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| 1 | Functional findings in irritable bowel syndrome显示文摘IBS 的病理生理学复杂、仍然不完全地知道。中央、外部的因素,包括的精神分析聚会因素,反常官方补给的活动性和分泌物,和内脏的超敏性,被认为贡献 IBS 的症状。几研究在 IBS 病人表明了改变的官方补给的运动机能,模式基于占优势的肠模式在 IBS 亚群之间不同。很少研究到目前为止在 IBS 探讨了官方补给的分泌物,但是有一些证据,在 IBS 病人的小肠支持改变的分泌物。内脏的超敏性当前被认为也许是在 IBS 的最重要的 pathophysiological 因素。重要地,几个外部、内部的因素能调制内脏的敏感,以及官方补给的活动性,并且在官方补给的道以内提高应答的海角到例如,应力和营养素在 IBS 病人被表明了。今天 IBS 被看在之上,包含在伤寒的反常功能是所谓的大脑勇气轴的 dysregulation 的混乱,自治或中枢神经系统,与可能在一些病人并且在其它的从圆周的信号的扰乱的中央处理统治的外部改变。 | Iris Posserud Amanda Ersryd Magnus Simrén | 2006 | World Journal of Gastroenterology2006，12，18： | 9 |
| 2 | 包括岛国在内的东非的海岸带管理:问题和应对行动述评显示文摘东非和西印度洋岛国的海岸线绵延11000多km,其海岸带居住着3000万~3500万人。这是一个具有显著地理、生态和人文多样性差异的地区,海岸生境独特,生物多样性程度很高。但由于普遍的贫穷,再加上人口迅速增长、不适当或不良的发展部署以及缺乏综合规划管理等因素,已导致许多海岸地区的环境退化和资源耗竭,还伴随着各种利害关系牵连者之间的冲突日益增加。严重的海岸污染和生境破坏往往限于主要城市的附近地区。然而,这些影响正在向人口较稀少的地区逐渐扩展。海岸带综合管理(ICZM)在该地区已被承认为一种有效的资源管理方法,而且许多ICZM计划已经在区域、国家和地方各层次上启动。本文评述这些计划,特别要涉及最近的和正在进行的ICZM行动,它们是由瑞典国际开发署(SIDA)以及其他赞助者和联合国有关机构资助的。 | Christine A.Coughanowr Magnus N.Ngoile Olof Lindén 朱志辉 | 1995 | 人类环境杂志1995，24，7： | 2 |
| 3 | Long-term effects of hypnotherapy in patients with refractory irritable bowel syndrome显示文摘 | Perjohan Lindfors Peter Unge Henry Nyhlin Brjánn Ljótsson Einar S. Bj?rnsson Hasse Abrahamsson Magnus Simrén | 2012 | Scandinavian Journal of Gastroenterology2012，，4： | 2 |
| 4 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 5 | A pilot study of colonic B cell pattern in irritable bowel syndrome显示文摘 | Johan Forshammar Stefan Isaksson Hans Strid Per-Ove Stotzer Henrik Sj?vall Magnus Simrén Lena ?hman | 2008 | Scandinavian Journal of Gastroenterology2008，，12： | 1 |
| 6 | ProbabUis-tic modelling of CO2 corrosion laboratory data usingneural networks显示文摘 | NESIC S MAGNUS N NIGEL M | 2001 | Corrosion Science2001，43，7： | 1 |
| 7 | Lactoferrin inhibits human papillomavirus binding and uptake in vitro显示文摘 | Peter Drobni Jonas N' aslund Magnus Evander | 2004 | Antiviral Research2004，64，： | 1 |
| 8 | Innovation systems: analytical and methodological issues显示文摘 | Bo Carlsson Staffan Jacobsson Magnus Holmén Annika Rickne | 2002 | Research Policy2002，，2： | 1 |
| 9 | Antifouling agent release from marine coatings-ion pair formation/dissolution for controlled release显示文摘 | Paul H Camilla F Magnus N | 2006 | Prog Org Coat2006，57，377： | 1 |
| 10 | Microvesicles as me- diators of intercellular communication in cancer-the e- merging science of cellular debris 显示文摘 | Lee TH D'Asti E Magnus N | 2011 | Semin Immuno- pathol2011，33，5： | 1 |
| 11 | The tunneled supraclavicular island flap: an optimized technique for head and neck reconstruction 显示文摘 | Pallua N Magnus Noah E | 2000 | Plast Reconstr Surg2000，105，3： | 1 |
| 12 | Infliximab as Rescue Therapy in Severe to Moderately Severe Ulcerative Colitis: A Randomized, Placebo-Controlled Study显示文摘 | Gunnar J?rnerot Erik Hertervig Ingalill Friis-Liby Lars Blomquist Per Karlén Christer Gr?nn? Mogens Vilien Magnus Str?m ?ke Danielsson Hans Verbaan Per M. Hellstr?m Anders Magnuson Bengt Curman | 2005 | Gastroenterology2005，，7： | 1 |
| 13 | Genetic pathways linking hemostasis and cancer显示文摘 | Garnier D Magnus N D'Asti E | 2012 | Thromb Res2012，1291，： | 1 |
| 14 | Neural network based system identification toolbox 显示文摘 | MAGNUS N | 1997 | Technical University of Denmark1997，，： | 1 |
| 15 | Biliary drainage for obstructive jaundice enhances hepatic energy status in humans: a 31-phosphorus magnetic resonance spectroscopy study 显示文摘 | Mann DV Lam WW Magnus Hjelm N | 2002 | Gut2002，50，1： | 1 |
| 16 | Growth in a Dual Economy显示文摘 | BLOMSTROM MAGNUS EDWARD N WOLFF | 1997 | World Development1997，25，10： | 1 |
| 17 | Thermally expand- able microspheres with excellent expansion characteristics at high temperature 显示文摘 | MAGNUS J OVE N ANNA K | 2010 | J Appl Polym Sci2010，117，： | 1 |
| 18 | Microvesicles as mediators of intercellular communication in cancer-the emerging science of cellular 'debris' 显示文摘 | Lee TH D'Asti E Magnus N | 2011 | Semin Immunopathol2011，33，2： | 1 |
| 19 | Combined manganese/iron oxides as oxygen carrier for chemical looping combustion with oxygen uncoupling (CLOU) in a circulating fluidized bed reactor system显示文摘 | Magnus Rydén Anders Lyngfelt Tobias Mattisson | 2011 | Energy Procedia2011，，： | 1 |
| 20 | Spasticity After Stroke: Its Occurrence and Association With Motor Impairments and Activity Limitations显示文摘 | Disa K. Sommerfeld Elsy U.-B. Eek Anna-Karin Svensson Lotta Widén Holmqvist Magnus H. von Arbin | 2004 | Stroke: Journal of the American Heart Association2004，，1： | 1 |
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