis.There was no significant difference in survival curves between the Positive Group and the Negative Group. CONCLUSION:Splenectomy should be performed to dissect No.10 LN for cases which have No.4sa,No. 4sb or No.11 LN metastasis.However,in cases where the tumor is located on the lesser curvature,splenectomy can be omitted. | Keishiro Aoyagi Kikuo Kouhuji Motoshi Miyagi Takuya Imaizumi Junya Kizaki Kazuo Shirouzu | 2010 | World Journal of Hepatology2010，2，2： | 26 |
| 2 | Molecular targeting therapy using bevacizumab for peritoneal metastasis from gastric cancer显示文摘AIM: To clarify the significance of vascular endothelial growth factor(VEGF) in peritoneal metastasis from gastric cancer, using the gastric cancer cell line MKN-45 compared with the high potential peritoneal dissemination gastric cancer cell line MKN-45 P. METHODS: The supernatant of culture medium of MKN-45 cells or MKN-45 P cells was collected and the concentrations were measured of various cytokines, matrix metalloproteinases, growth factor and angiogenic factors, including VEGF. We performed an initial pilot study to explore whether bevacizumab, a humanized monoclonal antibody against VEGF, had any suppressive effect on the peritoneal dissemination from gastric cancer in an experimental nude mouse modelof peritoneal metastasis. RESULTS: The concentrations of interleukin-6(IL-6), IL-8, VEGF and matrix metalloproteinase-2 protein in the culture supernatant were each significantly higher than each of those for MKN-45. In the in vivo study, the volume of ascites and the mitotic index were significantly lower in the therapy group than in the nontherapy group. The survival curve of the therapy group was significantly higher than that of the non-therapy group. These results suggested that VEGF was correlated with peritoneal metastasis from gastric cancer. CONCLUSION: Findings suggested that bevacizumab for inhibiting VEGF could suppress peritoneal dissemination from gastric cancer. | Keishiro Aoyagi Kikuo Kouhuji Motoshi Miyagi Junya Kizaki Taro Isobe Kousuke Hashimoto Kazuo Shirouzu | 2013 | World Journal of Critical Care Medicine2013，2，4： | 12 |
| 3 | Clinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver disease显示文摘AIM: Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD), and progresses to the end stage of liver disease. Biochemical markers of liver fibrosis are strongly associated with the degree of histological liver fibrosis in patients with chronic liver disease.However, data are few on the usefulness of markers in NAFLD patients. The aim of this study was to identify better noninvasive predictors of hepatic fibrosis, with special focus on markers of liver fibrosis, type Ⅵ collagen 7S domain and hyaluronic acid.METHODS: One hundred and twelve patients with histologically proven NAFLD were studied.RESULTS: The histological stage of NAFLD correlated with several clinical and biochemical variables, the extent of hepatic fibrosis and the markers of liver fibrosis were relatively strong associated. The best cutoff values to detect NASH were assessed by using receiver operating characteristic analysis: type Ⅵ collagen 7S domain ≥5.0 ng/mL, hyaluronic acid ≥43 ng/mL. Both markers had a high positive predictive value: type Ⅵ collagen 7S domain, 86% and hyaluronic acid,92%. Diagnostic accuracies of these markers were evaluated to detect severe fibrosis. Both markers showed high negative predictive values: type Ⅵ collagen 7S domain (≥5.0 ng/mL),84% and hyaluronic acid (≥50 ng/mL), 78%, and