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| 1 | Primary gastric mucosa associated lymphoid tissue lymphoma: Clinical data predicted treatment outcome显示文摘AIM: To determine clinical characteristics and treatment outcome of gastric lymphoma after chemotherapy and immuno-chemotherapy. METHODS: Thirty four patients with primary gastric mucosa associated lymphoid tissue (MALT) lymphoma (Ann Arbor stages Ⅰ to Ⅳ) were enrolled. All had upper gastric endoscopy, abdominal ultrasonography, CT and H pylori status assessment (histology and serology). After anti-H pylori treatment and initial chemotherapy, patients were re-examined every 4 mo. RESULTS: Histological regression of the lymphoma was complete in 22/34 (64.7%) and partial in 9 (26.5%) patients. Median follow up time for these 31 responders was 60 mo (range 48-120). No regression was noted in 3 patients. Among the 25 (73.5%) H pylori positive patients, the eradication rate was 100%.CONCLUSION: Using univariate analysis, predictive factors for overall survival were international prognostic index (IPI) score, hemoglobin level, erythrocyte sedimentation rate (ESR), and platelet numbers (P < 0.005). In addition to this, Cox proportion hazard model differentiate IPI score, ESR, and platelets as predictors of survival. | Milena Todorovic Bela Balint Miodrag Jevtic Nada Suvajdzic Amela Ceric Dragana Stamatovic Olivera Markovic Maja Perunicic Slobodan Marjanovic Miodrag Krstic | 2008 | World Journal of Gastroenterology2008，14，15： | 10 |
| 2 | Splenectomy with chemotherapy vs surgery alone as initial treatment for splenic marginal zone lymphoma显示文摘AIM:To evaluate the clinical characteristics of splenic marginal-zone lymphoma (SMZL) following antigen expression and the influence of therapeutic approaches on clinical outcome and overall survival (OS).METHODS: A total of 30 patients with typical histological and immunohistochemical SMZL patterns were examined. Splenectomy plus chemotherapy was applied in 20 patients, while splenectomy as a single treatment-option was performed in 10 patients. Prognostic factor and overall survival rate were analyzed.RESULTS: Complete remission (CR) was achieved in 20 (66.7%), partial remission (PR) in seven (23.3%), and lethal outcome due to disease progression occurred in three (10.0%) patients. Median survival of patients with a splenectomy was 93.0 mo and for patients with splenectomy plus chemotherapy it was 107.5 mo (Log rank=0.056, P>0.05). Time from onset of first symptoms to the beginning of the treatment (mean 9.4 mo) was influenced by spleen dimensions, as measured by computerized tomography and ultra-sound (t=2.558, P=0.018). Strong positivity (+++) of CD20 antigen expression in splenic tissue had a positive influence on OS (Log rank=5.244, P<0.05). The analysis of factors interfering with survival (by the Kaplan-Meier method) revealed that gender, general symptoms, clinical stage, and spleen infiltration type (nodular vs diffuse) had no significant (P>0.05) effects on the OS. The expression of other antigens (immunohistochemistry) also had no effect on survival-rate, as measured by a χ2 test (P>0.05).CONCLUSION: Initial splenectomy combined with chemotherapy has been shown to be beneficial due to its advanced remission rate/duration; however, a larger controlled clinical study is required to conf irm our findings. | Rajko Milosevic Milena Todorovic Bela Balint Miodrag Jevtic Miodrag Krstic Elizabeta Ristanovic Nebojsa Antonijevic Mirjana Pavlovic Maja Perunicic Milan Petrovic Biljana Mihaljevic | 2009 | World Journal of Gastroenterology2009，15，32： | 2 |
| 3 | Unusual presentation of gastric plasmablastic lymphoma in HIV-negative patient显示文摘 | Biljana Mihaljevic Milena Todorovic Bosko Andjelic Darko Antic Maja Perunicic Jovanovic | 2012 | Medical Oncology2012，，2： | 1 |
| 4 | Clinical characteristics of patients with lymphoproliferative neoplasms in the setting of systemic autoimmune diseases显示文摘 | Nada Suvajdzic Predrag Djurdjevic Milena Todorovic Maja Perunicic Roksanda Stojanovi? Aleksandra Novkovic Biljana Mihaljevic | 2012 | Medical Oncology2012，，3： | 1 |
| 5 | Is there a “gold” standard treatment for patients with isolated myeloid sarcoma?显示文摘 | Darko Antic Ivo Elezovic Natasa Milic Nada Suvajdzic Ana Vidovic Maja Perunicic Irena Djunic Mirjana Mitrovic Dragica Tomin | 2012 | Biomedicine & Pharmacotherapy2012，，： | 1 |
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