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| 1 | CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL. | Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed | 2018 | Cellular & Molecular Immunology2018，15，2： | 2 |
| 2 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 2 |
| 3 | Microwave drying kinetics of tomato pomace: Effect of osmotic dehydration显示文摘 | Mohammad Al-Harahsheh Ala’a H. Al-Muhtaseb T.R.A. Magee | 2008 | Chemical Engineering & Processing: Process Intensification2008，，1： | 2 |
| 4 | Moisture sorption isotherm characteristics of food products : A review显示文摘 | AI-MUHTASEB A H MCMINN W A M MAGEE T R A | 2002 | Food and Bioproducts Processing2002，80，2： | 1 |
| 5 | Carbetocin versus syn- tometrine for prevention of postpartum hemorrhage after cesarean section显示文摘 | Mohamed Maged A Ragab AS | 2016 | J Matern Fetal Neonatal Med2016，，： | 1 |
| 6 | Moisture Adsorption Behaviour of Oatmeal Biscuit and Oat Flakes显示文摘 | McMINN W A M McKEE D J MAGEE T R A | 2007 | Journal of Food Engineering2007，，79： | 1 |
| 7 | Dechlorination of PCB in the presence of plant nitrate reductase显示文摘 | MAGEE K D MICHAEL A ULLAH H | 2008 | Enviro Toxicol Pharmacol2008，25，： | 1 |
| 8 | Networkdesign for a grid hybrid transit servite 显示文摘 | Majid M A Quadrifoglio L Maged M D | 2004 | TransportationResearch Part A2004，38，1： | 1 |
| 9 | Effect of tea drinking on blood lipids,blood pressure and aspects of bowel habit显示文摘 | Bingham SA Vorster H Jerling JC Magee L Mulligan A Runswick S Cummings JH | | 0，，： | 1 |
| 10 | Microwave drying kinetics of tomato pomace: effect of osmotic dehydration 显示文摘 | HARAHSHEH M A MUHTASEB A H A MAGEE T R A | 2009 | Chemical Engineering and Processing2009，48，4： | 1 |
| 11 | Antibiotic prescribing and antibiotic resistance in community practice:retrospective study,1996-1998 显示文摘 | Magee J T Pritchard E L Fitzgerald K A | 1999 | Br Med J1999，319，： | 1 |
| 12 | Method for effective fluid diversion when performing a matrix acid stimulation in carbon- ate formations显示文摘 | MaGee J Buijse M A Pongratz R | 1997 | SPE1997，，： | 1 |
| 13 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 1 |
| 14 | Molecular cloning and characterization of mu-rine ICOS and identification of B7h as ICOS ligand显示文摘 | Mages H W Hutloff A Heuck C BiJchner K Himmelbauer H Oliveri F | 2000 | Eur J Immunol2000，30，： | 1 |
| 15 | Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand显示文摘 | Mages H W Hutloff A Heuck G | 2000 | Eur J Immunol2000，30，： | 1 |
| 16 | Expression of ICOS in vivo defines CD4 + effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10显示文摘 | L(o)hning M Hutloff A Kallinich T Mages H W Bonhagen K Radbruch A | 2003 | J Exp Med2003，197，： | 1 |
| 17 | Shrinkage characteristics of potatoes dehydrated under combined microwave and convective air conditions显示文摘 | Khraisheh M A M Cooper T J R Magee T R A | 1997 | J Drying Technology1997，15，34： | 1 |
| 18 | Safety and efficacy of sildenafil therapy in children with pulmonary hypertension显示文摘 | Karatza AA Bush A Magee AG | 2005 | Int J Cardiol2005，100，2： | 1 |
| 19 | Influence of excessive filler coating on the tensile properties of LDPE-calcium carbonate composites显示文摘 | Maged A Osman Ayman Atallah Ulrich W Suter | 2004 | Polymer2004，，45： | 1 |
| 20 | Transport of dissolved organic macromolecules and their effect on the transport of phenanthrene in porous media显示文摘 | Magee B R Lion L W Lemley A T 1991 | 1991 | Environ Sci Technol1991，15，： | 1 |
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