were significantly and independently associated with the presence of NASH or severe fibrosis by logistic regression analysis.CONCLUSION: Both markers of liver fibrosis are useful in discriminating NASH from fatty liver alone or patients with severe fibrosis from patients with non-severe fibrosis. | Hiroshi Sakugawa Tomofumi Nakayoshi Kasen Kobashigawa Tsuyoshi Yamashiro Tatsuji Maeshiro Satoru Miyagi Joji Shiroma Akiyo Toyama Tomokuni Nakayoshi Fukunori Kinjo Atsushi Saito | 2005 | World Journal of Gastroenterology2005，11，2： | 9 |
| 4 | Excessive portal flow causes graft failure in extremely small-for-size liver transplantation in pigs显示文摘AIM: To evaluate the effects of a portocaval shunt on the decrease of excessive portal flow for the prevention of sinusoidal microcirculatory injury in extremely smallfor-size liver transplantation in pigs.METHODS: The right lateral lobe of pigs, i.e. the 25%of the liver, was transplanted orthotopically. The pigs were divided into two groups: graft without portocaval shunt (n = 11) and graft with portocaval shunt (n=11).Survival rate, portal flow, hepatic arterial flow, and histological findings were investigated.RESULTS: In the group without portocaval shunt, all pigs except one died of liver dysfunction within 24 h after transplantation. In the group with portocaval shunt,eight pigs survived for more than 4 d. The portal flow volumes before and after transplantation in the group without portocaval shunt were 118.2±26.9 mL/min/100 g liver tissue and 270.5±72.9 mL/min/100 g liver tissue,respectively. On the other hand, in the group with portocaval shunt, those volumes were 124.2±27.8 mL/min/100 g liver tissue and 42.7±32.3 mL/min/100 g liver tissue, respectively (P<0.01). As for histological findings in the group without portocaval shunt, destruction of the sinusoidal lining and bleeding in the peri-portal areas were observed after reperfusion, but these findings were not recognized in the group with portocaval shunt.CONCLUSION: These results suggest that excessive portal flow is attributed to post transplant liver dysfunction after extreme small-for-size liver transplantation caused by sinusoidal microcirculatory injury. | Hong-Sheng Wang Nobuhiro Ohkohchi Yoshitaka Enomoto Masahiro Usuda Shigehito Miyagi Takeshi Asakura Hiroo Masuoka Takashi Aiso Keisuke Fukushima Tomohiro Narita Hideyuki Yamaya Atsushi Nakamura Satoshi Sekiguchi Naoki Kawagishi Akira Sato Susumu Satomi | 2005 | World Journal of Gastroenterology2005，11，44： | 8 |
| 5 | Long-term effect of lamivudine treatment on the incidence of hepatocellular carcinoma in patients with hepatitis B virus infection显示文摘 | Mika Kurokawa Naoki Hiramatsu Tsugiko Oze Takayuki Yakushijin Masanori Miyazaki Atsushi Hosui Takuya Miyagi Yuichi Yoshida Hisashi Ishida Tomohide Tatsumi Shinichi Kiso Tatsuya Kanto Akinori Kasahara Sadaharu Iio Yoshinori Doi Akira Yamada Masahide Oshita | 2012 | Journal of Gastroenterology2012，，5： | 4 |
| 6 | Hepatic osteodystrophy complicated with bone fracture in early infants with biliary atresia显示文摘Biliary atresia(BA) is one of the major hepatobiliary abnormalities in infants and one of the causes of hepatic osteodystrophy.Bone disease may be caused by the malabsorption of calcium and magnesium by vitamin D in hepatobiliary diseases in which bile flow into the intestines is deficient or absent.Bone fracture before Kasai hepatic portoenterostomy or within one month after the procedure in an infant with BA is very rare.We herein report two infants:one infant with BA who initially presented with a bone fracture before Kasai hepatic portoenterostomy,and the other at 4 wk after Kasai hepatic portoenterostomy,and also provide a review of the literature.Moreover,we conclude that clinicians should consider BA in infants with bone fracture during early infancy. | Tadao Okada Shohei Honda Hisayuki Miyagi Masashi Minato Akinobu Taketomi | 2012 | World Journal of Hepatology2012，4，10： | 3 |
