|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein显示文摘AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML). METHODS: The role of p53 and PML in regulating cy-totoxicity and gene transfer mediated by wild-type (wt) PV H-1 were explored in two pairs of isogenic human hepatoma cell lines with different p53 status. Further-more,H-1 PV infection was combined with cytostatic drug treatment. RESULTS: While the HCC cells with different p53 status studied were all susceptible to H-1 PV-induced apoptosis,the cytotoxicity of H-1 PV was morepronounced in p53-negative than in p53-positive cells. Apoptosis rates in p53-negative cell lines treated by genotoxic drugs were further enhanced by a treatment with H-1 PV. In flow cytometric analyses,H-1 PV infection resulted in a reduction of the mitochondrial transmembrane potential. In addition,H-1 PV cells showed a significant increase in PML expression. Knocking down PML expression resulted in a striking reduction of the level of H-1 PV infected tumor cell death. CONCLUSION: H-1 PV is a suitable agent to circumvent the resistance of p53-negative HCC cells to genotoxic agents,and it enhances the apoptotic process which is dependent on functional PML. Thus,H-1 PV and its oncolytic vector derivatives may be considered as therapeutic options for HCC,particularly for p53-negative tumors. | Maike Sieben Kerstin Herzer Maja Zeidler Vera Heinrichs Barbara Leuchs Martin Schuler Jan J Cornelis Peter R Galle Jean Rommelaere Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 2 |
| 2 | Development of a yield monito- ring system for citrus mechanical harvesting machines 显示文摘 | Maja J M Ehsani R | 2010 | Precision Agriculttre2010，11，5： | 1 |
| 3 | Hh-Gli signaling pathway functions and its therapeutic potential in cancer显示文摘 | Sonja L Maja R Vasna M | 2008 | Croat Chem Aeta2008，81，1： | 1 |
| 4 | Bacterial colonization and in- fection of electrophysiological cardiac devices detected with sonica- tion and swab culture显示文摘 | Martin R Maja W Richard K | 2010 | Circulation2010，121，： | 1 |
| 5 | A fuzzy habitat suitability index forPopulus euphratica in the Northern Amudarya delta(Uzbekistan)显示文摘 | NADJA R MAJA S MICHAEL M | 2005 | Ec-ological Modelling2005，184，： | 1 |
| 6 | Toward a Biochmical Understanding of human Intervertebral Disc Degeneration and Herniation,Contributions of NitricOxider,Interleukins,Prostaglandin E2,and Matrix Metalloproteinases显示文摘 | James D K Maja S R McLntyre L A | 1997 | Spine1997，22，10： | 1 |
| 7 | Familial Chilblain Lupus, a Monogenic Form of Cutaneous Lupus Erythematosus, Maps to Chromosome 3p显示文摘 | Min Ae Lee-Kirsch Maolian Gong Herbert Schulz Franz Rüschendorf Annette Stein Christiane Pfeiffer Annalisa Ballarini Manfred Gahr Norbert Hubner Maja Linné | 2006 | The American Journal of Human Genetics2006，，： | 1 |
| 8 | Two fruit counting techniques for citrus mechanical harvesting machinery显示文摘 | Ehsani M R Grift T E Maja J M | 2009 | Computers and Electronics in Agriculture2009，65，2： | 1 |
| 9 | Development of a yield monitoring system for citrus mechanical harvesting machines显示文摘 | Maja M Ehsani R | 2010 | Precision Agriculture2010，11，5： | 1 |
| 10 | A fuzzy habitat suitability index for Popu- lus euphratica in the Northern Amud-arya delta (Uzbekistan) 显示文摘 | NADJA R MAJA S MICHAEL M | 2005 | Ecological Modelling2005，184，： | 1 |
| 11 | Toward a biochemical understanding of human intervertebral disc degeneration and herniation显示文摘 | JAMES D K MAJA S R MCLNTYRE B S | 1997 | Spine1997，22，10： | 1 |
| 12 | Thermore- sponsive Polymers: Insights into Decisive Hydrogel Characteristics, Mechanisms of Gelation, and Prom- ising Biomedical Applications 显示文摘 | MAJA R M JULIJANA K PEGI A G | 2014 | Int J Pharm2014，，472： | 1 |
| 13 | Toward:a biochemical under- standing of human intervertebral disc degeneration and herniation 显示文摘 | James D K Maja S R Lori A M | 1997 | Spine1997，22，10： | 1 |
| 14 | Potato cysteine proteinase inhibitor gene family:molecular cloning,chatracterization and immunocytochemical localization studies显示文摘 | Kristina G Borut S Maja R | 1997 | Plant Molecular Biology1997，34，2： | 1 |
| 15 | Three-dimensional volume- rendered helical CT before laparoscopic adrenalectomy 显示文摘 | MAJA E BRIAN R ERICK M | 2003 | Radiology2003，229，3： | 1 |
| 16 | Fast purification of the filamentous potato virus Y using monolithic chromatographic supports显示文摘 | MATEVZ R MAJA R MAGDA T Z | 2013 | Journal of Chromatography A2013，1272，： | 1 |
| 17 | Prophylactic DNA immunization against multiple papillomavirus types 显示文摘 | Maja G Ivonne R Nadja CA | 2007 | Vaccine2007，25，23： | 1 |
| 18 | Toward a biochemical understanding of human intervertebral dics degeneration and herniation显示文摘 | James D K Majas R Lori A M | 1997 | Spine1997，22，10： | 1 |
| 19 | Changes in sensory properties and consumer acceptance of reduced fat pork Lyon-style and liver sausages containing inulin and citrus fiber as fat replacers显示文摘 | MAJA TOMASCHUNAS M ZRB R FISCHER J | 2013 | Meat Science2013，95，3： | 1 |
| 20 | Prophylactic DNA immunization against multiple papillomavirus types显示文摘 | MAJA G IVONNE R NADJA C A | 2007 | Vaccine2007，25，23： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员