| 7 | Global histone modification of H3K27 correlates with the outcomes in patients with metachronous liver metastasis of colorectal cancer显示文摘 | H. Tamagawa T. Oshima M. Numata N. Yamamoto M. Shiozawa S. Morinaga Y. Nakamura M. Yoshihara Y. Sakuma Y. Kameda M. Akaike N. Yukawa Y. Rino M. Masuda Y. Miyagi | 2013 | European Journal of Surgical Oncology2013，，6： | 2 |
| 8 | Effect of Portocaval Shunt on Residual Extreme Small Liver after Extended Hepatectomy in Porcine显示文摘 | HongSheng Wang MD PhD Nobuhiro Ohkohchi MD PhD Yoshitaka Enomoto MD Masahiro Usuda MD Shigehito Miyagi MD Hiroo Masuoka MD Satoshi Sekiguchi MD Naoki Kawagishi MD Keisei Fujimori MD Akira Sato MD Susumu Satomi MD PhD | 2006 | World Journal of Surgery2006，，11： | 2 |
| 9 | Effects of anti-inflammatory cytokine agent (FR167653) and serine protease inhibitor on warm ischemia-reperfusion injury of the liver graft显示文摘 | Miyagi S Ohkohchi N Oikawa K | 2004 | Transplantation2004，27，10： | 2 |
| 10 | Membrane process for emulsified waste containing mineral oils and nonionic surfactants (alkylphenolethoxylate)显示文摘 | Atsushi Miyagi Mitsutoshi Nakajima | 2002 | Water Research2002，，15： | 2 |
| 11 | Characteristics and prognosis of gastric cancer in young patients显示文摘 | Taro Isobe Kousuke Hashimoto Junya Kizaki Motoshi Miyagi Keishiro Aoyagi Kikuo Koufuji Kazuo Shirouzu | 2013 | Oncology Reports2013，，1： | 2 |
| 12 | Cube polarizers by the use of metal particles in anodic alumina films显示文摘 | TAKANO K SAITO M MIYAGI M | 1994 | Applied Optics1994，33，16： | 1 |
| 13 | Cytocidal effect and DNA damag of nedaplatin in vitro by simulating pharmacokinetic parameters显示文摘 | Miyagi Y Yamamoto J | 2001 | Cancer Chemother Pharmacol2001，47，4： | 1 |
| 14 | Natural killer cell is a major producer of interferon gamma that is critical for the IL-12-induced anti-tumor effect in mice 显示文摘 | UEMURA A T a KEHARA T MIYAGI T | 2010 | Cancer lmmunol lmmunother2010，59，3： | 1 |
| 15 | Effect of sex hormones on production of interleukin - 1 by human peripheral monocytes 显示文摘 | Morishita M Miyagi M lwamoto Y | 1999 | J Periodontol1999，70，7： | 1 |
| 16 | Magnetic resonance appearance of mutiple intracranial epidermoid cysts: intrathecal seeding of the cysts 显示文摘 | Miyagi Y Satoshi O Suzuki | 2000 | J Neurosurg2000，92，71： | 1 |
| 17 | Triple Primary Intracranial Tumors of Diffierent Cell Types:a Case Report显示文摘 | Miyagi A Maeda K Sugawara T | 1995 | No Shinkei Geka Neurological Surgery1995，23，6： | 1 |
| 18 | Tricuspid valve replacement for elderly patients with isolated tricuspid valve regurgitation; report of 2 cases 显示文摘 | MIYAGI N SHIRAI T OSHIMA N | 2007 | Kyobu C eka2007，60，3： | 1 |
| 19 | Altered expression of P2 receptor mRNAs in the basilar artery in a rat double hemorrhage model 显示文摘 | Carpenter RC Miao L Miyagi Y | 2001 | Stroke2001，32，： | 1 |
| 20 | Multiple brain tu- mors of different cell types an unruptured cerebral a- neurysm--Case report显示文摘 | Shigemori M Tokunaga T Miyagi J | 1991 | Neural Med Chir (Tokyo)1991，31，2： | 1 |
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